Orphan nuclear receptor TLX functions as a potent suppressor of oncogene-induced senescence in prostate cancer via its transcriptional co-regulation of the CDKN1A (p21WAF1/CIP1) and SIRT1 genes

Journal of Pathology

Volumn 236, Issue 1, 2015, Pages 103-115

  Wu, Dinglan ^a   Yu, Shan ^a   Jia, Lin ^a   Zou, Chang ^a   Xu, Zhenyu ^a   Xiao, Lijia ^a   Wong, Kam Bo ^a   Ng, Chi Fai ^a   Chan, Franky L ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

nuclear receptor; oncogene induced senescence; p21; prostate cancer; SIRT1; TLX

Indexed keywords

BETA GALACTOSIDASE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DNA; NUCLEAR RECEPTOR TLX; ORPHAN NUCLEAR RECEPTOR; SHORT HAIRPIN RNA; SIRTUIN 1; UNCLASSIFIED DRUG; CDKN1A PROTEIN, HUMAN; CDKN1A PROTEIN, MOUSE; CELL RECEPTOR; NR2E1 PROTEIN, HUMAN; NR2E1 PROTEIN, MOUSE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PTEN PROTEIN, HUMAN; SIRT1 PROTEIN, HUMAN; SIRT1 PROTEIN, MOUSE;

ARTICLE; CANCER CELL; CELL GROWTH; CHROMATIN IMMUNOPRECIPITATION; ENZYME ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUCIFERASE ASSAY; MALE; ONCOGENE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSTATE CANCER; RNA INTERFERENCE; SENESCENCE; ANIMAL; CELL AGING; CELL PROLIFERATION; CELL TRANSFORMATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROSTATE TUMOR; SCID MOUSE;

ANIMALS; CELL AGING; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN-DEPENDENT KINASE INHIBITOR P21; GENE EXPRESSION REGULATION; HUMANS; MALE; MICE, SCID; PROSTATIC NEOPLASMS; PTEN PHOSPHOHYDROLASE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIRTUIN 1;

EID: 84927698108     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4505     Document Type: Article

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