Systemic corticosteriod rapidly reverses bronchodilator subsensitivity induced by formoterol in asthmatic patients

American Journal of Respiratory and Critical Care Medicine

Volumn 156, Issue 1, 1997, Pages 28-35

  Tan, Kia Soong ^b   Grove, Alison ^b   Mclean, Alec ^b   Gnosspelius, Yvonne ^b   Hall, Ian P ^b   Lipworth, Brian J ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BECLOMETASONE DIPROPIONATE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; CORTICOSTEROID; FLUTICASONE PROPIONATE; FORMOTEROL; FORMOTEROL FUMARATE; HYDROCORTISONE; IPRATROPIUM BROMIDE; ISOPRENALINE; PLACEBO; PREDNISOLONE; SALMETEROL; THEOPHYLLINE;

ADULT; AIRWAY OBSTRUCTION; AREA UNDER THE CURVE; ARTICLE; ASTHMA; BRONCHODILATATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CROSSOVER PROCEDURE; DESENSITIZATION; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG TOLERANCE; FEMALE; FORCED EXPIRATORY VOLUME; HEART RATE; HUMAN; INHALATIONAL DRUG ADMINISTRATION; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

EID: 0002736850     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.156.1.9610113     Document Type: Article

References (28)

1. Derom, E. Y., and R. A. Pauwels. 1992. Time course of bronchodilating effect of inhaled formoterol, a potent and long-acting sympathomimetic. Thorax 47:30-33.
2. 2-agonists in the management of asthma. Drug Safety 7:54-70.
3. Yates, D. H., H. S. Sussman, M. J. Shaw, P. J. Barnes, and K. F. Chung. 1995. Regular formoterol treatment in mild asthma: effect on bronchial responsiveness during and after treatment. Am J. Respir. Crit. Care Med. 152:1170-1174.
4. Newnham, D. M., D. G. McDevitt, and B. J. Lipworth. 1994. Bronchodilator subsensitivity after chronic dosing with eformoterol in patients with asthma. Am. J. Med. 97:29-37.
5. 2-adrenoceptor responses after regular twice daily treatment with eformoterol dry powder in asthmatic patients. Thorax 50:497-504.
6. Bhagat, R., S. Kalra, V. A. Swyston, and D. W. Cockcroft. 1995. Rapid onset of tolerance to the bronchoprotective effect of salmeterol. Chest 108:1235-1239.
7. 2-adrenoceptor agonist, salmeterol, on airway hyperresponsiveness in patients with mild asthma. N. Engl. J. Med. 327:1198-1203.
8. Grove, A., and B. J. Lipworth. 1995. Bronchodilator subsensitivity to salbutamol after twice-daily salmeterol in asthmatic patients. Lancet 346:201-206.
9. Ramage, L., B. J. Lipworth, C. G. Ingram, I. A. Cree, and D. P. Dhillon. 1994. Reduced protection against exercise-induced bronchoconstriction after chronic dosing with salmeterol. Respir. Med. 88:363-368.
10. Kalra, S., V. A. Swystun, R. Bhagat, and D. W. Cockcroft. 1996. Inhaled corticosteroids do not prevent the development of tolerance to the bronchoprotective effect of salmeterol. Chest 109:953-956.
11. Booth, H., R. Bish, J. Walters, F. Whitehead, and E. H. Walters. 1996. Salmeterol tachyphylaxis in steroid treated asthmatic subjects. Thorax 51:1100-1104.
12. Hui, K. K. D., M. E. Connolly, and D. P. Tasbui. 1982. Reversal of human lymphocyte beta adrenoceptor desensitisation by glucocorticoids. Clin. Pharmacol. Ther. 32:566-571.
13. 2-receptors: accelerated restoration of beta-adrenoceptor responses by prednisolone and ketotifen. J. Clin. Invest. 76:1096-1101.
14. 2-bronchodilators. Eur. J. Clin. Pharmacol. 34:145-150.
15. Ellul-Micallef, R., F. F. Fenech. 1975. Effect of intravenous prednisolone in asthmatics with diminished adrenergic responsiveness. Lancet 2:1269-1270.
16. Holgate, S. T., C. J. Baldwin, and A. E. Tattersfield. 1977. Beta-adrenergic agonist resistance in normal human airways. Lancet 1:375-377.
17. American Thoracic Society. 1987. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease and asthma. Am. Rev. Respir. Dis. 36:225-244.
18. American Thoracic Society. 1987. Standardisation of spirometry - 1987 update. Am. Rev. Respir. Dis. 136:1285-1298.
19. 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects. Lancet 345:1213-1214.
20. Lipworth, B. J., A. D. Struthers, and D. G. McDevitt. 1989. Tachyphylaxis to systemic but not to airway responses during prolonged therapy with high-dose inhaled salbutamol in asthmatics. Am. Rev. Respir. Dis. 140:586-592.
21. 2-adrenoceptor responsiveness in patients with chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 142:338-342.
22. 2-adrenergic receptors desensitise in response to in vivo administered β-agonist. Am. J. Physiol. 269:709-714.
23. 2-adrenoceptors in human lung and peripheral mononuclear leukocytes of untreated and terbutaline treated patients. Chest 98:376-381.
24. Quing, F., M. M. Hayes, C. G. Rhodes, P. W. Ind, T. Jones, and J. M. B. Hughes. 1994. The effects of chronic salbutamol therapy on human β-adrenergic receptors: peripheral mononuclear leucocytes compared to lung tissue. Thorax 49:1046-1047.
25. 2-adrenergic receptor transcription in human lung. Am. J. Physiol. 12:L41-L46.
26. Davies, A. O., and R. J. Lefkowitz. 1984. Regulation of beta-adrenergic receptors by steroid hormones. Am. Rev. Physiol. 46:119-130.
27. 2-adrenoceptor function in asthmatic patients. Chest 108:343-347.
28. 2-adrenergic receptor structure. Pulm. Pharmacol. 8:1-10.