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Volumn 6, Issue 1, 2015, Pages

Expanded endothelial progenitor cells mitigate lung injury in septic mice

Author keywords

Cell therapies; Growth factors; Inflammation; Sepsis

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; PLATELET DERIVED GROWTH FACTOR; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; AUTACOID; CD133 ANTIGEN; GLYCOPROTEIN; LEUKOCYTE ANTIGEN; PEPTIDE; SIGNAL PEPTIDE;

EID: 84948472759     PISSN: None     EISSN: 17576512     Source Type: Journal    
DOI: 10.1186/s13287-015-0226-7     Document Type: Article
Times cited : (27)

References (37)
  • 1
    • 77954953191 scopus 로고    scopus 로고
    • Bone marrow-derived mononuclear cell therapy in experimental pulmonary and extrapulmonary acute lung injury
    • Araujo IM, Abreu SC, Maron-Gutierrez T, Cruz F, Fujisaki L, Carreira Jr H, et al. Bone marrow-derived mononuclear cell therapy in experimental pulmonary and extrapulmonary acute lung injury. Crit Care Med. 2010;38(8):1733-41. doi: 10.1097/CCM.0b013e3181e796d2.
    • (2010) Crit Care Med , vol.38 , Issue.8 , pp. 1733-1741
    • Araujo, I.M.1    Abreu, S.C.2    Maron-Gutierrez, T.3    Cruz, F.4    Fujisaki, L.5    Carreira, H.6
  • 2
    • 84887106459 scopus 로고    scopus 로고
    • Effects of mesenchymal stem cell therapy on the time course of pulmonary remodeling depend on the etiology of lung injury in mice
    • Maron-Gutierrez T, Silva JD, Asensi KD, Bakker-Abreu I, Shan Y, Diaz BL, et al. Effects of mesenchymal stem cell therapy on the time course of pulmonary remodeling depend on the etiology of lung injury in mice. Crit Care Med. 2013;41(11):e319-33. doi: 10.1097/CCM.0b013e31828a663e.
    • (2013) Crit Care Med , vol.41 , Issue.11 , pp. e319-e333
    • Maron-Gutierrez, T.1    Silva, J.D.2    Asensi, K.D.3    Bakker-Abreu, I.4    Shan, Y.5    Diaz, B.L.6
  • 3
    • 84885354468 scopus 로고    scopus 로고
    • Insult-dependent effect of bone marrow cell therapy on inflammatory response in a murine model of extrapulmonary acute respiratory distress syndrome
    • Maron-Gutierrez T, Silva JD, Cruz FF, Alegria S, Xisto DG, Assis EF, et al. Insult-dependent effect of bone marrow cell therapy on inflammatory response in a murine model of extrapulmonary acute respiratory distress syndrome. Stem Cell Res Ther. 2013;4(5):123. doi: 10.1186/scrt334.
    • (2013) Stem Cell Res Ther , vol.4 , Issue.5 , pp. 123
    • Maron-Gutierrez, T.1    Silva, J.D.2    Cruz, F.F.3    Alegria, S.4    Xisto, D.G.5    Assis, E.F.6
  • 4
    • 77950377767 scopus 로고    scopus 로고
    • Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweed-induced asthma
    • Nemeth K, Keane-Myers A, Brown JM, Metcalfe DD, Gorham JD, Bundoc VG, et al. Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweed-induced asthma. Proc Natl Acad Sci U S A. 2010;107(12):5652-7. doi: 10.1073/pnas.0910720107.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.12 , pp. 5652-5657
    • Nemeth, K.1    Keane-Myers, A.2    Brown, J.M.3    Metcalfe, D.D.4    Gorham, J.D.5    Bundoc, V.G.6
  • 5
    • 80052365615 scopus 로고    scopus 로고
    • Early and late effects of bone marrow-derived mononuclear cell therapy on lung and distal organs in experimental sepsis
    • Ornellas DS, Maron-Gutierrez T, Ornellas FM, Cruz FF, Oliveira GP, Lucas IH, et al. Early and late effects of bone marrow-derived mononuclear cell therapy on lung and distal organs in experimental sepsis. Respir Physiol Neurobiol. 2011;178(2):304-14. doi: 10.1016/j.resp.2011.06.029.
    • (2011) Respir Physiol Neurobiol , vol.178 , Issue.2 , pp. 304-314
    • Ornellas, D.S.1    Maron-Gutierrez, T.2    Ornellas, F.M.3    Cruz, F.F.4    Oliveira, G.P.5    Lucas, I.H.6
  • 6
    • 77956246824 scopus 로고    scopus 로고
    • Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis
    • Mei SH, Haitsma JJ, Dos Santos CC, Deng Y, Lai PF, Slutsky AS, et al. Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis. Am J Respir Crit Care Med. 2010;182(8):1047-57. doi: 10.1164/rccm.201001-0010OC.
    • (2010) Am J Respir Crit Care Med , vol.182 , Issue.8 , pp. 1047-1057
    • Mei, S.H.1    Haitsma, J.J.2    Dos Santos, C.C.3    Deng, Y.4    Lai, P.F.5    Slutsky, A.S.6
  • 7
    • 34848853276 scopus 로고    scopus 로고
    • Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1
    • Mei SH, McCarter SD, Deng Y, Parker CH, Liles WC, Stewart DJ. Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1. PLoS Med. 2007;4(9):e269. doi: 10.1371/journal.pmed.0040269.
    • (2007) PLoS Med , vol.4 , Issue.9 , pp. e269
    • Mei, S.H.1    McCarter, S.D.2    Deng, Y.3    Parker, C.H.4    Liles, W.C.5    Stewart, D.J.6
  • 8
    • 84872522183 scopus 로고    scopus 로고
    • Therapeutic effects of human mesenchymal stem cells in ex vivo human lungs injured with live bacteria
    • Lee JW, Krasnodembskaya A, McKenna DH, Song Y, Abbott J, Matthay MA. Therapeutic effects of human mesenchymal stem cells in ex vivo human lungs injured with live bacteria. Am J Respir Crit Care Med. 2013;187(7):751-60. doi: 10.1164/rccm.201206-0990OC.
    • (2013) Am J Respir Crit Care Med , vol.187 , Issue.7 , pp. 751-760
    • Lee, J.W.1    Krasnodembskaya, A.2    McKenna, D.H.3    Song, Y.4    Abbott, J.5    Matthay, M.A.6
  • 9
    • 70349392958 scopus 로고    scopus 로고
    • Allogeneic human mesenchymal stem cells for treatment of E. Coli endotoxin-induced acute lung injury in the ex vivo perfused human lung
    • Lee JW, Fang X, Gupta N, Serikov V, Matthay MA. Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Proc Natl Acad Sci U S A. 2009;106(38):16357-62. doi: 10.1073/pnas.0907996106.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.38 , pp. 16357-16362
    • Lee, J.W.1    Fang, X.2    Gupta, N.3    Serikov, V.4    Matthay, M.A.5
  • 10
    • 84856973179 scopus 로고    scopus 로고
    • Mesenchymal stem/stromal cells (MSCs): Role as guardians of inflammation
    • Prockop DJ, Oh JY. Mesenchymal stem/stromal cells (MSCs): role as guardians of inflammation. Mol Ther. 2012;20(1):14-20. doi: 10.1038/mt.2011.211.
    • (2012) Mol Ther , vol.20 , Issue.1 , pp. 14-20
    • Prockop, D.J.1    Oh, J.Y.2
  • 11
    • 84861162374 scopus 로고    scopus 로고
    • Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes
    • Krasnodembskaya A, Samarani G, Song Y, Zhuo H, Su X, Lee JW, et al. Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes. Am J Physiol Lung Cell Mol Physiol. 2012;302(10):L1003-13. doi: 10.1152/ajplung.00180.2011.
    • (2012) Am J Physiol Lung Cell Mol Physiol , vol.302 , Issue.10 , pp. L1003-L1013
    • Krasnodembskaya, A.1    Samarani, G.2    Song, Y.3    Zhuo, H.4    Su, X.5    Lee, J.W.6
  • 12
    • 84861873276 scopus 로고    scopus 로고
    • Mesenchymal stem cells enhance survival and bacterial clearance in murine Escherichia coli pneumonia
    • Gupta N, Krasnodembskaya A, Kapetanaki M, Mouded M, Tan X, Serikov V, et al. Mesenchymal stem cells enhance survival and bacterial clearance in murine Escherichia coli pneumonia. Thorax. 2012;67(6):533-9. doi: 10.1136/thoraxjnl-2011-201176.
    • (2012) Thorax , vol.67 , Issue.6 , pp. 533-539
    • Gupta, N.1    Krasnodembskaya, A.2    Kapetanaki, M.3    Mouded, M.4    Tan, X.5    Serikov, V.6
  • 13
    • 84860654915 scopus 로고    scopus 로고
    • Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury
    • Islam MN, Das SR, Emin MT, Wei M, Sun L, Westphalen K, et al. Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury. Nat Med. 2012;18(5):759-65. doi: 10.1038/nm.2736.
    • (2012) Nat Med , vol.18 , Issue.5 , pp. 759-765
    • Islam, M.N.1    Das, S.R.2    Emin, M.T.3    Wei, M.4    Sun, L.5    Westphalen, K.6
  • 14
    • 34347403684 scopus 로고    scopus 로고
    • The role of endothelial progenitor cells in sepsis
    • Beck GC, Rafat N, Yard B, Hanusch C. The role of endothelial progenitor cells in sepsis. Anaesthesist. 2007;56(5):423-8. doi: 10.1007/s00101-007-1183-z.
    • (2007) Anaesthesist , vol.56 , Issue.5 , pp. 423-428
    • Beck, G.C.1    Rafat, N.2    Yard, B.3    Hanusch, C.4
  • 15
    • 79959407347 scopus 로고    scopus 로고
    • Broken barriers: A new take on sepsis pathogenesis
    • Goldenberg NM, Steinberg BE, Slutsky AS, Lee WL. Broken barriers: a new take on sepsis pathogenesis. Sci Transl Med. 2011;3(88):88ps25. doi: 10.1126/scitranslmed.3002011.
    • (2011) Sci Transl Med , vol.3 , Issue.88 , pp. 88ps25
    • Goldenberg, N.M.1    Steinberg, B.E.2    Slutsky, A.S.3    Lee, W.L.4
  • 16
    • 79952478423 scopus 로고    scopus 로고
    • Endothelial progenitor cells (EPC) in sepsis with acute renal dysfunction (ARD)
    • Patschan SA, Patschan D, Temme J, Korsten P, Wessels JT, Koziolek M, et al. Endothelial progenitor cells (EPC) in sepsis with acute renal dysfunction (ARD). Crit Care. 2011;15(2):R94. doi: 10.1186/cc10100.
    • (2011) Crit Care , vol.15 , Issue.2 , pp. R94
    • Patschan, S.A.1    Patschan, D.2    Temme, J.3    Korsten, P.4    Wessels, J.T.5    Koziolek, M.6
  • 17
    • 53749095979 scopus 로고    scopus 로고
    • The increase of endothelial progenitor cells in the peripheral blood: A new parameter for detecting onset and severity of sepsis
    • 1:STN:280:DC%2BD1cnktVOlsw%3D%3D 18831938
    • Becchi C, Pillozzi S, Fabbri LP, Al Malyan M, Cacciapuoti C, Della Bella C, et al. The increase of endothelial progenitor cells in the peripheral blood: a new parameter for detecting onset and severity of sepsis. Int J Immunopathol Pharmacol. 2008;21(3):697-705.
    • (2008) Int J Immunopathol Pharmacol , vol.21 , Issue.3 , pp. 697-705
    • Becchi, C.1    Pillozzi, S.2    Fabbri, L.P.3    Al Malyan, M.4    Cacciapuoti, C.5    Della Bella, C.6
  • 18
    • 0031019745 scopus 로고    scopus 로고
    • Isolation of putative progenitor endothelial cells for angiogenesis
    • 1:CAS:528:DyaK2sXht1Clu7k%3D 9020076
    • Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science. 1997;275(5302):964-7.
    • (1997) Science , vol.275 , Issue.5302 , pp. 964-967
    • Asahara, T.1    Murohara, T.2    Sullivan, A.3    Silver, M.4    Van Der Zee, R.5    Li, T.6
  • 19
    • 12944253116 scopus 로고    scopus 로고
    • Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors
    • 1:CAS:528:DC%2BD3cXotV2gsA%3D%3D 10648408
    • Peichev M, Naiyer AJ, Pereira D, Zhu Z, Lane WJ, Williams M, et al. Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors. Blood. 2000;95(3):952-8.
    • (2000) Blood , vol.95 , Issue.3 , pp. 952-958
    • Peichev, M.1    Naiyer, A.J.2    Pereira, D.3    Zhu, Z.4    Lane, W.J.5    Williams, M.6
  • 20
    • 84902669918 scopus 로고    scopus 로고
    • Endothelial progenitor cells and a stromal cell-derived factor-1alpha analogue synergistically improve survival in sepsis
    • Fan H, Goodwin AJ, Chang E, Zingarelli B, Borg K, Guan S, et al. Endothelial progenitor cells and a stromal cell-derived factor-1alpha analogue synergistically improve survival in sepsis. Am J Respir Crit Care Med. 2014;189(12):1509-19. doi: 10.1164/rccm.201312-2163OC.
    • (2014) Am J Respir Crit Care Med , vol.189 , Issue.12 , pp. 1509-1519
    • Fan, H.1    Goodwin, A.J.2    Chang, E.3    Zingarelli, B.4    Borg, K.5    Guan, S.6
  • 21
    • 0035814766 scopus 로고    scopus 로고
    • Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia
    • 1:STN:280:DC%2BD3M3msFWlsQ%3D%3D 11156872
    • Kawamoto A, Gwon HC, Iwaguro H, Yamaguchi JI, Uchida S, Masuda H, et al. Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia. Circulation. 2001;103(5):634-7.
    • (2001) Circulation , vol.103 , Issue.5 , pp. 634-637
    • Kawamoto, A.1    Gwon, H.C.2    Iwaguro, H.3    Yamaguchi, J.I.4    Uchida, S.5    Masuda, H.6
  • 22
    • 76749131547 scopus 로고    scopus 로고
    • Are purified or expanded cord blood-derived CD133+ cells better at improving cardiac function?
    • Senegaglia AC, Barboza LA, Dallagiovanna B, Aita CA, Hansen P, Rebelatto CL, et al. Are purified or expanded cord blood-derived CD133+ cells better at improving cardiac function? Exp Biol Med. 2010;235(1):119-29. doi: 10.1258/ebm.2009.009194.
    • (2010) Exp Biol Med , vol.235 , Issue.1 , pp. 119-129
    • Senegaglia, A.C.1    Barboza, L.A.2    Dallagiovanna, B.3    Aita, C.A.4    Hansen, P.5    Rebelatto, C.L.6
  • 23
    • 47749084684 scopus 로고    scopus 로고
    • Dissimilar differentiation of mesenchymal stem cells from bone marrow, umbilical cord blood, and adipose tissue
    • Rebelatto CK, Aguiar AM, Moretao MP, Senegaglia AC, Hansen P, Barchiki F, et al. Dissimilar differentiation of mesenchymal stem cells from bone marrow, umbilical cord blood, and adipose tissue. Exp Biol Med. 2008;233(7):901-13. doi: 10.3181/0712-RM-356.
    • (2008) Exp Biol Med , vol.233 , Issue.7 , pp. 901-913
    • Rebelatto, C.K.1    Aguiar, A.M.2    Moretao, M.P.3    Senegaglia, A.C.4    Hansen, P.5    Barchiki, F.6
  • 26
    • 0042832200 scopus 로고    scopus 로고
    • Long-term mortality and medical care charges in patients with severe sepsis
    • Weycker D, Akhras KS, Edelsberg J, Angus DC, Oster G. Long-term mortality and medical care charges in patients with severe sepsis. Crit Care Med. 2003;31(9):2316-23. doi: 10.1097/01.CCM.0000085178.80226.0B.
    • (2003) Crit Care Med , vol.31 , Issue.9 , pp. 2316-2323
    • Weycker, D.1    Akhras, K.S.2    Edelsberg, J.3    Angus, D.C.4    Oster, G.5
  • 27
    • 84862518438 scopus 로고    scopus 로고
    • Circulating endothelial progenitor cells inversely associate with organ dysfunction in sepsis
    • Cribbs SK, Sutcliffe DJ, Taylor WR, Rojas M, Easley KA, Tang L, et al. Circulating endothelial progenitor cells inversely associate with organ dysfunction in sepsis. Intensive Care Med. 2012;38(3):429-36. doi: 10.1007/s00134-012-2480-9.
    • (2012) Intensive Care Med , vol.38 , Issue.3 , pp. 429-436
    • Cribbs, S.K.1    Sutcliffe, D.J.2    Taylor, W.R.3    Rojas, M.4    Easley, K.A.5    Tang, L.6
  • 28
    • 39049089650 scopus 로고    scopus 로고
    • Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade
    • Frank JA, Pittet JF, Wray C, Matthay MA. Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade. Thorax. 2008;63(2):147-53. doi: 10.1136/thx.2007.079608.
    • (2008) Thorax , vol.63 , Issue.2 , pp. 147-153
    • Frank, J.A.1    Pittet, J.F.2    Wray, C.3    Matthay, M.A.4
  • 29
    • 36849056773 scopus 로고    scopus 로고
    • IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice
    • Gasse P, Mary C, Guenon I, Noulin N, Charron S, Schnyder-Candrian S, et al. IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. J Clin Invest. 2007;117(12):3786-99. doi: 10.1172/JCI32285.
    • (2007) J Clin Invest , vol.117 , Issue.12 , pp. 3786-3799
    • Gasse, P.1    Mary, C.2    Guenon, I.3    Noulin, N.4    Charron, S.5    Schnyder-Candrian, S.6
  • 30
    • 0034967219 scopus 로고    scopus 로고
    • Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis
    • Kolb M, Margetts PJ, Anthony DC, Pitossi F, Gauldie J. Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis. J Clin Invest. 2001;107(12):1529-36. doi: 10.1172/JCI12568.
    • (2001) J Clin Invest , vol.107 , Issue.12 , pp. 1529-1536
    • Kolb, M.1    Margetts, P.J.2    Anthony, D.C.3    Pitossi, F.4    Gauldie, J.5
  • 31
  • 32
    • 0029892565 scopus 로고    scopus 로고
    • Proinflammatory activity in bronchoalveolar lavage fluids from patients with ARDS, a prominent role for interleukin-1
    • Pugin J, Ricou B, Steinberg KP, Suter PM, Martin TR. Proinflammatory activity in bronchoalveolar lavage fluids from patients with ARDS, a prominent role for interleukin-1. Am J Respir Crit Care Med. 1996;153(6 Pt 1):1850-6. doi: 10.1164/ajrccm.153.6.8665045.
    • (1996) Am J Respir Crit Care Med , vol.153 , Issue.6 , pp. 1850-1856
    • Pugin, J.1    Ricou, B.2    Steinberg, K.P.3    Suter, P.M.4    Martin, T.R.5
  • 33
    • 33745021587 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality
    • Yano K, Liaw PC, Mullington JM, Shih SC, Okada H, Bodyak N, et al. Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality. J Exp Med. 2006;203(6):1447-58. doi: 10.1084/jem.20060375.
    • (2006) J Exp Med , vol.203 , Issue.6 , pp. 1447-1458
    • Yano, K.1    Liaw, P.C.2    Mullington, J.M.3    Shih, S.C.4    Okada, H.5    Bodyak, N.6
  • 34
    • 84887539093 scopus 로고    scopus 로고
    • The angiogenic factors and their soluble receptors in sepsis: Friend, foe, or both?
    • Zhang RY, Liu YY, Qu HP, Tang YQ. The angiogenic factors and their soluble receptors in sepsis: friend, foe, or both? Crit Care. 2013;17(4):446. doi: 10.1186/cc12857.
    • (2013) Crit Care , vol.17 , Issue.4 , pp. 446
    • Zhang, R.Y.1    Liu, Y.Y.2    Qu, H.P.3    Tang, Y.Q.4
  • 35
    • 77953958239 scopus 로고    scopus 로고
    • Application of a PDGF-containing novel gel for cutaneous wound healing
    • Judith R, Nithya M, Rose C, Mandal AB. Application of a PDGF-containing novel gel for cutaneous wound healing. Life Sci. 2010;87(1-2):1-8. doi: 10.1016/j.lfs.2010.05.003.
    • (2010) Life Sci , vol.87 , Issue.1-2 , pp. 1-8
    • Judith, R.1    Nithya, M.2    Rose, C.3    Mandal, A.B.4
  • 36
    • 79958067556 scopus 로고    scopus 로고
    • Topical application of hPDGF-A-modified porcine BMSC and keratinocytes loaded on acellular HAM promotes the healing of combined radiation-wound skin injury in minipigs
    • Yan G, Sun H, Wang F, Wang J, Wang F, Zou Z, et al. Topical application of hPDGF-A-modified porcine BMSC and keratinocytes loaded on acellular HAM promotes the healing of combined radiation-wound skin injury in minipigs. Int J Radiat Biol. 2011;87(6):591-600. doi: 10.3109/09553002.2011.570854.
    • (2011) Int J Radiat Biol , vol.87 , Issue.6 , pp. 591-600
    • Yan, G.1    Sun, H.2    Wang, F.3    Wang, J.4    Wang, F.5    Zou, Z.6
  • 37
    • 84908372943 scopus 로고    scopus 로고
    • Beneficial effects of platelet-derived growth factor on hemorrhagic shock in rats and the underlying mechanisms
    • Liu L, Zhang J, Zhu Y, Xiao X, Peng X, Yang G, et al. Beneficial effects of platelet-derived growth factor on hemorrhagic shock in rats and the underlying mechanisms. Am J Physiol Heart Circ Physiol. 2014;307(9):H1277-87. doi: 10.1152/ajpheart.00006.2014.
    • (2014) Am J Physiol Heart Circ Physiol , vol.307 , Issue.9 , pp. H1277-H1287
    • Liu, L.1    Zhang, J.2    Zhu, Y.3    Xiao, X.4    Peng, X.5    Yang, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.