Osthole regulates TGF-β1 and MMP-2/9 expressions via activation of PPARα/γ in cultured mouse cardiac fibroblasts stimulated with angiotensin II

Journal of Pharmacy and Pharmaceutical Sciences

Volumn 16, Issue 5, 2013, Pages 732-741

  Chen, Rong ^a,b   Xue, Jie ^b   Xie, Meilin ^b  

^a THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; 3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; ANGIOTENSIN II; GELATINASE A; GELATINASE B; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; OSTHOLE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; FIBROBLAST CULTURE; GENE EXPRESSION; HEART MUSCLE FIBROSIS; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

ANGIOTENSIN II; ANIMALS; CELLS, CULTURED; COUMARINS; FIBROBLASTS; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MYOCARDIUM; NF-KAPPA B; PPAR ALPHA; PPAR GAMMA; RNA, MESSENGER; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84890519596     PISSN: None     EISSN: 14821826     Source Type: Journal    
DOI: 10.18433/j3hk5c     Document Type: Article

References (31)

1. Wynn TA, Ramalingam TR. Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med. 2012; 18: 1028-1040.
2. Kurihara T, Ozawa Y, Ishida S, Okano H, Tsubota K. Renin-angiotensin system hyperactivation can induce inflammation and retinal neural dysfunction. Int J Inflam. 2012; 2012:581695.
3. Rosenkranz S. TGF-beta1 and angiotensin networking in cardiac remodeling. Cardiovasc Res. 2004; 63: 423-432.
4. Border WA, Noble NA. Transforming growth factor-β in tissue fibrosis. N Engl J Med. 1994; 331: 1286-1292.
5. Ruiz-Ortega M, Rodríguez-Vita J, Sanchez-Lopez E, Carvajal G, Egido J. TGF-β signaling in vascular fibrosis. Cardiovasc Res. 2007; 74: 196-206.
6. Crabos M, Roth M, Hahn AW, Erne P. Characterization of angiotensin II receptors in cultured adult rat cardiac fibroblasts. Coupling to signaling systems and gene expression. J Clin Invest. 1994; 93: 2372-2378.
7. Dostal DE, Booz GW, Baker KM. Angiotensin II signalling pathways in cardiac fibroblasts: conventional versus novel mechanisms in mediating cardiac growth and function. Mol Cell Biochem. 1996; 157: 15-21.
8. Sadoshima J, Izumo S. Molecular characterization of angiotensin II-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype. Circ Res. 1993; 73: 413-423.
9. Zhou G, Kandala JC, Tyagi SC, Katwa LC, Weber KT. Effects of angiotensin II and aldosterone on collagen gene expression and protein turnover in cardiac fibroblasts. Mol Cell Biochem. 1996; 154: 171-178.
10. Lian QS. Progress in study of chemical constituents and pharmacological effects of the fruit of Cnidium monnieri. Chin Med Mater. 2003; 26: 141-144.
11. Liang HJ, Suk FM, Wang CK, Hung LF, Liu DZ, Chen NQ, Chen YC, Chang CC, Liang YC. Osthole, a potential antidiabetic agent, alleviates hyperglycemia in db/db mouse. Chem Biol Interact. 2009;181: 309-315.
12. Chen R, Xue J, Xie ML. Reduction of isoprenalineinduced myocardial TGF-β1 expression and fibrosis in osthole-treated mice. Toxicol Applied Pharm. 2011; 256: 168-173.
13. Blanquart C, Barbier O, Fruchart JC, Staels B, Glineur C. Peroxisome proliferator activated receptors: regulation of transcriptional activities and roles in inflammation. J Steroid Biochem Mol Biol. 2003; 85: 267-273.
14. Kim DJ, Murray IA, Burns AM, Gonzalez FJ, Perdew GH, Peters JM. Peroxisome proliferatoractivated receptor-beta/delta inhibits epidermal cell proliferation by down-regulation of kinase activity. J Biol Chem. 2005; 280: 9519-9527.
15. Carver W, Nagpal ML, Nachtigal M, Borg TK, Terracio L. Collagen expression in mechanically stimulated cardiac fibroblasts. Circ Res. 1991; 69: 116-122.
16. Campbell SE, Katwa LC. Angiotensin II stimulated expression of transforming growth factor-beta1 in cardiac fibroblasts and myofibroblasts. J Mol Cell Cardiol. 1997; 29: 1947-1958.
17. Wang X, Lu J, Khaidakov M, Mitra S, Ding Z, Raina S, Goyal T, Mehta JL. Aspirin suppresses cardiac fibroblast proliferation and collagen formation through downregulation of angiotensin type 1 receptor transcription. Toxicol Appl Pharmacol. 2012; 259: 346-354.
18. Chen K, Chen J, Li D, Zhang X, Mehta JL. Angiotensin II regulation of collagen type I expression in cardiac fibroblasts: modulation by PPAR-gamma ligand pioglitazone. Hypertension. 2004; 44: 655-661.
19. Diep Q, Benkiran K, Amiri F, Cohn JS, Endemann D, Schiffrin EL. PPAR alpha activator fenofibrate inhibits myocardial inflammation and fibrosis in angiotensin II-infused rats. J Mol Cell Cardiol. 2004; 36: 295-304.
20. Iglarz M, Touyz RM, Viel EC, Paradis P, Amiri F, Diep QN, Schiffrin EL. Peroxisome proliferatoractivated receptor-alpha and receptor-gamma activators prevent cardiac fibrosis in mineralocorticoid-dependent hypertension. Hypertension. 2003; 42: 737-743.
21. Ogata T, Miyauchi T, Sakai S, Takanashi M, Irukayama TY, Yamaguchi I. Myocardial fibrosis and diastolic dysfunction in deoxycorticosterone acetatesalt hypertensive rats is ameliorated by the peroxisome proliferator-activated receptor-alpha activator fenofibrate, partly by suppressing inflammatory responses associated with the nuclear factor-kappa-B pathway. J Am Coll Cardiol. 2004; 43: 1481-1488.
22. Shiomi T, Tsutsui H, Hayashidani S, Suematsu N, Ikeuchi M, Wen J, Ishibashi M, Kubota T, Egashira K, Takeshita A. Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates left ventricular remodeling and failure after experimental myocardial infarction. Circulation. 2002; 106: 3126-3132.
23. Bowie A, O'Neill LA. Oxidative stress and nuclear factor kappaB activation: a reassessment of the evidence in the light of recent discoveries. Biochem Pharmacol. 2000; 59: 13-23.
24. Ye H, Cai PC, Zhou Q, Ma WL. Transforming growth factor-beta1 suppresses the up-regulation of matrix metalloproteinase-2 by lung fibroblasts in response to tumor necrosis factor-alpha. Wound Repair Regen. 2011; 19: 392-399.
25. Howard EW, Crider BJ, Updike DL, Bullen EC, Parks EE, Haaksma CJ, Sherry DM, Tomasek JJ. MMP-2 expression by fibroblasts is suppressed by the myofibroblast phenotype. Exp Cell Res. 2012; 318:1542-1553.
26. Wu L, Derynck R. Essential role of TGF-beta signaling inglucose-induced cell hypertrophy. Dev Cell. 2009; 17: 35-48.
27. Yu Q, Stamenkovic I. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGFbeta andpromotes tumor invasion and angiogenesis. Genes Dev. 2000; 14: 163-176.
28. Benbow U, Brinckerhoff CE. The AP-1 site and MMP gene regulation: what is all the fuss about? Matrix Biol. 1997; 15: 519-526.
29. Westermarck J, Kähäri VM. Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J. 1999; 13: 781-792.
30. Kehrer JP, Biswal SS, La E, Thuillier P, Datta K, Fischer SM, Vanden Heuvel JP. Inhibition of peroxisome-proliferator-activated receptor (PPAR) alpha by MK886. Biochem J. 2001; 356:899-906.
31. Leesnitzer LM, Parks DJ, Bledsoe RK, Cobb JE, Collins JL, Consler TG, Davis RG, Hull-Ryde EA, Lenhard JM, Patel L, Plunket KD, Shenk JL, Stimmel JB, Therapontos C, Willson TM, Blanchard SG. Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662. Biochemistry. 2002; 41: 6640-6650.