메뉴 건너뛰기




Volumn 167, Issue , 2016, Pages 231-250

Checkpoint blockade for the treatment of advanced melanoma

Author keywords

Immune checkpoint; Immune related adverse events; Immune related response criteria; Immunotherapy; Melanoma

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; DACARBAZINE; IPILIMUMAB; NIVOLUMAB; PROGRAMMED CELL DEATH 1 RECEPTOR ANTIBODY; RECEPTOR ANTIBODY; TUMOR MARKER; UNCLASSIFIED DRUG; ANTIBODY; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; PROGRAMMED DEATH 1 RECEPTOR;

EID: 84948807267     PISSN: 09273042     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-319-22539-5_9     Document Type: Chapter
Times cited : (39)

References (112)
  • 1
    • 0023270567 scopus 로고
    • A new member of the immunoglobulin superfamily–CTLA-4
    • Brunet JF, Denizot F, Luciani MF et al (1987) A new member of the immunoglobulin superfamily–CTLA-4. Nature 328(6127):267–270
    • (1987) Nature , vol.328 , Issue.6127 , pp. 267-270
    • Brunet, J.F.1    Denizot, F.2    Luciani, M.F.3
  • 2
    • 0029120245 scopus 로고
    • CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
    • Krummel MF, Allison JP (1995) CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med 182(2):459–465
    • (1995) J Exp Med , vol.182 , Issue.2 , pp. 459-465
    • Krummel, M.F.1    Allison, J.P.2
  • 3
    • 0030694234 scopus 로고    scopus 로고
    • The emerging role of CTLA-4 as an immune attenuator
    • Thompson CB, Allison JP (1997) The emerging role of CTLA-4 as an immune attenuator. Immunity 7(4):445–450
    • (1997) Immunity , vol.7 , Issue.4 , pp. 445-450
    • Thompson, C.B.1    Allison, J.P.2
  • 4
    • 0028484545 scopus 로고
    • CTLA-4 can function as a negative regulator of T cell activation
    • Walunas TL, Lenschow DJ, Bakker CY et al (1994) CTLA-4 can function as a negative regulator of T cell activation. Immunity 1(5):405–413
    • (1994) Immunity , vol.1 , Issue.5 , pp. 405-413
    • Walunas, T.L.1    Lenschow, D.J.2    Bakker, C.Y.3
  • 6
    • 0029899783 scopus 로고    scopus 로고
    • CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
    • Krummel MF, Allison JP (1996) CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J Exp Med 183(6):2533–2540
    • (1996) J Exp Med , vol.183 , Issue.6 , pp. 2533-2540
    • Krummel, M.F.1    Allison, J.P.2
  • 7
    • 0029953858 scopus 로고    scopus 로고
    • CTLA-4 ligation blocks CD28-dependent T cell activation
    • Walunas TL, Bakker CY, Bluestone JA (1996) CTLA-4 ligation blocks CD28-dependent T cell activation. J Exp Med 183(6):2541–2550
    • (1996) J Exp Med , vol.183 , Issue.6 , pp. 2541-2550
    • Walunas, T.L.1    Bakker, C.Y.2    Bluestone, J.A.3
  • 10
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
    • Waterhouse P, Penninger JM, Timms E et al (1995) Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270(5238):985–988
    • (1995) Science , vol.270 , Issue.5238 , pp. 985-988
    • Waterhouse, P.1    Penninger, J.M.2    Timms, E.3
  • 11
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH (1995) Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3(5):541–547
    • (1995) Immunity , vol.3 , Issue.5 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3    Lynch, W.P.4    Bluestone, J.A.5    Sharpe, A.H.6
  • 12
    • 0031405867 scopus 로고    scopus 로고
    • Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells
    • Chambers CA, Sullivan TJ, Allison JP (1997) Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells. Immunity 7 (6):885–895
    • (1997) Immunity , vol.7 , Issue.6 , pp. 885-895
    • Chambers, C.A.1    Sullivan, T.J.2    Allison, J.P.3
  • 13
    • 0028867835 scopus 로고
    • Manipulation of costimulatory signals to enhance antitumor T-cell responses
    • Allison JP, Hurwitz AA, Leach DR (1995) Manipulation of costimulatory signals to enhance antitumor T-cell responses. Curr Opin Immunol 7(5):682–686
    • (1995) Curr Opin Immunol , vol.7 , Issue.5 , pp. 682-686
    • Allison, J.P.1    Hurwitz, A.A.2    Leach, D.R.3
  • 14
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • Leach DR, Krummel MF, Allison JP (1996) Enhancement of antitumor immunity by CTLA-4 blockade. Science 271(5256):1734–1736
    • (1996) Science , vol.271 , Issue.5256 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 15
    • 0030743846 scopus 로고    scopus 로고
    • Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer
    • Kwon ED, Hurwitz AA, Foster BA et al (1997) Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer. Proc Natl Acad Sci USA 94 (15):8099–8103
    • (1997) Proc Natl Acad Sci USA , vol.94 , Issue.15 , pp. 8099-8103
    • Kwon, E.D.1    Hurwitz, A.A.2    Foster, B.A.3
  • 16
    • 0030853610 scopus 로고    scopus 로고
    • Enhanced induction of antitumor T-cell responses by cytotoxic T lymphocyte-associated molecule-4 blockade: The effect is manifested only at the restricted tumor-bearing stages
    • Yang YF, Zou JP, Mu J et al (1997) Enhanced induction of antitumor T-cell responses by cytotoxic T lymphocyte-associated molecule-4 blockade: the effect is manifested only at the restricted tumor-bearing stages. Cancer Res 57(18):4036–4041
    • (1997) Cancer Res , vol.57 , Issue.18 , pp. 4036-4041
    • Yang, Y.F.1    Zou, J.P.2    Mu, J.3
  • 17
    • 0033213599 scopus 로고    scopus 로고
    • CTLA-4 blockade reverses CD8+ T cell tolerance to tumor by a CD4+ T cell- and IL-2-dependent mechanism
    • Shrikant P, Khoruts A, Mescher MF (1999) CTLA-4 blockade reverses CD8+ T cell tolerance to tumor by a CD4+ T cell- and IL-2-dependent mechanism. Immunity 11(4):483– 493
    • (1999) Immunity , vol.11 , Issue.4 , pp. 483-493
    • Shrikant, P.1    Khoruts, A.2    Mescher, M.F.3
  • 18
    • 0033613173 scopus 로고    scopus 로고
    • In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance
    • Sotomayor EM, Borrello I, Tubb E, Allison JP, Levitsky HI (1999) In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance. Proc Natl Acad Sci USA 96(20):11476–11481
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.20 , pp. 11476-11481
    • Sotomayor, E.M.1    Borrello, I.2    Tubb, E.3    Allison, J.P.4    Levitsky, H.I.5
  • 19
    • 84878936788 scopus 로고    scopus 로고
    • Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells
    • Selby MJ, Engelhardt JJ, Quigley M et al (2013) Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells. Cancer immunology research 1(1):32–42
    • (2013) Cancer Immunology Research , vol.1 , Issue.1 , pp. 32-42
    • Selby, M.J.1    Engelhardt, J.J.2    Quigley, M.3
  • 20
    • 84884271914 scopus 로고    scopus 로고
    • Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma
    • Simpson TR, Li F, Montalvo-Ortiz W et al (2013) Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. J Exp Med 210(9):1695–1710
    • (2013) J Exp Med , vol.210 , Issue.9 , pp. 1695-1710
    • Simpson, T.R.1    Li, F.2    Montalvo-Ortiz, W.3
  • 21
    • 68149155982 scopus 로고    scopus 로고
    • Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies
    • Peggs KS, Quezada SA, Chambers CA, Korman AJ, Allison JP (2009) Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. J Exp Med 206(8):1717–1725
    • (2009) J Exp Med , vol.206 , Issue.8 , pp. 1717-1725
    • Peggs, K.S.1    Quezada, S.A.2    Chambers, C.A.3    Korman, A.J.4    Allison, J.P.5
  • 22
    • 0033592924 scopus 로고    scopus 로고
    • Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy
    • Kwon ED, Foster BA, Hurwitz AA et al (1999) Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy. Proc Natl Acad Sci USA 96(26):15074–15079
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.26 , pp. 15074-15079
    • Kwon, E.D.1    Foster, B.A.2    Hurwitz, A.A.3
  • 23
    • 69949085196 scopus 로고    scopus 로고
    • Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody
    • Dewan MZ, Galloway AE, Kawashima N et al (2009) Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody. Clin Cancer Res 15(17):5379–5388
    • (2009) Clin Cancer Res , vol.15 , Issue.17 , pp. 5379-5388
    • Dewan, M.Z.1    Galloway, A.E.2    Kawashima, N.3
  • 24
    • 12244252335 scopus 로고    scopus 로고
    • Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer
    • Demaria S, Kawashima N, Yang AM et al (2005) Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer. Clin Cancer Res 11(2 Pt 1):728–734
    • (2005) Clin Cancer Res , vol.11 , Issue.2 , pp. 728-734
    • Demaria, S.1    Kawashima, N.2    Yang, A.M.3
  • 25
    • 0032404099 scopus 로고    scopus 로고
    • Realization of the therapeutic potential of CTLA-4 blockade in low-dose chemotherapy-treated tumor-bearing mice
    • Mokyr MB, Kalinichenko T, Gorelik L, Bluestone JA (1998) Realization of the therapeutic potential of CTLA-4 blockade in low-dose chemotherapy-treated tumor-bearing mice. Cancer Res 58(23):5301–5304
    • (1998) Cancer Res , vol.58 , Issue.23 , pp. 5301-5304
    • Mokyr, M.B.1    Kalinichenko, T.2    Gorelik, L.3    Bluestone, J.A.4
  • 26
    • 33749353175 scopus 로고    scopus 로고
    • Efficient loading of dendritic cells following cryo and radiofrequency ablation in combination with immune modulation induces anti-tumour immunity
    • den Brok MH, Sutmuller RP, Nierkens S et al (2006) Efficient loading of dendritic cells following cryo and radiofrequency ablation in combination with immune modulation induces anti-tumour immunity. Br J Cancer 95(7):896–905
    • (2006) Br J Cancer , vol.95 , Issue.7 , pp. 896-905
    • Den Brok, M.H.1    Sutmuller, R.P.2    Nierkens, S.3
  • 27
    • 11144353596 scopus 로고    scopus 로고
    • CTLA-4 blockade in combination with xenogeneic DNA vaccines enhances T-cell responses, tumor immunity and autoimmunity to self antigens in animal and cellular model systems
    • Gregor PD, Wolchok JD, Ferrone CR et al (2004) CTLA-4 blockade in combination with xenogeneic DNA vaccines enhances T-cell responses, tumor immunity and autoimmunity to self antigens in animal and cellular model systems. Vaccine 22(13–14):1700–1708
    • (2004) Vaccine , vol.22 , Issue.13-14 , pp. 1700-1708
    • Gregor, P.D.1    Wolchok, J.D.2    Ferrone, C.R.3
  • 28
    • 0032544067 scopus 로고    scopus 로고
    • CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma
    • Hurwitz AA, Yu TF, Leach DR, Allison JP (1998) CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma. Proc Natl Acad Sci USA 95(17):10067–10071
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.17 , pp. 10067-10071
    • Hurwitz, A.A.1    Yu, T.F.2    Leach, D.R.3    Allison, J.P.4
  • 29
    • 0033517152 scopus 로고    scopus 로고
    • Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation
    • van Elsas A, Hurwitz AA, Allison JP (1999) Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. J Exp Med 190(3):355–366
    • (1999) J Exp Med , vol.190 , Issue.3 , pp. 355-366
    • van Elsas, A.1    Hurwitz, A.A.2    Allison, J.P.3
  • 30
    • 17944364189 scopus 로고    scopus 로고
    • Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: Comparison of prophylaxis and therapy
    • van Elsas A, Sutmuller RP, Hurwitz AA et al (2001) Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy. J Exp Med 194(4):481–489
    • (2001) J Exp Med , vol.194 , Issue.4 , pp. 481-489
    • van Elsas, A.1    Sutmuller, R.P.2    Hurwitz, A.A.3
  • 31
    • 0034194329 scopus 로고    scopus 로고
    • Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade
    • Hurwitz AA, Foster BA, Kwon ED et al (2000) Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade. Cancer Res 60 (9):2444–2448
    • (2000) Cancer Res , vol.60 , Issue.9 , pp. 2444-2448
    • Hurwitz, A.A.1    Foster, B.A.2    Kwon, E.D.3
  • 33
    • 70350234739 scopus 로고    scopus 로고
    • Tumor vaccines expressing flt3 ligand synergize with ctla-4 blockade to reject preimplanted tumors
    • Curran MA, Allison JP (2009) Tumor vaccines expressing flt3 ligand synergize with ctla-4 blockade to reject preimplanted tumors. Cancer Res 69(19):7747–7755
    • (2009) Cancer Res , vol.69 , Issue.19 , pp. 7747-7755
    • Curran, M.A.1    Allison, J.P.2
  • 34
    • 29844436043 scopus 로고    scopus 로고
    • The effect of a therapeutic dendritic cell-based cancer vaccination depends on the blockage of CTLA-4 signaling
    • Met O, Wang M, Pedersen AE, Nissen MH, Buus S, Claesson MH (2006) The effect of a therapeutic dendritic cell-based cancer vaccination depends on the blockage of CTLA-4 signaling. Cancer Lett 231(2):247–256
    • (2006) Cancer Lett , vol.231 , Issue.2 , pp. 247-256
    • Met, O.1    Wang, M.2    Pedersen, A.E.3    Nissen, M.H.4    Buus, S.5    Claesson, M.H.6
  • 35
    • 3442883353 scopus 로고    scopus 로고
    • Two distinct pathways of immuno-modulation improve potency of p53 immunization in rejecting established tumors
    • Daftarian P, Song GY, Ali S et al (2004) Two distinct pathways of immuno-modulation improve potency of p53 immunization in rejecting established tumors. Cancer Res 64 (15):5407–5414
    • (2004) Cancer Res , vol.64 , Issue.15 , pp. 5407-5414
    • Daftarian, P.1    Song, G.Y.2    Ali, S.3
  • 36
    • 0038745486 scopus 로고    scopus 로고
    • Generation of antitumor immunity by cytotoxic T lymphocyte epitope peptide vaccination, CpG-oligodeoxynucleotide adjuvant, and CTLA-4 blockade
    • Davila E, Kennedy R, Celis E (2003) Generation of antitumor immunity by cytotoxic T lymphocyte epitope peptide vaccination, CpG-oligodeoxynucleotide adjuvant, and CTLA-4 blockade. Cancer Res 63(12):3281–3288
    • (2003) Cancer Res , vol.63 , Issue.12 , pp. 3281-3288
    • Davila, E.1    Kennedy, R.2    Celis, E.3
  • 37
    • 57649123650 scopus 로고    scopus 로고
    • Recombinant vesicular stomatitis virus targeted to Her2/neu combined with anti-CTLA4 antibody eliminates implanted mammary tumors
    • Gao Y, Whitaker-Dowling P, Griffin JA, Barmada MA, Bergman I (2009) Recombinant vesicular stomatitis virus targeted to Her2/neu combined with anti-CTLA4 antibody eliminates implanted mammary tumors. Cancer Gene Ther 16(1):44–52
    • (2009) Cancer Gene Ther , vol.16 , Issue.1 , pp. 44-52
    • Gao, Y.1    Whitaker-Dowling, P.2    Griffin, J.A.3    Barmada, M.A.4    Bergman, I.5
  • 38
    • 0003311698 scopus 로고    scopus 로고
    • MDX-010 (Human anti-CTLA4): A phase I trial in malignant melanoma
    • abstr 56
    • Tchekmedyian S et al (2002) MDX-010 (human anti-CTLA4): a phase I trial in malignant melanoma. Proc Am Soc Clin Oncol 21(abstr 56)
    • (2002) Proc am Soc Clin Oncol , vol.21
    • Tchekmedyian, S.1
  • 39
    • 75249100054 scopus 로고    scopus 로고
    • Ipilimumab monotherapy in patients with pretreated advanced melanoma: A randomised, double-blind, multicentre, phase 2, dose-ranging study
    • Wolchok JD, Neyns B, Linette G et al (2010) Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study. Lancet Oncol 11(2):155–164
    • (2010) Lancet Oncol , vol.11 , Issue.2 , pp. 155-164
    • Wolchok, J.D.1    Neyns, B.2    Linette, G.3
  • 40
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O’Day SJ, McDermott DF et al (2010) Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 363(8):711–723
    • (2010) N Engl J Med , vol.363 , Issue.8 , pp. 711-723
    • Hodi, F.S.1    O’Day, S.J.2    McDermott, D.F.3
  • 41
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert C, Thomas L, Bondarenko I et al (2011) Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 364(26):2517–2526
    • (2011) N Engl J Med , vol.364 , Issue.26 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3
  • 42
    • 73149092567 scopus 로고    scopus 로고
    • Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
    • Wolchok JD, Hoos A, O’Day S et al (2009) Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin Cancer Res 15(23):7412–7420
    • (2009) Clin Cancer Res , vol.15 , Issue.23 , pp. 7412-7420
    • Wolchok, J.D.1    Hoos, A.2    O’Day, S.3
  • 43
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O’Day SJ, McDermott DF et al (2010) Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 363(8):711–723
    • (2010) N Engl J Med , vol.363 , Issue.8 , pp. 711-723
    • Hodi, F.S.1    O’Day, S.J.2    McDermott, D.F.3
  • 44
    • 61349114199 scopus 로고    scopus 로고
    • Ipilimumab: Controversies in its development, utility and autoimmune adverse events
    • Weber J (2009) Ipilimumab: controversies in its development, utility and autoimmune adverse events. Cancer Immunol Immunother 58(5):823–830
    • (2009) Cancer Immunol Immunother , vol.58 , Issue.5 , pp. 823-830
    • Weber, J.1
  • 45
    • 78449244037 scopus 로고    scopus 로고
    • The emerging toxicity profiles of anti-CTLA-4 antibodies across clinical indications
    • Di Giacomo AM, Biagioli M, Maio M (2010) The emerging toxicity profiles of anti-CTLA-4 antibodies across clinical indications. Semin Oncol 37(5):499–507
    • (2010) Semin Oncol , vol.37 , Issue.5 , pp. 499-507
    • Di Giacomo, A.M.1    Biagioli, M.2    Maio, M.3
  • 46
    • 84867760126 scopus 로고    scopus 로고
    • Ipilimumab-induced Immune-related renal failure—A case report
    • Forde PM, Rock K, Wilson G, O’Byrne KJ (2012) Ipilimumab-induced Immune-related renal failure—A case report. Anticancer Res 32(10):4607–4608
    • (2012) Anticancer Res , vol.32 , Issue.10 , pp. 4607-4608
    • Forde, P.M.1    Rock, K.2    Wilson, G.3    O’Byrne, K.J.4
  • 47
    • 84857517981 scopus 로고    scopus 로고
    • Posterior reversible encephalopathy syndrome during ipilimumab therapy for malignant melanoma
    • Maur M, Tomasello C, Frassoldati A, Dieci MV, Barbieri E, Conte P (2012) Posterior reversible encephalopathy syndrome during ipilimumab therapy for malignant melanoma. J Clin Oncol 30(6):e76–e78
    • (2012) J Clin Oncol , vol.30 , Issue.6 , pp. e76-e78
    • Maur, M.1    Tomasello, C.2    Frassoldati, A.3    Dieci, M.V.4    Barbieri, E.5    Conte, P.6
  • 48
    • 84866669341 scopus 로고    scopus 로고
    • Characteristics and management of immunerelated adverse effects associated with ipilimumab, a new immunotherapy for metastatic melanoma
    • Andrews S, Holden R (2012) Characteristics and management of immunerelated adverse effects associated with ipilimumab, a new immunotherapy for metastatic melanoma. Cancer Manage Res 4:299–307
    • (2012) Cancer Manage Res , vol.4 , pp. 299-307
    • Andrews, S.1    Holden, R.2
  • 49
    • 33744792341 scopus 로고    scopus 로고
    • Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4
    • Beck KE, Blansfield JA, Tran KQ et al (2006) Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4. J Clin Oncol 24 (15):2283–2289
    • (2006) J Clin Oncol , vol.24 , Issue.15 , pp. 2283-2289
    • Beck, K.E.1    Blansfield, J.A.2    Tran, K.Q.3
  • 50
    • 84865553349 scopus 로고    scopus 로고
    • How recent advances in immunotherapy are changing the standard of care for patients with metastatic melanoma
    • Wolchok J (2012) How recent advances in immunotherapy are changing the standard of care for patients with metastatic melanoma. Ann Oncol 23(Suppl 8): viii15–21
    • (2012) Ann Oncol , vol.23 , pp. 15-21
    • Wolchok, J.1
  • 52
    • 77949274549 scopus 로고    scopus 로고
    • Anti-CTLA-4 antibody therapy associated autoimmune hypophysitis: Serious immune related adverse events across a spectrum of cancer subtypes
    • Dillard T, Yedinak CG, Alumkal J, Fleseriu M (2010) Anti-CTLA-4 antibody therapy associated autoimmune hypophysitis: serious immune related adverse events across a spectrum of cancer subtypes. Pituitary 13(1):29–38
    • (2010) Pituitary , vol.13 , Issue.1 , pp. 29-38
    • Dillard, T.1    Yedinak, C.G.2    Alumkal, J.3    Fleseriu, M.4
  • 53
    • 70449881133 scopus 로고    scopus 로고
    • Anti-CTLA-4 therapy-related autoimmune hypophysitis in a melanoma patient
    • Kaehler KC, Egberts F, Lorigan P, Hauschild A (2009) Anti-CTLA-4 therapy-related autoimmune hypophysitis in a melanoma patient. Melanoma Res 19(5):333–334
    • (2009) Melanoma Res , vol.19 , Issue.5 , pp. 333-334
    • Kaehler, K.C.1    Egberts, F.2    Lorigan, P.3    Hauschild, A.4
  • 54
    • 84948830700 scopus 로고    scopus 로고
    • https://www.hcp.yervoy.com/pages/rems.aspx
  • 56
    • 84937620817 scopus 로고    scopus 로고
    • Severe relapse in a multiple sclerosis patient associated with ipilimumab treatment of melanoma
    • Gettings EJ, Hackett CT, Scott TF (2014) Severe relapse in a multiple sclerosis patient associated with ipilimumab treatment of melanoma. Multiple Sclerosis
    • (2014) Multiple Sclerosis
    • Gettings, E.J.1    Hackett, C.T.2    Scott, T.F.3
  • 57
    • 77950285080 scopus 로고    scopus 로고
    • Association of peripheral blood absolute lymphocyte count (ALC) and clinical activity in patients (pts) with advanced melanoma treated with ipilimumab [abstract]
    • Berman D et al (2009) Association of peripheral blood absolute lymphocyte count (ALC) and clinical activity in patients (pts) with advanced melanoma treated with ipilimumab [abstract]. J Clin Oncol 27:3020
    • (2009) J Clin Oncol , vol.27 , pp. 3020
    • Berman, D.1
  • 58
    • 77950258677 scopus 로고    scopus 로고
    • Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting: Lymphocyte count after 2 doses correlates with survival
    • Ku GY, Yuan J, Page DB et al (2010) Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting: lymphocyte count after 2 doses correlates with survival. Cancer 116(7):1767–1775
    • (2010) Cancer , vol.116 , Issue.7 , pp. 1767-1775
    • Ku, G.Y.1    Yuan, J.2    Page, D.B.3
  • 59
    • 58149483422 scopus 로고    scopus 로고
    • CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit
    • Yuan J, Gnjatic S, Li H et al (2008) CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit. Proc Natl Acad Sci USA 105(51):20410–20415
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.51 , pp. 20410-20415
    • Yuan, J.1    Gnjatic, S.2    Li, H.3
  • 60
    • 80053648839 scopus 로고    scopus 로고
    • Integrated NY-ESO-1 antibody and CD8 + T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab
    • Yuan J, Adamow M, Ginsberg BA et al (2011) Integrated NY-ESO-1 antibody and CD8 + T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab. Proc Natl Acad Sci USA 108:16723–16728
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 16723-16728
    • Yuan, J.1    Adamow, M.2    Ginsberg, B.A.3
  • 61
    • 40449116396 scopus 로고    scopus 로고
    • ICOS controls the pool size of effector-memory and regulatory T cells
    • Burmeister Y, Lischke T, Dahler AC et al (2008) ICOS controls the pool size of effector-memory and regulatory T cells. J Immunol 180(2):774–782
    • (2008) J Immunol , vol.180 , Issue.2 , pp. 774-782
    • Burmeister, Y.1    Lischke, T.2    Dahler, A.C.3
  • 62
    • 54449091476 scopus 로고    scopus 로고
    • CTLA-4 blockade increases IFNgamma-producing CD4+ ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients
    • Liakou CI, Kamat A, Tang DN et al (2008) CTLA-4 blockade increases IFNgamma-producing CD4+ ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients. Proc Natl Acad Sci USA 105(39):14987–14992
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.39 , pp. 14987-14992
    • Liakou, C.I.1    Kamat, A.2    Tang, D.N.3
  • 63
    • 77952337834 scopus 로고    scopus 로고
    • Preoperative CTLA-4 blockade: Tolerability and immune monitoring in the setting of a presurgical clinical trial
    • Carthon BC, Wolchok JD, Yuan J et al (2010) Preoperative CTLA-4 blockade: tolerability and immune monitoring in the setting of a presurgical clinical trial. Clin Cancer Res 16 (10):2861–2871
    • (2010) Clin Cancer Res , vol.16 , Issue.10 , pp. 2861-2871
    • Carthon, B.C.1    Wolchok, J.D.2    Yuan, J.3
  • 64
    • 82155168544 scopus 로고    scopus 로고
    • A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma
    • Hamid O, Schmidt H, Nissan A et al (2011) A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma. J Transl Med 9:204
    • (2011) J Transl Med , vol.9 , pp. 204
    • Hamid, O.1    Schmidt, H.2    Nissan, A.3
  • 65
    • 84862769116 scopus 로고    scopus 로고
    • An immune-active tumor microenvironment favors clinical response to ipilimumab
    • Ji RR, Chasalow SD, Wang L et al (2012) An immune-active tumor microenvironment favors clinical response to ipilimumab. Cancer Immunol Immunother 61(7):1019–1031
    • (2012) Cancer Immunol Immunother , vol.61 , Issue.7 , pp. 1019-1031
    • Ji, R.R.1    Chasalow, S.D.2    Wang, L.3
  • 66
    • 84918828514 scopus 로고    scopus 로고
    • Genetic basis for clinical response to CTLA-4 blockade in melanoma
    • Snyder A, Makarov V, Merghoub T et al (2014) Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med 371(23):2189–2199
    • (2014) N Engl J Med , vol.371 , Issue.23 , pp. 2189-2199
    • Snyder, A.1    Makarov, V.2    Merghoub, T.3
  • 67
    • 0026700235 scopus 로고
    • Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
    • Ishida Y, Agata Y, Shibahara K, Honjo T (1992) Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J 11 (11):3887–3895
    • (1992) EMBO J , vol.11 , Issue.11 , pp. 3887-3895
    • Ishida, Y.1    Agata, Y.2    Shibahara, K.3    Honjo, T.4
  • 68
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • Freeman GJ, Long AJ, Iwai Y et al (2000) Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 192(7):1027–1034
    • (2000) J Exp Med , vol.192 , Issue.7 , pp. 1027-1034
    • Freeman, G.J.1    Long, A.J.2    Iwai, Y.3
  • 69
    • 33645846313 scopus 로고    scopus 로고
    • Tissue expression of PD-L1 mediates peripheral T cell tolerance
    • Keir ME, Liang SC, Guleria I et al (2006) Tissue expression of PD-L1 mediates peripheral T cell tolerance. J Exp Med 203(4):883–895
    • (2006) J Exp Med , vol.203 , Issue.4 , pp. 883-895
    • Keir, M.E.1    Liang, S.C.2    Guleria, I.3
  • 70
    • 73949088551 scopus 로고    scopus 로고
    • PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
    • Francisco LM, Salinas VH, Brown KE et al (2009) PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med 206(13):3015–3029
    • (2009) J Exp Med , vol.206 , Issue.13 , pp. 3015-3029
    • Francisco, L.M.1    Salinas, V.H.2    Brown, K.E.3
  • 71
    • 0033180181 scopus 로고    scopus 로고
    • Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    • Nishimura H, Nose M, Hiai H, Minato N, Honjo T (1999) Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 11(2):141–151
    • (1999) Immunity , vol.11 , Issue.2 , pp. 141-151
    • Nishimura, H.1    Nose, M.2    Hiai, H.3    Minato, N.4    Honjo, T.5
  • 72
    • 0035846991 scopus 로고    scopus 로고
    • Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice
    • Nishimura H, Okazaki T, Tanaka Y et al (2001) Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science 291(5502):319–322
    • (2001) Science , vol.291 , Issue.5502 , pp. 319-322
    • Nishimura, H.1    Okazaki, T.2    Tanaka, Y.3
  • 73
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
    • Dong H, Strome SE, Salomao DR et al (2002) Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nature Med 8(8):793–800
    • (2002) Nature Med , vol.8 , Issue.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3
  • 74
    • 78650265250 scopus 로고    scopus 로고
    • New monoclonal antibodies against B-cell antigens: Possible new strategies for diagnosis of primary cutaneous B-cell lymphomas
    • Fanoni D, Tavecchio S, Recalcati S et al (2011) New monoclonal antibodies against B-cell antigens: possible new strategies for diagnosis of primary cutaneous B-cell lymphomas. Immunol Lett 134(2):157–160
    • (2011) Immunol Lett , vol.134 , Issue.2 , pp. 157-160
    • Fanoni, D.1    Tavecchio, S.2    Recalcati, S.3
  • 75
    • 84888352977 scopus 로고    scopus 로고
    • Clinical and pharmacodynamic (PD) results of a phase I trial with AMP-224 (B7-DC Fc) that binds to the PD-1 receptor
    • abstr 3044
    • Jeffrey R, Infante JDP, Burris HA et al (2013) Clinical and pharmacodynamic (PD) results of a phase I trial with AMP-224 (B7-DC Fc) that binds to the PD-1 receptor. J Clin Oncol 31 (suppl; abstr 3044)
    • (2013) J Clin Oncol , vol.31
    • Jeffrey, R.1    Infante, J.2    Burris, H.A.3
  • 76
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR et al (2012) Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 366(26):2443–2454
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 77
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (Anti-PD-1) in melanoma
    • Hamid O, Robert C, Daud A et al (2013) Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 369(2):134–144
    • (2013) N Engl J Med , vol.369 , Issue.2 , pp. 134-144
    • Hamid, O.1    Robert, C.2    Daud, A.3
  • 78
    • 84898973055 scopus 로고    scopus 로고
    • Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab
    • Topalian SL, Sznol M, McDermott DF et al (2014) Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J Clin Oncol Official J Am Soc Clin Oncol 32(10):1020–1030
    • (2014) J Clin Oncol Official J am Soc Clin Oncol , vol.32 , Issue.10 , pp. 1020-1030
    • Topalian, S.L.1    Sznol, M.2    McDermott, D.F.3
  • 79
    • 84925222119 scopus 로고    scopus 로고
    • Nivolumab in previously untreated melanoma without BRAF mutation
    • Robert C, Long GV, Brady B et al (2014) Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med 372:320–330
    • (2014) N Engl J Med , vol.372 , pp. 320-330
    • Robert, C.1    Long, G.V.2    Brady, B.3
  • 80
    • 84908354848 scopus 로고    scopus 로고
    • Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: A randomised dose-comparison cohort of a phase 1 trial
    • Robert C, Ribas A, Wolchok JD et al (2014) Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial. Lancet
    • (2014) Lancet
    • Robert, C.1    Ribas, A.2    Wolchok, J.D.3
  • 81
    • 84907613231 scopus 로고    scopus 로고
    • Phase 2, multicenter, safety and efficacy study of pidilizumab in patients with metastatic melanoma
    • abstr 9001
    • Atkins MB, Kudchadkar R, Sznol M et al (2014) Phase 2, multicenter, safety and efficacy study of pidilizumab in patients with metastatic melanoma. J Clin Oncol 32(5 s) (suppl; abstr 9001)
    • (2014) J Clin Oncol , vol.32 , Issue.5 s
    • Atkins, M.B.1    Kudchadkar, R.2    Sznol, M.3
  • 82
    • 34447646310 scopus 로고    scopus 로고
    • Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
    • Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ (2007) Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity 27(1):111–122
    • (2007) Immunity , vol.27 , Issue.1 , pp. 111-122
    • Butte, M.J.1    Keir, M.E.2    Phamduy, T.B.3    Sharpe, A.H.4    Freeman, G.J.5
  • 83
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQ et al (2012) Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 366(26):2455–2465
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 84
    • 84905698694 scopus 로고    scopus 로고
    • Inhibition of PD-L1 by MPDL3280A and clinical activity in pts with metastatic urothelial bladder cancer (UBC)
    • abstr 5011
    • Powles T, Vogelzang NJ, Fine GD et al (2014) Inhibition of PD-L1 by MPDL3280A and clinical activity in pts with metastatic urothelial bladder cancer (UBC). J Clin Oncol 32(5 s) (suppl; abstr 5011)
    • (2014) J Clin Oncol , vol.32 , Issue.5 s
    • Powles, T.1    Vogelzang, N.J.2    Fine, G.D.3
  • 85
    • 84907521154 scopus 로고    scopus 로고
    • Preliminary data from a multi-arm expansion study of MEDI4736, an anti-PD-L1 antibody
    • abstr 3002
    • Segal NH, Anto SJ, Brahmer JR et al (2014) Preliminary data from a multi-arm expansion study of MEDI4736, an anti-PD-L1 antibody. J Clin Oncol 32(5 s) (suppl; abstr 3002)
    • (2014) J Clin Oncol , vol.32 , Issue.5 s
    • Segal, N.H.1    Anto, S.J.2    Brahmer, J.R.3
  • 86
    • 84887262315 scopus 로고    scopus 로고
    • A study of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic tumors
    • abstr 3000
    • Herbst RS, Gordon MS, Fine GD et al (2013) A study of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic tumors. J Clin Oncol 31 (suppl; abstr 3000)
    • (2013) J Clin Oncol , vol.31
    • Herbst, R.S.1    Gordon, M.S.2    Fine, G.D.3
  • 87
    • 84912134974 scopus 로고    scopus 로고
    • Phase I open-label, multiple ascending dose trial of MSB0010718C, an anti-PD-L1 monoclonal antibody, in advanced solid malignancies
    • abstr 3064
    • Heery CR, O’Sullivan Coyne GH, Madan RA et al (2014) Phase I open-label, multiple ascending dose trial of MSB0010718C, an anti-PD-L1 monoclonal antibody, in advanced solid malignancies. J Clin Oncol 32(5 s) (suppl; abstr 3064)
    • (2014) J Clin Oncol , vol.32 , Issue.5 s
    • Heery, C.R.1    O’Sullivan, C.G.H.2    Madan, R.A.3
  • 88
    • 38649094865 scopus 로고    scopus 로고
    • The heterogeneity of the kinetics of response to ipilimumab in metastatic melanoma: Patient cases
    • Saenger YM, Wolchok JD (2008) The heterogeneity of the kinetics of response to ipilimumab in metastatic melanoma: patient cases. Cancer Immun 8:1
    • (2008) Cancer Immun , vol.8 , pp. 1
    • Saenger, Y.M.1    Wolchok, J.D.2
  • 89
    • 73149092567 scopus 로고    scopus 로고
    • Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
    • Wolchok JD, Hoos A, O’Day S et al (2009) Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin Cancer Res Official J Am Assoc Cancer Res 15(23):7412–7420
    • (2009) Clin Cancer Res Official J am Assoc Cancer Res , vol.15 , Issue.23 , pp. 7412-7420
    • Wolchok, J.D.1    Hoos, A.2    O’Day, S.3
  • 90
    • 77957273591 scopus 로고    scopus 로고
    • Improved endpoints for cancer immunotherapy trials
    • Hoos A, Eggermont AM, Janetzki S et al (2010) Improved endpoints for cancer immunotherapy trials. J Natl Cancer Inst 102(18):1388–1397
    • (2010) J Natl Cancer Inst , vol.102 , Issue.18 , pp. 1388-1397
    • Hoos, A.1    Eggermont, A.M.2    Janetzki, S.3
  • 91
    • 84922097884 scopus 로고    scopus 로고
    • Evaluation of immune-related response criteria (IrRC) in patients (pts) with advanced melanoma (MEL) treated with the anti-PD-1 monoclonal antibody MK-3475
    • abstr 3006
    • Hodi FS, Ribas, A., Daud A et al (2014) Evaluation of immune-related response criteria (irRC) in patients (pts) with advanced melanoma (MEL) treated with the anti-PD-1 monoclonal antibody MK-3475. J Clin Oncol 32(5 s) (suppl; abstr 3006)
    • (2014) J Clin Oncol , vol.32 , Issue.5 s
    • Hodi, F.S.1    Ribas, A.2    Daud, A.3
  • 92
    • 84925622262 scopus 로고    scopus 로고
    • A phase 3 randomized, open-label study of nivolumab (Anti-PD-1; BMS-936558; ONO-4538) versus investigator’s choice chemotherapy (ICC) in patients with advanced melanoma after prior anti-CTLA-4 therapy
    • Weber J, Minor D, D’Angelo S et al (2014) A phase 3 randomized, open-label study of nivolumab (anti-PD-1; BMS-936558; ONO-4538) versus investigator’s choice chemotherapy (ICC) in patients with advanced melanoma after prior anti-CTLA-4 therapy. Eur Soc Med Oncol
    • (2014) Eur Soc Med Oncol
    • Weber, J.1    Minor, D.2    D’Angelo, S.3
  • 93
    • 84881128653 scopus 로고    scopus 로고
    • Developing a common language for tumor response to immunotherapy: Immune-related response criteria using unidimensional measurements
    • Nishino M, Giobbie-Hurder A, Gargano M, Suda M, Ramaiya NH, Hodi FS (2013) Developing a common language for tumor response to immunotherapy: immune-related response criteria using unidimensional measurements. Clin Cancer Res Official J Am Assoc Cancer Res 19(14):3936–3943
    • (2013) Clin Cancer Res Official J am Assoc Cancer Res , vol.19 , Issue.14 , pp. 3936-3943
    • Nishino, M.1    Giobbie-Hurder, A.2    Gargano, M.3    Suda, M.4    Ramaiya, N.H.5    Hodi, F.S.6
  • 94
    • 84892866206 scopus 로고    scopus 로고
    • Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or -naive melanoma
    • Weber JS, Kudchadkar RR, Yu B et al (2013) Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or -naive melanoma. J Clin Oncol 31(34):4311–4318
    • (2013) J Clin Oncol , vol.31 , Issue.34 , pp. 4311-4318
    • Weber, J.S.1    Kudchadkar, R.R.2    Yu, B.3
  • 95
    • 84880736969 scopus 로고    scopus 로고
    • Association of tumor PD-L1 expression and immune biomarkers with clinical activity in patients (Pts) with advanced solid tumors treated with nivolumab (anti-PD-1; BMS-936558; ONO-4538)
    • abstr 3016
    • Grosso J HC, Inzunza D et al (2013) Association of tumor PD-L1 expression and immune biomarkers with clinical activity in patients (pts) with advanced solid tumors treated with nivolumab (anti-PD-1; BMS-936558; ONO-4538). J Clin Oncol 31 (suppl; abstr 3016)
    • (2013) J Clin Oncol , vol.31
    • Grosso, J.1    Inzunza, D.2
  • 96
    • 84904024273 scopus 로고    scopus 로고
    • Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy
    • Taube JM, Klein A, Brahmer JR et al (2014) Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Clin Cancer Res Official J Am Assoc Cancer Res 20:5064–5074
    • (2014) Clin Cancer Res Official J am Assoc Cancer Res , vol.20 , pp. 5064-5074
    • Taube, J.M.1    Klein, A.2    Brahmer, J.R.3
  • 98
    • 33846118474 scopus 로고    scopus 로고
    • Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma
    • Parsa AT, Waldron JS, Panner A et al (2007) Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma. Nature Med 13(1):84–88
    • (2007) Nature Med , vol.13 , Issue.1 , pp. 84-88
    • Parsa, A.T.1    Waldron, J.S.2    Panner, A.3
  • 99
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • Wolchok JD, Kluger H, Callahan MK et al (2013) Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med 369(2):122–133
    • (2013) N Engl J Med , vol.369 , Issue.2 , pp. 122-133
    • Wolchok, J.D.1    Kluger, H.2    Callahan, M.K.3
  • 101
    • 84908664534 scopus 로고    scopus 로고
    • Ipilimumab plus sargramostim vs ipilimumab alone for treatment of metastatic melanoma: A randomized clinical trial
    • Hodi FS, Lee S, McDermott DF et al (2014) Ipilimumab plus sargramostim vs ipilimumab alone for treatment of metastatic melanoma: a randomized clinical trial. JAMA 312 (17):1744–1753
    • (2014) JAMA , vol.312 , Issue.17 , pp. 1744-1753
    • Hodi, F.S.1    Lee, S.2    McDermott, D.F.3
  • 102
    • 84875785905 scopus 로고    scopus 로고
    • Hepatotoxicity with combination of vemurafenib and ipilimumab
    • Ribas A, Hodi FS, Callahan M, Konto C, Wolchok J (2013) Hepatotoxicity with combination of vemurafenib and ipilimumab. N Engl J Med 368(14):1365–1366
    • (2013) N Engl J Med , vol.368 , Issue.14 , pp. 1365-1366
    • Ribas, A.1    Hodi, F.S.2    Callahan, M.3    Konto, C.4    Wolchok, J.5
  • 103
    • 84912135461 scopus 로고    scopus 로고
    • Phase 1 study of the BRAF inhibitor dabrafenib (D) with or without the MEK inhibitor trametinib (T) in combination with ipilimumab (Ipi) for V600E/K mutation–positive unresectable or metastatic melanoma (MM)
    • abstr 2511
    • Puzanov I, Callahan M, Linette G, Patel S, Luke JJ, Sosman JA, Jedd DW, Omid H, Minor DR, Orford KW, Hug BA, Ma B, Matthys GM, Hoos A (2014) Phase 1 study of the BRAF inhibitor dabrafenib (D) with or without the MEK inhibitor trametinib (T) in combination with ipilimumab (Ipi) for V600E/K mutation–positive unresectable or metastatic melanoma (MM). ASCO J Clin Oncol 32(5 s) (suppl; abstr 2511)
    • (2014) ASCO J Clin Oncol , vol.32 , Issue.5 s
    • Puzanov, I.1    Callahan, M.2    Linette, G.3    Patel, S.4    Luke, J.J.5    Sosman, J.A.6    Jedd, D.W.7    Omid, H.8    Minor, D.R.9    Orford, K.W.10    Hug, B.A.11    Ma, B.12    Matthys, G.M.13    Hoos, A.14
  • 104
    • 84875039618 scopus 로고    scopus 로고
    • Combining radiotherapy and cancer immunotherapy: A paradigm shift
    • Formenti SC, Demaria S (2013) Combining radiotherapy and cancer immunotherapy: a paradigm shift. J Natl Cancer Inst 105(4):256–265
    • (2013) J Natl Cancer Inst , vol.105 , Issue.4 , pp. 256-265
    • Formenti, S.C.1    Demaria, S.2
  • 105
    • 84893876109 scopus 로고    scopus 로고
    • Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice
    • Deng L, Liang H, Burnette B et al (2014) Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice. J Clin Invest 124(2):687–695
    • (2014) J Clin Invest , vol.124 , Issue.2 , pp. 687-695
    • Deng, L.1    Liang, H.2    Burnette, B.3
  • 106
    • 84904207094 scopus 로고    scopus 로고
    • Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model
    • Belcaid Z, Phallen JA, Zeng J et al (2014) Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model. PLoS ONE 9(7):e101764
    • (2014) Plos ONE , vol.9 , Issue.7
    • Belcaid, Z.1    Phallen, J.A.2    Zeng, J.3
  • 107
    • 84857815877 scopus 로고    scopus 로고
    • Immunologic correlates of the abscopal effect in a patient with melanoma
    • Postow MA, Callahan MK, Barker CA et al (2012) Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med 366(10):925–931
    • (2012) N Engl J Med , vol.366 , Issue.10 , pp. 925-931
    • Postow, M.A.1    Callahan, M.K.2    Barker, C.A.3
  • 108
    • 84880322946 scopus 로고    scopus 로고
    • Case records of the Massachusetts general hospital. Case 21-2013. A 68-year-old man with metastatic melanoma
    • Sullivan RJ, Lawrence DP, Wargo JA, Oh KS, Gonzalez RG, Piris A (2013) Case records of the Massachusetts general hospital. Case 21-2013. A 68-year-old man with metastatic melanoma. N Engl J Med 369(2):173–183
    • (2013) N Engl J Med , vol.369 , Issue.2 , pp. 173-183
    • Sullivan, R.J.1    Lawrence, D.P.2    Wargo, J.A.3    Oh, K.S.4    Gonzalez, R.G.5    Piris, A.6
  • 109
    • 84904061705 scopus 로고    scopus 로고
    • Abscopal effects of radiotherapy on advanced melanoma patients who progressed after ipilimumab immunotherapy
    • Grimaldi AM, Simeone E, Giannarelli D et al (2014) Abscopal effects of radiotherapy on advanced melanoma patients who progressed after ipilimumab immunotherapy. Oncoimmunology 3:e28780
    • (2014) Oncoimmunology , vol.3
    • Grimaldi, A.M.1    Simeone, E.2    Giannarelli, D.3
  • 110
    • 84893877031 scopus 로고    scopus 로고
    • Concurrent radiotherapy and ipilimumab immunotherapy for patients with melanoma
    • Barker CA, Postow MA, Khan SA et al (2013) Concurrent radiotherapy and ipilimumab immunotherapy for patients with melanoma. Cancer Immunol Res 1(2):92–98
    • (2013) Cancer Immunol Res , vol.1 , Issue.2 , pp. 92-98
    • Barker, C.A.1    Postow, M.A.2    Khan, S.A.3
  • 111
    • 84862124594 scopus 로고    scopus 로고
    • Phase 1 study of stereotactic body radiotherapy and interleukin-2—tumor and immunological responses
    • 137ra74
    • Seung SK, Curti BD, Crittenden M et al (2012) Phase 1 study of stereotactic body radiotherapy and interleukin-2—tumor and immunological responses. Sci Trans Med 4 (137):137ra74
    • (2012) Sci Trans Med , vol.4 , Issue.137
    • Seung, S.K.1    Curti, B.D.2    Crittenden, M.3
  • 112
    • 84936147067 scopus 로고    scopus 로고
    • Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
    • O Larkin et al (2015) Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N Engl J Med 373(1):23–24
    • (2015) N Engl J Med , vol.373 , Issue.1 , pp. 23-24
    • Larkin, O.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.