Effects of inflammation and acute β-agonist inhalation on β2-AR signaling in human airways

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 271, Issue 4 15-4, 1996, Pages

  Penn, Raymond B ^a   Shaver, Joseph R ^a   Zangrilli, James G ^a   Pollice, Mary ^a   Fish, James E ^a   Peters, Stephen P ^a   Benovic, Jeffrey L ^a  

^a THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

Author keywords

allergy; asthma; bronchoalveolar lavage; desensitization; epithelium; G protein coupled receptor; segmental antigen challenge; adrenergic receptor

Indexed keywords

BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP; GUANINE NUCLEOTIDE BINDING PROTEIN;

AIRWAY; ALLERGY; ARTICLE; ASTHMA; BRONCHOSCOPY; CLINICAL ARTICLE; DESENSITIZATION; HUMAN; HUMAN CELL; INFLAMMATION; LUNG LAVAGE; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; RESPIRATORY EPITHELIUM;

EID: 0029905912     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1996.271.4.l601     Document Type: Article

References (38)

1. Bai, T. R., J. C. W. Mak, and P. J. Barnes. A comparison of β-adrenergic receptors and in vitro relaxant responses to isoproterenol in asthmatic airway smooth muscle. Am. J. Respir. Cell Mol. Biol. 6: 647-651, 1992.
2. Brooks, S. M., K. McGowan, I. L. Bernstein, P. Altenau, and J. Peagler. Relationship between numbers of beta adrenergic receptors in lymphocytes and disease severity in asthma. J. Allergy Clin. Immunol. 63: 401-406, 1979.
3. Busse, W. W., G. Sharpe, A. Smith, M. Arbabian, L. Borgen, A. Ruoho. The effect of protacterol treatment on beta-adrenergic bronchodilation and polymorphonuclear leukocyte response. Am. Rev. Respir. Dis. 132: 1194-1198, 1985.
4. Cockcroft, D. W., C. P. McParland, S. A. Britto, V. A. Swystun, and B. C. Rutherford. Regular inhaled salfautamol and airway responsiveness to allergen. Lancet 342: 833-37, 1993.
5. Conolly, M. E., and J. K. Greenacre. The lymphocyte β-adrenoreceptor in normal subjects and patients with bronchial asthma. J. Clin. Invest. 58: 1307-1316, 1976.
6. Conolly, M. E., D. P. Tashkin, K. K. P. Hui, M. R. Littner, and R. N. Wolfe. Selective subsensitization of beta-adrenergic receptors in central airways of asthmatics and normal subjects during long-term therapy with inhaled salbutamol. J. Allergy Clin. Immanol. 70: 423-431, 1982.
7. Davis, C., and M. E. Conolly. Tachyphylaxis to beta-adrenoceptor agonists in human bronchial smooth muscle: studies in vitro. Br. J. Clin. Pharmacol. 10: 417-423, 1980.
8. Davis, P. B., C. L. Siliski, C. M. Kercsmar, and M. Infeld. β-Adrenergic receptors on human tracheal epithelial cells in primary culture. Am. J. Physiol. 258 (Cell Physiol. 27): C71-C76, 1990.
9. Dupuis, R., D. S. Collins, Y. Y. Koh, M. Pollice, K. H. Albertine, J. E. Fish, and S. P. Peters. Effect of antigen dose on the recruitment of inflammatory cells to the lung by segmental antigen challenge. J. Allergy Clin. Immunol. 89: 850-857, 1992.
10. Gomez, J., and J. L. Benovic. Molecular and regulatory properties of the adenylyl cyclase coupled β-adrenergic receptors. In: Molecular Biology of Receptors and Transporters: Receptors, edited by M. Friedlander and M. Mueckler. New York: Academic, 1992, p. 1-34.
11. Hadcock, J. R., J. D. Port, M. S. Gelman, and C. C. Malbon. Cross-talk between tyrosine kinase and G-protein-linked receptors. J. Biol. Chem. 267: 26017-26022, 1992.
12. 1α2. J. Biol. Chem. 265: 14784-14790, 1990.
13. Hall, I. P., and M. Kotlikoff. Use of cultured airway myocytes for study of airway smooth muscle. Am. J. Physiol. 268 (Lung Cell. Mol. Physiol. 12): L1-L11, 1995.
14. Kelsen, S. G., I. A. Mardini, S. Zhou, J. L. Benovic, and N. C. Higgins. A technique to harvest viable tracheobronchial epithelial cells from living human donors. Am. J. Respir. Cell Mol. Biol. 7: 66-72, 1992.
15. 2-adrenergic receptor. J. Biol. Chem. 269: 13084-13087, 1994.
16. Liu, M. C., W. C. Hubbard, D. Proud, B. A. Stealy, S. J. Galli, A. Kagey-Sobotka, E. R. Bleecker, and L. M. Lichtenstein. Immediate and late inflammatory responses to ragweed antigen challenge of the peripheral airways in allergic asthmatics. Am. Rev. Respir. Dis. 144: 51-58, 1991.
17. 2-adrenergic receptor desensitization: Delineation with specific inhibitors. J. Biol. Chem. 265: 3202-3209, 1990.
18. Morrison, K. J., Y. Gao, and P. M. Vanhoutte. β-Adrenoceptors and the epithelial layers in airways. Life Sci. 52: 2123-2130, 1993.
19. Nijkamp, F. P. β-Adrenergic receptors in the lung: an introduction. Life Sci. 52: 2073-2082. 1993.
20. Nijkamp, F. P., and P. A. Henricks. Receptors in airway disease. Beta-adrenoceptors in lung inflammation. Am. Rev. Respir. Dis. 141, Suppl.: S145-S150, 1990.
21. O'Connor, J., G. C. Kane, M. Tolino, M. Pollice, J. E. Fish, and S. P. Peters. Inhaled salbutamol does not inhibit cellular influx or lung injury produced by segmental antigen challenge in humans. Pulm. Pharmacol. 8: 237-243, 1995.
22. 2-mediated adenylyl cyclase activity in human airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 11: 496-505, 1994.
23. Port, J. D., J. R. Hadcock, and C. C. Malbon. Cross-regulation between G-protein-mediated pathways: acute activation of the inhibitory pathway of adenylyl cyclase reduces β-adrenergic receptor phosphorylation and increases β-adrenergic responsiveness. J. Biol. Chem. 267: 8468-8472, 1992.
24. Ramage, L., B. J. Lipworth, C. G. Ingram, I. A. Cree, and D. P. Dhillon. Reduced protection against exercise induced bronchoconstriction after chronic dosing with salmeterol. Respir. Med. 88: 363-368, 1994.
25. 2+ and cAMP messenger system in regulation of smooth muscle contraction. Am. J. Physiol. 258 (Lung. Cell. Mol. Physiol. 2): L279-L288, 1990.
26. Rosenthal, H. E. A graphical method for the determination and presentation of binding parameters in a complex system. Anal. Biochem. 20: 525-532, 1967.
27. Schuster, A., R. Kozlik, and D. Reinhardt. Influence of short- and long-term inhalation of salbutamol on lung function and β-adrenoreceptors of mononuclear blood cells in asthmatic children. Eur. J. Pediatr. 150: 209-213, 1991.
28. Sears, M. R., D. R. Taylor, C. G. Print, D. C. Lake, Q. Li, E. M. Flannery, D. M. Yates, M. K. Lucas, and G. P. Herbison. Regular inhaled beta-agonist treatment in bronchial asthma. Lancet 336, 1391-1396, 1990.
29. Shaver, J. R., J. J. O'Connor, M. Pollice, S. K. Cho, G. C, Kane, J. E. Fish, and S. P. Peters. Pulmonary inflammation after segmental ragweed challenge in allergic asthmatics and nonasthmatic subjects. Am. J. Respir. Crit. Care Med. 152: 1189-1197, 1995.
30. Sheffer, A. L. Guidelines for the Diagnosis and Management of Asthma. National Asthma Education Program. Expert Panel Report. Bethesda, MD: National Heart, Lung, and Blood Institute, 1991. (National Institutes of Health Pub. No. 91-3042)
31. Spahr-Schopfer, I. A., J. Lerman, E. Cutz, M. T. Newhouse, and M. Dolovich. Proximate delivery of a large experimental dose of salbutamol MDI induces epithelial cell airway lesions in intubated rabbits. Am. J. Respir. Crit. Care Med. 150: 790-794, 1994.
32. Spitzer, W. O., S. Suissa, P. Ernst, R. I. Horwitz, B. Habbick, D. Cockroft, J.-F. Boivin, M. McNutt, A. S. Buist, and A. S. Rebuck, The use of β-agonists and the risk of death and near-death from asthma. N. Engl. J. Med. 326: 501-506, 1992.
33. 2-adrenergic receptors desensitize in response to in vivo administered β-agonist. Am. J. Physiol. 269 (Lung Cell. Mol. Physiol. 13): L709-L714, 1995.
34. Vathenen, A. S., B. G. Higgins, A. J. Knox, J. R. Britton, and A. E. Tattersfield. Rebound increase in bronchial responsiveness after treatment with inhaled terbutaline. Lancet 1: 554-558, 1988.
35. Virchow, J. C., Jr., C. Walker, D. Hafner, C. Kortsik, P. Werner, H. Matthys, and C. Kroegel. T cells and cytokines in bronchoalveolar lavage fluid after segmental allergen provocation in atopic asthma. Am. J. Respir. Crit. Care Med. 151: 960-968, 1995.
36. Wenzel, S. E., J. Y. Westcott, and G. L. Larsen. Bronchoalveolar lavage fluid mediator levels 5 minutes after allergen challenge in atopic subjects with asthma: relationship to the development of late asthmatic responses. J. Allergy Clin. Immunol. 87: 540-548, 1991.
37. Wenzel, S. E., J. Y. Westcott, H. R. Smith, and G. L. Larsen. Spectrum of prostanoid release after bronchoalveolar allergen challenge in atopic asthmatics and in control groups. Am. Rev. Respir. Dis. 139: 450-457, 1989.
38. Wilson, A. F. Aerosol delivery systems. In: Bronchial Asthma: Mechanisms and Therapeutics, edited by E. B. Wilson and M. Stein. Boston, MA: Little Brown, 1993, p. 749-755.