Quercetin in combination with vitamins (C and E) improves oxidative stress and renal injury in cadmium intoxicated rats

European Review for Medical and Pharmacological Sciences

Volumn 14, Issue 11, 2010, Pages 903-914

  Milton Prabu, S ^a   Shagirtha, K ^a   Renugadevi, J ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Antioxidant; Cadmium; Kidney; Oxidative stress; Quercetin; Vitamins (C and E)

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; CADMIUM; CARBONYL DERIVATIVE; CATALASE; CREATININE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; LIPID HYDROPEROXIDE; QUERCETIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THIOL DERIVATIVE; UREA; URIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; CREATININE URINE LEVEL; ENZYME ACTIVITY; HISTOPATHOLOGY; INTOXICATION; KIDNEY INJURY; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN CARBONYLATION; RAT; RENAL PROTECTION; UREA BLOOD LEVEL; URIC ACID BLOOD LEVEL;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; CADMIUM; GLUTATHIONE; KIDNEY; LIPID PEROXIDATION; MALE; OXIDATIVE STRESS; QUERCETIN; RATS; RATS, WISTAR; VITAMIN E;

EID: 79951822443     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (70)

1. JARUP L, BERGLUND M, ELINDER C, NORDBERG G, VAHTER M. Health effects of cadmium exposure - A review of literature and a risk estimate. Scand J Work Environ Health 1998; 24: 1-52.
2. WAISBERG M, JOSEPH P, HALE B, BEYERSMANN D. Molecular mechanisms of cadmium carcinogenesis. Toxicology 2003; 192: 95-117.
3. GALARIS D, EVANGELOU A. The role of oxidative stress in mechanisms of metal-induced carcinogenesis. Crit Rev Oncol Hematol 2002; 42: 93-103.
4. ERCAL N, GURER-ORHAN H, AYKIN-BURNS N. Toxic metals and oxidative stress. Part I: Mechanisms involved in metal-induced oxidative damage. Curr Top Med Chem 2001; 1: 529-539.
5. THEVENOD F, FRIEDMANN JM, KATSEN AD, HAUSER IA. Upregulation of multidrug resistance P-glycoprotein via nuclear factor-kappa β activation protects kidney proximal tubule cells from cadmium and reactive oxygen species induced apoptosis. J Biol Chem 2000; 275: 1887-1896.
6. SZUSTER-CLESIELSKA A, STACHURA A, SLOTWINSKA M, KAMINSKA T, SNIEZK R, PADUCH R, ABRAMCZYK D, FILAR J, KANDEFER-SZERSZEN M. The inhibitory effect of zinc on cadmium induced cell apoptosis and reactive oxygen species (ROS) production in cell cultures. Toxicology 2000; 145: 159-171.
7. MANCA D, RICARD AC, TROTTIER B, CHEVALIER G. Studies on lipid peroxidation in rat tissues following administration of low and moderate doses of cadmium chloride. Toxicology 1991; 67: 303-323.
8. SATARUG S, BAKER JR, URBENJAPOL M, HASWELL-ELKINS M, REILLY PE, WILLIAMS DJ, MOORE MR. A global perspective on cadmium pollution and toxicity in nonoccupationally exposed population. Toxicol Lett 2003; 137: 65-83.
9. HALLIWELL B, GUTTERIDGE JMC. Role of free-radicals and catalytic metal-ions in human-disease-an overview. Method Enzymol 1990; 186: 1-85.
10. GOLDBERG DM, HANH SE, PARKES JG. Beyond alcohol: beverage consumption and cardiovascular mortality. Clin Chim Acta 1995; 237: 155-187.
11. SAMPSON L, RIMM E, HOLLMAN PC, DE VRIES JH, KATAN MB. Flavonol and flavone intakes in US health professionals. J Am Diet Assoc 2002; 102: 1414-1420.
12. ROBAK J, GRYGLEWSKI RJ. Flavonoids are scavengers of superoxide anions. Biochem Pharmacol 1988; 37: 837-841.
13. SANHUEZA J, VALDES J, CAMPOS R, GARRIDO A, VALENZUELA A. Changes in the xanthine dehydrogenase/xanthine oxidase-ratio in the kidney subjected to ischemia-reperfusion stress: preventive effect of some flavonoids. Res Commun Chem Pathol Pharmacol 1992; 78: 211-218.
14. CHAN HM, ZHU LF, ZHONG R, GRANT D, GOYER RA, CHERIAN MG. Nephrotoxicity in rats following kidney transplantation from cadmium-exposed rats. Toxicol Appl Pharmacol 1993; 123: 89-96.
15. JOVANOVIC SV, STEENKEN S, SIMIC MG, HARA Y. Antioxidant properties of flavonoids: reduction potentials and electron transfer reactions of flavonoid radicals. In: Rice-Evans CA and Packer L. (Eds.), Flavonoids in Health and Disease, Marcel Dekker, New York, 1998; pp. 137-161.
16. ERLUND T, KOSONEN GA, ALFIHAN JM, MAENPAA J, PERTTUNEN K, KENRAALI J, PARANTAINEN J, ARO A. Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers. Eur J Clin Pharmacol 2000; 56: 545-553.
17. FANG YZ, YANG S, WU Z. Free radicals, antioxidants and nutrition. Nutrition 2002; 18: 872-879.
18. BOREK C. Dietary antioxidant and human cancer. Integr Cancer Ther 2004; 3: 333-341.
19. SCHNEIDER C. Chemistry and biology of vitamin E. Mol Nutr Food Chem 2005; 49: 7-30.
20. YOUNG IS, WOODSIDE JV. Antioxidants in health and disease. J Clin Pathol 2001; 54: 176-186.
21. AHN DU, KIM SM. Effect of superoxide and superoxide generating systems on the prooxidant effect of iron in oil emulsion and raw turkey homogenates. Poultry Sci 1998; 77: 1428-1435.
22. HEINECKE JW. IS the emperor wearing clothes? Clinical trials of vitamin E and the LDL oxidation hypothesis. Arterioscl Thromb Vasc Biol 2001; 21: 1261-1264.
23. ULKER S, MCMASTER D, MCKEOWN PP, BAYRAKTUTAN U. Antioxidant vitamin C and E ameliorate hyperglycaemia induced oxidative stress in coronary endothelial cells. Diabetes Obes Metab 2004; 6: 442-451.
24. ROSALKI SB, RAV D, LCHMAN D, PRENTICE M. Determination of serum gamma-glutamyl transpeptidase activity and its clinical applications. Ann Clin Biochem 1970; 7: 143-147.
25. NIEHIAUS WG, SAMUELSSON D. Formation of malondialdehyde from phospholipid arachidonate during microsomal lipid peroxidation. Eur J Biochem 1968; 6: 126-130.
26. JIANG ZY, HUNT JV, WOLFF SD. Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein. Anal Biochem 1992; 202: 384-389.
27. LEVINE RL, GARLAND D, OKIDNEY CN, AMIC A, CUMENT I, LENZ AG, AHN BW, SHALTIEL S, STADTMAN ER. Determination of carbonyl content in oxidatively modified proteins. Method Enzymol 1990; 186: 464-478.
28. MORON MS, DESPIERRE JW, MINNERVIK B. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and kidney. Biochim Biophys Acta 1979; 582: 67-78.
29. ELLMAN GL. Tissue sulfhydryl groups. Arch Biochem Biophys 1959; 82: 70-77.
30. OMAYE ST, TURNBULL JD, SAUBERLICH HE. Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids. Method Enzymol 1979; 62: 3-11.
31. DESAI ID. Vitamin E analysis method for animal tissues. Method Enzymol 1984; 105: 138-143.
32. KAKKAR P, DAS B, VISWANATHAN PN. A modified spectrophotometric assay of superoxide dismutase. Indian J Biochem Biophys 1984; 21: 130-132.
33. SINHA AK. Colorimetric assay of catalase. Ann Biochem 1972; 47: 389-394.
34. ROTRUCK JT, ROPE AL, GANTHER HF, SWASON AB. Selenium: biochemical role as a component of glutathione peroxidase. Science 1973; 179: 588-590.
35. HABIG WH, PABST MJ, JAKPOLY WB. Glutathione transferase: a first enzymatic step in mercapturic acid formation. J Biol Chem 1974; 249: 7130-7139.
36. HORN HD, BURNS FH. Assay of glutathione reductase activity. In: Bergmeyer HV (Ed.), Methods of Enzymatic Analysis. Academic Press, New York, USA, 1978; pp. 142-146.
37. BEUTLER E. Active transport of glutathione disulfide from erythrocytes. In: Larson A, Orrenius S, Holmgren A, Mannerwik B. (Eds.), Functions of Glutathione, Biochemical, Physiological, Toxicological and Clinical Aspects. Raven Press, New York, USA, 1983; p. 65.
38. LOWRY OH, ROSENBROUGH MJ, FARR AL, RANDALL RJ. Protein measurement with Folin-phenol reagent. J Biol Chem 1951; 193: 265-275.
39. RAZA M, AHMAD M, GADO A, AL-SHABANAH O. A comparison of hepatoprotective activities of amino guanidine and N-acetyl cysteine in rat against the toxic damage induced by azathioprine. Comp Biochem Physiol 2003; 134: 451-456.
40. CHENOWETH M, HAKE C. The smaller halogenated aliphatic hydrocarbons. Ann Rev Pharmacol 1962; 2: 363-398.
41. DROZDZ R, PARMENTIER C, HACHAD H, LEROY P, SIEST G, WELLMAN M. γ-Glutamyl transferase dependent generation of reactive oxygen species from a glutathione/ transferrin system. Free Radical Biol Med 1998; 25: 786-792.
42. WHITFIELD JB. Gamma glutamyl transferase. Crit Rev Clin Lab Sci 2001; 38: 263-355.
43. LEE MH, SOON S, MOON JO. The flavonoid naringenin inhibits dimethylnitrosamine induced kidney damage in rats. Biol Pharm Bull 2004; 27: 72-76.
44. JANBAZ KH, SAEED SA, GILANI AH. Studies on the protective effects of caffeic acid and quercetin on chemical-induced hepatotoxicity in rodents. Phytomedicine 2004; 11: 424-430.
45. JIN T, NORDBERG M, FRECH W, DUMONT X, BERNARD A, YE TT, KONG Q, WANG Z, LI P, LUNDSTROM NG, LI Y, NORDBERG GF. Cadmium biomonitoring and renal dysfunction among a population environmentally exposed to cadmium from smelting in China. Biometals 2002; 15: 397-410.
46. SHIMADA T, TAKAMURE Y, SHIMADA A, YASUTAKE A, WAALKES MP, IMAMURA Y. Strain differences of cadmium-induced hepatotoxicity in Wistar-imamichi and Fischer 344 rats: involvement of cadmium accumulation. Toxicology 2004; 203: 189-197.
47. EL-SHARAKY AS, MOHAMMED GB, KANDEEL KM, WAHBY MM. An electrochemical approach to characterization of metallothione: direct evidence of interaction of cadmium with cysteine residue. In: Proceedings of the XXV-International Conference on Co-ordination Chemistry, Nanjing, China, July 2631, 1987.
48. THAMPI HBS, MANOJ G, LEELAMMA S, MENON VP. Dietary fiber and lipid peroxidation: effect of dietary fiber on levels of lipids and lipid peroxides in high fat diet. Ind J Exp Biol 1991; 29: 563-567.
49. LEIBOVITZ BE, SIEGEL BV. Aspects of free radical reactions in biological systems: aging. J Gerontol 1980; 35: 45-56.
50. COSKUN O, KANTER M, AHMETKORKMAZ A, SUKRUOTER S. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and β-cell damage in rat pancreas. Pharmacol Res 2005; 51: 117-123.
51. BOOTS AW, LI H, SCHINS PF, DUFFIN R, HEEMSKERK JWM, BAST A, HAENEN RMM. The quercetin paradox. Toxicol Appl Pharmacol 2007; 222: 89-96.
52. KALENDER S, KALENDER Y, OGUTCU A, UZUNHISARCIKLI M, DURAK D, ACIKGOZ F. Endosulfan-induced cardiotoxicity and free radical metabolism in rats: the protective effect of vitamin E. Toxicology 2004; 202: 227-235.
53. SHACTER E, WILLIAMS JA, STADTMAN ER, LEVINE RC. Determination of carbonyl groups in oxidized protein. In: Punchard NA, Kelly KJ (Eds.), Free Radicals - A Practical Approach. Oxford University Press, Oxford, 1996; pp. 159-170.
54. STADTMAN ER, BERLETT BS. Reactive oxygen mediated protein oxidation in aging and disease. Drug Met Rev 1998; 30: 225-243.
55. AGARWAL R. Chronic kidney disease is associated with oxidative stress independent of hypertension. Clin Nephrol 2004; 61: 377-383.
56. STOHS SJ, BAGCHI D. Oxidative mechanisms in the toxicity of metal ions. Free Radical Biol Med 1995; 18: 321-336.
57. PARI L, MURUGAVEL P. Role of diallyl tetrasulfide in ameliorating the cadmium induced biochemical changes in rats. Environ Toxicol Pharmacol 2005; 20: 493-500.
58. MORALES AI, VICENTE-SANCHEZ C, EGIDO J, AREVALO MA, LOPEZNOVOA JM. Protective effect of quercetin on experimental chronic cadmium nephrotoxicity in rats is based on its antioxidant properties. Food Chem Toxicol 2006; 44: 20922100.
59. PHARIKAL K, DAS PC, DEY CD, DASGUPTA S. Tissue ascorbate as a metabolic marker in cadmium toxicity. Int J Vit Nutr Res 1988; 58: 306-311.
60. PAVLOVIC SZ, ONJANVOIC BI, STAJN AS, ZIKIC RV, SAICIC ZS, PETROVIC VM. The effects of coenzyme Q10 on blood ascorbic acid, vitamin E and lipid peroxide in chronic cadmium intoxication. J Environ Pathol Toxicol Oncol 2001; 20: 133-144.
61. Mates M. Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Toxicology 2000; 153: 83-104.
62. RANA SVS, ALLEN T, SINGH R. Inevitable glutathione, then and now. Indian J Exp Biol 2002; 40: 706-716.
63. HUSAIN SR, CILLARD J, CILLARD P. Hydroxyl radical scavenging activity of flavonoids. Phytochemistry 1987; 26: 2489-2491.
64. ROBAK J, GRYGLEWSKI RJ. Flavonoids are scavengers of superoxide anions. Biochem Pharmacol 1988; 37: 837-841.
65. RICE-EVANS CA, MILLER NJ, PAGANGA G. Antioxidant properties of phenolic compounds. Trends Plant Sci 1997; 2: 152-159.
66. KIM MR, LEE JY, LEE HH, ARYAL DK, KIM YG, KIM SK, Woo ER, KANG KW. Antioxidative effects of quercetin glycosides isolated from the flower buds of Tussilago farfara L. Food Chem Toxicol 2006; 44: 1299-1307.
67. PACE A, SAVARESE A, PICARDO M, MARESCA V, PACETTI U, DELMONTE G. Neuroprotective effect of vitamin E supplementation in-patient treated with cisplatin chemotherapy. J Clin Oncol 2003; 21: 927-931.
68. KIRMAN NH, GALIANA S, GAETANI GE. Functions of catalase bound NADPH. J Biol Chem 1987; 262: 660-666.
69. CASALINO E, CALZARETTI G, SBLANO C, LANDRISCINA C. Molecular inhibitory mechanisms of antioxidant enzymes in rat kidney and kidney by cadmium. Toxicology 2002; 179: 37-50.
70. SUNITHA S, NAGARAJ M, VARALAKSHMI P. Hepatoprotective effect of lupeol and lupeol linoleate on tissue antioxidant defense system in cadmium induced hepatotoxicity in rats. Fitoterapia 2001; 72: 516-523.