Effective elimination of dabigatran by haemodialysis: A phase I single-centre study in patients with end-stage renal disease

Thrombosis and Haemostasis

Volumn 109, Issue 4, 2013, Pages 596-605

  Khadzhynov, Dmytro ^a   Wagner, Frank ^a   Formella, Stephan ^b   Wiegert, Erol ^a   Moschetti, Viktoria ^b   Slowinski, Torsten ^a   Neumayer, Hans H ^a   Liesenfeld, Karl Heinz ^b   Lehr, Thorsten ^b   Härtter, Sebastian ^b   Friedman, Jeffrey ^c   Peters, Harm ^a   Clemens, Andreas ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^c BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

Dabigatran etexilate; Direct thrombin inhibitor (DTI); Elimination; Haemodialysis; Pharmacokinetics

Indexed keywords

DABIGATRAN ETEXILATE; HEPARIN;

ABSENCE OF SIDE EFFECTS; ADULT; ANTICOAGULATION; AREA UNDER THE CURVE; ARTICLE; BLOOD FLOW; BLOOD SAMPLING; CLINICAL ARTICLE; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG SAFETY; DRUG TOLERABILITY; HEART ATRIUM FIBRILLATION; HEMODIALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; KIDNEY FAILURE; LOW DRUG DOSE; MALE; MULTIPLE DRUG DOSE; PARTIAL THROMBOPLASTIN TIME; PHARMACODYNAMICS; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; THROMBIN TIME;

ADULT; ANTITHROMBINS; BENZIMIDAZOLES; BERLIN; BETA-ALANINE; BLOOD COAGULATION; DRUG ADMINISTRATION SCHEDULE; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; REGRESSION ANALYSIS; RENAL DIALYSIS;

EID: 84875926001     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH12-08-0573     Document Type: Article

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