Osthole suppresses migration and invasion of A549 human lung cancer cells through inhibition of matrix metalloproteinase-2 and matrix metallopeptidase-9 in vitro

Molecular Medicine Reports

Volumn 6, Issue 5, 2012, Pages 1018-1022

  Xu, Xiao Man ^a   Zhang, Yi ^a   Qu, Dan ^a   Feng, Xue Wei ^a   Chen, Yu ^a   Zhao, Li ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

A549 lung cancer cells; Invasion; Migration; Osthole

Indexed keywords

GELATINASE A; GELATINASE B; OSTHOLE;

ARTICLE; CANCER CELL; CANCER INVASION; CELL MIGRATION; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CANCER; METASTASIS;

CALCIUM CHANNEL BLOCKERS; CELL LINE, TUMOR; CELL MOVEMENT; CNIDIUM; COUMARINS; HUMANS; LUNG NEOPLASMS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; PLANTS, MEDICINAL;

CNIDIUM MONNIERI;

EID: 84866463562     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.1044     Document Type: Article

References (28)

1. Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin 55: 74-108, 2005. (Pubitemid 40372904)
2. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T and Thun MJ: Cancer statistics, 2008. CA Cancer J Clin 58: 71-96, 2008. (Pubitemid 351521864)
3. Molina JR, Yang P, Cassivi SD, Schild SE and Adjei AA: Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc 83: 584-594, 2008. (Pubitemid 351720831)
4. Erridge SC, Møller H, Price A and Brewster D: International comparisons of survival from lung cancer: pitfalls and warnings. Nat Clin Pract Oncol 4: 570-577, 2007. (Pubitemid 47534756)
5. Wang T, Nelson RA, Bogardus A and Grannis FW Jr: Five-year lung cancer survival: which advanced stage nonsmall cell lung cancer patients attain long-term survival? Cancer 116: 1518-1525, 2010.
6. Gupta GP and Massagué J: Cancer metastasis: building a framework. Cell 127: 679-695, 2006. (Pubitemid 44781029)
7. Yilmaz M, Christofori G and Lehembre F: Distinct mechanisms of tumor invasion and metastasis. Trends Mol Med 13: 535-541, 2007. (Pubitemid 350123764)
8. Guh JH, Yu SM, Ko FN, Wu TS and Teng CM: Antiproliferative effect in rat vascular smooth muscle cells by osthole, isolated from Angelica pubescens. Eur J Pharmacol 298: 191-197, 1996. (Pubitemid 26081888)
9. Ko FN, Wu TS, Liou MJ, Huang TF and Teng CM: Vasorelaxation of rat thoracic aorta caused by osthole isolated from Angelica pubescens. Eur J Pharmacol 219: 29-34, 1992.
10. Zimecki M, Artym J, Cisowski W, Mazol I, Włodarczyk M and Gleńsk M: Immunomodulatory and anti-inflammatory activity of selected osthole derivatives. Z Naturforsch C 64: 361-368, 2009.
11. Cai J, Yu B, Xu G and Wu J: Studies on the quality of fructus Cnidii-comparison of antibacterial action. Zhongguo Zhong Yao Za Zhi 16: 451-453, 510, 1991 (In Chinese).
12. Matsuda H, Tomohiro N, Ido Y and Kubo M: Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol. Biol Pharm Bull 25: 809-812, 2002. (Pubitemid 40036723)
13. Hung CM, Kuo DH, Chou CH, Su YC, Ho CT and Way TD: Osthole suppresses hepatocyte growth factor (HGF)-induced epithelial-mesenchymal transition via repression of the c-Met/Akt/mTOR pathway in human breast cancer cells. J Agric Food Chem 59: 9683-9690, 2011.
14. Chou SY, Hsu CS, Wang KT, Wang MC and Wang CC: Antitumor effects of Osthol from Cnidium monnieri: an in vitro and in vivo study. Phytother Res 21: 226-230, 2007.
15. Yang LL, Wang MC, Chen LG and Wang CC: Cytotoxic activity of coumarins from the fruits of Cnidium monnieri on leukemia cell lines. Planta Med 69: 1091-1095, 2003.
16. Xu X, Zhang Y, Qu D, Jiang T and Li S: Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway. J Exp Clin Cancer Res 30: 33, 2011.
17. Nguyen DX, Bos PD and Massagué J: Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 9: 274-284, 2009.
18. Lazennec G and Richmond A: Chemokines and chemokine receptors: new insights into cancer-related inflammation. Trends Mol Med 16: 133-144, 2010.
19. Zlotnik A: Chemokines and cancer. Int J Cancer 119: 2026-2029, 2006.
20. Nguyen DX and Massagué J: Genetic determinants of cancer metastasis. Nat Rev Genet 8: 341-352, 2007. (Pubitemid 46625811)
21. Ho YT, Yang JS, Li TC, Lin JJ, Lin JG, Lai KC, Ma CY, Wood WG and Chung JG: Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-kappaB, u-PA and MMP-2 and -9. Cancer Lett 279: 155-162, 2009.
22. Wang L, Ling Y, Chen Y, Li CL, Feng F, You QD, Lu N and Guo QL: Flavonoid baicalein suppresses adhesion, migration and invasion of MDA-MB-231 human breast cancer cells. Cancer Lett 297: 42-48, 2010.
23. Ni L, Feng Y, Wan H, Ma Q, Fan L, Qian Y, Li Q, Xiang Y and Gao B: Angiotensin-(1-7) inhibits the migration and invasion of A549 human lung adenocarcinoma cells through inactivation of the PI3K/Akt and MAPK signaling pathways. Oncol Rep 27: 783-790, 2012.
24. Hua H, Li M, Luo T, Yin Y and Jiang Y: Matrix metalloproteinases in tumorigenesis: an evolving paradigm. Cell Mol Life Sci 68: 3853-3868, 2011.
25. Roomi MW, Monterrey JC, Kalinovsky T, Niedzwiecki A and Rath M: Modulation of MMP-2 and MMP-9 by cytokines, mitogens and inhibitors in lung cancer and malignant mesothelioma cell lines. Oncol Rep 22: 1283-1291, 2009.
26. Park JK, Park SH, So K, Bae IH, Yoo YD and Um HD: ICAM-3 enhances the migratory and invasive potential of human non-small cell lung cancer cells by inducing MMP-2 and MMP-9 via Akt and CREB. Int J Oncol 36: 181-192, 2010.
27. Hung WC, Tseng WL, Shiea J and Chang HC: Skp2 overexpression increases the expression of MMP-2 and MMP-9 and invasion of lung cancer cells. Cancer Lett 288: 156-161, 2010.
28. Yang D, Gu T, Wang T, Tang Q and Ma C: Effects of osthole on migration and invasion in breast cancer cells. Biosci Biotechnol Biochem 74: 1430-1434, 2010.