Osthole ameliorates acute myocardial infarction in rats by decreasing the expression of inflammatory-related cytokines, diminishing MMP-2 expression and activating p-ERK

International Journal of Molecular Medicine

Volumn 37, Issue 1, 2016, Pages 207-216

  Duan, Juan ^a   Yang, Yu ^a   Liu, Hong ^a   Dou, Peng Cheng ^a   Tan, Sheng Yu ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Acute myocardial infarction; Endothelial nitric oxide synthase; Inflammatory; Matrix metalloproteinase 2; Mitogen activated protein kinases; Osthole

Indexed keywords

CASEIN KINASE; CASPASE 3; CASPASE 9; CASPASE RECRUITMENT DOMAIN PROTEIN 4; CREATINE KINASE MB; CYCLOOXYGENASE 2; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GELATINASE A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; OSTHOLE; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TROPONIN T; TUMOR NECROSIS FACTOR ALPHA; CASPASE RECRUITMENT DOMAIN PROTEIN 15; COUMARIN DERIVATIVE; IMMUNOLOGICAL ADJUVANT; NOD2 PROTEIN, RAT; TUMOR NECROSIS FACTOR;

ACUTE HEART INFARCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HEART INFARCTION SIZE; HEART PROTECTION; MALE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT MODEL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ACUTE DISEASE; ANIMAL; BLOOD; CARDIAC MUSCLE; CHEMISTRY; CNIDIUM; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HEART; IMMUNOLOGY; METABOLISM; MYOCARDIAL INFARCTION; PATHOLOGY; SIGNAL TRANSDUCTION; WISTAR RAT;

ACUTE DISEASE; ADJUVANTS, IMMUNOLOGIC; ANIMALS; CNIDIUM; COUMARINS; CYCLOOXYGENASE 2; GENE EXPRESSION REGULATION; HEART; INTERLEUKIN-1BETA; INTERLEUKIN-6; MALE; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; MYOCARDIAL INFARCTION; MYOCARDIUM; NF-KAPPA B; NOD1 SIGNALING ADAPTOR PROTEIN; NOD2 SIGNALING ADAPTOR PROTEIN; RATS; RATS, WISTAR; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84948783472     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2015.2402     Document Type: Article

References (43)

1. Bradshaw PJ, Trafalski S, Hung J, Briffa TG and Einarsdóttir K: Outcomes after first percutaneous coronary intervention for acute myocardial infarction according to patient funding source. BMC Health Serv Res 14: 405, 2014.
2. Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, Dai S, Ford ES, Fox CS, Franco S, et al: Heart disease and stroke statistics-2014 update: a report from the American Heart Association. Circulation 129: e28-e292, 2014.
3. Wollenweber T, Roentgen P, Schäfer A, Schatka I, Zwadlo C, Brunkhorst T, Berding G, Bauersachs J and Bengel FM: Characterizing the inflammatory tissue response to acute myocardial infarction by clinical multimodality noninvasive imaging. Circ Cardiovasc Imaging 7: 811-818, 2014.
4. Könnecke H and Bechmann I: The role of microglia and matrix metalloproteinases involvement in neuroinflammation and gliomas. Clin Dev Immunol 2013: 914104, 2013.
5. Squire IB, Evans J, Ng LL, Loftus IM and Thompson MM: Plasma MMP-9 and MMP-2 following acute myocardial infarction in man: correlation with echocardiographic and neurohumoral parameters of left ventricular dysfunction. J Card Fail 10: 328-333, 2004.
6. Schaeffer HJ and Weber MJ: Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol Cell Biol 19: 2435-2444, 1999.
7. Yue TL, Wang C, Gu JL, Ma XL, Kumar S, Lee JC, Feuerstein GZ, Thomas H, Maleeff B and Ohlstein EH: Inhibition of extracellular signal-regulated kinase enhances Ischemia/Reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion injury in isolated perfused heart. Circ Res 86: 692-699, 2000.
8. Aikawa R, Komuro I, Yamazaki T, Zou Y, Kudoh S, Tanaka M, Shiojima I, Hiroi Y and Yazaki Y: Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats. J Clin Invest 100: 1813-1821, 1997.
9. Wang Y, Su B, Sah VP, Brown JH, Han J and Chien KR: Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells. J Biol Chem 273: 5423-5426, 1998.
10. Mackay K and Mochly-Rosen D: An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia. J Biol Chem 274: 6272-6279, 1999.
11. Nam HH, Jun DW, Jeon HJ, Lee JS, Saeed WK and Kim EK: Osthol attenuates hepatic steatosis via decreased triglyceride synthesis not by insulin resistance. World J Gastroenterol 20: 11753-11761, 2014.
12. Chen R, Xue J and Xie M: Osthole regulates TGF-β1 and MMP-2/9 expressions via activation of PPARα/γ in cultured mouse cardiac fibroblasts stimulated with angiotensin II. J Pharm Pharm Sci 16: 732-741, 2013.
13. Yu HP, Liu FC, Tsai YF and Hwang TL: Osthole attenuates hepatic injury in a rodent model of trauma-hemorrhage. PLoS One 8: e65916, 2013.
14. Wang XY, Dong WP, Bi SH, Pan ZG, Yu H, Wang XW, Ma T, Wang J and Zhang WD: Protective effects of osthole against myocardial ischemia/reperfusion injury in rats. Int J Mol Med 32: 365-372, 2013.
15. Hoda MN, Li W, Ahmad A, Ogbi S, Zemskova MA, Johnson MH, Ergul A, Hill WD, Hess DC and Sazonova IY: Sex-independent neuroprotection with minocycline after experimental thromboembolic stroke. Exp Transl Stroke Med 3: 16, 2011.
16. Hoda MN, Siddiqui S, Herberg S, Periyasamy-Thandavan S, Bhatia K, Hafez SS, Johnson MH, Hill WD, Ergul A, Fagan SC, et al: Remote ischemic perconditioning is effective alone and in combination with intravenous tissue-type plasminogen activator in murine model of embolic stroke. Stroke 43: 2794-2799, 2012.
17. Kilickesmez KO, Bingöl G, Bulut L, Sinan UY, Abaci O, Ersanli M and Gurmen T: Relationship between serum endothelin-1 level and spontaneous reperfusion in patients with acute myocardial infarction. Coron Artery Dis 26: 37-41, 2015.
18. Dziewierz A, Rakowski T and Dudek D: Abciximab in the management of acute myocardial infarction with ST-segment elevation: evidence-based treatment, current clinical use, and future perspectives. Ther Clin Risk Manag 10: 567-576, 2014.
19. Wei M, Mo SL, Nabar NR, Chen Y, Zhang JJ, He QL, Zou XN, Liu XG, Sun LB and Zhou SF: Modification of rat model of sciatica induced by lumber disc herniation and the anti-inflammatory effect of osthole given by epidural catheterization. Pharmacology 90: 251-263, 2012.
20. Yang G, Fang Z, Liu Y, Zhang H, Shi X, Ji Q, Lin Q and Lin R: Protective effects of Chinese traditional medicine buyang huanwu decoction on myocardial injury. Evid Based Complement Alternat Med 2011: 930324, 2011.
21. Balligand JL and Cannon PJ: Nitric oxide synthases and cardiac muscle. Autocrine and paracrine influences. Arterioscler Thromb Vasc Biol 17: 1846-1858, 1997.
22. Sumeray MS, Rees DD and Yellon DM: Infarct size and nitric oxide synthase in murine myocardium. J Mol Cell Cardiol 32: 35-42, 2000.
23. Yao L, Lu P, Li Y, Yang L, Feng H, Huang Y, Zhang D, Chen J and Zhu D: Osthole relaxes pulmonary arteries through endothelial phosphatidylinositol 3-kinase/Akt-eNOS-NO signaling pathway in rats. Eur J Pharmacol 699: 23-32, 2013.
24. Yang SM, Chan YL, Hua KF, Chang JM, Chen HL, Tsai YJ, Hsu YJ, Chao LK, Feng-Ling Y, Tsai YL, et al: Osthole improves an accelerated focal segmental glomerulosclerosis model in the early stage by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF-κB-mediated COX-2 expression and apoptosis. Free Radic Biol Med 73: 260-269, 2014.
25. Stein A, Mohr F, Laux M, Thieme S, Lorenz B, Cetindis M, Hackl J, Groha P, Demetz G, Schulz S, et al: Erythropoietin-induced progenitor cell mobilisation in patients with acute ST-segment-elevation myocardial infarction and restenosis. Thromb Haemost 107: 769-774, 2012.
26. Turner NA, Das A, Warburton P, O'Regan DJ, Ball SG and Porter KE: Interleukin-1alpha stimulates proinflammatory cytokine expression in human cardiac myofibroblasts. Am J Physiol Heart Circ Physiol 297: H1117-H1127, 2009.
27. Zheng Y, Lu M, Ma L, Zhang S, Qiu M and Ma X: Osthole ameliorates renal ischemia-reperfusion injury by inhibiting inflammatory response. Urol Int 91: 350-356, 2013.
28. Chao X, Zhou J, Chen T, Liu W, Dong W, Qu Y, Jiang X, Ji X, Zhen H and Fei Z: Neuroprotective effect of osthole against acute ischemic stroke on middle cerebral ischemia occlusion in rats. Brain Res 1363: 206-211, 2010.
29. Wang KF, Huang PH, Chiang CH, Hsu CY, Leu HB, Chen JW and Lin SJ: Usefulness of plasma matrix metalloproteinase-9 level in predicting future coronary revascularization in patients after acute myocardial infarction. Coron Artery Dis 24: 23-28, 2013.
30. Periasamy S, Mo FE, Chen SY, Chang CC and Liu MY: Sesamol attenuates isoproterenol-induced acute myocardial infarction via inhibition of matrix metalloproteinase-2 and-9 expression in rats. Cell Physiol Biochem 27: 273-280, 2011.
31. Dai F, Xiao GL and Pan J: Correlation between serum MMP-2 and MMP-9 in patients with acute myocardial infarction before and after PCI. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 25: 716-718, 2009 (In Chinese).
32. Xu XM, Zhang Y, Qu D, Feng XW, Chen Y and Zhao L: Osthole suppresses migration and invasion of A549 human lung cancer cells through inhibition of matrix metalloproteinase-2 and matrix metallopeptidase-9 in vitro. Mol Med Rep 6: 1018-1022, 2012.
33. Yang D, Gu T, Wang T, Tang Q and Ma C: Effects of osthole on migration and invasion in breast cancer cells. Biosci Biotechnol Biochem 74: 1430-1434, 2010.
34. Liu X, Gu J, Fan Y, Shi H and Jiang M: Baicalin attenuates acute myocardial infarction of rats via mediating the mitogen-activated protein kinase pathway. Biol Pharm Bull 36: 988-994, 2013.
35. Shimada K, Nakamura M, Ishida E, Kishi M and Konishi N: Roles of p38-and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis. Carcinogenesis 24: 1067-1075, 2003.
36. Hreniuk D, Garay M, Gaarde W, Monia BP, McKay RA and Cioffi CL: Inhibition of c-Jun N-terminal kinase 1, but not c-Jun N-terminal kinase 2, suppresses apoptosis induced by ischemia/reoxygenation in rat cardiac myocytes. Mol Pharmacol 59: 867-874, 2001.
37. Barancik M, Htun P, Strohm C, Kilian S and Schaper W: Inhibition of the cardiac p38-MAPK pathway by SB203580 delays ischemic cell death. J Cardiovasc Pharmacol 35: 474-483, 2000.
38. Wang W, Xu J, Li L, Wang P, Ji X, Ai H, Zhang L and Li L: Neuroprotective effect of morroniside on focal cerebral ischemia in rats. Brain Res Bull 83: 196-201, 2010.
39. Tanaka M, Mokhtari GK, Terry RD, Balsam LB, Lee KH, Kofidis T, Tsao PS and Robbins RC: Overexpression of human copper/zinc superoxide dismutase (SOD1) suppresses ischemia-reperfusion injury and subsequent development of graft coronary artery disease in murine cardiac grafts. Circulation 110 (Suppl 1): II200-II206, 2004.
40. Guo J, Li HZ, Wang LC, Zhang WH, Li GW, Xing WJ, Wang R and Xu CQ: Increased expression of calcium-sensing receptors in atherosclerosis confers hypersensitivity to acute myocardial infarction in rats. Mol Cell Biochem 366: 345-354, 2012.
41. Shokoohinia Y, Hosseinzadeh L, Moieni-Arya M, Mostafaie A and Mohammadi-Motlagh HR: Osthole attenuates doxorubicin-induced apoptosis in PC12 cells through inhibition of mitochondrial dysfunction and ROS production. BioMed Res Int 2014: 156848, 2014.
42. Ding Y, Lu X, Hu X, Ma J and Ding H: Osthole inhibits proliferation and induces apoptosis in human osteosarcoma cells. Int J Clin Pharmacol Ther 52: 112-117, 2014.
43. Zheng Y, Lu M, Ma L, Zhang S, Qiu M and Wang Y: Osthole ameliorates renal ischemia-reperfusion injury in rats. J Surg Res 183: 347-354, 2013.