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Volumn 31, Issue 12, 2015, Pages 1106-1115

Role of quercetin in cadmium-induced oxidative stress, neuronal damage, and apoptosis in rats

Author keywords

Cadmium; neuronal apoptosis; neuronal damage; oxidative stress; quercetin; rats

Indexed keywords

ANTIOXIDANT; CADMIUM CHLORIDE; CASP3 PROTEIN, RAT; CASPASE 3; MALONALDEHYDE; NERVE PROTEIN; NEUROPROTECTIVE AGENT; OXIDOREDUCTASE; QUERCETIN; CATALASE; GLUTATHIONE PEROXIDASE; SUPEROXIDE DISMUTASE;

EID: 84948659656     PISSN: 07482337     EISSN: 14770393     Source Type: Journal    
DOI: 10.1177/0748233713486960     Document Type: Article
Times cited : (58)

References (59)
  • 1
    • 0021318441 scopus 로고
    • Catalase in vitro
    • Aebi H (1974) Catalase in vitro. Methods in Enzymology 105: 121–126.
    • (1974) Methods in Enzymology , vol.105 , pp. 121-126
    • Aebi, H.1
  • 2
    • 0024364268 scopus 로고
    • Chelating and free radical scavenging mechanism of inhibitory action of rutin and quercetin in lipid peroxidation
    • Afanas'ev IB, Dorozhko AI, Brodskii AV, Kostyuk VA, Potapovitch AI (1989) Chelating and free radical scavenging mechanism of inhibitory action of rutin and quercetin in lipid peroxidation. Biochemical Pharmacology 38: 1763–1769.
    • (1989) Biochemical Pharmacology , vol.38 , pp. 1763-1769
    • Afanas'ev, I.B.1    Dorozhko, A.I.2    Brodskii, A.V.3    Kostyuk, V.A.4    Potapovitch, A.I.5
  • 5
    • 33751002324 scopus 로고    scopus 로고
    • Cadmium: cellular effects, modifications of biomolecules, modulation of DNA repair and genotoxic consequences (a review)
    • Bertin G, Averbeck D (2006) Cadmium: cellular effects, modifications of biomolecules, modulation of DNA repair and genotoxic consequences (a review). Biochimie 88: 1549–1559.
    • (2006) Biochimie , vol.88 , pp. 1549-1559
    • Bertin, G.1    Averbeck, D.2
  • 6
    • 0004881319 scopus 로고    scopus 로고
    • Free radical mediated toxic injury to the nervous system
    • In: Wallace KB (ed) Oxford, UK: Taylor and Francis
    • Bondy SC (1997) Free radical mediated toxic injury to the nervous system. In: Wallace KB (ed) Free Radical Toxicology. Oxford, UK: Taylor and Francis, pp. 221–248.
    • (1997) Free Radical Toxicology , pp. 221-248
    • Bondy, S.C.1
  • 8
    • 33746533375 scopus 로고    scopus 로고
    • Protective effect of quercetin, a natural flavonoid against neuronal damage after transient global cerebral ischemia
    • Cho JY, Kim IS, Jang YH, Kim AR, Lee SR (2006) Protective effect of quercetin, a natural flavonoid against neuronal damage after transient global cerebral ischemia. Neuroscience Letters 404: 330–335.
    • (2006) Neuroscience Letters , vol.404 , pp. 330-335
    • Cho, J.Y.1    Kim, I.S.2    Jang, Y.H.3    Kim, A.R.4    Lee, S.R.5
  • 9
    • 0345669749 scopus 로고    scopus 로고
    • Polyphenolic flavonoids differ in their antiapoptotic effi- cacy in hydrogen peroxide treated human vascular en- dothelial cells
    • Choi YJ, Kang JS, Park JH, Lee YJ, Choi JS, Kang YH (2003) Polyphenolic flavonoids differ in their antiapoptotic effi- cacy in hydrogen peroxide treated human vascular en- dothelial cells. Journal of Nutrition 133: 985–991.
    • (2003) Journal of Nutrition , vol.133 , pp. 985-991
    • Choi, Y.J.1    Kang, J.S.2    Park, J.H.3    Lee, Y.J.4    Choi, J.S.5    Kang, Y.H.6
  • 10
    • 0029942808 scopus 로고    scopus 로고
    • Cadmium accumulation and metallothionein expression in brain of mice at different stages of development
    • Choudhuri S, Liu WL, Berman NE, Klaassen CD (1996) Cadmium accumulation and metallothionein expression in brain of mice at different stages of development. Toxicology Letters 84: 127–133.
    • (1996) Toxicology Letters , vol.84 , pp. 127-133
    • Choudhuri, S.1    Liu, W.L.2    Berman, N.E.3    Klaassen, C.D.4
  • 11
    • 0033923816 scopus 로고    scopus 로고
    • Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium
    • Chuang SM, Wang IC, Yang JL (2000) Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium. Carcinogenesis 21: 1423–1432.
    • (2000) Carcinogenesis , vol.21 , pp. 1423-1432
    • Chuang, S.M.1    Wang, I.C.2    Yang, J.L.3
  • 13
    • 0030988742 scopus 로고    scopus 로고
    • Biochemistry and pathology of radical mediated protein oxidation
    • Dean RT, Flu S, Stocker R, Davies MJ (1997) Biochemistry and pathology of radical mediated protein oxidation. Biochemical Journal 324: 1–18.
    • (1997) Biochemical Journal , vol.324 , pp. 1-18
    • Dean, R.T.1    Flu, S.2    Stocker, R.3    Davies, M.J.4
  • 14
    • 0033660577 scopus 로고    scopus 로고
    • Role of beta-carotene in ameliorating the cadmium-induced oxidative stress in rat brain and testis
    • El-Missiry MA, Shalaby F (2000) Role of beta-carotene in ameliorating the cadmium-induced oxidative stress in rat brain and testis. Journal of Biochemical and Molecular Toxicology 14: 238–243.
    • (2000) Journal of Biochemical and Molecular Toxicology , vol.14 , pp. 238-243
    • El-Missiry, M.A.1    Shalaby, F.2
  • 15
    • 84863209695 scopus 로고    scopus 로고
    • Protective effects of kolaviron and quercetin on cadmium-induced testicular damage and endocrine pathology in rats
    • Farombi EO, Adedara IA, Akinrinde SA, Ojo OO, Eboh AS (2012) Protective effects of kolaviron and quercetin on cadmium-induced testicular damage and endocrine pathology in rats. Andrologia 44(4): 273–284.
    • (2012) Andrologia , vol.44 , Issue.4 , pp. 273-284
    • Farombi, E.O.1    Adedara, I.A.2    Akinrinde, S.A.3    Ojo, O.O.4    Eboh, A.S.5
  • 16
    • 0032557581 scopus 로고    scopus 로고
    • Disruption of the intracellular sulfhydryl homeostasis by cadmium-induced oxidative stress leads to protein thiolation and ubiquitination in neuronal cells
    • Figueiredo-Pereira ME, Yakushin S, Cohen G (1998) Disruption of the intracellular sulfhydryl homeostasis by cadmium-induced oxidative stress leads to protein thiolation and ubiquitination in neuronal cells. Journal of Biological Chemistry 273: 12703–12709.
    • (1998) Journal of Biological Chemistry , vol.273 , pp. 12703-12709
    • Figueiredo-Pereira, M.E.1    Yakushin, S.2    Cohen, G.3
  • 17
    • 18344399012 scopus 로고    scopus 로고
    • Stimulation of p38 mitogen-activated kinase is an early regulatory event for the cadmium-induced apoptosis in human promonocytes cells
    • Galán A, García-Bermejo ML, Troyano A, Vilaboa NE, de Blas E, Kazanietz MG et al. (2000) Stimulation of p38 mitogen-activated kinase is an early regulatory event for the cadmium-induced apoptosis in human promonocytes cells. Journal of Biological Chemistry 275: 11418–11424.
    • (2000) Journal of Biological Chemistry , vol.275 , pp. 11418-11424
    • Galán, A.1    García-Bermejo, M.L.2    Troyano, A.3    Vilaboa, N.E.4    de Blas, E.5    Kazanietz, M.G.6
  • 18
    • 33745013111 scopus 로고    scopus 로고
    • Oxidative stress and neurodegeneration: where are we now?
    • Halliwell B (2006) Oxidative stress and neurodegeneration: where are we now? Journal of Neurochemistry 97: 1634–1658.
    • (2006) Journal of Neurochemistry , vol.97 , pp. 1634-1658
    • Halliwell, B.1
  • 19
    • 0019423594 scopus 로고
    • Use of avidin-biotin-peroxidase complex (ABC) in immunperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures
    • Hsu SM, Raine L, Fanger H (1981) Use of avidin-biotin-peroxidase complex (ABC) in immunperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. Journal of Histochemistry and Cytochemistry 29: 577–580.
    • (1981) Journal of Histochemistry and Cytochemistry , vol.29 , pp. 577-580
    • Hsu, S.M.1    Raine, L.2    Fanger, H.3
  • 20
    • 0036274808 scopus 로고    scopus 로고
    • Radioprotective effects of exogenous glutathione against whole-body gamma-ray irradiation: age- and gender-related changes in malondialdehyde levels, superoxide dismutase and catalase activities in rat liver
    • Inal ME, Akgun A, Kahraman A (2002) Radioprotective effects of exogenous glutathione against whole-body gamma-ray irradiation: age- and gender-related changes in malondialdehyde levels, superoxide dismutase and catalase activities in rat liver. Methods and Findings in Experimental and Clinical Pharmacology 24: 209–212.
    • (2002) Methods and Findings in Experimental and Clinical Pharmacology , vol.24 , pp. 209-212
    • Inal, M.E.1    Akgun, A.2    Kahraman, A.3
  • 21
    • 84997910148 scopus 로고    scopus 로고
    • Protective effects of quercetine on the neuronal injury in frontal cortex after chronic toluene exposure
    • Epub ahead of print 17 January 2012.
    • Kanter M (2012) Protective effects of quercetine on the neuronal injury in frontal cortex after chronic toluene exposure. Toxicology and Industrial Health. Epub ahead of print 17 January 2012.
    • (2012) Toxicology and Industrial Health
    • Kanter, M.1
  • 22
    • 84856475646 scopus 로고    scopus 로고
    • Protective effects of quercetin against apoptosis and oxidative stress in streptozotocin-induced diabetic rat testis
    • Kanter M, Aktas C, Erboga M (2012) Protective effects of quercetin against apoptosis and oxidative stress in streptozotocin-induced diabetic rat testis. Food and Chemical Toxicology 50(3–4): 719–725.
    • (2012) Food and Chemical Toxicology , vol.50 , Issue.3-4 , pp. 719-725
    • Kanter, M.1    Aktas, C.2    Erboga, M.3
  • 23
    • 84856540774 scopus 로고    scopus 로고
    • Neuroprotective effects of caffeic acid phenethyl ester on experimental traumatic brain injury in rats
    • Kerman M, Kanter M, Coskun KK, Erboga M, Gurel A (2012) Neuroprotective effects of caffeic acid phenethyl ester on experimental traumatic brain injury in rats. Journal of Molecular Histology 43: 49–57.
    • (2012) Journal of Molecular Histology , vol.43 , pp. 49-57
    • Kerman, M.1    Kanter, M.2    Coskun, K.K.3    Erboga, M.4    Gurel, A.5
  • 24
    • 12844251358 scopus 로고    scopus 로고
    • Identification of ASK1, MKK4, JNK, c-Jun, and caspase-3 as a signaling cascade involved in cadmium-induced neuronal cell apoptosis
    • Kim S, Moon C, Eun S, Ryu P, Jo S (2005) Identification of ASK1, MKK4, JNK, c-Jun, and caspase-3 as a signaling cascade involved in cadmium-induced neuronal cell apoptosis. Biochemical and Biophysical Research Communications 328: 326–334.
    • (2005) Biochemical and Biophysical Research Communications , vol.328 , pp. 326-334
    • Kim, S.1    Moon, C.2    Eun, S.3    Ryu, P.4    Jo, S.5
  • 25
    • 0030566884 scopus 로고    scopus 로고
    • Mechanism of cadmium-induced cytotoxicity in rat hepatocytes: cadmium-induced active oxygen-related permeability changes of the plasma membrane
    • Koizumi T, Shirakura H, Kumagai H, Tatsumoto H, Suzuki KT (1996) Mechanism of cadmium-induced cytotoxicity in rat hepatocytes: cadmium-induced active oxygen-related permeability changes of the plasma membrane. Toxicology 114: 125–134.
    • (1996) Toxicology , vol.114 , pp. 125-134
    • Koizumi, T.1    Shirakura, H.2    Kumagai, H.3    Tatsumoto, H.4    Suzuki, K.T.5
  • 27
    • 0029908940 scopus 로고    scopus 로고
    • Oxidative stressmediated neurotoxicity of cadmium
    • Kumar R, Agarwal AK, Seth PK (1996) Oxidative stressmediated neurotoxicity of cadmium. Toxicology Letters 89: 65–69.
    • (1996) Toxicology Letters , vol.89 , pp. 65-69
    • Kumar, R.1    Agarwal, A.K.2    Seth, P.K.3
  • 28
    • 0026095778 scopus 로고
    • Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives. Relationship to antioxidant activity and to iron ion-reducing ability
    • Laughton MJ, Evans PJ, Moroney MA, Hoult JR, Halliwell B (1991) Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives. Relationship to antioxidant activity and to iron ion-reducing ability. Biochemical Pharmacology 42: 1673–1681.
    • (1991) Biochemical Pharmacology , vol.42 , pp. 1673-1681
    • Laughton, M.J.1    Evans, P.J.2    Moroney, M.A.3    Hoult, J.R.4    Halliwell, B.5
  • 30
    • 33644851854 scopus 로고    scopus 로고
    • Cadmium induces reactive oxygen species generation and lipid peroxidation in cortical neurons in culture
    • Lopez E, Arce C, Oset-Gasque MJ, Canadas S, Gonzales MP (2006) Cadmium induces reactive oxygen species generation and lipid peroxidation in cortical neurons in culture. Free Radical Biology and Medicine 40: 940–951.
    • (2006) Free Radical Biology and Medicine , vol.40 , pp. 940-951
    • Lopez, E.1    Arce, C.2    Oset-Gasque, M.J.3    Canadas, S.4    Gonzales, M.P.5
  • 31
    • 0037349147 scopus 로고    scopus 로고
    • Apoptosis and necrosis: two distinct events induced by cadmium in cortical neurons in culture
    • Lopez E, Figueroa S, Oset-Gasque M, Gonzalez MP (2003) Apoptosis and necrosis: two distinct events induced by cadmium in cortical neurons in culture. British Journal of Pharmacology 138: 901–911.
    • (2003) British Journal of Pharmacology , vol.138 , pp. 901-911
    • Lopez, E.1    Figueroa, S.2    Oset-Gasque, M.3    Gonzalez, M.P.4
  • 33
    • 79951822443 scopus 로고    scopus 로고
    • Quercetin in combination with vitamins (C and E) improves oxidative stress and renal injury incadmium intoxicated rats
    • Milton Prabu S, Shagirtha K, Renugadevi J (2010) Quercetin in combination with vitamins (C and E) improves oxidative stress and renal injury incadmium intoxicated rats. European Review of Medical and Pharmacological Sciences 1 4(11): 903–914.
    • (2010) European Review of Medical and Pharmacological Sciences , vol.14 , Issue.11 , pp. 903-914
    • Milton Prabu, S.1    Shagirtha, K.2    Renugadevi, J.3
  • 35
    • 33749558205 scopus 로고    scopus 로고
    • Protective effect of quercetin on experimental chronic cadmium nephrotoxicity in rats is based on its antioxidant properties
    • Morales AI, Vicente-Sánchez C, Sandoval JM, Egido J, Mayoral P, Arévalo MA et al. (2006a) Protective effect of quercetin on experimental chronic cadmium nephrotoxicity in rats is based on its antioxidant properties. Food and Chemical Toxicology 44(12): 2092–2100.
    • (2006) Food and Chemical Toxicology , vol.44 , Issue.12 , pp. 2092-2100
    • Morales, A.I.1    Vicente-Sánchez, C.2    Sandoval, J.M.3    Egido, J.4    Mayoral, P.5    Arévalo, M.A.6
  • 36
    • 30644476948 scopus 로고    scopus 로고
    • Increase in intracellular Cd2+ concentration of rat cerebellar granule neurons incubated with cadmium chloride: cadmium cytotoxicity under external Ca2+-free condition
    • Nishimura Y, Yamaguchi JY, Kanada A, Horimoto K, Kanemaru K, Satoh M et al. (2006) Increase in intracellular Cd2+ concentration of rat cerebellar granule neurons incubated with cadmium chloride: cadmium cytotoxicity under external Ca2+-free condition. Toxicology in Vitro 20: 211–216.
    • (2006) Toxicology in Vitro , vol.20 , pp. 211-216
    • Nishimura, Y.1    Yamaguchi, J.Y.2    Kanada, A.3    Horimoto, K.4    Kanemaru, K.5    Satoh, M.6
  • 37
    • 0021287993 scopus 로고
    • General aspects of cadmium: transport, uptake and metabolism by the kidney
    • Nordberg M (1984) General aspects of cadmium: transport, uptake and metabolism by the kidney. Environmental Health Perspectives 54: 13–20.
    • (1984) Environmental Health Perspectives , vol.54 , pp. 13-20
    • Nordberg, M.1
  • 38
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid rection
    • Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid rection. Analytical Biochemistry 95: 351–358.
    • (1979) Analytical Biochemistry , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 40
    • 0014108436 scopus 로고
    • Studies on the quantitative and qualitative characterisation of erythrocyte glutathione peroxidase
    • Paglia DE, Valentine WN (1967) Studies on the quantitative and qualitative characterisation of erythrocyte glutathione peroxidase. Journal of Laboratory and Clinical Medicine 70: 158–169.
    • (1967) Journal of Laboratory and Clinical Medicine , vol.70 , pp. 158-169
    • Paglia, D.E.1    Valentine, W.N.2
  • 41
    • 79952986535 scopus 로고    scopus 로고
    • The role of ASIC1a in neuroprotection elicited by quercetin in focal cerebral ischemia
    • Pandeya AK, Hazaria PP, Patnaik R, Mishra AK (2011) The role of ASIC1a in neuroprotection elicited by quercetin in focal cerebral ischemia. Brain Research 1383: 289–299.
    • (2011) Brain Research , vol.1383 , pp. 289-299
    • Pandeya, A.K.1    Hazaria, P.P.2    Patnaik, R.3    Mishra, A.K.4
  • 42
    • 77957116879 scopus 로고    scopus 로고
    • Amelioration of cadmium-induced oxidative stress, impairment in lipids and plasma lipoproteins by the combined treatment with quercetin and α-tocopherol in rats
    • Prabu SM, Shagirtha K, Renugadevi J (2010) Amelioration of cadmium-induced oxidative stress, impairment in lipids and plasma lipoproteins by the combined treatment with quercetin and α-tocopherol in rats. Journal of Food Science 75(7): 132–140.
    • (2010) Journal of Food Science , vol.75 , Issue.7 , pp. 132-140
    • Prabu, S.M.1    Shagirtha, K.2    Renugadevi, J.3
  • 43
    • 77955510512 scopus 로고    scopus 로고
    • Quercetin protects against oxidative stress-related renal dysfunction by cadmium in rats
    • Renugadevi J, Prabu SM (2010) Quercetin protects against oxidative stress-related renal dysfunction by cadmium in rats. Experimental and Toxicologic Pathology 62(5): 471–481.
    • (2010) Experimental and Toxicologic Pathology , vol.62 , Issue.5 , pp. 471-481
    • Renugadevi, J.1    Prabu, S.M.2
  • 44
    • 0035118236 scopus 로고    scopus 로고
    • Cadmium induced apoptosis and genotoxicity in rainbow trout hepatocytes through generation of reactive oxygen species
    • Risso De Faverney C, Devaux A, Lafaurie M, Girard JP, Bailly B, Rahmani R (2001) Cadmium induced apoptosis and genotoxicity in rainbow trout hepatocytes through generation of reactive oxygen species. Aquatic Toxicology 53: 65–76.
    • (2001) Aquatic Toxicology , vol.53 , pp. 65-76
    • Risso De Faverney, C.1    Devaux, A.2    Lafaurie, M.3    Girard, J.P.4    Bailly, B.5    Rahmani, R.6
  • 47
    • 33745630335 scopus 로고    scopus 로고
    • COX-2 is associated with cadmiuminduced ICAM-1 expression in cerebrovascular endothelial cells
    • Seok SM, Park DH, Kim YC, Moon CH, Jung YS, Baik EJ et al. (2006) COX-2 is associated with cadmiuminduced ICAM-1 expression in cerebrovascular endothelial cells. Toxicology Letters 165: 212–220.
    • (2006) Toxicology Letters , vol.165 , pp. 212-220
    • Seok, S.M.1    Park, D.H.2    Kim, Y.C.3    Moon, C.H.4    Jung, Y.S.5    Baik, E.J.6
  • 50
    • 0023543145 scopus 로고
    • Possible role of regional, superoxide dismutase activity and lipid peroxide levels in cadmium neurotoxicity: in vivo and in vitro studies in growing rats
    • Shukla GS, Hussain T, Chandra SV (1987) Possible role of regional, superoxide dismutase activity and lipid peroxide levels in cadmium neurotoxicity: in vivo and in vitro studies in growing rats. Life Sciences 41: 2215–2221.
    • (1987) Life Sciences , vol.41 , pp. 2215-2221
    • Shukla, G.S.1    Hussain, T.2    Chandra, S.V.3
  • 51
    • 0024346254 scopus 로고
    • Glutathione peroxidase and catalase in liver, kidney, testis and brain regions of rats following cadmium exposure and subsequent withdrawal
    • Shukla GS, Hussain T, Srivastava RS, Chandra SV (1989) Glutathione peroxidase and catalase in liver, kidney, testis and brain regions of rats following cadmium exposure and subsequent withdrawal. Industrial Health 29: 59–69.
    • (1989) Industrial Health , vol.29 , pp. 59-69
    • Shukla, G.S.1    Hussain, T.2    Srivastava, R.S.3    Chandra, S.V.4
  • 52
    • 0023952554 scopus 로고
    • A simple method for clinical assay of superoxide dismutase
    • Sun Y, Oberley LW, Li Y (1988) A simple method for clinical assay of superoxide dismutase. Clinical Chemistry 34: 497–500.
    • (1988) Clinical Chemistry , vol.34 , pp. 497-500
    • Sun, Y.1    Oberley, L.W.2    Li, Y.3
  • 56
    • 0030068017 scopus 로고    scopus 로고
    • In vivo studies of cadmium-induced apoptosis in testicular tissue of the rat and its modulation by a chelating agent
    • Xu C, Johnson JE, Singh PK, Jones MM, Yan H, Carter CE (1996) In vivo studies of cadmium-induced apoptosis in testicular tissue of the rat and its modulation by a chelating agent. Toxicology 107: 1–8.
    • (1996) Toxicology , vol.107 , pp. 1-8
    • Xu, C.1    Johnson, J.E.2    Singh, P.K.3    Jones, M.M.4    Yan, H.5    Carter, C.E.6
  • 57
    • 0030804272 scopus 로고    scopus 로고
    • Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury
    • Yakovlev AG, Knoblach SM, Fan L, Fox GB, Goodnight R, Faden AI (1997) Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. Journal of Neuroscience 17: 7415–7424.
    • (1997) Journal of Neuroscience , vol.17 , pp. 7415-7424
    • Yakovlev, A.G.1    Knoblach, S.M.2    Fan, L.3    Fox, G.B.4    Goodnight, R.5    Faden, A.I.6
  • 58
    • 0034641936 scopus 로고    scopus 로고
    • Apoptosis in the nervous system
    • Yuan J, Yankner BA (2000) Apoptosis in the nervous system. Nature 407: 802–809.
    • (2000) Nature , vol.407 , pp. 802-809
    • Yuan, J.1    Yankner, B.A.2
  • 59
    • 33744525840 scopus 로고    scopus 로고
    • Age-related changes in glutathione and glutathione-related enzymes in rat brain
    • Zhu Y, Carvey PM, Ling Z (2006) Age-related changes in glutathione and glutathione-related enzymes in rat brain. Brain Research 1090: 35–44.
    • (2006) Brain Research , vol.1090 , pp. 35-44
    • Zhu, Y.1    Carvey, P.M.2    Ling, Z.3


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