IL-13 desensitizes β2-adrenergic receptors in human airway epithelial cells through a 15-lipoxygenase/G protein receptor kinase 2 mechanism

Journal of Allergy and Clinical Immunology

Volumn 135, Issue 5, 2015, Pages 1144-1153.e9

  Albano, Giusy D ^a,c   Zhao, Jinming ^a   Etling, Emily B ^a   Park, Seo Young ^b   Hu, Haizhen ^a   Trudeau, John B ^a   Profita, Mirella ^c   Wenzel, Sally E ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c CNR   (Italy)

Author keywords

15 lipoxygenase 1; asthma; cAMP; G protein receptor kinase 2; IL 13; phosphatidylethanolamine binding protein 1; 2 adrenergic receptor

Indexed keywords

ARACHIDONATE 15 LIPOXYGENASE; BETA ADRENERGIC RECEPTOR; CORTICOSTEROID; INTERLEUKIN 13; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; SMALL INTERFERING RNA; BETA 2 ADRENERGIC RECEPTOR; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR KINASE 2; ISOPRENALINE; PEBP1 PROTEIN, HUMAN; PROTEIN BINDING;

ADULT; ARTICLE; ASTHMA; CLINICAL ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DESENSITIZATION; EPITHELIUM CELL; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; LUNG ALVEOLUS EPITHELIUM CELL; MALE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RESPIRATORY EPITHELIUM; CASE CONTROL STUDY; DRUG EFFECTS; GENE SILENCING; GENETICS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PHOSPHORYLATION; RESPIRATORY TRACT MUCOSA;

ADULT; ARACHIDONATE 15-LIPOXYGENASE; ASTHMA; CASE-CONTROL STUDIES; CYCLIC AMP; FEMALE; G-PROTEIN-COUPLED RECEPTOR KINASE 2; GENE KNOCKDOWN TECHNIQUES; HUMANS; INTERLEUKIN-13; ISOPROTERENOL; MALE; MIDDLE AGED; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; PHOSPHORYLATION; PROTEIN BINDING; RECEPTORS, ADRENERGIC, BETA-2; RESPIRATORY MUCOSA;

EID: 84948719714     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.02.006     Document Type: Article

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