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Volumn , Issue , 2013, Pages 157-180

Novel proteasome inhibitors

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[No Author keywords available]

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EID: 84948164402     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4614-5260-7_7     Document Type: Chapter
Times cited : (1)

References (78)
  • 1
    • 0037111832 scopus 로고    scopus 로고
    • Phase i trial of the proteasome inhibitor ps-341 in patients with refractory hematologic malignancies
    • Orlowski RZ, Stinchcombe TE, Mitchell BS et al (2002) Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. J Clin Oncol 20 (22):4420-7
    • (2002) J Clin Oncol , vol.20 , Issue.22 , pp. 4420-4427
    • Orlowski, R.Z.1    Stinchcombe, T.E.2    Mitchell, B.S.3
  • 2
    • 0037973279 scopus 로고    scopus 로고
    • A phase 2 study of bortezomib in relapsed, refractory myeloma
    • Richardson PG, Barlogie B, Berenson J et al (2003) A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med 348 (26):2609-17
    • (2003) N Engl J Med , vol.348 , Issue.26 , pp. 2609-2617
    • Richardson, P.G.1    Barlogie, B.2    Berenson, J.3
  • 3
    • 20444433230 scopus 로고    scopus 로고
    • Bortezomib or high-dose dexametha-sone for relapsed multiple myeloma
    • Richardson PG, Sonneveld P, Schuster MW et al (2005) Bortezomib or high-dose dexametha-sone for relapsed multiple myeloma. N Engl J Med 352 (24):2487-98
    • (2005) N Engl J Med , vol.352 , Issue.24 , pp. 2487-2498
    • Richardson, P.G.1    Sonneveld, P.2    Schuster, M.W.3
  • 4
    • 34548539381 scopus 로고    scopus 로고
    • Randomized phase iii study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: Combination therapy improves time to progression
    • Orlowski RZ, Nagler A, Sonneveld P et al (2007) Randomized phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: combination therapy improves time to progression. J Clin Oncol25 (25):3892-901
    • (2007) J Clin Oncol , vol.25 , Issue.25 , pp. 3892-3901
    • Orlowski, R.Z.1    Nagler, A.2    Sonneveld, P.3
  • 5
    • 50449086728 scopus 로고    scopus 로고
    • Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma
    • San Miguel JF, Schlag R, Khuageva NK et al (2008) Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma. N Engl J Med 359 (9):906-17
    • (2008) N Engl J Med , vol.359 , Issue.9 , pp. 906-917
    • San Miguel, J.F.1    Schlag, R.2    Khuageva, N.K.3
  • 6
    • 0027980319 scopus 로고
    • Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on mhc class i molecules
    • Rock KL, Gramm C, Rothstein L et al (1994) Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78:761-71
    • (1994) Cell , vol.78 , pp. 761-771
    • Rock, K.L.1    Gramm, C.2    Rothstein, L.3
  • 7
    • 41549133200 scopus 로고    scopus 로고
    • Proteasome inhibitors in cancer therapy: Lessons from the first decade
    • Orlowski RZ, Kuhn DJ (2008) Proteasome inhibitors in cancer therapy: lessons from the first decade. Clin Cancer Res 14 (6):1649-57
    • (2008) Clin Cancer Res , vol.14 , Issue.6 , pp. 1649-1657
    • Orlowski, R.Z.1    Kuhn, D.J.2
  • 8
    • 70450227260 scopus 로고    scopus 로고
    • Proteasome inhibitors in the treatment of multiple myeloma
    • Shah JJ, Orlowski RZ (2009) Proteasome inhibitors in the treatment of multiple myeloma. Leukemia 23 (11):1964-79
    • (2009) Leukemia , vol.23 , Issue.11 , pp. 1964-1979
    • Shah, J.J.1    Orlowski, R.Z.2
  • 9
    • 77649237033 scopus 로고    scopus 로고
    • Building on bortezomib: Second-generation proteasome inhibitors as anti-cancer therapy
    • Dick LR, Fleming PE (2010) Building on bortezomib: second-generation proteasome inhibitors as anti-cancer therapy. Drug Discov Today 15 (5-6):243-249
    • (2010) Drug Discov Today , vol.15 , Issue.5-6 , pp. 243-249
    • Dick, L.R.1    Fleming, P.E.2
  • 10
    • 0032539702 scopus 로고    scopus 로고
    • Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids
    • Adams J, Behnke M, Chen S et al (1998) Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids. Bioorg Med Chem Lett 8 (4):333-8
    • (1998) Bioorg Med Chem Lett , vol.8 , Issue.4 , pp. 333-338
    • Adams, J.1    Behnke, M.2    Chen, S.3
  • 11
    • 0033152760 scopus 로고    scopus 로고
    • Proteasome inhibitors: A novel class of potent and effective antitumor agents
    • Adams J, Palombella VJ, Sausville EA et al (1999) Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res 59 (11):2615-22
    • (1999) Cancer Res , vol.59 , Issue.11 , pp. 2615-2622
    • Adams, J.1    Palombella, V.J.2    Sausville, E.A.3
  • 12
    • 0027050714 scopus 로고
    • Epoxomicin, a new antitumor agent of microbial origin
    • Hanada M, Sugawara K, Kaneta K et al (1992) Epoxomicin, a new antitumor agent of microbial origin. J Antibiot 45 (11):1746-1752
    • (1992) J Antibiot , vol.45 , Issue.11 , pp. 1746-1752
    • Hanada, M.1    Sugawara, K.2    Kaneta, K.3
  • 13
    • 0033517032 scopus 로고    scopus 로고
    • Total synthesis of the potent proteasome inhibitor epoxomicin: A useful tool for understanding proteasome biology
    • Sin N, Kim KB, Elofsson M et al (1999) Total synthesis of the potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biology. Bioorg Med Chem Lett9:2283-2288
    • (1999) Bioorg Med Chem Lett , vol.9 , pp. 2283-2288
    • Sin, N.1    Kim, K.B.2    Elofsson, M.3
  • 14
    • 0033621047 scopus 로고    scopus 로고
    • Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity
    • Meng L, Mohan R, Kwok BH, Elofsson M, Sin N, Crews CM (1999) Epoxomicin, a potent and selective proteasome inhibitor, exhibits in vivo antiinflammatory activity. Proc Natl Acad Sci USA 96 (18):10403-10408
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.18 , pp. 10403-10408
    • Meng, L.1    Mohan, R.2    Kwok, B.H.3    Elofsson, M.4    Sin, N.5    Crews, C.M.6
  • 15
    • 0033530887 scopus 로고    scopus 로고
    • Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: Insights into specificity and potency
    • Kim KB, Myung J, Sin N, Crews CM (1999) Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: insights into specificity and potency. Bioorg Med Chem Lett 9 (23):3335-3340
    • (1999) Bioorg Med Chem Lett , vol.9 , Issue.23 , pp. 3335-3340
    • Kim, K.B.1    Myung, J.2    Sin, N.3    Crews, C.M.4
  • 16
    • 36148944490 scopus 로고    scopus 로고
    • Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma
    • Kuhn DJ, Chen Q, Voorhees PM et al (2007) Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma. Blood 110 (9):3281-3290
    • (2007) Blood , vol.110 , Issue.9 , pp. 3281-3290
    • Kuhn, D.J.1    Chen, Q.2    Voorhees, P.M.3
  • 17
    • 34447116376 scopus 로고    scopus 로고
    • Antitumor activity of pr-171, a novel irreversible inhibitor of the proteasome
    • Demo SD, Kirk CJ, Aujay MA et al (2007) Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome. Cancer Res 67 (13):6383-6391
    • (2007) Cancer Res , vol.67 , Issue.13 , pp. 6383-6391
    • Demo, S.D.1    Kirk, C.J.2    Aujay, M.A.3
  • 18
    • 70350708810 scopus 로고    scopus 로고
    • Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome
    • Parlati F, Lee SJ, Aujay M et al (2009) Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome. Blood 114 (16):3439-47
    • (2009) Blood , vol.114 , Issue.16 , pp. 3439-3447
    • Parlati, F.1    Lee, S.J.2    Aujay, M.3
  • 19
    • 53049106757 scopus 로고    scopus 로고
    • The bh3-only mimetic abt-737 synergizes the antineoplastic activity of proteasome inhibitors in lymphoid malignancies
    • Paoluzzi L, Gonen M, Bhagat G et al (2008) The BH3-only mimetic ABT-737 synergizes the antineoplastic activity of proteasome inhibitors in lymphoid malignancies. Blood 112 (7): 2906-16
    • (2008) Blood , vol.112 , Issue.7 , pp. 2906-2916
    • Paoluzzi, L.1    Gonen, M.2    Bhagat, G.3
  • 20
    • 45949094910 scopus 로고    scopus 로고
    • Targeting bcl-2 family members with the bh3 mimetic at-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of b-cell lymphoma
    • Paoluzzi L, Gonen M, Gardner JR et al (2008) Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma. Blood 111 (11):5350-8
    • (2008) Blood , vol.111 , Issue.11 , pp. 5350-5358
    • Paoluzzi, L.1    Gonen, M.2    Gardner, J.R.3
  • 21
    • 77953937449 scopus 로고    scopus 로고
    • The pan-hdac inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human dlbcl cells in vitro and in vivo
    • Dasmahapatra G, Lembersky D, Kramer L et al (2010) The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo. Blood 115 (22):4478-87
    • (2010) Blood , vol.115 , Issue.22 , pp. 4478-4487
    • Dasmahapatra, G.1    Lembersky, D.2    Kramer, L.3
  • 22
    • 84929623397 scopus 로고    scopus 로고
    • Selective inhibition of cdk4/cdk6 sensitizes bone marrow myeloma cells for killing by proteasome inhibitors carfil zomib and pr-047 through cell cycle-dependent expression of pro-apoptotic noxa and bim
    • DiLiberto M, Huang X, Zewdu R et al (2009) Selective inhibition of CDK4/CDK6 sensitizes bone marrow myeloma cells for killing by proteasome inhibitors carfil zomib and PR-047 through cell cycle-dependent expression of pro-apoptotic Noxa and Bim. Blood (ASH Annual Meeting Abstract) 114:2854
    • (2009) Blood (ASH Annual Meeting Abstract) , vol.114 , pp. 2854
    • Di Liberto, M.1    Huang, X.2    Zewdu, R.3
  • 23
    • 84929620199 scopus 로고    scopus 로고
    • Induction of sequential g1 arrest and synchronous s phase entry by reversible cdk4/cdk6 inhibition sensitizes myeloma cells for cytotoxic killing through loss of irf-4
    • Huang X, Di Liberto M, Ely S et al (2009) Induction of sequential G1 arrest and synchronous S phase entry by reversible CDK4/CDK6 inhibition sensitizes myeloma cells for cytotoxic killing through loss of IRF-4. Blood (ASH Annual Meeting Abstract) 114:299
    • (2009) Blood (ASH Annual Meeting Abstract) , vol.114 , pp. 299
    • Huang, X.1    Di Liberto, M.2    Ely, S.3
  • 24
    • 72549116835 scopus 로고    scopus 로고
    • A phase 1 dose escalation study of the safety and pharmacokinetics of the novel proteasome inhibitor carfilzomib (Pr-171) in patients with hematologic malignancies
    • O’Connor OA, Stewart AK, Vallone M et al (2009) A phase 1 dose escalation study of the safety and pharmacokinetics of the novel proteasome inhibitor carfilzomib (PR-171) in patients with hematologic malignancies. Clin Cancer Res 15 (22):7085-91
    • (2009) Clin Cancer Res , vol.15 , Issue.22 , pp. 7085-7091
    • O’ Connor, O.A.1    Stewart, A.K.2    Vallone, M.3
  • 26
    • 50249150555 scopus 로고    scopus 로고
    • Phase 1 single agent antitumor activity of twice weekly consecutive day dosing of the proteasome inhibitor carfilzomib (Pr-171) in hematologic malignancies
    • Alsina M, Trudel S, Vallone M, Molineaux C, Kunkel L, Goy A (2007) Phase 1 single agent antitumor activity of twice weekly consecutive day dosing of the proteasome inhibitor carfilzomib (PR-171) in hematologic malignancies. Blood (ASH Annual Meeting Abstract)110:411
    • (2007) Blood (ASH Annual Meeting Abstract) , vol.110 , pp. 411
    • Alsina, M.1    Trudel, S.2    Vallone, M.3    Molineaux, C.4    Kunkel, L.5    Goy, A.6
  • 27
    • 70349643684 scopus 로고    scopus 로고
    • Final results of px-171-003-a0, part 1 of an open-label, single-arm, phase ii study of carfilzomib (Cfz) in patients (pts) with relapsed and refractory multiple myeloma (mm). J clin oncol 27(15s)
    • Jagannath S, Vij R, Stewart K et al (2009) Final results of PX-171-003-A0, part 1 of an open-label, single-arm, phase II study of carfilzomib (CFZ) in patients (pts) with relapsed and refractory multiple myeloma (MM). J Clin Oncol 27(15s), ASCO Annual Meeting Abstract 8504
    • (2009) ASCO Annual Meeting Abstract , pp. 8504
    • Jagannath, S.1    Vij, R.2    Stewart, K.3
  • 28
    • 70349643684 scopus 로고    scopus 로고
    • Final results of px-171-003-a0, part 1 of an open-label, single-arm, phase ii study of carfilzomib (Cfz) in patients (pts) with relapsed and refractory multiple myeloma (mm). J clin oncol 27(15s)
    • (2009)
    • Jagannath S, Vij R, Stewart K et al (2009) Final results of PX-171-003-A0, part 1 of an open-label, single-arm, phase II study of carfilzomib (CFZ) in patients (pts) with relapsed and refractory multiple myeloma (MM). J Clin Oncol 27(15s), ASCO Annual Meeting Abstract. http://www.onyx-pharm.com/view.cfm/690/Onyx-Pharmaceuticals-Announces-Positive-Top-Line-Carfilzomib-Data-from-Phase-2b-Study; 2010.
    • (2010) ASCO Annual Meeting Abstract
    • Jagannath, S.1    Vij, R.2    Stewart, K.3
  • 29
    • 77249116395 scopus 로고    scopus 로고
    • Px-171-004, an ongoing open-label, phase ii study of single-agent carfilzomib (Cfz) in patients with relapsed or refractory myeloma (mm); updated results from the bortezomib-treated cohort
    • Siegel D, Wang L, Orlowski RZ et al (2009) PX-171-004, an ongoing open-label, phase II study of single-agent carfilzomib (CFZ) in patients with relapsed or refractory myeloma (MM); updated results from the bortezomib-treated cohort. Blood (ASH Annual Meeting Abstract)114:303
    • (2009) Blood (ASH Annual Meeting Abstract) , vol.114 , pp. 303
    • Siegel, D.1    Wang, L.2    Orlowski, R.Z.3
  • 30
    • 77249146098 scopus 로고    scopus 로고
    • Updated results of bortezomib-naive patients in px-171-004, an ongoing open-label, phase ii study of single-agent carfilzomib (Cfz) in patients with relapsed or refractory myeloma (mm)
    • Wang L, Siegel D, Kaufman JL et al (2009) Updated results of bortezomib-naive patients in PX-171-004, an ongoing open-label, phase II study of single-agent carfilzomib (CFZ) in patients with relapsed or refractory myeloma (MM). Blood (ASH Annual Meeting Abstract)114:302
    • (2009) Blood (ASH Annual Meeting Abstract) , vol.114 , pp. 302
    • Wang, L.1    Siegel, D.2    Kaufman, J.L.3
  • 31
    • 73349115580 scopus 로고    scopus 로고
    • Multicenter, phase i, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma
    • Richardson PG, Weller E, Jagannath S et al (2009) Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma. J Clin Oncol 27 (34):5713-5719
    • (2009) J Clin Oncol , vol.27 , Issue.34 , pp. 5713-5719
    • Richardson, P.G.1    Weller, E.2    Jagannath, S.3
  • 32
    • 77954618168 scopus 로고    scopus 로고
    • Lenalidomide, bortezomib, and dexametha-sone combination therapy in patients with newly diagnosed multiple myeloma
    • Richardson PG, Weller E, Lonial S et al (2010) Lenalidomide, bortezomib, and dexametha-sone combination therapy in patients with newly diagnosed multiple myeloma. Blood116 (5):679-86
    • (2010) Blood , vol.116 , Issue.5 , pp. 679-686
    • Richardson, P.G.1    Weller, E.2    Lonial, S.3
  • 33
    • 84869021235 scopus 로고    scopus 로고
    • Dose-escalation study of carfilzomib (Cfz) plus lenalidomide (len) plus low-dose dexamethasone (dex) (crd) in relapsed/refractory multiple myeloma (r/r mm). J clin oncol 28(15s)
    • Bensinger W, Wang M, Orlowski RZ et al (2010) Dose-escalation study of carfilzomib (CFZ) plus lenalidomide (LEN) plus low-dose dexamethasone (Dex) (CRd) in relapsed/refractory multiple myeloma (R/R MM). J Clin Oncol 28(15s), ASCO Annual Meeting Abstract 8029
    • (2010) ASCO Annual Meeting Abstract , pp. 8029
    • Bensinger, W.1    Wang, M.2    Orlowski, R.Z.3
  • 34
    • 79953664594 scopus 로고    scopus 로고
    • Preclinical pharmacology and in vitro characterization of pr-047, an oral inhibitor of the 20s proteasome
    • Muchamuel T, Aujay M, Bennett MK et al (2008) Preclinical pharmacology and in vitro characterization of PR-047, an oral inhibitor of the 20S proteasome. Blood (ASH Annual Meeting Abstract) 112:3671
    • (2008) Blood (ASH Annual Meeting Abstract) , vol.112 , pp. 3671
    • Muchamuel, T.1    Aujay, M.2    Bennett, M.K.3
  • 35
    • 65649139708 scopus 로고    scopus 로고
    • Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (Pr-047)
    • Zhou HJ, Aujay MA, Bennett MK et al (2009) Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047). J Med Chem 52 (9):3028-38
    • (2009) J Med Chem , vol.52 , Issue.9 , pp. 3028-3038
    • Zhou, H.J.1    Aujay, M.A.2    Bennett, M.K.3
  • 36
    • 84929641099 scopus 로고    scopus 로고
    • Dose intensive administration of pr-047, a novel orally bioavailable inhibitor of the 20s proteasome, is well tolerated in experimental animals
    • Muchamuel T, Kapur S, Kirk CJ et al (2009) Dose intensive administration of PR-047, a novel orally bioavailable inhibitor of the 20S proteasome, is well tolerated in experimental animals. Blood (ASH Annual Meeting Abstract) 114:4910
    • (2009) Blood (ASH Annual Meeting Abstract) , vol.114 , pp. 4910
    • Muchamuel, T.1    Kapur, S.2    Kirk, C.J.3
  • 37
    • 77953264178 scopus 로고    scopus 로고
    • Selective inhibition of chymotrypsin-like activity of the immunoproteasome and constitutive proteasome in waldenstrom macroglobulinemia
    • Roccaro AM, Sacco A, Aujay M et al (2010) Selective inhibition of chymotrypsin-like activity of the immunoproteasome and constitutive proteasome in Waldenstrom macroglobulinemia. Blood 115 (20):4051-60
    • (2010) Blood , vol.115 , Issue.20 , pp. 4051-4060
    • Roccaro, A.M.1    Sacco, A.2    Aujay, M.3
  • 38
    • 77649236854 scopus 로고    scopus 로고
    • Induction of sustained early g1 arrest by selective inhibition of cdk4 and cdk6 primes myeloma cells for synergistic killing by protea-some inhibitors carfilzomib and pr-047
    • Huang X, Bailey K, Di Liberto M et al (2008) Induction of sustained early G1 arrest by selective inhibition of CDK4 and CDK6 primes myeloma cells for synergistic killing by protea-some inhibitors carfilzomib and PR-047. Blood (ASH Annual Meeting Abstract) 112:3670
    • (2008) Blood (ASH Annual Meeting Abstract) , vol.112 , pp. 3670
    • Huang, X.1    Bailey, K.2    Di Liberto, M.3
  • 39
    • 0037455147 scopus 로고    scopus 로고
    • Salinosporamide a: A highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora
    • Feling RH, Buchanan GO, Mincer TJ, Kauffman CA, Jensen PR, Fenical W (2003)Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora. Angew Chem Int Ed Engl 42 (3):355-7
    • (2003) Angew Chem Int Ed Engl , vol.42 , Issue.3 , pp. 355-357
    • Feling, R.H.1    Buchanan, G.O.2    Mincer, T.J.3    Kauffman, C.A.4    Jensen, P.R.5    Fenical, W.6
  • 40
    • 0032502719 scopus 로고    scopus 로고
    • Lactacystin, proteasome function, and cell fate
    • Fenteany G, Schreiber SL (1998) Lactacystin, proteasome function, and cell fate. J Biol Chem273 (15):8545-8
    • (1998) J Biol Chem , vol.273 , Issue.15 , pp. 8545-8548
    • Fenteany, G.1    Schreiber, S.L.2
  • 41
    • 77952969442 scopus 로고    scopus 로고
    • Concise formal synthesis of (-)-salinosporamide a (marizomib) using a regio- and stereoselective epoxidation and reductive oxirane ring-opening strategy
    • Ling T, Potts BC, Macherla VR (2010) Concise formal synthesis of (-)-salinosporamide A (marizomib) using a regio- and stereoselective epoxidation and reductive oxirane ring-opening strategy. J Org Chem 75 (11):3882-5
    • (2010) J Org Chem , vol.75 , Issue.11 , pp. 3882-3885
    • Ling, T.1    Potts, B.C.2    Macherla, V.R.3
  • 42
    • 27644562277 scopus 로고    scopus 로고
    • A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from bortezomib
    • Chauhan D, Catley L, Li G et al (2005) A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib. Cancer Cell8(5):407-19
    • (2005) Cancer Cell , vol.8 , Issue.5 , pp. 407-419
    • Chauhan, D.1    Catley, L.2    Li, G.3
  • 43
    • 77951682116 scopus 로고    scopus 로고
    • Pharmacodynamic and efficacy studies of the novel proteasome inhibitor npi-0052 (Mari-zomib) in a human plasmacytoma xenograft murine model
    • Singh AV, Palladino MA, Lloyd GK, Potts BC, Chauhan D, Anderson KC (2010)Pharmacodynamic and efficacy studies of the novel proteasome inhibitor NPI-0052 (mari-zomib) in a human plasmacytoma xenograft murine model. Br J Haematol 149 (4):550-9
    • (2010) Br J Haematol , vol.149 , Issue.4 , pp. 550-559
    • Singh, A.V.1    Palladino, M.A.2    Lloyd, G.K.3    Potts, B.C.4    Chauhan, D.5    Erson, K.C.6
  • 44
    • 34948881265 scopus 로고    scopus 로고
    • Salinosporamide a (Npi-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of nf-kappab regulated gene products
    • Ahn KS, Sethi G, Chao TH et al (2007) Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products. Blood 110 (7):2286-95
    • (2007) Blood , vol.110 , Issue.7 , pp. 2286-2295
    • Ahn, K.S.1    Sethi, G.2    Chao, T.H.3
  • 45
    • 38949125853 scopus 로고    scopus 로고
    • Combination of proteasome inhibitors bortezomib and npi-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma
    • Chauhan D, Singh A, Brahmandam M et al (2008) Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma. Blood 111 (3): 1654-1664
    • (2008) Blood 111 , vol.3
    • Chauhan, D.1    Singh, A.2    Brahmandam, M.3
  • 46
    • 44649148060 scopus 로고    scopus 로고
    • Dual targeting of the proteasome regulates survival and homing in waldenstrom macroglobulinemia
    • Roccaro AM, Leleu X, Sacco A et al (2008) Dual targeting of the proteasome regulates survival and homing in Waldenstrom macroglobulinemia. Blood 111 (9):4752-63
    • (2008) Blood , vol.111 , Issue.9 , pp. 4752-4763
    • Roccaro, A.M.1    Leleu, X.2    Sacco, A.3
  • 47
    • 77949315484 scopus 로고    scopus 로고
    • Combination of novel proteasome inhibitor npi-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma
    • Chauhan D, Singh AV, Ciccarelli B, Richardson PG, Palladino MA, Anderson KC (2010)Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma. Blood 115 (4):834-45
    • (2010) Blood , vol.115 , Issue.4 , pp. 834-845
    • Chauhan, D.1    Singh, A.V.2    Ciccarelli, B.3    Richardson, P.G.4    Palladino, M.A.5    Erson, K.C.6
  • 48
    • 84929618404 scopus 로고    scopus 로고
    • Targeting cdk4/6 in combination therapy overcomes proteasome inhibitor resistance in multiple myeloma through synergistic mitochondria depolarization
    • Huang X, Louie T, Di Liberto M et al (2007) Targeting cdk4/6 in combination therapy overcomes proteasome inhibitor resistance in multiple myeloma through synergistic mitochondria depolarization. Blood (ASH Annual Meeting Abstracts) 110:667
    • (2007) Blood (ASH Annual Meeting Abstracts) , vol.110 , pp. 667
    • Huang, X.1    Louie, T.2    Di Liberto, M.3
  • 49
    • 54249168789 scopus 로고    scopus 로고
    • Phase 1 clinical trial of a novel proteasome inhibitor (Npi-0052) in patients with lymphomas and solid tumors
    • Kurzrock R, Hamlin P, Younes A et al (2007) Phase 1 clinical trial of a novel proteasome inhibitor (NPI-0052) in patients with lymphomas and solid tumors. Blood (ASH Annual Meeting Abstract) 110:4504
    • (2007) Blood (ASH Annual Meeting Abstract) , vol.110 , pp. 4504
    • Kurzrock, R.1    Hamlin, P.2    Younes, A.3
  • 50
    • 70350779117 scopus 로고    scopus 로고
    • First-in-human phase 1 dose escalation study of npi-0052, a novel proteasome inhibitor, in patients with lymphoma and solid tumor
    • Hamlin PA, Aghajanian C, Hong D et al (2008) First-in-human phase 1 dose escalation study of NPI-0052, a novel proteasome inhibitor, in patients with lymphoma and solid tumor. Blood (ASH Annual Meeting Abstracts) 112:4939
    • (2008) Blood (ASH Annual Meeting Abstracts) , vol.112 , pp. 4939
    • Hamlin, P.A.1    Aghajanian, C.2    Hong, D.3
  • 51
    • 84948147303 scopus 로고    scopus 로고
    • First-in-human phase i study of the novel structure proteasome inhibitor npi-0052. J clin oncol 27(15s):3516
    • Hamlin PA, Aghajanian C, Younes A et al (2009) First-in-human phase I study of the novel structure proteasome inhibitor NPI-0052. J Clin Oncol 27(15s):3516, ASCO Annual Meeting Abstract
    • (2009) ASCO Annual Meeting Abstract
    • Hamlin, P.A.1    Aghajanian, C.2    Younes, A.3
  • 52
    • 84948184313 scopus 로고    scopus 로고
    • Clinical trial of npi-0052 (2nd generation proteasome inhibitor) in patients having advanced malignancies with expanded rp2d cohorts in lymphoma and cll. Blood 112:4934
    • Price T, Padrik P, Townsend A et al (2008) Clinical trial of NPI-0052 (2nd generation proteasome inhibitor) in patients having advanced malignancies with expanded RP2D cohorts in lymphoma and CLL. Blood 112:4934, ASH Annual Meeting Abstract
    • (2008) ASH Annual Meeting Abstract
    • Price, T.1    Padrik, P.2    Townsend, A.3
  • 53
    • 84948184031 scopus 로고    scopus 로고
    • Clinical trial of npi-0052 in advanced malignancies including lymphoma and leukemia (Advanced malignancies arm). J clin oncol 27(15s):3582
    • Townsend AR, Millward M, Price T et al (2009) Clinical trial of NPI-0052 in advanced malignancies including lymphoma and leukemia (advanced malignancies arm). J Clin Oncol 27(15s):3582, ASCO Annual Meeting Abstract
    • (2009) ASCO Annual Meeting Abstract
    • Townsend, A.R.1    Millward, M.2    Price, T.3
  • 54
    • 84948128208 scopus 로고    scopus 로고
    • Phase 1 clinical trial of the novel structure proteasome inhibitor npi-0052. Blood 114:2693
    • Spencer A, Millward M, Mainwaring P et al (2009) Phase 1 clinical trial of the novel structure proteasome inhibitor NPI-0052. Blood 114:2693, ASH Annual Meeting Abstract
    • (2009) ASH Annual Meeting Abstract
    • Spencer, A.1    Millward, M.2    Mainwaring, P.3
  • 55
    • 79951489147 scopus 로고    scopus 로고
    • Phase 1 clinical trial of the novel structure proteasome inhibitor npi-0052 in patients with relapsed and relapsed/refractory multiple myeloma (mm)
    • Richardson P, Hofmeister C, Jakubowiak A et al (2009) Phase 1 clinical trial of the novel structure proteasome inhibitor NPI-0052 in patients with relapsed and relapsed/refractory multiple myeloma (MM). Blood (ASH Annual Meeting Abstract) 114:431
    • (2009) Blood (ASH Annual Meeting Abstract) , vol.114 , pp. 431
    • Richardson, P.1    Hofmeister, C.2    Jakubowiak, A.3
  • 56
    • 39749143840 scopus 로고    scopus 로고
    • Discovery of a potent, selective, and orally active proteasome inhibitor for the treatment of cancer
    • Dorsey BD, Iqbal M, Chatteijee S et al (2008) Discovery of a potent, selective, and orally active proteasome inhibitor for the treatment of cancer. J Med Chem 51 (4):1068-72
    • (2008) J Med Chem , vol.51 , Issue.4 , pp. 1068-1072
    • Dorsey, B.D.1    Iqbal, M.2    Chatteijee, S.3
  • 57
    • 41949110089 scopus 로고    scopus 로고
    • Cep-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib
    • Piva R, Ruggeri B, Williams M et al (2008) CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib. Blood111 (5):2765-75
    • (2008) Blood , vol.111 , Issue.5 , pp. 2765-2775
    • Piva, R.1    Ruggeri, B.2    Williams, M.3
  • 58
    • 77956915133 scopus 로고    scopus 로고
    • Phenylboronic-acid-based carbohydrate binders as antiviral therapeutics: Monophenylboronic acids
    • Trippier PC, McGuigan C, Balzarini J (2010) Phenylboronic-acid-based carbohydrate binders as antiviral therapeutics: monophenylboronic acids. Antivir Chem Chemother 20 (6):249-57
    • (2010) Antivir Chem Chemother , vol.20 , Issue.6 , pp. 249-257
    • Trippier, P.C.1    McGuigan, C.2    Balzarini, J.3
  • 59
    • 75149157969 scopus 로고    scopus 로고
    • The proteasome inhibitor cep-18770 enhances the anti-myeloma activity of bortezomib and melphalan
    • Sanchez E, Li M, Steinberg JA et al (2010) The proteasome inhibitor CEP-18770 enhances the anti-myeloma activity of bortezomib and melphalan. Br J Haematol 148 (4):569-81
    • (2010) Br J Haematol , vol.148 , Issue.4 , pp. 569-581
    • Sanchez, E.1    Li, M.2    Steinberg, J.A.3
  • 60
    • 84929641100 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of the new proteasome inhibitor cep-18770 preliminary results from a phase i study
    • Annual ASMS Meeting Abstract 452
    • Marangon E, Sala F, Sessa C, et al. Pharmacokinetics and pharmacodynamics of the new proteasome inhibitor CEP-18770 Preliminary results from a phase I study. J Am Soc Mass Spectrom 2009;20(5, Supplement 1):Annual ASMS Meeting Abstract 452
    • (2009) J am Soc Mass Spectrom , vol.20 , Issue.5
    • Marangon, E.1    Sala, F.2    Sessa, C.3
  • 61
    • 77950238258 scopus 로고    scopus 로고
    • Evaluation of the proteasome inhibitor mln9708 in preclinical models of human cancer
    • Kupperman E, Lee EC, Cao Y et al (2010) Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer. Cancer Res 70 (5):1970-80
    • (2010) Cancer Res , vol.70 , Issue.5 , pp. 1970-1980
    • Kupperman, E.1    Lee, E.C.2    Cao, Y.3
  • 62
    • 84948147689 scopus 로고    scopus 로고
    • Antitumor activity of mln9708, a second-generation proteasome inhibitor, in preclinical models of lymphoma. Blood 114:3724
    • Donelan J, Bannerman B, Bano K et al (2009) Antitumor activity of MLN9708, a second-generation proteasome inhibitor, in preclinical models of lymphoma. Blood 114:3724, ASH Annual Meeting Abstract
    • (2009) ASH Annual Meeting Abstract
    • Donelan, J.1    Bannerman, B.2    Bano, K.3
  • 63
    • 84948173720 scopus 로고    scopus 로고
    • Mln9708 elicits pharmacodynamic response in the bone marrow compartment and has strong antitumor activity in a preclinical intraosseous model of plasma cell malignancy. Blood 114:1834
    • Lee E, Bannerman B, Fitzgerald M et al (2009) MLN9708 elicits pharmacodynamic response in the bone marrow compartment and has strong antitumor activity in a preclinical intraosseous model of plasma cell malignancy. Blood 114:1834, ASH Annual Meeting Abstract
    • (2009) ASH Annual Meeting Abstract
    • Lee, E.1    Bannerman, B.2    Fitzgerald, M.3
  • 64
    • 84948145665 scopus 로고    scopus 로고
    • Evaluating the antitumor activity of mln9708 in a disseminated mouse model of double transgenic imyc ca/bcl-xl plasma cell malignancy. Blood 114:3835
    • Fitzgerald M, Cao Y, Bannerman B et al (2009) Evaluating the antitumor activity of MLN9708 in a disseminated mouse model of double transgenic iMyc Ca/Bcl-XL plasma cell malignancy. Blood 114:3835, ASH Annual Meeting Abstract
    • (2009) ASH Annual Meeting Abstract
    • Fitzgerald, M.1    Cao, Y.2    Bannerman, B.3
  • 65
    • 84948123613 scopus 로고    scopus 로고
    • The novel proteasome inhibitor mln9708 demonstrates efficacy in a genetically-engineered mouse model of denovo plasma cell malignancy. Blood 114:3849
    • Janz S, Van Ness BG, Neppalli V et al (2009) The novel proteasome inhibitor MLN9708 demonstrates efficacy in a genetically-engineered mouse model of denovo plasma cell malignancy. Blood 114:3849, ASH Annual Meeting Abstract
    • (2009) ASH Annual Meeting Abstract
    • Janz, S.1    Van Ness, B.G.2    Neppalli, V.3
  • 66
    • 84948168438 scopus 로고    scopus 로고
    • First-in-human, phase i dose-escalation study of investigational drug mln9708, a second-generation proteasome inhibitor, in advanced nonhematologic malignancies. J clin oncol 28:3071
    • Rodler ET, Infante JR, Siu LL et al (2010) First-in-human, phase I dose-escalation study of investigational drug MLN9708, a second-generation proteasome inhibitor, in advanced nonhematologic malignancies. J Clin Oncol 28:3071, ASCO Annual Meeting Abstract
    • (2010) ASCO Annual Meeting Abstract
    • Rodler, E.T.1    Infante, J.R.2    Siu, L.L.3
  • 67
    • 1042278905 scopus 로고    scopus 로고
    • Proteasome and peptidase function in mhc-class-i-mediated antigen presentation
    • Kloetzel PM, Ossendorp F (2004) Proteasome and peptidase function in MHC-class-I-mediated antigen presentation. Curr Opin Immunol 16 (1):76-81
    • (2004) Curr Opin Immunol , vol.16 , Issue.1 , pp. 76-81
    • Kloetzel, P.M.1    Ossendorp, F.2
  • 68
    • 66549099025 scopus 로고    scopus 로고
    • Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors
    • Kuhn DJ, Hunsucker SA, Chen Q, Voorhees PM, Orlowski M, Orlowski RZ (2009) Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors. Blood113 (19):4667-4676
    • (2009) Blood , vol.113 , Issue.19 , pp. 4667-4676
    • Kuhn, D.J.1    Hunsucker, S.A.2    Chen, Q.3    Voorhees, P.M.4    Orlowski, M.5    Orlowski, R.Z.6
  • 69
    • 67650388103 scopus 로고    scopus 로고
    • A selective inhibitor of the immunoprotea-some subunit lmp7 blocks cytokine production and attenuates progression of experimental arthritis
    • Muchamuel T, Basler M, Aujay MA et al (2009) A selective inhibitor of the immunoprotea-some subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis. Nat Med 15(7):781-787
    • (2009) Nat Med , vol.15 , Issue.7 , pp. 781-787
    • Muchamuel, T.1    Basler, M.2    Aujay, M.A.3
  • 70
    • 0142250392 scopus 로고    scopus 로고
    • Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: A review of the rationale and clinical evidence
    • Trikha M, Corringham R, Klein B, Rossi JF (2003) Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence. Clin Cancer Res9 (13):4653-65
    • (2003) Clin Cancer Res , vol.9 , Issue.13 , pp. 4653-4665
    • Trikha, M.1    Corringham, R.2    Klein, B.3    Rossi, J.F.4
  • 71
    • 33644866173 scopus 로고    scopus 로고
    • Novel therapeutic strategies targeting growth factor signalling cascades in multiple myeloma
    • Yasui H, Hideshima T, Richardson PG, Anderson KC (2006) Novel therapeutic strategies targeting growth factor signalling cascades in multiple myeloma. Br J Haematol 132 (4): 385-97
    • (2006) Br J Haematol , vol.132 , Issue.4 , pp. 385-397
    • Yasui, H.1    Hideshima, T.2    Richardson, P.G.3    Erson, K.C.4
  • 72
    • 35648995976 scopus 로고    scopus 로고
    • Interleukin-6 and its receptor in cancer: Implications for translational therapeutics
    • Hong DS, Angelo LS, Kurzrock R (2007) Interleukin-6 and its receptor in cancer: implications for Translational Therapeutics. Cancer 110 (9):1911-28
    • (2007) Cancer , vol.110 , Issue.9 , pp. 1911-1928
    • Hong, D.S.1    Angelo, L.S.2    Kurzrock, R.3
  • 73
    • 35948943113 scopus 로고    scopus 로고
    • Inhibition of interleukin-6 signaling with cnto 328 enhances the activity of bortezomib in preclinical models of multiple myeloma
    • Voorhees PM, Chen Q, Kuhn DJ et al (2007) Inhibition of interleukin-6 signaling with CNTO 328 enhances the activity of bortezomib in preclinical models of multiple myeloma. Clin Cancer Res 13 (21):6469-78
    • (2007) Clin Cancer Res , vol.13 , Issue.21 , pp. 6469-6478
    • Voorhees, P.M.1    Chen, Q.2    Kuhn, D.J.3
  • 74
    • 65349129390 scopus 로고    scopus 로고
    • Targeted inhibition of interleukin-6 with cnto 328 sensitizes pre-clinical models of multiple myeloma to dexamethasone-mediated cell death
    • Voorhees PM, Chen Q, Small GW et al (2009) Targeted inhibition of interleukin-6 with CNTO 328 sensitizes pre-clinical models of multiple myeloma to dexamethasone-mediated cell death. Br J Haematol 145 (4):481-90
    • (2009) Br J Haematol , vol.145 , Issue.4 , pp. 481-490
    • Voorhees, P.M.1    Chen, Q.2    Small, G.W.3
  • 75
    • 84948181880 scopus 로고    scopus 로고
    • Singh AV, Bandi M, Aujay M et al (2009) PR-924, a selective inhibitor of the immunoprotea-some subunit LMP-7 blocks multiple myeloma cell growth both in vitro and In vivo. Blood 114:612, ASH Annual Meeting Abstract
    • Singh, A.V.1    Bandi, M.2    Aujay, M.3
  • 76
    • 20044381304 scopus 로고    scopus 로고
    • Bortezomib in recurrent and/or refractory multiple myeloma. Initial clinical experience in patients with impaired renal function
    • Jagannath S, Barlogie B, Berenson JR et al (2005) Bortezomib in recurrent and/or refractory multiple myeloma. Initial clinical experience in patients with impaired renal function. Cancer103 (6): 1195-200
    • (2005) Cancer , vol.103 , Issue.6 , pp. 1195-1200
    • Jagannath, S.1    Barlogie, B.2    Berenson, J.R.3
  • 77
    • 33947201310 scopus 로고    scopus 로고
    • Activity and safety of bortezomib in multiple myeloma patients with advanced renal failure: A multicenter retrospective study
    • Chanan-Khan AA, Kaufman JL, Mehta J et al (2007) Activity and safety of bortezomib in multiple myeloma patients with advanced renal failure: a multicenter retrospective study. Blood 109 (6):2604-2606
    • (2007) Blood , vol.109 , Issue.6 , pp. 2604-2606
    • Chanan-Khan, A.A.1    Kaufman, J.L.2    Mehta, J.3
  • 78
    • 59649110741 scopus 로고    scopus 로고
    • Pegylated liposomal doxorubicin plus borte-zomib in relapsed or refractory multiple myeloma: Efficacy and safety in patients with renal function impairment
    • Blade J, Sonneveld P, SanMiguel F et al (2008) Pegylated liposomal doxorubicin plus borte-zomib in relapsed or refractory multiple myeloma: efficacy and safety in patients with renal function impairment. Clin Lymphoma Myeloma 8 (6):352-355
    • (2008) Clin Lymphoma Myeloma , vol.8 , Issue.6 , pp. 352-355
    • Blade, J.1    Sonneveld, P.2    San Miguel, F.3


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