Persistent increases in Ca2+ influx through Cav1.2 shortens action potential and causes Ca2+ overload-induced afterdepolarizations and arrhythmias

Basic Research in Cardiology

Volumn 111, Issue 1, 2016, Pages 1-16

  Zhang, Xiaoying ^a,b   Ai, Xiaojie ^b,f   Nakayama, Hiroyuki ^c   Chen, Biyi ^d   Harris, David M ^e   Tang, Mingxin ^b   Xie, Yuping ^d   Szeto, Christopher ^b   Li, Yingxin ^b   Li, Ying ^b,g   Zhang, Hongyu ^b   Eckhart, Andrea D ^h   Koch, Walter J ^b   Molkentin, Jeffery D ^c   Chen, Xiongwen ^a,b  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CINCINNATI   (United States)

^d UNIVERSITY OF IOWA   (United States)

^e UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

^f SHANGHAI JIAO TONG UNIVERSITY   (China)

^g Second Artillery General Hospital   (China)

^h MedThink Communications   (United States)

Author keywords

Afterdepolarizations; L type calcium channel or Cav1.2; Potassium currents; Short QT; 2a subunit

Indexed keywords

CALCIUM CHANNEL; CALCIUM CHANNEL CAV1.2; CALCIUM CHANNEL L TYPE; SODIUM CALCIUM EXCHANGE PROTEIN; UNCLASSIFIED DRUG; CACNB2 PROTEIN, MOUSE; CALCIUM; L-TYPE CALCIUM CHANNEL ALPHA(1C);

ACTION POTENTIAL DURATION; AFTERDEPOLARIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARRHYTHMOGENESIS; ARTICLE; ATRIOVENTRICULAR BLOCK; CALCIUM CURRENT; CALCIUM SIGNALING; CALCIUM TRANSPORT; CHANNEL GATING; CONTROLLED STUDY; HEART ARRHYTHMIA; HEART DEPOLARIZATION; HEART MUSCLE FIBROSIS; HEART MUSCLE NECROSIS; HEART VENTRICLE EXTRASYSTOLE; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE TACHYCARDIA; MOUSE; NONHUMAN; POTASSIUM CURRENT; SARCOPLASMIC RETICULUM; SHORT QT INTERVAL; SUDDEN DEATH; TRANSGENIC MOUSE; ACTION POTENTIAL; ANIMAL; CARDIAC MUSCLE CELL; CONFOCAL MICROSCOPY; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; WESTERN BLOTTING;

ACTION POTENTIALS; ANIMALS; ARRHYTHMIAS, CARDIAC; BLOTTING, WESTERN; CALCIUM; CALCIUM CHANNELS, L-TYPE; MICE; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; MYOCYTES, CARDIAC;

EID: 84948418246     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-015-0523-4     Document Type: Article

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