A simple mechanistic explanation for original antigenic sin and its alleviation by adjuvants

Journal of the Royal Society Interface

Volumn 12, Issue 112, 2015, Pages

  Ndifon, Wilfred ^a,b,c  

^a AFRICAN INSTITUTE FOR MATHEMATICAL SCIENCES   (South Africa)

^b AFRICAN INSTITUTE FOR MATHEMATICAL SCIENCES   (Ghana)

^c STELLENBOSCH UNIVERSITY   (South Africa)

Author keywords

Influenza virus; Mathematical modelling; Suboptimal immunity; Vaccine effectiveness; Virus dynamics

Indexed keywords

CELLS; CHEMICAL ACTIVATION; DATA STORAGE EQUIPMENT; LYMPHOCYTES; MATHEMATICAL MODELS; VIRUSES;

ADAPTIVE IMMUNITY; BIOLOGICAL MECHANISMS; DENDRITIC CELLS; INFLUENZA VIRUS; LYMPHOCYTE ACTIVATION; SUBOPTIMAL IMMUNITY; VIRUS DYNAMICS;

ANTIGENS;

ANTIGEN; IMMUNOLOGICAL ADJUVANT;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANTIBODY RESPONSE; ANTIGEN FUNCTION; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CELL COUNT; CONTROLLED STUDY; CROSS REACTION; DENDRITIC CELL; HELPER CELL; IMMUNE RESPONSE; INFLUENZA VIRUS; LYMPHOCYTE ACTIVATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MOUSE; NONHUMAN; ORIGINAL ANTIGENIC SIN; REGULATORY T LYMPHOCYTE; ANIMAL; BIOLOGICAL MODEL; DRUG EFFECTS; HUMAN; IMMUNOLOGY;

ADAPTIVE IMMUNITY; ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGENS; DENDRITIC CELLS; HUMANS; MODELS, IMMUNOLOGICAL; T-LYMPHOCYTES, REGULATORY;

EID: 84948687406     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2015.0627     Document Type: Article

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