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Volumn 114, Issue 6, 2015, Pages 1113-1126

Practical management of bleeding in patients receiving non-vitamin K antagonist oral anticoagulants

Author keywords

Bleeding management; Bleeding profiles; Non vitamin K oral anticoagulant; Real world data; Reversal agent

Indexed keywords

ANDEXANET ALFA; ANTICOAGULANT AGENT; ANTIVITAMIN K; APIXABAN; CIRAPARANTAG; DABIGATRAN; EDOXABAN; FONDAPARINUX; IDARUCIZUMAB; LOW MOLECULAR WEIGHT HEPARIN; NON VITAMIN K ANTAGONIST ORAL ANTICOAGULANT; PROTHROMBIN COMPLEX; RECOMBINANT BLOOD CLOTTING FACTOR 7A; RIVAROXABAN; UNCLASSIFIED DRUG; WARFARIN; ANTIDOTE; ANTITHROMBIN; BLOOD CLOTTING FACTOR; BLOOD CLOTTING FACTOR 10A INHIBITOR; RECOMBINANT PROTEIN;

EID: 84948737936     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH15-03-0222     Document Type: Review
Times cited : (51)

References (120)
  • 2
    • 84894514116 scopus 로고    scopus 로고
    • Warfarin and atrial fibrillation: From ideal to real the warfarin affaire
    • Molteni M, Cimminiello C. Warfarin and atrial fibrillation: from ideal to real the warfarin affaire. Thromb J 2014; 12: 5.
    • (2014) Thromb J , vol.12 , pp. 5
    • Molteni, M.1    Cimminiello, C.2
  • 3
    • 84880327613 scopus 로고    scopus 로고
    • Oral apixaban for the treatment of acute venous thromboembolism
    • Agnelli G, et al. Oral apixaban for the treatment of acute venous thromboembolism. N Engl J Med 2013; 369: 799-808.
    • (2013) N Engl J Med , vol.369 , pp. 799-808
    • Agnelli, G.1
  • 4
    • 84885618705 scopus 로고    scopus 로고
    • Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism
    • The Hokusai-VTE Investigators. Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism. N Engl J Med 2013; 369: 1406-1415.
    • (2013) N Engl J Med , vol.369 , pp. 1406-1415
    • The Hokusai-VTE Investigators1
  • 5
    • 84884336961 scopus 로고    scopus 로고
    • Oral rivaroxaban versus standard therapy for the treatment of symptomatic venous thromboembolism: A pooled analysis of the EINSTEINDVT and PE randomized studies
    • Prins MH, et al. Oral rivaroxaban versus standard therapy for the treatment of symptomatic venous thromboembolism: a pooled analysis of the EINSTEINDVT and PE randomized studies. Thromb J 2013; 11: 21.
    • (2013) Thromb J , vol.11 , pp. 21
    • Prins, M.H.1
  • 6
    • 84894295323 scopus 로고    scopus 로고
    • Treatment of acute venous thromboembolism with dabigatran or warfarin and pooled analysis
    • Schulman S, et al. Treatment of acute venous thromboembolism with dabigatran or warfarin and pooled analysis. Circulation 2014; 129: 764-772.
    • (2014) Circulation , vol.129 , pp. 764-772
    • Schulman, S.1
  • 7
    • 80052592404 scopus 로고    scopus 로고
    • Rivaroxaban versus warfarin in nonvalvular atrial fibrillation
    • Patel MR, et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 2011; 365: 883-891.
    • (2011) N Engl J Med , vol.365 , pp. 883-891
    • Patel, M.R.1
  • 8
    • 70349306707 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in patients with atrial fibrillation
    • Connolly SJ, et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 2009; 361: 1139-1151.
    • (2009) N Engl J Med , vol.361 , pp. 1139-1151
    • Connolly, S.J.1
  • 9
    • 78049490509 scopus 로고    scopus 로고
    • Newly identified events in the RE-LY trial
    • Connolly SJ, et al. Newly identified events in the RE-LY trial. N Engl J Med 2010; 363: 1875-1876.
    • (2010) N Engl J Med , vol.363 , pp. 1875-1876
    • Connolly, S.J.1
  • 10
    • 84907863384 scopus 로고    scopus 로고
    • Additional events in the RE-LY trial
    • Connolly SJ, et al. Additional events in the RE-LY trial. N Engl J Med 2014; 371: 1464-1465.
    • (2014) N Engl J Med , vol.371 , pp. 1464-1465
    • Connolly, S.J.1
  • 11
    • 80052825103 scopus 로고    scopus 로고
    • Apixaban versus warfarin in patients with atrial fibrillation
    • Granger CB, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2011; 365: 981-992.
    • (2011) N Engl J Med , vol.365 , pp. 981-992
    • Granger, C.B.1
  • 12
    • 84888362796 scopus 로고    scopus 로고
    • Edoxaban versus warfarin in patients with atrial fibrillation
    • Giugliano RP, et al. Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med 2013; 369: 2093-2104.
    • (2013) N Engl J Med , vol.369 , pp. 2093-2104
    • Giugliano, R.P.1
  • 13
    • 84903313469 scopus 로고    scopus 로고
    • Bleeding events among new starters and switchers to dabigatran compared with warfarin in atrial fibrillation
    • Larsen TB, et al. Bleeding events among new starters and switchers to dabigatran compared with warfarin in atrial fibrillation. Am J Med 2014; 127: 650-656.
    • (2014) Am J Med , vol.127 , pp. 650-656
    • Larsen, T.B.1
  • 14
    • 84905747093 scopus 로고    scopus 로고
    • Rates, management, and outcome of rivaroxaban bleeding in daily care: Results from the Dresden NOAC registry
    • Beyer-Westendorf J, et al. Rates, management, and outcome of rivaroxaban bleeding in daily care: results from the Dresden NOAC registry. Blood 2014; 124: 955-962.
    • (2014) Blood , vol.124 , pp. 955-962
    • Beyer-Westendorf, J.1
  • 15
    • 84908541406 scopus 로고    scopus 로고
    • Addressing barriers to optimal oral anticoagulation use and persistence among patients with atrial fibrillation: Proceedings, Washington, DC, December 3-4, 2012
    • Hess PL, et al. Addressing barriers to optimal oral anticoagulation use and persistence among patients with atrial fibrillation: Proceedings, Washington, DC, December 3-4, 2012. Am Heart J 2014; 168: 239-247.
    • (2014) Am Heart J , vol.168 , pp. 239-247
    • Hess, P.L.1
  • 16
    • 84869838484 scopus 로고    scopus 로고
    • Efficacy and safety of novel oral anticoagulants for treatment of acute venous thromboembolism: Direct and adjusted indirect meta-analysis of randomised controlled trials
    • Fox BD, et al. Efficacy and safety of novel oral anticoagulants for treatment of acute venous thromboembolism: direct and adjusted indirect meta-analysis of randomised controlled trials. Br Med J 2012; 345: e7498.
    • (2012) Br Med J , vol.345
    • Fox, B.D.1
  • 17
    • 84896741977 scopus 로고    scopus 로고
    • Effectiveness and safety of novel oral anticoagulants as compared with vitamin K antagonists in the treatment of acute symptomatic venous thromboembolism: A systematic review and meta-analysis
    • van der Hulle T, et al. Effectiveness and safety of novel oral anticoagulants as compared with vitamin K antagonists in the treatment of acute symptomatic venous thromboembolism: a systematic review and meta-analysis. J Thromb Haemost 2014; 12: 320-328.
    • (2014) J Thromb Haemost , vol.12 , pp. 320-328
    • van der Hulle, T.1
  • 18
    • 84907221429 scopus 로고    scopus 로고
    • Clinical and safety outcomes associated with treatment of acute venous thromboembolism: A systematic review and meta-analysis
    • Castellucci LA, et al. Clinical and safety outcomes associated with treatment of acute venous thromboembolism: a systematic review and meta-analysis. J Am Med Assoc 2014; 312: 1122-1135.
    • (2014) J Am Med Assoc , vol.312 , pp. 1122-1135
    • Castellucci, L.A.1
  • 19
    • 84900513089 scopus 로고    scopus 로고
    • Indirect treatment comparison of new oral anticoagulants for the treatment of acute venous thromboembolism
    • Kang N, Sobieraj DM. Indirect treatment comparison of new oral anticoagulants for the treatment of acute venous thromboembolism. Thromb Res 2014; 133: 1145-1151.
    • (2014) Thromb Res , vol.133 , pp. 1145-1151
    • Kang, N.1    Sobieraj, D.M.2
  • 20
    • 84939880319 scopus 로고    scopus 로고
    • Indirect comparison of dabigatran, rivaroxaban, apixaban and edoxaban for the treatment of acute venous thromboembolism
    • Mantha S, Ansell J. Indirect comparison of dabigatran, rivaroxaban, apixaban and edoxaban for the treatment of acute venous thromboembolism. J Thromb Thrombol 2015; 39: 155-165.
    • (2015) J Thromb Thrombol , vol.39 , pp. 155-165
    • Mantha, S.1    Ansell, J.2
  • 21
    • 71849117615 scopus 로고    scopus 로고
    • Dabigatran versus warfarin in the treatment of acute venous thromboembolism
    • Schulman S, et al. Dabigatran versus warfarin in the treatment of acute venous thromboembolism. N Engl J Med 2009; 361: 2342-2352.
    • (2009) N Engl J Med , vol.361 , pp. 2342-2352
    • Schulman, S.1
  • 22
    • 78650619315 scopus 로고    scopus 로고
    • Oral rivaroxaban for symptomatic venous thromboembolism
    • The EINSTEIN Investigators. Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med 2010; 363: 2499-2510.
    • (2010) N Engl J Med , vol.363 , pp. 2499-2510
    • The EINSTEIN Investigators1
  • 23
    • 84859385808 scopus 로고    scopus 로고
    • Oral rivaroxaban for the treatment of symptomatic pulmonary embolism
    • The EINSTEIN-PE Investigators. Oral rivaroxaban for the treatment of symptomatic pulmonary embolism. N Engl J Med 2012; 366: 1287-1297.
    • (2012) N Engl J Med , vol.366 , pp. 1287-1297
    • The EINSTEIN-PE Investigators1
  • 24
    • 84873596181 scopus 로고    scopus 로고
    • Apixaban for extended treatment of venous thromboembolism
    • Agnelli G, et al. Apixaban for extended treatment of venous thromboembolism. N Engl J Med 2013; 368: 699-708.
    • (2013) N Engl J Med , vol.368 , pp. 699-708
    • Agnelli, G.1
  • 25
    • 84874003257 scopus 로고    scopus 로고
    • Extended use of dabigatran, warfarin, or placebo in venous thromboembolism
    • Schulman S, et al. Extended use of dabigatran, warfarin, or placebo in venous thromboembolism. N Engl J Med 2013; 368: 709-718.
    • (2013) N Engl J Med , vol.368 , pp. 709-718
    • Schulman, S.1
  • 26
    • 84876695740 scopus 로고    scopus 로고
    • 2012 focused update of the ESC Guidelines for the management of atrial fibrillation: An update of the 2010 ESC Guidelines for the management of atrial fibrillation. Developed with the special contribution of the European Heart Rhythm Association
    • Camm AJ, et al. 2012 focused update of the ESC Guidelines for the management of atrial fibrillation: an update of the 2010 ESC Guidelines for the management of atrial fibrillation. Developed with the special contribution of the European Heart Rhythm Association. Eur Heart J 2012; 33: 2719-2747.
    • (2012) Eur Heart J , vol.33 , pp. 2719-2747
    • Camm, A.J.1
  • 27
    • 84908220640 scopus 로고    scopus 로고
    • 2014 AHA/ACC/HRS Guideline for the management of patients with atrial fibrillation: A report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society
    • January CT, et al. 2014 AHA/ACC/HRS Guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol 2014; 64: e1-e76.
    • (2014) J Am Coll Cardiol , vol.64 , pp. e1-e76
    • January, C.T.1
  • 28
    • 84890359770 scopus 로고    scopus 로고
    • New oral anticoagulants and the risk of intracranial hemorrhage: Traditional and Bayesian meta-analysis and mixed treatment comparison of randomized trials of new oral anticoagulants in atrial fibrillation
    • Chatterjee S, et al. New oral anticoagulants and the risk of intracranial hemorrhage: traditional and Bayesian meta-analysis and mixed treatment comparison of randomized trials of new oral anticoagulants in atrial fibrillation. J Am Med Assoc Neurol 2013; 70: 1486-1490.
    • (2013) J Am Med Assoc Neurol , vol.70 , pp. 1486-1490
    • Chatterjee, S.1
  • 29
    • 84896117299 scopus 로고    scopus 로고
    • Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: A meta-analysis of randomised trials
    • Ruff CT, et al. Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. Lancet 2014; 383: 955-962.
    • (2014) Lancet , vol.383 , pp. 955-962
    • Ruff, C.T.1
  • 30
    • 84863981277 scopus 로고    scopus 로고
    • Meta-analysis of efficacy and safety of new oral anticoagulants (dabigatran, rivaroxaban, apixaban) versus warfarin in patients with atrial fibrillation
    • Miller CS, et al. Meta-analysis of efficacy and safety of new oral anticoagulants (dabigatran, rivaroxaban, apixaban) versus warfarin in patients with atrial fibrillation. Am J Cardiol 2012; 110: 453-460.
    • (2012) Am J Cardiol , vol.110 , pp. 453-460
    • Miller, C.S.1
  • 31
    • 84865138532 scopus 로고    scopus 로고
    • Indirect comparisons of new oral anticoagulant drugs for efficacy and safety when used for stroke prevention in atrial fibrillation
    • Lip GYH, et al. Indirect comparisons of new oral anticoagulant drugs for efficacy and safety when used for stroke prevention in atrial fibrillation. J Am Coll Cardiol 2012; 60: 738-746.
    • (2012) J Am Coll Cardiol , vol.60 , pp. 738-746
    • Lip, G.Y.H.1
  • 32
    • 34547433185 scopus 로고    scopus 로고
    • Death and disability from warfarin-associated intracranial and extracranial hemorrhages
    • Fang MC, et al. Death and disability from warfarin-associated intracranial and extracranial hemorrhages. Am J Med 2007; 120: 700-705.
    • (2007) Am J Med , vol.120 , pp. 700-705
    • Fang, M.C.1
  • 33
    • 84908543945 scopus 로고    scopus 로고
    • Organ-specific bleeding patterns of anticoagulant therapy: Lessons from clinical trials
    • Vanassche T, et al. Organ-specific bleeding patterns of anticoagulant therapy: lessons from clinical trials. Thromb Haemost 2014; 112: 918-923.
    • (2014) Thromb Haemost , vol.112 , pp. 918-923
    • Vanassche, T.1
  • 34
    • 34548455445 scopus 로고    scopus 로고
    • Independent predictors of stroke in patients with atrial fibrillation: A systematic review
    • The Stroke Risk in Atrial Fibrillation Working Group. Independent predictors of stroke in patients with atrial fibrillation: a systematic review. Neurology 2007; 69: 546-554.
    • (2007) Neurology , vol.69 , pp. 546-554
  • 35
    • 46749096473 scopus 로고    scopus 로고
    • Contra: 'Warfarin should be the drug of choice for thromboprophylaxis in elderly patients with atrial fibrillation'. Caveats regarding use of oral anticoagulant therapy among elderly patients with atrial fibrillation
    • Hylek EM. Contra: 'Warfarin should be the drug of choice for thromboprophylaxis in elderly patients with atrial fibrillation'. Caveats regarding use of oral anticoagulant therapy among elderly patients with atrial fibrillation. Thromb Haemost 2008; 100: 16-17.
    • (2008) Thromb Haemost , vol.100 , pp. 16-17
    • Hylek, E.M.1
  • 36
    • 84904040755 scopus 로고    scopus 로고
    • Efficacy and safety of rivaroxaban compared with warfarin among elderly patients with nonvalvular atrial fibrillation in the Rivaroxaban Once daily, oral, direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF)
    • Halperin JL, et al. Efficacy and safety of rivaroxaban compared with warfarin among elderly patients with nonvalvular atrial fibrillation in the Rivaroxaban Once daily, oral, direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF). Circulation 2014; 130: 138-146.
    • (2014) Circulation , vol.130 , pp. 138-146
    • Halperin, J.L.1
  • 37
    • 84904047925 scopus 로고    scopus 로고
    • Efficacy and safety of apixaban compared with warfarin according to age for stroke prevention in atrial fibrillation: Observations from the ARISTOTLE trial
    • Halvorsen S, et al. Efficacy and safety of apixaban compared with warfarin according to age for stroke prevention in atrial fibrillation: observations from the ARISTOTLE trial. Eur Heart J 2014; 35: 1864-1872.
    • (2014) Eur Heart J , vol.35 , pp. 1864-1872
    • Halvorsen, S.1
  • 38
    • 79958126202 scopus 로고    scopus 로고
    • Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: An analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial
    • Eikelboom JW, et al. Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: an analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial. Circulation 2011; 123: 2363-2372.
    • (2011) Circulation , vol.123 , pp. 2363-2372
    • Eikelboom, J.W.1
  • 39
    • 84904764432 scopus 로고    scopus 로고
    • Novel oral anticoagulants in patients with renal insufficiency: A meta-analysis of randomized trials
    • Sardar P, et al. Novel oral anticoagulants in patients with renal insufficiency: a meta-analysis of randomized trials. Can J Cardiol 2014; 30: 888-897.
    • (2014) Can J Cardiol , vol.30 , pp. 888-897
    • Sardar, P.1
  • 40
    • 84896766005 scopus 로고    scopus 로고
    • Consistency of safety profile of new oral anticoagulants in patients with renal failure
    • Lega JC, et al. Consistency of safety profile of new oral anticoagulants in patients with renal failure. J Thromb Haemost 2014; 12: 337-343.
    • (2014) J Thromb Haemost , vol.12 , pp. 337-343
    • Lega, J.C.1
  • 41
    • 0037111563 scopus 로고    scopus 로고
    • Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis
    • Prandoni P, et al. Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis. Blood 2002; 100: 3484-3488.
    • (2002) Blood , vol.100 , pp. 3484-3488
    • Prandoni, P.1
  • 42
    • 84922032437 scopus 로고    scopus 로고
    • Oral rivaroxaban versus enoxaparin with vitamin K antagonist for the treatment of symptomatic venous thromboembolism in patients with cancer (EINSTEIN-DVT and EINSTEIN-PE): A pooled subgroup analysis of two randomised controlled trials
    • Prins MH, et al. Oral rivaroxaban versus enoxaparin with vitamin K antagonist for the treatment of symptomatic venous thromboembolism in patients with cancer (EINSTEIN-DVT and EINSTEIN-PE): a pooled subgroup analysis of two randomised controlled trials. Lancet Haematol 2014; 1: e37-e46.
    • (2014) Lancet Haematol , vol.1 , pp. e37-e46
    • Prins, M.H.1
  • 43
    • 84928074718 scopus 로고    scopus 로고
    • Direct oral anticoagulants in patients with VTE and cancer: A systematic review and meta-analysis
    • Vedovati MC, et al. Direct oral anticoagulants in patients with VTE and cancer: a systematic review and meta-analysis. Chest 2015; 147: 475-483.
    • (2015) Chest , vol.147 , pp. 475-483
    • Vedovati, M.C.1
  • 44
    • 84902172555 scopus 로고    scopus 로고
    • Bleeding risk of patients with acute venous thromboembolism taking nonsteroidal anti-inflammatory drugs or aspirin
    • Davidson BL, et al. Bleeding risk of patients with acute venous thromboembolism taking nonsteroidal anti-inflammatory drugs or aspirin. J Am Med Assoc Intern Med 2014; 174: 947-953.
    • (2014) J Am Med Assoc Intern Med , vol.174 , pp. 947-953
    • Davidson, B.L.1
  • 45
    • 84873569160 scopus 로고    scopus 로고
    • Concomitant Use of Antiplatelet Therapy with Dabigatran or Warfarin in the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) Trial
    • Dans AL, et al. Concomitant Use of Antiplatelet Therapy with Dabigatran or Warfarin in the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) Trial. Circulation 2013; 127: 634-640.
    • (2013) Circulation , vol.127 , pp. 634-640
    • Dans, A.L.1
  • 46
    • 84925650701 scopus 로고    scopus 로고
    • Characterizing major bleeding in patients with nonvalvular atrial fibrillation: A pharmacovigilance study of 27 467 patients taking rivaroxaban
    • Tamayo S, et al. Characterizing major bleeding in patients with nonvalvular atrial fibrillation: a pharmacovigilance study of 27 467 patients taking rivaroxaban. Clin Cardiol 2015; 38: 63-68.
    • (2015) Clin Cardiol , vol.38 , pp. 63-68
    • Tamayo, S.1
  • 47
    • 84878292470 scopus 로고    scopus 로고
    • Efficacy and safety of dabigatran etexilate and warfarin in "realworld" patients with atrial fibrillation: A prospective nationwide cohort study
    • Larsen TB, et al. Efficacy and safety of dabigatran etexilate and warfarin in "realworld" patients with atrial fibrillation: a prospective nationwide cohort study. J Am Coll Cardiol 2013; 61: 2264-2273.
    • (2013) J Am Coll Cardiol , vol.61 , pp. 2264-2273
    • Larsen, T.B.1
  • 48
    • 84925313759 scopus 로고    scopus 로고
    • Major bleeding with dabigatran and rivaroxaban in patients with atrial fibrillation: A real-world setting
    • Fontaine GV, et al. Major bleeding with dabigatran and rivaroxaban in patients with atrial fibrillation: a real-world setting. Clin Appl Thromb Hemost 2014; 20: 665-672.
    • (2014) Clin Appl Thromb Hemost , vol.20 , pp. 665-672
    • Fontaine, G.V.1
  • 50
    • 84924034859 scopus 로고    scopus 로고
    • Cardiovascular, bleeding, and mortality risks in elderly Medicare patients treated with dabigatran or warfarin for non-valvular atrial fibrillation
    • Graham DJ, et al. Cardiovascular, bleeding, and mortality risks in elderly Medicare patients treated with dabigatran or warfarin for non-valvular atrial fibrillation. Circulation 2015; 131: 157-164.
    • (2015) Circulation , vol.131 , pp. 157-164
    • Graham, D.J.1
  • 51
    • 84875780959 scopus 로고    scopus 로고
    • Dabigatran and postmarketing reports of bleeding
    • Southworth MR, et al. Dabigatran and postmarketing reports of bleeding. N Engl J Med 2013; 368: 1272-1274.
    • (2013) N Engl J Med , vol.368 , pp. 1272-1274
    • Southworth, M.R.1
  • 54
    • 84877978738 scopus 로고    scopus 로고
    • Risk profiles and antithrombotic treatment of patients newly diagnosed with atrial fibrillation at risk of stroke: Perspectives from the international, observational, prospective GARFIELD Registry
    • Kakkar AK, et al. Risk profiles and antithrombotic treatment of patients newly diagnosed with atrial fibrillation at risk of stroke: perspectives from the international, observational, prospective GARFIELD Registry. PLoS One 2013; 8: e63479.
    • (2013) PLoS One , vol.8
    • Kakkar, A.K.1
  • 55
    • 84985898952 scopus 로고    scopus 로고
    • International normalized ratio control and 1-year outcomes in patients with newly diagnosed atrial fibrillation: The GARFIELD Registry
    • Abstract P2656
    • Haas S, et al. International normalized ratio control and 1-year outcomes in patients with newly diagnosed atrial fibrillation: the GARFIELD Registry. Eur Heart J 2014; 35 Abstract P2656.
    • (2014) Eur Heart J , vol.35
    • Haas, S.1
  • 56
    • 84948829149 scopus 로고    scopus 로고
    • Truly low-risk patients with newly diagnosed non-valvular atrial fibrillation at risk of stroke: 1-year outcomes from the GARFIELD Registry
    • Abstract P2646
    • Bassand JP, et al. Truly low-risk patients with newly diagnosed non-valvular atrial fibrillation at risk of stroke: 1-year outcomes from the GARFIELD Registry. Eur Heart J 2014; 35 Abstract P2646.
    • (2014) Eur Heart J , vol.35
    • Bassand, J.P.1
  • 57
    • 84896709161 scopus 로고    scopus 로고
    • Design and rationale of Global Registry on Long-term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation: A global registry program on long-term oral antithrombotic treatment in patients with atrial fibrillation
    • Huisman MV, et al. Design and rationale of Global Registry on Long-term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation: a global registry program on long-term oral antithrombotic treatment in patients with atrial fibrillation. Am Heart J 2014; 167: 329-334.
    • (2014) Am Heart J , vol.167 , pp. 329-334
    • Huisman, M.V.1
  • 58
    • 84948829150 scopus 로고    scopus 로고
    • Antithrombotic treatment pattern and baseline characteristics of dabigatran and vitamin K antagonist cohorts in North America - The GLORIA-AF registry program
    • Abstract P4394
    • Huisman MV, et al. Antithrombotic treatment pattern and baseline characteristics of dabigatran and vitamin K antagonist cohorts in North America - The GLORIA-AF registry program. Eur Heart J 2014; 35 Abstract P4394.
    • (2014) Eur Heart J , vol.35
    • Huisman, M.V.1
  • 59
    • 84899050921 scopus 로고    scopus 로고
    • Variations in cause and management of atrial fibrillation in a prospective registry of 15,400 emergency department patients in 46 countries: The RE-LY Atrial Fibrillation Registry
    • Oldgren J, et al. Variations in cause and management of atrial fibrillation in a prospective registry of 15,400 emergency department patients in 46 countries: the RE-LY Atrial Fibrillation Registry. Circulation 2014; 129: 1568-1576.
    • (2014) Circulation , vol.129 , pp. 1568-1576
    • Oldgren, J.1
  • 60
    • 84888197736 scopus 로고    scopus 로고
    • Management and outcomes of major bleeding during treatment with dabigatran or warfarin
    • Majeed A, et al. Management and outcomes of major bleeding during treatment with dabigatran or warfarin. Circulation 2013; 128: 2325-2332.
    • (2013) Circulation , vol.128 , pp. 2325-2332
    • Majeed, A.1
  • 61
    • 84900992940 scopus 로고    scopus 로고
    • Major bleeding in patients with atrial fibrillation receiving apixaban or warfarin: The ARISTOTLE Trial (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation): Predictors, Characteristics, and Clinical Outcomes
    • Hylek EM, et al. Major bleeding in patients with atrial fibrillation receiving apixaban or warfarin: The ARISTOTLE Trial (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation): Predictors, Characteristics, and Clinical Outcomes. J Am Coll Cardiol 2014; 63: 2141-2147.
    • (2014) J Am Coll Cardiol , vol.63 , pp. 2141-2147
    • Hylek, E.M.1
  • 62
    • 84861616750 scopus 로고    scopus 로고
    • Intracranial hemorrhage in atrial fibrillation patients during anticoagulation with warfarin or dabigatran: The RE-LY trial
    • Hart RG, et al. Intracranial hemorrhage in atrial fibrillation patients during anticoagulation with warfarin or dabigatran: the RE-LY trial. Stroke 2012; 43: 1511-1517.
    • (2012) Stroke , vol.43 , pp. 1511-1517
    • Hart, R.G.1
  • 63
    • 84899934698 scopus 로고    scopus 로고
    • Intracranial hemorrhage among patients with atrial fibrillation anticoagulated with warfarin or rivaroxaban: The rivaroxaban once daily, oral, direct Factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation
    • Hankey GJ, et al. Intracranial hemorrhage among patients with atrial fibrillation anticoagulated with warfarin or rivaroxaban: the rivaroxaban once daily, oral, direct Factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation. Stroke 2014; 45: 1304-1312.
    • (2014) Stroke , vol.45 , pp. 1304-1312
    • Hankey, G.J.1
  • 64
    • 84863989146 scopus 로고    scopus 로고
    • Periprocedural bleeding and thromboembolic events with dabigatran compared with warfarin: Results from the randomized evaluation of long-term anticoagulation therapy (RE-LY) randomized trial
    • Healey JS, et al. Periprocedural bleeding and thromboembolic events with dabigatran compared with warfarin: results from the randomized evaluation of long-term anticoagulation therapy (RE-LY) randomized trial. Circulation 2012; 126: 343-348.
    • (2012) Circulation , vol.126 , pp. 343-348
    • Healey, J.S.1
  • 65
    • 84900470694 scopus 로고    scopus 로고
    • Outcomes of temporary interruption of rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: Results from the Rivaroxaban Once daily, oral, direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF)
    • Sherwood MW, et al. Outcomes of temporary interruption of rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: results from the Rivaroxaban Once daily, oral, direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF). Circulation 2014; 129: 1850-1859.
    • (2014) Circulation , vol.129 , pp. 1850-1859
    • Sherwood, M.W.1
  • 66
    • 84901718244 scopus 로고    scopus 로고
    • Peri-interventional management of novel oral anticoagulants in daily care: Results from the prospective Dresden NOAC registry
    • Beyer-Westendorf J, et al. Peri-interventional management of novel oral anticoagulants in daily care: results from the prospective Dresden NOAC registry. Eur Heart J 2014; 35: 1888-1896.
    • (2014) Eur Heart J , vol.35 , pp. 1888-1896
    • Beyer-Westendorf, J.1
  • 67
    • 84863301351 scopus 로고    scopus 로고
    • Poor prognosis in warfarin-associated intracranial hemorrhage despite anticoagulation reversal
    • Dowlatshahi D, et al. Poor prognosis in warfarin-associated intracranial hemorrhage despite anticoagulation reversal. Stroke 2012; 43: 1812-1817.
    • (2012) Stroke , vol.43 , pp. 1812-1817
    • Dowlatshahi, D.1
  • 68
    • 84893179904 scopus 로고    scopus 로고
    • Mortality in vitamin K antagonist-related intracerebral bleeding treated with plasma or 4-factor prothrombin complex concentrate
    • Majeed A, et al. Mortality in vitamin K antagonist-related intracerebral bleeding treated with plasma or 4-factor prothrombin complex concentrate. Thromb Haemost 2014; 111: 233-239.
    • (2014) Thromb Haemost , vol.111 , pp. 233-239
    • Majeed, A.1
  • 69
    • 84975237335 scopus 로고    scopus 로고
    • Bayer Pharma AG. Accessed April 28, 2015
    • Bayer Pharma AG. Xarelto® (rivaroxaban) Summary of Product Characteristics. 2015. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/ EPAR_-_Product_Information/human/000944/WC500057108.pdf. Accessed April 28, 2015.
    • (2015) Xarelto® (rivaroxaban) Summary of Product Characteristics.
  • 70
    • 84941997771 scopus 로고    scopus 로고
    • Janssen Pharmaceuticals Inc. Accessed April 28, 2015
    • Janssen Pharmaceuticals Inc. Xarelto® (rivaroxaban) Prescribing Information. 2015. Available at: http://www.xareltohcp.com/sites/default/files/pdf/xarel to_0.pdf. Accessed April 28, 2015.
    • (2015) Xarelto® (rivaroxaban) Prescribing Information.
  • 71
    • 84948766209 scopus 로고    scopus 로고
    • Bristol-Myers Squibb, Pfizer. Accessed April 28, 2015
    • Bristol-Myers Squibb, Pfizer. Eliquis® (apixaban) Summary of Product Characteristics. 2014. Available at: http://www.ema.europa.eu/docs/en_GB/docu ment_library/EPAR_-_Product_Information/human/ 002148/WC500107728.pdf. Accessed April 28, 2015.
    • (2014) Eliquis® (apixaban) Summary of Product Characteristics.
  • 72
    • 84907059295 scopus 로고    scopus 로고
    • Bristol-Myers Squibb Company, Pfizer Inc. Accessed April 28, 2015
    • Bristol-Myers Squibb Company, Pfizer Inc. Eliquis® (apixaban) Prescribing Information. 2014. Available at: http://packageinserts.bms.com/pi/pi_eliquis.pdf. Accessed April 28, 2015.
    • (2014) Eliquis® (apixaban) Prescribing Information.
  • 73
    • 79951853372 scopus 로고    scopus 로고
    • Boehringer Ingelheim International GmbH. Accessed April 28, 2015
    • Boehringer Ingelheim International GmbH. Pradaxa® (dabigatran etexilate) Summary of Product Characteristics. 2015. Available at: http://www.ema.euro pa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/ 000829/WC500041059.pdf. Accessed April 28, 2015.
    • (2015) Pradaxa® (dabigatran etexilate) Summary of Product Characteristics.
  • 74
    • 84992512720 scopus 로고    scopus 로고
    • Boehringer Ingelheim Pharmaceuticals Inc. Accessed April 28, 2015
    • Boehringer Ingelheim Pharmaceuticals Inc. Pradaxa® (dabigatran etexilate) Prescribing Information. 2015. Available at: http://bidocs.boehringer-ingelheim. com/BIWebAccess/ViewServlet.ser?docBase=renetnt&folderPath=/ Prescribing%20Information/PIs/Pradaxa/Pradaxa.pdf. Accessed April 28, 2015.
    • (2015) Pradaxa® (dabigatran etexilate) Prescribing Information.
  • 75
    • 84877301336 scopus 로고    scopus 로고
    • European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation
    • Heidbuchel H, et al. European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation. Europace 2013; 15: 625-651.
    • (2013) Europace , vol.15 , pp. 625-651
    • Heidbuchel, H.1
  • 76
    • 84880571372 scopus 로고    scopus 로고
    • Management of major bleeding complications and emergency surgery in patients on long-term treatment with direct oral anticoagulants, thrombin or Factor-Xa inhibitors: Proposals of the Working Group on Perioperative Haemostasis (GIHP) - March 2013
    • Pernod G, et al. Management of major bleeding complications and emergency surgery in patients on long-term treatment with direct oral anticoagulants, thrombin or Factor-Xa inhibitors: proposals of the Working Group on Perioperative Haemostasis (GIHP) - March 2013. Arch Cardiovasc Dis 2013; 106: 382-393.
    • (2013) Arch Cardiovasc Dis , vol.106 , pp. 382-393
    • Pernod, G.1
  • 77
    • 84882374529 scopus 로고    scopus 로고
    • Laboratory testing of rivaroxaban in routine clinical practice: When, how, and which assays
    • Lindhoff-Last E, et al. Laboratory testing of rivaroxaban in routine clinical practice: When, how, and which assays. Ann Med 2013; 45: 423-429.
    • (2013) Ann Med , vol.45 , pp. 423-429
    • Lindhoff-Last, E.1
  • 78
    • 84880785759 scopus 로고    scopus 로고
    • Gastrointestinal bleeding with the new oral anticoagulants--defining the issues and the management strategies
    • Desai J, et al. Gastrointestinal bleeding with the new oral anticoagulants--defining the issues and the management strategies. Thromb Haemost 2013; 110: 205-212.
    • (2013) Thromb Haemost , vol.110 , pp. 205-212
    • Desai, J.1
  • 79
    • 84923913745 scopus 로고    scopus 로고
    • How I use fibrinogen replacement therapy in acquired bleeding
    • Levy JH, Goodnough LT. How I use fibrinogen replacement therapy in acquired bleeding. Blood 2015; 125: 1387-1393.
    • (2015) Blood , vol.125 , pp. 1387-1393
    • Levy, J.H.1    Goodnough, L.T.2
  • 80
    • 77949421739 scopus 로고    scopus 로고
    • Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: An open-label, parallel-group, single-centre study
    • Stangier J, et al. Influence of renal impairment on the pharmacokinetics and pharmacodynamics of oral dabigatran etexilate: an open-label, parallel-group, single-centre study. Clin Pharmacokinet 2010; 49: 259-268.
    • (2010) Clin Pharmacokinet , vol.49 , pp. 259-268
    • Stangier, J.1
  • 81
    • 84875926001 scopus 로고    scopus 로고
    • Effective elimination of dabigatran by haemodialysis. A phase I single-centre study in patients with end-stage renal disease
    • Khadzhynov D, et al. Effective elimination of dabigatran by haemodialysis. A phase I single-centre study in patients with end-stage renal disease. Thromb Haemost 2013; 109: 596-605.
    • (2013) Thromb Haemost , vol.109 , pp. 596-605
    • Khadzhynov, D.1
  • 82
    • 84864370719 scopus 로고    scopus 로고
    • Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban. A randomised crossover ex vivo study in healthy volunteers
    • Marlu R, et al. Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban. A randomised crossover ex vivo study in healthy volunteers. Thromb Haemost 2012; 108: 217-224.
    • (2012) Thromb Haemost , vol.108 , pp. 217-224
    • Marlu, R.1
  • 83
    • 84875053456 scopus 로고    scopus 로고
    • The use of FEIBA(R) in the correction of coagulation abnormalities induced by dabigatran
    • Khoo TL, et al. The use of FEIBA(R) in the correction of coagulation abnormalities induced by dabigatran. Int J Lab Hematol 2013; 35: 222-224.
    • (2013) Int J Lab Hematol , vol.35 , pp. 222-224
    • Khoo, T.L.1
  • 84
    • 84892921288 scopus 로고    scopus 로고
    • Reversal of apixaban induced alterations in hemostasis by different coagulation factor concentrates: Significance of studies in vitro with circulating human blood
    • Escolar G, et al. Reversal of apixaban induced alterations in hemostasis by different coagulation factor concentrates: significance of studies in vitro with circulating human blood. PLoS One 2013; 8: e78696.
    • (2013) PLoS One , vol.8
    • Escolar, G.1
  • 85
    • 84922565475 scopus 로고    scopus 로고
    • Measurement and reversal of prophylactic and therapeutic peak levels of rivaroxaban: An in vitro study
    • Körber MK, et al. Measurement and reversal of prophylactic and therapeutic peak levels of rivaroxaban: an in vitro study. Clin Appl Thromb Hemost 2014; 20: 735-740.
    • (2014) Clin Appl Thromb Hemost , vol.20 , pp. 735-740
    • Körber, M.K.1
  • 86
    • 84923769426 scopus 로고    scopus 로고
    • Multimodal assessment of non-specific hemostatic agents for apixaban reversal
    • Martin AC, et al. Multimodal assessment of non-specific hemostatic agents for apixaban reversal. J Thromb Haemost 2015; 13: 426-436.
    • (2015) J Thromb Haemost , vol.13 , pp. 426-436
    • Martin, A.C.1
  • 87
    • 84865773023 scopus 로고    scopus 로고
    • Reversal of dabigatran anticoagulation by prothrombin complex concentrate (Beriplex P/N) in a rabbit model
    • Pragst I, et al. Reversal of dabigatran anticoagulation by prothrombin complex concentrate (Beriplex P/N) in a rabbit model. J Thromb Haemost 2012; 10: 1841-1848.
    • (2012) J Thromb Haemost , vol.10 , pp. 1841-1848
    • Pragst, I.1
  • 88
    • 84655176578 scopus 로고    scopus 로고
    • Evaluation of prothrombin complex concentrate and recombinant activated Factor VII to reverse rivaroxaban in a rabbit model
    • Godier A, et al. Evaluation of prothrombin complex concentrate and recombinant activated Factor VII to reverse rivaroxaban in a rabbit model. Anesthesiology 2012; 116: 94-102.
    • (2012) Anesthesiology , vol.116 , pp. 94-102
    • Godier, A.1
  • 89
    • 84865793090 scopus 로고    scopus 로고
    • Prothrombin complex concentrates reduce blood loss in murine coagulopathy induced by warfarin, but not in that induced by dabigatran etexilate
    • Lambourne MD, et al. Prothrombin complex concentrates reduce blood loss in murine coagulopathy induced by warfarin, but not in that induced by dabigatran etexilate. J Thromb Haemost 2012; 10: 1830-1840.
    • (2012) J Thromb Haemost , vol.10 , pp. 1830-1840
    • Lambourne, M.D.1
  • 90
    • 84879671176 scopus 로고    scopus 로고
    • Reversal of rivaroxaban anticoagulation by haemostatic agents in rats and primates
    • Perzborn E, et al. Reversal of rivaroxaban anticoagulation by haemostatic agents in rats and primates. Thromb Haemost 2013; 110: 162-172.
    • (2013) Thromb Haemost , vol.110 , pp. 162-172
    • Perzborn, E.1
  • 91
    • 84886258579 scopus 로고    scopus 로고
    • Evaluation of recombinant activated Factor VII, prothrombin complex concentrate, and fibrinogen concentrate to reverse apixaban in a rabbit model of bleeding and thrombosis
    • Martin AC, et al. Evaluation of recombinant activated Factor VII, prothrombin complex concentrate, and fibrinogen concentrate to reverse apixaban in a rabbit model of bleeding and thrombosis. Int J Cardiol 2013; 168: 4228-4233.
    • (2013) Int J Cardiol , vol.168 , pp. 4228-4233
    • Martin, A.C.1
  • 92
    • 84876288671 scopus 로고    scopus 로고
    • Hemostatic therapy in experimental intracerebral hemorrhage associated with rivaroxaban
    • Zhou W, et al. Hemostatic therapy in experimental intracerebral hemorrhage associated with rivaroxaban. Stroke 2013; 44: 771-778.
    • (2013) Stroke , vol.44 , pp. 771-778
    • Zhou, W.1
  • 93
    • 84893157687 scopus 로고    scopus 로고
    • Prothrombin complex concentrates and a specific antidote to dabigatran are effective ex-vivo in reversing the effects of dabigatran in an anticoagulation/ liver trauma experimental model
    • Grottke O, et al. Prothrombin complex concentrates and a specific antidote to dabigatran are effective ex-vivo in reversing the effects of dabigatran in an anticoagulation/ liver trauma experimental model. Crit Care 2014; 18: R27.
    • (2014) Crit Care , vol.18
    • Grottke, O.1
  • 94
    • 84931264466 scopus 로고    scopus 로고
    • Reversal of dabigatran anticoagulation ex vivo: Porcine study comparing prothrombin complex concentrates and idarucizumab
    • Honickel M, et al. Reversal of dabigatran anticoagulation ex vivo: Porcine study comparing prothrombin complex concentrates and idarucizumab. Thromb Haemost 2015; 113: 728-740.
    • (2015) Thromb Haemost , vol.113 , pp. 728-740
    • Honickel, M.1
  • 95
    • 80053571188 scopus 로고    scopus 로고
    • Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: A randomized, placebo-controlled, crossover study in healthy subjects
    • Eerenberg ES, et al. Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation 2011; 124: 1573-1579.
    • (2011) Circulation , vol.124 , pp. 1573-1579
    • Eerenberg, E.S.1
  • 96
    • 84908502375 scopus 로고    scopus 로고
    • Comparison of three- and four-factor prothrombin complex concentrates on the anticoagulant effects of rivaroxaban in healthy volunteers
    • Levi M, et al. Comparison of three- and four-factor prothrombin complex concentrates on the anticoagulant effects of rivaroxaban in healthy volunteers. J Thromb Haemost 2014; 12: 1428-1436.
    • (2014) J Thromb Haemost , vol.12 , pp. 1428-1436
    • Levi, M.1
  • 97
    • 84948448159 scopus 로고    scopus 로고
    • Incidence and outcomes of gastrointestinal hemorrhage in patients with atrial fibrillation treated with rivaroxaban or warfarin: Results from the ROCKET AF trial
    • Perlstein I, et al. Incidence and outcomes of gastrointestinal hemorrhage in patients with atrial fibrillation treated with rivaroxaban or warfarin: results from the ROCKET AF trial. Blood 2014; 124: 345
    • (2014) Blood , vol.124 , pp. 345
    • Perlstein, I.1
  • 98
    • 84923903585 scopus 로고    scopus 로고
    • Edoxaban effects on bleeding following punch biopsy and reversal by a 4-factor prothrombin complex concentrate
    • Zahir H, et al. Edoxaban effects on bleeding following punch biopsy and reversal by a 4-factor prothrombin complex concentrate. Circulation 2015; 131: 82-90.
    • (2015) Circulation , vol.131 , pp. 82-90
    • Zahir, H.1
  • 99
    • 3142622908 scopus 로고    scopus 로고
    • Identification of prothrombin as a major thrombogenic agent in prothrombin complex concentrates
    • Dusel CH, et al. Identification of prothrombin as a major thrombogenic agent in prothrombin complex concentrates. Blood Coagul Fibrinolysis 2004; 15: 405-411
    • (2004) Blood Coagul Fibrinolysis , vol.15 , pp. 405-411
    • Dusel, C.H.1
  • 100
    • 80051887979 scopus 로고    scopus 로고
    • Increasing concentrations of prothrombin complex concentrate induce disseminated intravascular coagulation in a pig model of coagulopathy with blunt liver injury
    • Grottke O, et al. Increasing concentrations of prothrombin complex concentrate induce disseminated intravascular coagulation in a pig model of coagulopathy with blunt liver injury. Blood 2011; 118: 1943-1951.
    • (2011) Blood , vol.118 , pp. 1943-1951
    • Grottke, O.1
  • 101
    • 84904129516 scopus 로고    scopus 로고
    • Management of major bleeding events in patients treated with rivaroxaban vs. warfarin: Results from the ROCKET AF trial
    • Piccini JP, et al. Management of major bleeding events in patients treated with rivaroxaban vs. warfarin: results from the ROCKET AF trial. Eur Heart J 2014; 35: 1873-1880.
    • (2014) Eur Heart J , vol.35 , pp. 1873-1880
    • Piccini, J.P.1
  • 102
    • 84883749228 scopus 로고    scopus 로고
    • Management of bleeding associated with dabigatran and rivaroxaban: A survey of current practices
    • Baumann Kreuziger LM, Reding MT. Management of bleeding associated with dabigatran and rivaroxaban: a survey of current practices. Thromb Res 2013; 132: e161-e163.
    • (2013) Thromb Res , vol.132 , pp. e161-e163
    • Baumann Kreuziger, L.M.1    Reding, M.T.2
  • 103
    • 84878460192 scopus 로고    scopus 로고
    • A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation Factor Xa
    • Lu G, et al. A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation Factor Xa. Nat Med 2013; 19: 446-451.
    • (2013) Nat Med , vol.19 , pp. 446-451
    • Lu, G.1
  • 104
    • 84896638883 scopus 로고    scopus 로고
    • A phase 2 randomized, double-blind, placebo-controlled trial demonstrating reversal of rivaroxaban-induced anticoagulation in healthy subjects by andexanet alfa (PRT064445), an antidote for FXa inhibitors
    • (ASH Annual Meeting Abstracts); Abstract 3636
    • Crowther M, et al. A phase 2 randomized, double-blind, placebo-controlled trial demonstrating reversal of rivaroxaban-induced anticoagulation in healthy subjects by andexanet alfa (PRT064445), an antidote for FXa inhibitors. Blood (ASH Annual Meeting Abstracts) 2013; 122 Abstract 3636.
    • (2013) Blood , pp. 122
    • Crowther, M.1
  • 105
    • 84885203373 scopus 로고    scopus 로고
    • A phase 2 randomized, double-blind, placebo-controlled trial of PRT064445, a novel, universal antidote for direct and indirect Factor Xa inhibitors
    • Abstract AS 20.1
    • Crowther M, et al. A phase 2 randomized, double-blind, placebo-controlled trial of PRT064445, a novel, universal antidote for direct and indirect Factor Xa inhibitors. J Thromb Haemost 2013; 11 Abstract AS 20.1.
    • (2013) J Thromb Haemost , vol.11
    • Crowther, M.1
  • 106
    • 84922938167 scopus 로고    scopus 로고
    • ANNEXA-A: A phase 3 randomized, double-blind, placebocontrolled trial, demonstrating reversal of apixaban-induced anticoagulation in older subjects by andexanet alfa (PRT064445), a universal antidote for Factor Xa (fXa) inhibitors
    • Abstract 2116
    • Crowther M, et al. ANNEXA-A: a phase 3 randomized, double-blind, placebocontrolled trial, demonstrating reversal of apixaban-induced anticoagulation in older subjects by andexanet alfa (PRT064445), a universal antidote for Factor Xa (fXa) inhibitors. Circulation 2014; 130 Abstract 2116.
    • (2014) Circulation , vol.130
    • Crowther, M.1
  • 107
    • 84948746294 scopus 로고    scopus 로고
    • ANNEXA-R: A phase 3 randomized, double-blind, placebocontrolled trial, demonstrating reversal of rivaroxaban-induced anticoagulation in older subjects by andexanet alfa (PRT064445), a universal antidote for Factor Xa (FXa) inhibitors
    • Abstract A23
    • Gold MA, et al. ANNEXA-R: a phase 3 randomized, double-blind, placebocontrolled trial, demonstrating reversal of rivaroxaban-induced anticoagulation in older subjects by andexanet alfa (PRT064445), a universal antidote for Factor Xa (FXa) inhibitors. J Am Coll Cardiol 2015; 65 Abstract A23.
    • (2015) J Am Coll Cardiol , pp. 65
    • Gold, M.A.1
  • 108
    • 84879548455 scopus 로고    scopus 로고
    • A specific antidote for dabigatran: Functional and structural characterization
    • Schiele F, et al. A specific antidote for dabigatran: functional and structural characterization. Blood 2013; 121: 3554-3562.
    • (2013) Blood , vol.121 , pp. 3554-3562
    • Schiele, F.1
  • 109
    • 84896397052 scopus 로고    scopus 로고
    • A specific antidote for dabigatran: Immediate, complete and sustained reversal of dabigatran induced anticoagulation in healthy male volunteers
    • Abstract A17765
    • Glund S, et al. A specific antidote for dabigatran: immediate, complete and sustained reversal of dabigatran induced anticoagulation in healthy male volunteers. Circulation 2013; 128 Abstract A17765.
    • (2013) Circulation , vol.128
    • Glund, S.1
  • 110
    • 84925503252 scopus 로고    scopus 로고
    • Idarucizumab, a specific antidote for dabigatran: Immediate, complete and sustained reversal of dabigatran induced anticoagulation in elderly and renally impaired subjects
    • Glund S, et al. Idarucizumab, a specific antidote for dabigatran: immediate, complete and sustained reversal of dabigatran induced anticoagulation in elderly and renally impaired subjects. Blood 2014; 124: 344.
    • (2014) Blood , vol.124 , pp. 344
    • Glund, S.1
  • 111
    • 84938836381 scopus 로고    scopus 로고
    • Idarucizumab for dabigatran reversal
    • Epub ahead of print
    • Pollack CV Jr, et al. Idarucizumab for dabigatran reversal. N Engl J Med 2015; Epub ahead of print.
    • (2015) N Engl J Med
    • Pollack, C.V.1
  • 112
    • 84948829151 scopus 로고    scopus 로고
    • Aripazine reverses unfractionated and low molecular weight heparins, fondaparinux and new Xa and IIa oral anticoagulants: Report of Phase I/II clinical trial with edoxaban
    • Abstract A4766
    • Ansell JE, et al. Aripazine reverses unfractionated and low molecular weight heparins, fondaparinux and new Xa and IIa oral anticoagulants: report of Phase I/II clinical trial with edoxaban. Eur Heart J 2014; 35 Abstract A4766.
    • (2014) Eur Heart J , vol.35
    • Ansell, J.E.1
  • 113
    • 84870813335 scopus 로고    scopus 로고
    • Guideline on the management of bleeding in patients on antithrombotic agents
    • Makris M, et al. Guideline on the management of bleeding in patients on antithrombotic agents. Br J Haematol 2012; 160: 35-46.
    • (2012) Br J Haematol , vol.160 , pp. 35-46
    • Makris, M.1
  • 114
    • 84870924316 scopus 로고    scopus 로고
    • Emergency management of bleeding associated with old and new oral anticoagulants
    • Peacock WF, et al. Emergency management of bleeding associated with old and new oral anticoagulants. Clin Cardiol 2012; 35: 730-737.
    • (2012) Clin Cardiol , vol.35 , pp. 730-737
    • Peacock, W.F.1
  • 115
    • 84878652588 scopus 로고    scopus 로고
    • Incidence and outcomes of gastrointestinal hemorrhage in patients with atrial fibrillation treated with rivaroxaban or warfarin: Results from the ROCKET AF trial
    • Nessel C, et al. Incidence and outcomes of gastrointestinal hemorrhage in patients with atrial fibrillation treated with rivaroxaban or warfarin: results from the ROCKET AF trial. Chest 2012; 142: 84A-84A.
    • (2012) Chest , vol.142 , pp. 84A-84A
    • Nessel, C.1
  • 116
    • 84925341478 scopus 로고    scopus 로고
    • Real life efficacy and safety of dabigatran for stroke prevention in atrial fibrillation: Updated results of the prospective NOAC registry (NCT01588119)
    • Abstract 4871
    • Beyer-Westendorf J, et al. Real life efficacy and safety of dabigatran for stroke prevention in atrial fibrillation: updated results of the prospective NOAC registry (NCT01588119). Eur Heart J 2013; 34 Abstract 4871.
    • (2013) Eur Heart J , vol.34
    • Beyer-Westendorf, J.1
  • 117
    • 84878451205 scopus 로고    scopus 로고
    • Dabigatran use in Danish atrial fibrillation patients in 2011: A nationwide study
    • Sørensen R, et al. Dabigatran use in Danish atrial fibrillation patients in 2011: a nationwide study. Br Med J Open 2013; 3.
    • (2013) Br Med J Open , pp. 3
    • Sørensen, R.1
  • 118
    • 84919666605 scopus 로고    scopus 로고
    • Bleeding rates in Veterans Affairs patients with atrial fibrillation who switch from warfarin to dabigatran
    • Vaughan Sarrazin MS, et al. Bleeding rates in Veterans Affairs patients with atrial fibrillation who switch from warfarin to dabigatran. Am J Med 2014; 127: 1179-1185.
    • (2014) Am J Med , vol.127 , pp. 1179-1185
    • Vaughan Sarrazin, M.S.1
  • 119
    • 84920566138 scopus 로고    scopus 로고
    • Risk of bleeding with dabigatran in atrial fibrillation
    • Hernandez I, et al. Risk of bleeding with dabigatran in atrial fibrillation. J Am Med Assoc Intern Med 2015; 175: 18-24.
    • (2015) J Am Med Assoc Intern Med , vol.175 , pp. 18-24
    • Hernandez, I.1
  • 120
    • 84922313320 scopus 로고    scopus 로고
    • Reversal of enoxaparin-induced anticoagulation in healthy subjects by andexanet alfa (PRT064445), an antidote for direct and indirect fXa inhibitors - A phase 2 randomized, double-blind, placebo-controlled trial
    • Abstract COA01
    • Crowther M, et al. Reversal of enoxaparin-induced anticoagulation in healthy subjects by andexanet alfa (PRT064445), an antidote for direct and indirect fXa inhibitors - a phase 2 randomized, double-blind, placebo-controlled trial. J Thromb Haemost 2014; 12 Abstract COA01.
    • (2014) J Thromb Haemost , vol.12
    • Crowther, M.1


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