Long-range inhibitor-induced conformational regulation of human IRE1α endoribonuclease activity

Molecular Pharmacology

Volumn 88, Issue 6, 2015, Pages 1011-1023

  Concha, Nestor O ^a   Smallwood, Angela ^a   Bonnette, William ^a   Totoritis, Rachel ^a   Zhang, Guofeng ^a   Federowicz, Kelly ^a   Yang, Jingsong ^a   Qi, Hongwei ^a   Chen, Stephanie ^a   Campobasso, Nino ^a   Choudhry, Anthony E ^a   Shuster, Leanna E ^a   Evans, Karen A ^a   Ralph, Jeff ^a   Sweitzer, Sharon ^a   Heerding, Dirk A ^a   Buser, Carolyn A ^a   Su, Dai Shi ^a   DeYoung, M Phillip ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3,4 DICHLOROBENZYL) N (4 METHYLBENZYL) 2,7 DIAZASPIRO (4 5 ) DECANE 7 CARBOXAMIDE; DIMER; GLUTAMINE; INOSITOL REQUIRING ENZYME 1 ALPHA; LYSINE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN IRE1; RIBONUCLEASE; STAUROSPORINE; UNCLASSIFIED DRUG; ERN1 PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE;

ALPHA HELIX; ANIMAL CELL; ARTICLE; BINDING SITE; CHEMICAL REACTION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME INHIBITION; HYDROGEN BOND; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CRYSTALLIZATION; DRUG EFFECTS; ENZYME ACTIVATION; HUMAN; METABOLISM; PHYSIOLOGY; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE;

CELL LINE, TUMOR; CRYSTALLIZATION; ENDORIBONUCLEASES; ENZYME ACTIVATION; HUMANS; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES;

EID: 84948658980     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.115.100917     Document Type: Article

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