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Volumn 30, Issue 2, 2012, Pages 302-308

Cyclosporine A inhibits breast cancer cell growth by downregulating the expression of pyruvate kinase subtype M2

Author keywords

Adenosine triphosphate; Breast cancer cells; Cyclosporine A; Pyruvate kinase M2

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYCLOSPORIN A; PYRUVATE KINASE; PYRUVATE KINASE M2; UNCLASSIFIED DRUG;

EID: 84863552719     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2012.989     Document Type: Article
Times cited : (57)

References (33)
  • 1
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O: On the origin of cancer cells. Science 123: 309-314, 1956.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 2
    • 23044500915 scopus 로고    scopus 로고
    • Pyruvate kinase type M2 and its role in tumor growth and spreading
    • Mazurek S, Boschek CB, Hugo F, et al: Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin Cancer Biol 15: 300-308, 2005.
    • (2005) Semin Cancer Biol , vol.15 , pp. 300-308
    • Mazurek, S.1    Boschek, C.B.2    Hugo, F.3
  • 3
    • 82755166890 scopus 로고    scopus 로고
    • Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses
    • Anastasiou D, Poulogiannis G, Asara JM, et al: Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science 334: 1278-1283, 2011.
    • (2011) Science , vol.334 , pp. 1278-1283
    • Anastasiou, D.1    Poulogiannis, G.2    Asara, J.M.3
  • 4
    • 84856913587 scopus 로고    scopus 로고
    • Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression
    • Jan 23, (Epub ahead of print). doi: 10.1084/jem.20111487
    • Goldberg MS and Sharp PA: Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression. J Exp Med: Jan 23, 2012 (Epub ahead of print). doi: 10.1084/jem.20111487.
    • (2012) J Exp Med
    • Goldberg, M.S.1    Sharp, P.A.2
  • 5
    • 82555170271 scopus 로고    scopus 로고
    • Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation
    • Yang W, Xia Y, Ji H, et al: Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation. Nature 480: 118-122, 2011.
    • (2011) Nature , vol.480 , pp. 118-122
    • Yang, W.1    Xia, Y.2    Ji, H.3
  • 6
    • 40749163248 scopus 로고    scopus 로고
    • The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
    • Christofk HR, Vander Heiden MG, Harris MH, et al: The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 452: 230-233, 2008.
    • (2008) Nature , vol.452 , pp. 230-233
    • Christofk, H.R.1    Vander Heiden, M.G.2    Harris, M.H.3
  • 7
    • 40749099894 scopus 로고    scopus 로고
    • Pyruvate kinase M2 is a phosphotyrosine-binding protein
    • Christofk HR, Vander Heiden MG, Wu N, et al: Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature 452: 181-186, 2008.
    • (2008) Nature , vol.452 , pp. 181-186
    • Christofk, H.R.1    Vander Heiden, M.G.2    Wu, N.3
  • 8
    • 7944226627 scopus 로고    scopus 로고
    • Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes
    • Altenberg B and Greulich KO: Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes. Genomics 84: 1014-1020, 2004.
    • (2004) Genomics , vol.84 , pp. 1014-1020
    • Altenberg, B.1    Greulich, K.O.2
  • 9
    • 0027418815 scopus 로고
    • Human P-glycoprotein transports cyclosporin A and FK506
    • Saeki T, Ueda K, Tanigawara Y, et al: Human P-glycoprotein transports cyclosporin A and FK506. J Biol Chem 268: 6077-6080, 1993.
    • (1993) J Biol Chem , vol.268 , pp. 6077-6080
    • Saeki, T.1    Ueda, K.2    Tanigawara, Y.3
  • 10
    • 0034456656 scopus 로고    scopus 로고
    • Multidrug resistance transporters and modulation
    • Tan B, Piwnica-Worms D and Ratner L: Multidrug resistance transporters and modulation. Curr Opin Oncol 12: 450-458, 2000.
    • (2000) Curr Opin Oncol , vol.12 , pp. 450-458
    • Tan, B.1    Piwnica-Worms, D.2    Ratner, L.3
  • 11
    • 4243091738 scopus 로고    scopus 로고
    • Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring
    • Englund G, Hallberg P, Artursson P, et al: Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring. BMC Med 2: 8, 2004.
    • (2004) BMC Med , vol.2 , pp. 8
    • Englund, G.1    Hallberg, P.2    Artursson, P.3
  • 12
    • 3843151567 scopus 로고    scopus 로고
    • Effect of cyclosporine A on the tissue distribution and pharmacokinetics of etoposide
    • Carcel-Trullols J, Torres-Molina F, Araico A, et al: Effect of cyclosporine A on the tissue distribution and pharmacokinetics of etoposide. Cancer Chemother Pharmacol 54: 153-160, 2004.
    • (2004) Cancer Chemother Pharmacol , vol.54 , pp. 153-160
    • Carcel-Trullols, J.1    Torres-Molina, F.2    Araico, A.3
  • 13
    • 34047109147 scopus 로고    scopus 로고
    • Interactions of cyclosporin A with breast cancer resistance protein
    • Xia CQ, Liu N, Miwa GT, et al: Interactions of cyclosporin A with breast cancer resistance protein. Drug Metab Dispos 35: 576-582, 2007.
    • (2007) Drug Metab Dispos , vol.35 , pp. 576-582
    • Xia, C.Q.1    Liu, N.2    Miwa, G.T.3
  • 14
    • 0027076340 scopus 로고
    • Characterization of normal breast epithelial cells in primary cultures: Differentiation and growth factor receptors studies
    • Berthon P, Pancino G, de Cremoux P, et al: Characterization of normal breast epithelial cells in primary cultures: differentiation and growth factor receptors studies. In Vitro Cell Dev Biol 28A: 716-724, 1992.
    • (1992) In Vitro Cell Dev Biol , vol.28 A , pp. 716-724
    • Berthon, P.1    Pancino, G.2    De Cremoux, P.3
  • 15
    • 42149109109 scopus 로고    scopus 로고
    • Integrin beta 1 regulates phagosome maturation in macrophages through Rac expression
    • Wang QQ, Li H, Oliver T, et al: Integrin beta 1 regulates phagosome maturation in macrophages through Rac expression. J Immunol 180: 2419-2428, 2008.
    • (2008) J Immunol , vol.180 , pp. 2419-2428
    • Wang, Q.Q.1    Li, H.2    Oliver, T.3
  • 16
    • 79958099199 scopus 로고    scopus 로고
    • MicroRNA-98 negatively regulates IL-10 production and endotoxin tolerance in macrophages after LPS stimulation
    • Liu Y, Chen Q, Song Y, et al: MicroRNA-98 negatively regulates IL-10 production and endotoxin tolerance in macrophages after LPS stimulation. FEBS Lett 585: 1963-1968, 2011.
    • (2011) FEBS Lett , vol.585 , pp. 1963-1968
    • Liu, Y.1    Chen, Q.2    Song, Y.3
  • 17
    • 21844468220 scopus 로고    scopus 로고
    • Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
    • Dombrauckas JD, Santarsiero BD and Mesecar AD: Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis. Biochemistry 44: 9417-9429, 2005.
    • (2005) Biochemistry , vol.44 , pp. 9417-9429
    • Dombrauckas, J.D.1    Santarsiero, B.D.2    Mesecar, A.D.3
  • 18
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25: 402-408, 2001.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 19
    • 0242709362 scopus 로고    scopus 로고
    • Bioluminescence ATP monitoring as a surrogate marker for microbial load on hands and surfaces in the home
    • Larson EL, Aiello AE, Gomez-Duarte C, et al: Bioluminescence ATP monitoring as a surrogate marker for microbial load on hands and surfaces in the home. Food Microbiol 20: 735-739, 2003.
    • (2003) Food Microbiol , vol.20 , pp. 735-739
    • Larson, E.L.1    Aiello, A.E.2    Gomez-Duarte, C.3
  • 20
    • 0032432557 scopus 로고    scopus 로고
    • Use of intracellular pH and annexin-V flow cytometric assays to monitor apoptosis and its suppression by bcl-2 over-expression in hybridoma cell culture
    • Ishaque A and Al-Rubeai M: Use of intracellular pH and annexin-V flow cytometric assays to monitor apoptosis and its suppression by bcl-2 over-expression in hybridoma cell culture. J Immunol Methods 221: 43-57, 1998.
    • (1998) J Immunol Methods , vol.221 , pp. 43-57
    • Ishaque, A.1    Al-Rubeai, M.2
  • 21
    • 0030900980 scopus 로고    scopus 로고
    • Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis
    • Leist M, Single B, Castoldi AF, et al: Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. J Exp Med 185: 1481-1486, 1997.
    • (1997) J Exp Med , vol.185 , pp. 1481-1486
    • Leist, M.1    Single, B.2    Castoldi, A.F.3
  • 22
    • 33744969828 scopus 로고    scopus 로고
    • Energy deregulation: Licensing tumors to grow
    • Garber K: Energy deregulation: licensing tumors to grow. Science 312: 1158-1159, 2006.
    • (2006) Science , vol.312 , pp. 1158-1159
    • Garber, K.1
  • 23
    • 0024166362 scopus 로고
    • Human M2-type pyruvate kinase: CDNA cloning, chromosomal assignment and expression in hepatoma
    • Tani K, Yoshida MC, Satoh H, et al: Human M2-type pyruvate kinase: cDNA cloning, chromosomal assignment and expression in hepatoma. Gene 73: 509-516, 1988.
    • (1988) Gene , vol.73 , pp. 509-516
    • Tani, K.1    Yoshida, M.C.2    Satoh, H.3
  • 24
    • 0033574227 scopus 로고    scopus 로고
    • Regulation of pyruvate kinase M gene expression
    • Yamada K and Noguchi T: Regulation of pyruvate kinase M gene expression. Biochem Biophys Res Commun 256: 257-262, 1999.
    • (1999) Biochem Biophys Res Commun , vol.256 , pp. 257-262
    • Yamada, K.1    Noguchi, T.2
  • 25
    • 84865334837 scopus 로고    scopus 로고
    • Diagnostic value of fecal tumor M2-pyruvate kinase for CRC screening: A systematic review and meta-analysis
    • Jan 19, (Epub ahead of print). doi: 10.1002/ijc.27442
    • Li R, Liu J, Xue H, et al: Diagnostic value of fecal tumor M2-pyruvate kinase for CRC screening: A systematic review and meta-analysis. Int J Cancer: Jan 19, 2012 (Epub ahead of print). doi: 10.1002/ijc.27442.
    • (2012) Int J Cancer
    • Li, R.1    Liu, J.2    Xue, H.3
  • 26
    • 0034451876 scopus 로고    scopus 로고
    • Comparison of the tumor markers tumor M2-PK, CEA, CYFRA 21-1, NSE and SCC in the diagnosis of lung cancer
    • Schneider J, Velcovsky HG, Morr H, et al: Comparison of the tumor markers tumor M2-PK, CEA, CYFRA 21-1, NSE and SCC in the diagnosis of lung cancer. Anticancer Res 20: 5053-5058, 2000.
    • (2000) Anticancer Res , vol.20 , pp. 5053-5058
    • Schneider, J.1    Velcovsky, H.G.2    Morr, H.3
  • 27
    • 0842300413 scopus 로고    scopus 로고
    • Comparison of tumor M2-pyruvate kinase (tumor M2-PK), carcinoembryonic antigen (CEA), carbohydrate antigens CA 19-9 and CA 72-4 in the diagnosis of gastrointestinal cancer
    • Schneider J and Schulze G: Comparison of tumor M2-pyruvate kinase (tumor M2-PK), carcinoembryonic antigen (CEA), carbohydrate antigens CA 19-9 and CA 72-4 in the diagnosis of gastrointestinal cancer. Anticancer Res 23: 5089-5093, 2003.
    • (2003) Anticancer Res , vol.23 , pp. 5089-5093
    • Schneider, J.1    Schulze, G.2
  • 28
    • 33747616250 scopus 로고    scopus 로고
    • Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway
    • Buchholz M, Schatz A, Wagner M, et al: Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway. EMBO J 25: 3714-3724, 2006.
    • (2006) EMBO J , vol.25 , pp. 3714-3724
    • Buchholz, M.1    Schatz, A.2    Wagner, M.3
  • 29
    • 69749097044 scopus 로고    scopus 로고
    • Cyclosporine A inhibits colorectal cancer proliferation probably by regulating expression levels of c-Myc, p21(WAF1/CIP1) and proliferating cell nuclear antigen
    • Masuo T, Okamura S, Zhang Y, et al: Cyclosporine A inhibits colorectal cancer proliferation probably by regulating expression levels of c-Myc, p21(WAF1/CIP1) and proliferating cell nuclear antigen. Cancer Lett 285: 66-72, 2009.
    • (2009) Cancer Lett , vol.285 , pp. 66-72
    • Masuo, T.1    Okamura, S.2    Zhang, Y.3
  • 30
    • 0035929325 scopus 로고    scopus 로고
    • Structural and functional linkages between subunit interfaces in mammalian pyruvate kinase
    • Wooll JO, Friesen RH, White MA, et al: Structural and functional linkages between subunit interfaces in mammalian pyruvate kinase. J Mol Biol 312: 525-540, 2001.
    • (2001) J Mol Biol , vol.312 , pp. 525-540
    • Wooll, J.O.1    Friesen, R.H.2    White, M.A.3
  • 31
    • 37849026029 scopus 로고    scopus 로고
    • Regulatory T cells and tumour immunity - Observations in mice and men
    • Gallimore A and Godkin A: Regulatory T cells and tumour immunity - observations in mice and men. Immunology 123: 157-163, 2008.
    • (2008) Immunology , vol.123 , pp. 157-163
    • Gallimore, A.1    Godkin, A.2
  • 32
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel TJ, Coukos G, Zou L, et al: Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 10: 942-949, 2004.
    • (2004) Nat Med , vol.10 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3
  • 33
    • 33746228122 scopus 로고    scopus 로고
    • FOXP3 controls regulatory T cell function through cooperation with NFAT
    • Wu Y, Borde M, Heissmeyer V, et al: FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 126: 375-387, 2006.
    • (2006) Cell , vol.126 , pp. 375-387
    • Wu, Y.1    Borde, M.2    Heissmeyer, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.