Hepatic TLR4 signaling is activated by LPS from digestive tract during SARA, and epigenetic mechanisms contribute to enforced TLR4 expression

Oncotarget

Volumn 6, Issue 36, 2015, Pages 38578-38590

  Chang, Guangjun ^a   Zhuang, Su ^a   Seyfert, Hans Martin ^b   Zhang, Kai ^a   Xu, Tianle ^a   Jin, Di ^a   Guo, Junfei ^a   Shen, Xiangzhen ^a  

^a NANJING AGRICULTURAL UNIVERSITY   (China)

^b LEIBNIZ INSTITUTE FOR FARM ANIMAL BIOLOGY FBN   (Germany)

Author keywords

Epigenetic mechanisms; Immune response; Immunity; Immunology and Microbiology Section; Liver; LPS translocation; subacute ruminal acidosis; TLR4 signaling

Indexed keywords

LIPOPOLYSACCHARIDE; MESSENGER RNA; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA;

ACIDOSIS; ANIMAL EXPERIMENT; ARTICLE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; DEMETHYLATION; DNA METHYLATION; EPIGENETICS; GENE EXPRESSION; GOAT; HEPATITIS; INNATE IMMUNITY; LIVER LEVEL; MILK; NONHUMAN; PORTAL VEIN; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STOMACH PH; SUBACUTE RUMINAL ACIDOSIS; TLR4 GENE; ANIMAL; BIOSYNTHESIS; BLOOD; BOVINE; GASTROINTESTINAL TRACT; GENETIC EPIGENESIS; GENETICS; GOAT DISEASE; IMMUNOLOGY; METABOLISM; PATHOLOGY; RUMEN; VETERINARY;

ACIDOSIS; ANIMALS; CATTLE; EPIGENESIS, GENETIC; GASTROINTESTINAL TRACT; GOAT DISEASES; GOATS; HEPATITIS; LIPOPOLYSACCHARIDES; RUMEN; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84948783316     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.6161     Document Type: Article

References (44)

1. Gozho GN, Krause DO and Plaizier JC. Rumen lipopolysaccharide and inflammation during grain adaptation and subacute ruminal acidosis in steers. J Dairy Sci. 2006; 89:4404-4413.
2. Li S, Khafipour E, Krause DO, Kroeker A, Rodriguez-Lecompte JC, Gozho GN and Plaizier JC. Effects of subacute ruminal acidosis challenges on fermentation and endotoxins in the rumen and hindgut of dairy cows. J Dairy Sci. 2012; 95:294-303.
3. Dong HB, Wang SQ, Jia YY, Ni YD, Zhang YS, Zhuang S, Shen XZ and Zhao RQ. Long-term effects of subacute ruminal acidosis (SARA) on milk quality and hepatic gene expression in lactating goats fed a high-concentrate diet. Plos One. 2013; 8:e82850.
4. Garrett EF, Pereira MN, Nordlund KV, Armentano LE, Goodger WJ and Oetzel GR. Diagnostic methods for the detection of subacute ruminal acidosis in dairy cows. J Dairy Sci. 1999; 82:1170-1178.
5. Emmanuel DGV, Madsen KL, Churchill TA, Dunn SM and Ametaj BN. Acidosis and lipopolysaccharide from Escherichia coli B: 055 cause hyperpermeability of rumen and colon tissues. J Dairy Sci. 2007; 90:5552-5557.
6. Tao S, Duanmu Y, Dong H, Tian J, Ni Y and Zhao R. A high-concentrate diet induced colonic epithelial barrier disruption is associated with the activating of cell apoptosis in lactating goats. BMC veterinary research. 2014; 10:235.
7. Liu JH, Xu TT, Zhu WY and Mao SY. A high-grain diet alters the omasal epithelial structure and expression of tight junction proteins in a goat model. Vet J. 2014; 201:95-100.
8. Jia YY, Wang SQ, Ni YD, Zhang YS, Zhuang S and Shen XZ. High concentrate-induced subacute ruminal acidosis (SARA) increases plasma acute phase proteins (APPs) and cortisol in goats. Animal. 2014; 8:1433-1438.
9. Zhou J, Dong GZ, Ao CJ, Zhang S, Qiu M, Wang X, Wu YX, Erdene K, Jin L, Lei CL and Zhang Z. Feeding a high-concentrate corn straw diet increased the release of endotoxin in the rumen and pro-inflammatory cytokines in the mammary gland of dairy cows. BMC veterinary research. 2014; 10:172.
10. Khafipour E, Krause DO and Plaizier JC. A grain-based subacute ruminal acidosis challenge causes translocation of lipopolysaccharide and triggers inflammation. J Dairy Sci. 2009; 92:1060-1070.
11. Plaizier JC, Khafipour E, Li S, Gozho GN and Krause DO. Subacute ruminal acidosis (SARA), endotoxins and health consequences. Anim Feed Sci Tech. 2012; 172:9-21.
12. Dong GZ, Liu SM, Wu YX, Lei CL, Zhou J and Zhang S. Diet-induced bacterial immunogens in the gastrointestinal tract of dairy cows: Impacts on immunity and metabolism. Acta Vet Scand. 2011; 53:48.
13. Sass G, Heinlein S, Agli A, Bang R, Schumann J and Tiegs G. Cytokine expression in three mouse models of experimental hepatitis. Cytokine. 2002; 19:115-120.
14. Ji XH, Sun KY, Feng YH and Yin GQ. Changes of inflammation-associated cytokine expressions during early phase of experimental endotoxic shock in macaques. World J Gastroentero. 2004; 10:3026-3033.
15. Akira S, Takeda K and Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol. 2001; 2:675-680.
16. Beutler B and Rietschel ET. Innate immune sensing and its roots: the story of endotoxin. Nat Rev Immunol. 2003; 3:169-176.
17. Hatada EN, Krappmann D and Scheidereit C. NF-kappa B and the innate immune response. Curr Opin Immun. 2000; 12:52-58.
18. Karin M and Lin A. NF-[kappa]B at the crossroads of life and death. Nat Immunol. 2002; 3:221-227.
19. Jiang L, Sorensen P, Rontved C, Vels L and Ingvartsen KL. Gene expression profiling of liver from dairy cows treated intra-mammary with lipopolysaccharide. BMC Genomics. 2008; 9:12.
20. Vels L, Rontved CM, Bjerring M and Ingvartsen KL. Cytokine and acute phase protein gene expression in repeated liver biopsies of dairy cows with a lipopolysaccharide-induced mastitis. J Dairy Sci. 2009; 92:922-934.
21. Liu SZ, Shi XM, Bauer I, Gunther J and Seyfert HM. Lingual antimicrobial peptide and IL-8 expression are oppositely regulated by the antagonistic effects of NF-kappa B p65 and C/EBP beta in mammary epithelial cells. Mol Immunol. 2011; 48:895-908.
22. Wiench M, Miranda TB and Hager GL. Control of nuclear receptor function by local chromatin structure. Febs J. 2011; 278:2211-2230.
23. Foster SL, Hargreaves DC and Medzhitov R. Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature. 2007; 447:972-978.
24. Biswas SK and Lopez-Collazo E. Endotoxin tolerance: new mechanisms, molecules and clinical significance. Trends Immunol. 2009; 30:475-487.
25. Gozho GN, Plaizier JC, Krause DO, Kennedy AD and Wittenberg KM. Subacute ruminal acidosis induces ruminal lipopolysaccharide endotoxin release and triggers an inflammatory response. J Dairy Sci. 2005; 88:1399-1403.
26. Dong GZ, Qiu M, Ao CJ, Zhou J, Khas E, Wang X, Zhang Z and Yang Y. Feeding a high-concentrate corn straw diet induced epigenetic alterations in the mammary tissue of dairy cows. Plos One. 2014; 9:e107659.
27. Li S, Kroeker A, Khafipour E, Rodriguez JC, Krause DO and Plaizier JC. Effects of subacute ruminal acidosis challenges on lipopolysaccharide endotoxin (LPS) in the rumen, cecum, and feces of dairy cows. J Dairy Sci. 2010; 93:433-434.
28. Steele MA, Croom J, Kahler M, AlZahal O, Hook SE, Plaizier K and McBride BW. Bovine rumen epithelium undergoes rapid structural adaptations during grain-induced subacute ruminal acidosis. Am J Physiol-Regul Integr Comp Physiol. 2011; 300:R1515-R1523.
29. Liu JH, Xu TT, Zhu WY and Mao SY. High-grain feeding alters caecal bacterial microbiota composition and fermentation and results in caecal mucosal injury in goats. Brith J Nutr. 2014; 112:416-427.
30. Kim HM, Park BS, Kim JI, Kim SE, Lee J, Oh SC, Enkhbayar P, Matsushima N, Lee H, Yoo OJ and Lee JO. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist eritoran. Cell. 2007; 130:906-917.
31. Hayden MS and Ghosh S. NF-kappa B in immunobiology. Cell Res. 2011; 21:223-244.
32. Kawai T and Akira S. TLR signaling. Cell Death Differ. 2006; 13:816-825.
33. Vallabhapurapu S and Karin M. Regulation and function of NF-kappa B transcription factors in the immune system. Annu Rev Immunol. 2009; 27:693-733.
34. Chang G, Petzl W, Vanselow J, Günther J, Shen X and Seyfert H-M. Epigenetic mechanisms contribute to enhanced expression of immune response genes in the liver of cows after experimentally induced escherichia coli mastitis. Vet J. 2015; 203:339-341.
35. Kooistra SM and Helin K. Molecular mechanisms and potential functions of histone demethylases. Nat Rev Mol Cell Bio. 2012; 13:297-311.
36. Pereira F, Barbachano A, Singh PK, Campbell MJ, Munoz A and Larriba MJ. Vitamin D has wide regulatory effects on histone demethylase genes. Cell Cycle. 2012; 11:1081-1089.
37. Bhandari SK, Ominski KH, Wittenberg KM and Plaizier JC. Effects of chop length of alfalfa and corn silage on milk production and rumen fermentation of dairy cows. J Dairy Sci. 2007; 90:2355-2366.
38. Khafipour E, Krause DO and Plaizier JC. Alfalfa pellet-induced subacute ruminal acidosis in dairy cows increases bacterial endotoxin in the rumen without causing inflammation. J Dairy Sci. 2009; 92:1712-1724.
39. Chang GJ, Zhang K, Xu TL, Jin D, Seyfert HM, Shen XZ and Zhuang S. Feeding a high-grain diet reduces the percentage of LPS clearance and enhances immune gene expression in goat liver. BMC Vet Res. 2015; 11:11.
40. Rao SH, Procko E and Shannon MF. Chromatin remodeling, measured by a novel real-time polymerase chain reaction assay, across the proximal promoter region of the IL-2 gene. J Immunol. 2001; 167:4494-4503.
41. Vanselow J, Yang W, Herrmann J, Zerbe H, Schuberth HJ, Petzl W, Tomek W and Seyfert HM. DNA-remethylation around a STAT5-binding enhancer in the alpha S1-casein promoter is associated with abrupt shutdown of alpha S1-casein synthesis during acute mastitis. J Mol Endocrinol. 2006; 37:463-477.
42. De Oliveira NFP, Andia DC, Planello AC, Pasetto S, Marques MR, Nociti FH, Line SRP and De Souza AP. TLR2 and TLR4 gene promoter methylation status during chronic periodontitis. J Clin Periodontol. 2011; 38:975-983.
43. de Faria Amormino SA, Arao TC, Saraiva AM, Gomez RS, Dutra WO, da Costa JE, de Fatima Correia Silva J and Moreira PR. Hypermethylation and low transcription of TLR2 gene in chronic periodontitis. Hum Immunol. 2013; 74:1231-1236.
44. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970; 227:680-685.