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Volumn 26, Issue 6, 2015, Pages 585-593

Methanolic extract of Moringa oleifera leaves improves glucose tolerance, glycogen synthesis and lipid metabolism in alloxan-induced diabetic rats

Author keywords

Alloxan; glucose tolerance; hepatic glycogen synthase; Moringa oleifera; muscle glycogen synthase

Indexed keywords

ALKALOID DERIVATIVE; ALLOXAN; CHOLESTEROL; FLAVONOID; GLUCOSE; GLYCOGEN; GLYCOGEN SYNTHASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; METHANOL; METHANOLIC EXTRACT OF MORINGA OLEIFERA; MORINGA OLEIFERA EXTRACT; PLANT MEDICINAL PRODUCT; SAPONIN DERIVATIVE; SODIUM CHLORIDE; TANNIN DERIVATIVE; TRIACYLGLYCEROL; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL; PLANT EXTRACT;

EID: 84948435745     PISSN: 07926855     EISSN: 21910286     Source Type: Journal    
DOI: 10.1515/jbcpp-2014-0129     Document Type: Article
Times cited : (68)

References (37)
  • 1
    • 36549069114 scopus 로고    scopus 로고
    • New hepatic targets for glycaemic control in diabetes
    • Agius L. New hepatic targets for glycaemic control in diabetes. Best Pract Res Clin Endocrinol Metab 2007;21:587-605.
    • (2007) Best Pract Res Clin Endocrinol Metab , vol.21 , pp. 587-605
    • Agius, L.1
  • 2
    • 0036787463 scopus 로고    scopus 로고
    • Skeletal muscle insulin resistance in obesity-associated type 2 diabetes in monkeys is linked to a defect in insulin activation of protein kinase C-zeta/lambda/iota
    • Standaert ML, Ortmeyer HK, Sajan MP, Kanoh Y, Bandyopadhyay G, Hansen BC, et al. Skeletal muscle insulin resistance in obesity-associated type 2 diabetes in monkeys is linked to a defect in insulin activation of protein kinase C-zeta/lambda/iota. Diabetes 2002;51:2936-43.
    • (2002) Diabetes , vol.51 , pp. 2936-2943
    • Standaert, M.L.1    Ortmeyer, H.K.2    Sajan, M.P.3    Kanoh, Y.4    Bandyopadhyay, G.5    Hansen, B.C.6
  • 3
    • 70349563930 scopus 로고    scopus 로고
    • Definition, epidemiology and classification of diabetes in children and adolescents
    • Craig ME, Hattersley A, Donaghue KC. Definition, epidemiology and classification of diabetes in children and adolescents. Pediatr Diabetes 2009;10:3-12.
    • (2009) Pediatr Diabetes , vol.10 , pp. 3-12
    • Craig, M.E.1    Hattersley, A.2    Donaghue, K.C.3
  • 4
    • 0037427309 scopus 로고    scopus 로고
    • Antioxidant properties of various solvent extracts of total phenolic constituents from three different agroclimatic origins of drumstick tree (Moringa oleifera Lam.) leaves
    • Siddhuraju P, Becker K. Antioxidant properties of various solvent extracts of total phenolic constituents from three different agroclimatic origins of drumstick tree (Moringa oleifera Lam.) leaves. J Agr Food Chem 2003;51:2144-55.
    • (2003) J Agr Food Chem , vol.51 , pp. 2144-2155
    • Siddhuraju, P.1    Becker, K.2
  • 5
    • 84863411315 scopus 로고    scopus 로고
    • Experimental assessment of Moringa oleifera leaf and fruit for its antistress, antioxidant, and scavenging potential using in vitro and in vivo assays
    • 519084
    • Luqman S, Srivastava S, Kumar R, Maurya AK, Chanda D. Experimental assessment of Moringa oleifera leaf and fruit for its antistress, antioxidant, and scavenging potential using in vitro and in vivo assays. Evid Based Complement Alternat Med 2012;519084:1-12.
    • (2012) Evid Based Complement Alternat Med , pp. 1-12
    • Luqman, S.1    Srivastava, S.2    Kumar, R.3    Maurya, A.K.4    Chanda, D.5
  • 6
    • 0029133162 scopus 로고
    • Studies on the antiulcer activity of Moringa leaf extract on gastric ulcer models in rats
    • Pal SK, Mukherjee PK, Saha BP. Studies on the antiulcer activity of Moringa leaf extract on gastric ulcer models in rats. Phytotherapy Research 1995;9:463-5.
    • (1995) Phytotherapy Research , vol.9 , pp. 463-465
    • Pal, S.K.1    Mukherjee, P.K.2    Saha, B.P.3
  • 7
    • 33846629681 scopus 로고
    • Antimicrobial action of the leaf extract of Moringa oleifera Lam
    • Pal SK, Mukherjee P, Kaha K, Pal M, Saha BP. Antimicrobial action of the leaf extract of Moringa oleifera Lam. Anc Sci Life 1995;14:197-9.
    • (1995) Anc Sci Life , vol.14 , pp. 197-199
    • Pal, S.K.1    Mukherjee, P.2    Kaha, K.3    Pal, M.4    Saha, B.P.5
  • 8
    • 70449417910 scopus 로고    scopus 로고
    • Adoption of Moringa to combat under-nutrition viewed through the lens of the Diffusion of innovations theory
    • Thurber MD, Fahey JW. Adoption of Moringa to combat under-nutrition viewed through the lens of the "Diffusion of innovations" theory. Ecol Food Nutr 2009;48:212-5.
    • (2009) Ecol Food Nutr , vol.48 , pp. 212-215
    • Thurber, M.D.1    Fahey, J.W.2
  • 9
    • 0033836595 scopus 로고    scopus 로고
    • Role of Moringa leaf extract in the regulation of thyroid hormone status in adult male and female rats
    • Tahiliani P, Kar A. Role of Moringa leaf extract in the regulation of thyroid hormone status in adult male and female rats. Pharmacol Res 2000;41:319-23.
    • (2000) Pharmacol Res , vol.41 , pp. 319-323
    • Tahiliani, P.1    Kar, A.2
  • 10
    • 0037216916 scopus 로고    scopus 로고
    • Comparative evaluation of hypoglycemic activity of some Indian medicinal plants in alloxan diabetic rats
    • Kar A, Choudhary BK, Bandyopadhyay NG. Comparative evaluation of hypoglycemic activity of some Indian medicinal plants in alloxan diabetic rats. J Ethnophamacol 2003;l84:105-8.
    • (2003) J Ethnophamacol , vol.184 , pp. 105-108
    • Kar, A.1    Choudhary, B.K.2    Bandyopadhyay, N.G.3
  • 12
    • 84904057563 scopus 로고    scopus 로고
    • Extract of Moringa leaves ameliorates streptozotocin-induced diabetes mellitus in adult rats
    • Yassa HD, Tohamy AF. Extract of Moringa leaves ameliorates streptozotocin-induced diabetes mellitus in adult rats. Acactions ota Histochemica 2014;116:844-54.
    • (2014) Acactions Ota Histochemica , vol.116 , pp. 844-854
    • Yassa, H.D.1    Tohamy, A.F.2
  • 13
    • 84948403089 scopus 로고    scopus 로고
    • Vitro insulinotropic of various extracts of Moringa oleifera leaves
    • Ojo OO. In vitro insulinotropic of various extracts of Moringa oleifera leaves. Nig J Biotech 2014;26:14-20.
    • (2014) Nig J Biotech , vol.26 , pp. 14-20
    • Ojo, O.O.1
  • 14
    • 84869077769 scopus 로고    scopus 로고
    • Antioxidant activity, total phenolic and total flavonoid contents of whole plant extracts Torilis leptophylla L
    • Saeed M, Khan MR, Shabbir M. Antioxidant activity, total phenolic and total flavonoid contents of whole plant extracts Torilis leptophylla L. BMC Complement Altern Med 2012;12:221.
    • (2012) BMC Complement Altern Med , vol.12 , pp. 221
    • Saeed, M.1    Khan, M.R.2    Shabbir, M.3
  • 15
    • 0037409121 scopus 로고    scopus 로고
    • Antioxidant capacity of phenolic phytochemicals from various cultivars of plums
    • Kim DO, Jeong SW, Lee CY. Antioxidant capacity of phenolic phytochemicals from various cultivars of plums. Food Chem 2003;81:321-6.
    • (2003) Food Chem , vol.81 , pp. 321-326
    • Kim, D.O.1    Jeong, S.W.2    Lee, C.Y.3
  • 17
    • 84869882396 scopus 로고    scopus 로고
    • Antidiabetic effect of sorghum extract on hepatic gluconeogenesis of streptozotocin-induced diabetic rats
    • Kim J, Park Y. Antidiabetic effect of sorghum extract on hepatic gluconeogenesis of streptozotocin-induced diabetic rats. Nutr Metab 2012;9:106.
    • (2012) Nutr Metab , vol.9 , pp. 106
    • Kim, J.1    Park, Y.2
  • 18
    • 0034595862 scopus 로고    scopus 로고
    • Metformin treatment enhances insulin stimulated glucose transport in skeletal muscle of Sprague Dawley rats
    • Borst SE, Snellen HG, Lai HL. Metformin treatment enhances insulin stimulated glucose transport in skeletal muscle of Sprague Dawley rats. Life Sci 2000;67:165-74.
    • (2000) Life Sci , vol.67 , pp. 165-174
    • Borst, S.E.1    Snellen, H.G.2    Lai, H.L.3
  • 19
    • 84856551414 scopus 로고    scopus 로고
    • Anti diabetic effect of cherries in alloxan induced diabetic rats
    • Lachin T, Reza H. Anti diabetic effect of cherries in alloxan induced diabetic rats. Recent Pat Endocr Metab Immune Drug Discov 2012;6:67-72.
    • (2012) Recent Pat Endocr Metab Immune Drug Discov , vol.6 , pp. 67-72
    • Lachin, T.1    Reza, H.2
  • 20
    • 0142217919 scopus 로고    scopus 로고
    • Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitus
    • Silva-Sousa YT, Peres LC, Foss MC. Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitus. Braz Dental J 2003;14:87-93.
    • (2003) Braz Dental J , vol.14 , pp. 87-93
    • Silva-Sousa, Y.T.1    Peres, L.C.2    Foss, M.C.3
  • 21
    • 0036151953 scopus 로고    scopus 로고
    • Effects of sodium molybdate on carbohydrate metabolizing enzymes in alloxaninduced diabetic rats
    • Panneerselvam RS, Govindaswamy S. Effects of sodium molybdate on carbohydrate metabolizing enzymes in alloxaninduced diabetic rats. J Nutr Biochem 2002;13:21-6.
    • (2002) J Nutr Biochem , vol.13 , pp. 21-26
    • Panneerselvam, R.S.1    Govindaswamy, S.2
  • 22
    • 0023748601 scopus 로고    scopus 로고
    • Alloxan: History and mechanism of action
    • Lenzen RS, Panten MF. Alloxan: history and mechanism of action. Diabetologia 1998;31:337-42.
    • (1998) Diabetologia , vol.31 , pp. 337-342
    • Lenzen, R.S.1    Panten, M.F.2
  • 23
    • 1842662457 scopus 로고    scopus 로고
    • Insulin secretagogues from Moringa oleifera with cyclooxygenase enzyme and lipid peroxidation inhibitory activities
    • Francis JA, Jayaprakasam B, Olson LK, Nair MG. Insulin secretagogues from Moringa oleifera with cyclooxygenase enzyme and lipid peroxidation inhibitory activities. Helv Chim Acta 2004;87:317-26.
    • (2004) Helv Chim Acta , vol.87 , pp. 317-326
    • Francis, J.A.1    Jayaprakasam, B.2    Olson, L.K.3    Nair, M.G.4
  • 24
    • 67349251182 scopus 로고    scopus 로고
    • Effect of Moringa Oleifera Lam leaves aqueous extract therapy on hyperglycemic rats
    • Jaiswal D, Kumar RP, Kumar A, Mehta S, Watal G. Effect of Moringa Oleifera Lam. leaves aqueous extract therapy on hyperglycemic rats. J Ethnophamacol 2009;123:392-6.
    • (2009) J Ethnophamacol , vol.123 , pp. 392-396
    • Jaiswal, D.1    Kumar, R.P.2    Kumar, A.3    Mehta, S.4    Watal, G.5
  • 25
    • 40849085405 scopus 로고    scopus 로고
    • Medicinal plants and the treatment of diabetes in Sengal; Survey with patients
    • Dieye AM, Sarr A, Diop SN, Ndiaye M, Sy GY, Diarra M, et al. Medicinal plants and the treatment of diabetes in Sengal; survey with patients. Fundam Clin Pharm 2008;2:211-6.
    • (2008) Fundam Clin Pharm , vol.2 , pp. 211-216
    • Dieye, A.M.1    Sarr, A.2    Diop, S.N.3    Ndiaye, M.4    Sy, G.Y.5    Diarra, M.6
  • 26
    • 84883788778 scopus 로고    scopus 로고
    • Identification of bioactive candidate compounds responsible for oxidative challenge from hydro-ethanolic extract of Moringa oleifera leaves
    • Karthivashan G, Tangestani Fard M, Arulselvan P, Abas F, Fakurazi S. Identification of bioactive candidate compounds responsible for oxidative challenge from hydro-ethanolic extract of Moringa oleifera leaves. J Food Sci 2013;78: C1368-75.
    • (2013) J Food Sci , vol.78 , pp. C1368-C1375
    • Karthivashan, G.1    Tangestani Fard, M.2    Arulselvan, P.3    Abas, F.4    Fakurazi, S.5
  • 27
    • 13244259179 scopus 로고    scopus 로고
    • Tannic acid stimulates glucose transport and inhibits adipocyte differentiation in 3T3-L1 cells
    • Liu X, Kim J, Li Y, Li J, Liu F, Chen X. Tannic acid stimulates glucose transport and inhibits adipocyte differentiation in 3T3-L1 cells. J Nutri 2005;135:165-71.
    • (2005) J Nutri , vol.135 , pp. 165-171
    • Liu, X.1    Kim, J.2    Li, Y.3    Li, J.4    Liu, F.5    Chen, X.6
  • 28
    • 84860373602 scopus 로고    scopus 로고
    • Protective effect of tannins from Ficus racemosa in hypercholesterolemia and diabetes induced vascular tissue damage in rats
    • Velayutham R, Sankaradoss N, Ahamed KF. Protective effect of tannins from Ficus racemosa in hypercholesterolemia and diabetes induced vascular tissue damage in rats. Asian Pac J Trop Med 2012;5:367-73.
    • (2012) Asian Pac J Trop Med , vol.5 , pp. 367-373
    • Velayutham, R.1    Sankaradoss, N.2    Ahamed, K.F.3
  • 29
    • 14644397194 scopus 로고    scopus 로고
    • Effects of Syzygium cordatum (Hochst.) [Myrtaceae] leaf extract on plasma glucose and hepatic glycogen in streptozotocin-induced diabetic rats
    • Musabayane CT, Mahlalela N, Shode FO, Ojewole JA. Effects of Syzygium cordatum (Hochst.) [Myrtaceae] leaf extract on plasma glucose and hepatic glycogen in streptozotocin-induced diabetic rats. J Ethnopharmacol 2005;97:485-90.
    • (2005) J Ethnopharmacol , vol.97 , pp. 485-490
    • Musabayane, C.T.1    Mahlalela, N.2    Shode, F.O.3    Ojewole, J.A.4
  • 30
    • 0347123324 scopus 로고    scopus 로고
    • Ethanolic extract of Ocimum sanctum leaves partially attenuates streptozotocin induced alterations in glycogen content and carbohydrate metabolism in rats
    • Vats V, Yadav SP, Grover JK. Ethanolic extract of Ocimum sanctum leaves partially attenuates streptozotocin induced alterations in glycogen content and carbohydrate metabolism in rats. J Ethnopharmacol 2004;90:155-60.
    • (2004) J Ethnopharmacol , vol.90 , pp. 155-160
    • Vats, V.1    Yadav, S.P.2    Grover, J.K.3
  • 33
    • 9444262473 scopus 로고    scopus 로고
    • Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes
    • Krssak M, Brehm A, Bernroider E, Anderwald C, Nowotny P, Man CD, et al. Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes. Diabetes 2004;53:3048-56.
    • (2004) Diabetes , vol.53 , pp. 3048-3056
    • Krssak, M.1    Brehm, A.2    Bernroider, E.3    Anderwald, C.4    Nowotny, P.5    Man, C.D.6
  • 34
    • 0035936763 scopus 로고    scopus 로고
    • New perspectives into the molecular pathogenesis and treatment of type 2 diabetes
    • Saltiel AR. New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell 2001;04:517-29.
    • (2001) Cell , vol.4 , pp. 517-529
    • Saltiel, A.R.1
  • 35
    • 33747377855 scopus 로고    scopus 로고
    • Effect of aqueous bark extract of Garuga pinnata Roxb. in streptozotocin-nicotinamide induced type II diabetes mellitus
    • Shirwaikar AK, Barik R. Effect of aqueous bark extract of Garuga pinnata Roxb. in streptozotocin-nicotinamide induced type II diabetes mellitus. J Ethnophamacol 2006;107:285-90.
    • (2006) J Ethnophamacol , vol.107 , pp. 285-290
    • Shirwaikar, A.K.1    Barik, R.2
  • 36
    • 0035140416 scopus 로고    scopus 로고
    • Flavonoids protect LDL from oxidation and attenuate atherosclerosis
    • Fuhrman B, Aviram M. Flavonoids protect LDL from oxidation and attenuate atherosclerosis. Curr Opin Lipidol 2001;12:41-8.
    • (2001) Curr Opin Lipidol , vol.12 , pp. 41-48
    • Fuhrman, B.1    Aviram, M.2
  • 37
    • 0036775850 scopus 로고    scopus 로고
    • Comparative content of some bioactive compounds in apples, peaches and pears and their influence on lipids and antioxidant capacity in rats
    • Leontowics HS, Gorinstein S, Lojek A, Leontowics M, Soliva-Fortuny R, Park YS, et al. Comparative content of some bioactive compounds in apples, peaches and pears and their influence on lipids and antioxidant capacity in rats. J Nutri Biochem 2002;13:603-10.
    • (2002) J Nutri Biochem , vol.13 , pp. 603-610
    • Leontowics, H.S.1    Gorinstein, S.2    Lojek, A.3    Leontowics, M.4    Soliva-Fortuny, R.5    Park, Y.S.6


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