Concise formal synthesis of (-)-salinosporamide a (marizomib) using a regio- and stereoselective epoxidation and reductive oxirane ring-opening strategy

Journal of Organic Chemistry

Volumn 75, Issue 11, 2010, Pages 3882-3885

  Ling, Taotao ^a   Potts, Barbara C ^a   MacHerla, Venkat R ^a  

^a Nereus Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FORMAL SYNTHESIS; FUNCTIONALIZED; KEY FEATURE; NPI-0052; OXIRANE RING; PROTEASOME INHIBITORS; PYRROLIDINONE; SALINOSPORAMIDE A; SEQUENTIAL CONSTRUCTION; STEREO-SELECTIVE; STEREOCENTERS;

STEREOSELECTIVITY;

SYNTHESIS (CHEMICAL);

ETHYLENE OXIDE; SALINOSPORAMIDE A;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; STEREOCHEMISTRY;

EPOXY COMPOUNDS; ETHYLENE OXIDE; LACTONES; PROTEASOME ENDOPEPTIDASE COMPLEX; PYRROLES; PYRROLIDINONES; STEREOISOMERISM;

EID: 77952969442     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo100432g     Document Type: Article

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