Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 48, 2015, Pages 14805-14810

  Vien, Thuy N ^a   Modgil, Amit ^a   Abramian, Armen M ^a   Jurd, Rachel ^a   Walker, Joshua ^a   Brandon, Nicholas J ^b   Terunuma, Miho ^c   Rudolph, Uwe ^d   Maguire, Jamie ^a   Davies, Paul A ^a   Moss, Stephen J ^a,e  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ASTRAZENECA   (United Kingdom)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

^d MCLEAN HOSPITAL   (United States)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Autism spectrum disorder; GABA receptor; Phasic inhibition; Phosphorylation; Tonic inhibition

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR BETA3; GEPHYRIN; KAINIC ACID; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN TYROSINE KINASE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ALANINE; GABRB3 PROTEIN, MOUSE; SERINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTISM; COMORBIDITY; COMPULSION; CONTROLLED STUDY; DENDRITIC SPINE; ENDOCYTOSIS; EXCITATORY POSTSYNAPTIC POTENTIAL; EXOCYTOSIS; FRAGILE X SYNDROME; HIPPOCAMPUS; HOMOZYGOTE; MEMBRANE STEADY POTENTIAL; MOTOR COORDINATION; MOUSE; NONHUMAN; PATCH CLAMP TECHNIQUE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SEIZURE; SEIZURE SUSCEPTIBILITY; SOCIAL INTERACTION; ANIMAL; ANIMAL BEHAVIOR; BIOTINYLATION; C57BL MOUSE; CELL MEMBRANE; COMPLICATION; DISEASE MODEL; ELECTROENCEPHALOGRAPHY; ELECTROPHYSIOLOGY; EPILEPSY; FEAR; GENE EXPRESSION REGULATION; GENE TARGETING; GENETICS; MALE; METABOLISM; MUTATION; PHOSPHORYLATION; SOCIAL BEHAVIOR; SYNAPSE;

ALANINE; ANIMALS; AUTISM SPECTRUM DISORDER; BEHAVIOR, ANIMAL; BIOTINYLATION; CELL MEMBRANE; DENDRITIC SPINES; DISEASE MODELS, ANIMAL; ELECTROENCEPHALOGRAPHY; ELECTROPHYSIOLOGICAL PHENOMENA; EPILEPSY; FEAR; GAMMA-AMINOBUTYRIC ACID; GENE EXPRESSION REGULATION; GENE KNOCK-IN TECHNIQUES; HIPPOCAMPUS; MALE; MICE; MICE, INBRED C57BL; MUTATION; PHENOTYPE; PHOSPHORYLATION; RECEPTORS, GABA-A; SERINE; SOCIAL BEHAVIOR; SYNAPSES;

EID: 84948680382     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1514657112     Document Type: Article

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