GABAA receptor membrane trafficking regulates spine maturity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 30, 2009, Pages 12500-12505

  Jacob, Tija C ^a   Wan, Qin ^e   Vithlani, Mansi ^a   Saliba, Richard S ^a   Succol, Francesca ^c   Pangalos, Menelas N ^d   Moss, Stephen J ^a,b  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^d PFIZER INC   (United States)

^e NATIONAL EYE INSTITUTE   (United States)

Author keywords

Endocytosis; Inhibition; Phosphorylation

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ADAPTOR PROTEIN; CLATHRIN; MEMBRANE RECEPTOR; RECEPTOR SUBUNIT;

ARTICLE; BEHAVIOR; CELL SURFACE; DENDRITE; ENDOCYTOSIS; HUMAN; HUMAN CELL; NERVE CELL; NERVE CELL PLASTICITY; PRIORITY JOURNAL; PROTEIN BINDING; SPINE; SYNAPSE; SYNAPTIC INHIBITION; SYNAPTIC TRANSMISSION;

ANIMALS; BIOLOGICAL TRANSPORT; CELL LINE; CELL MEMBRANE; CELLS, CULTURED; DENDRITIC SPINES; ENDOCYTOSIS; GABA ANTAGONISTS; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; HUMANS; INHIBITORY POSTSYNAPTIC POTENTIALS; MICROSCOPY, CONFOCAL; MUTATION; NEURAL INHIBITION; NEURONS; PATCH-CLAMP TECHNIQUES; PICROTOXIN; PROTEIN SUBUNITS; RATS; RECEPTORS, GABA-A;

EID: 68149132556     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0903943106     Document Type: Article

References (20)

1. Jacob TC, Moss SJ, Jurd R (2008) GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition. Nat Rev Neurosci 9:331-343.
2. Bogdanov Y, et al. (2006) Synaptic GABAA receptors are directly recruited from their extrasynaptic counterparts. EMBO J 25:4381-4389.
3. Jacob TC, et al. (2005) Gephyrin regulates the cell surface dynamics of synaptic GABAA receptors. J Neurosci 25:10469-10478.
4. Kittler JT, et al. (2000) Constitutive endocytosis ofGABAAreceptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J Neurosci 20:7972-7977.
5. Haucke V, Wenk MR, Chapman ER, Farsad K, De Camilli P (2000) Dual interaction of synaptotagmin with mu2- and alpha-adaptin facilitates clathrin-coated pit nucleation. EMBO J 19:6011-6019.
6. Haucke V (2006) Cargo takes control of endocytosis. Cell 127:35-37.
7. Kittler JT, et al. (2005) Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmission. Proc Natl Acad Sci USA 102:14871-14876.
8. Sekine-Aizawa Y, Huganir RL (2004) Imaging of receptor trafficking by using alphabungarotoxin-binding-site-tagged receptors. Proc Natl Acad Sci USA 101:17114-17119.
9. Saliba RS,MichelsG,JacobTC,PangalosMN,Moss SJ(2007)Activity- dependentubiquitination of GABAA receptors regulates their accumulation at synaptic sites. 27:13341-13351.
10. Saliba RS, Pangalos M, Moss SJ (2008) The ubiquitin-like protein Plic-1 enhances the membrane insertion of GABAA receptors by increasing their stability within the endoplasmic reticulum. J Biol Chem 283:18538-18544.
11. Kittler JT, et al. (2008) Regulation of synaptic inhibitionbyphospho- dependentbinding of the AP2 complex to a YECL motif in the GABAA receptor {gamma}2 subunit. 105:3616-3621.
12. Hinkle DJ, Macdonald RL (2003) Beta subunit phosphorylation selectively increases fast desensitization and prolongs deactivation of alpha1beta1gamma2L and alpha1beta3gamma2L GABA(A) receptor currents. J Neurosci 23:11698-11710.
13. Porter NM, Twyman RE, Uhler MD, Macdonald RL (1990) Cyclic AMP-dependent protein kinase decreases GABAA receptor current in mouse spinal neurons. Neuron 5:789-796.
14. Brandon NJ, Jovanovic JN, Smart TG, Moss SJ (2002) Receptor for activated C kinase-1 facilitates protein kinase C-dependent phosphorylation and functional modulation of GABA(A) receptors with the activation of G-protein-coupled receptors. J Neurosci 22:6353-6361.
15. Wooltorton JR, Moss SJ, Smart TG (1997) Pharmacological and physiological characterization of murine homomeric beta3 GABA(A) receptors. Eur J Neurosci 9:2225-2235.
16. TaylorPM,et al. (1999) Identification ofaminoacid residues withinGABA(A)receptor beta subunits that mediate both homomeric and heteromeric receptor expression. J Neurosci 19:6360-6371.
17. El-Husseini AE, Schnell E, Chetkovich DM, Nicoll RA, Bredt DS (2000) PSD-95 involvement in maturation of excitatory synapses. Science 290:1364-1368.
18. Ehrlich I, KleinM,RumpelS,MalinowR(2007)PSD-95is required for activity-drivensynapse stabilization. Proc Natl Acad Sci USA 104:4176-4181.
19. Bourne JN, Harris KM (2008) Balancing structure and function at hippocampal dendritic spines. 31:47-67.
20. BenediktssonAM,Schachtele SJ, Green SH, DaileyME(2005) Ballistic labelinganddynamic imaging of astrocytes in organotypic hippocampal slice cultures. J Neurosci Methods 141:41-53.