Deficits in spatial memory correlate with modified γ-aminobutyric acid type A receptor tyrosine phosphorylation in the hippocampus

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 47, 2009, Pages 20039-20044

  Tretter, Verena ^a   Revilla Sanchez, Raquel ^b   Houston, Catriona ^a   Terunuma, Miho ^b   Havekes, Robbert ^c   Florian, Cédrick ^c   Jurd, Rachel ^b   Vithlani, Mansi ^a,b   Michels, Guido ^d   Couve, Andrés ^e   Sieghart, Werner ^f   Brandon, Nicholas ^g   Abel, Ted ^c   Smart, Trevor G ^a   Moss, Stephen J ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF COLOGNE   (Germany)

^e UNIVERSITY OF CHILE   (Chile)

^f MEDICAL UNIVERSITY OF VIENNA   (Austria)

^g PFIZER INC   (United States)

Author keywords

Cognition; GABAA receptor; Inhibitory synapses

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CELL MIGRATION; CONTROLLED STUDY; ENDOCYTOSIS; HIPPOCAMPUS; INHIBITORY POSTSYNAPTIC POTENTIAL; MALE; MODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PYRAMIDAL NERVE CELL; RECOGNITION; SPATIAL MEMORY;

ANIMALS; GENE KNOCK-IN TECHNIQUES; HIPPOCAMPUS; MALE; MEMORY; MICE; MICE, INBRED C57BL; MUTATION; PATCH-CLAMP TECHNIQUES; PHOSPHORYLATION; RECEPTORS, GABA-A; SPATIAL BEHAVIOR; TYROSINE;

ANIMALIA;

EID: 73949152962     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0908840106     Document Type: Article

References (24)

1. A receptor subtypes. Curr Top Med Chem 2:795-816.
2. A receptor subtypes: Dissecting their pharmacological functions. Trends Pharmacol Sci 22:188-194.
3. A receptor trafficking, channel activity, and functional plasticity of inhibitory synapses. Pharmacol Ther 102:195-221.
4. Rudolph U, Mohler H (2006) GABA-based therapeutic approaches: GABAA receptor subtype functions. Curr Opin Pharmacol 6:18-23.
5. A receptor trafficking and its role in the dynamic modulation of neuronal inhibition. Nat Rev Neurosci 9:331-343.
6. A receptor gamma 2 subunit in rat brain. Neuropharmacology 41:745-752.
7. A receptors by tyrosine phosphorylation. Nature 377:344-348.
8. Terunuma M, et al. (2004) GABAA receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein. J Neurosci 24:7074-7084.
9. A receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus. J Neurosci 28:376-384.
10. A receptor gamma2 subunit. Proc Natl Acad Sci USA 105:3616-3621.
11. A receptors are directly recruited from their extrasynaptic counterparts. EMBO J 25:4381-4389.
12. Sassoe-Pognetto M, Fritschy JM (2000) Mini-review: Gephyrin, a major postsynaptic protein of GABAergic synapses. Eur J Neurosci 12:2205-2210.
13. A-receptor subunits in the rat retina. J Comp Neurol 357:1-14.
14. A receptor subtypes with gephyrin at postsynaptic sites. J Comp Neurol 420:481-498.
15. Stupien G, Florian C, Roullet P (2003) Involvement of the hippocampal CA3-region in acquisition and in memory consolidation of spatial but not in object information in mice. Neurobiol Learn Mem 80:32-41.
16. Hunsaker MR, Allan KD, Kesner RP (2007) Role of dCA3 efferents via the fimbria in the acquisition of a delay nonmatch to place task. Hippocampus 17:494-502.
17. Ennaceur A, Delacour J (1988) A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. Behav Brain Res 31:47-59.
18. Fortin G, Jungbluth S, Lumsden A, Champagnat J (1999) Segmental specification of GABAergic inhibition during development of hindbrain neural networks. Nat Neurosci 2:873-877.
19. Lumsden A, Gulisano M (1997) Neocortical neurons: Where do they come from? Science 278:402-403.
20. A receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum. J Neurosci 12:1063-1076.
21. Liu X, Wang Q, Haydar TF, Bordey A (2005) Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors. Nat Neurosci 8:1179-1187.
22. A receptor activation. J Physiol 550:785-800.
23. A receptor alpha 1 and gamma 2 subunits in human temporal lobe, hippocampus and basal ganglia: An implication for consideration on age-related epilepsy. Epilepsy Res 71:47-53.
24. Bussey TJ, Duck J, Muir JL, Aggleton JP (2000) Distinct patterns of behavioural impairments resulting from fornix transection or neurotoxic lesions of the perirhinal and postrhinal cortices in the rat. Behav Brain Res 111:187-202.