A 3′ untranslated region variant in FMR1 eliminates neuronal activity-dependent translation of FMRP by disrupting binding of the RNA-binding protein HuR

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 47, 2015, Pages E6553-E6561

  Suhl, Joshua A ^a   Muddashetty, Ravi S ^a   Anderson, Bart R ^a   Ifrim, Marius F ^a   Visootsak, Jeannie ^a   Bassell, Gary J ^a   Warren, Stephen T ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autism; FMR1; FMRP; Fragile X syndrome; HuR

Indexed keywords

3,5 DIHYDROXYPHENYLGLYCINE; FIREFLY LUCIFERASE; FRAGILE X MENTAL RETARDATION PROTEIN; HUR PROTEIN; RNA; 3' UNTRANSLATED REGION; ELAV LIKE PROTEIN 1; GLUTAMATE RECEPTOR; LUCIFERASE; MESSENGER RNA; PROTEIN BINDING;

3' UNTRANSLATED REGION; ALLELE; ANIMAL EXPERIMENT; BRAIN CELL; CLINICAL ASSESSMENT; CONFERENCE PAPER; CONTROLLED STUDY; CROSS LINKING; FRAGILE X MENTAL RETARDATION 1 GENE; GENE; GENOTYPE; HUMAN; IMMUNOPRECIPITATION; IN VITRO STUDY; INTELLECTUAL IMPAIRMENT; INTRACELLULAR SPACE; MALE; MOUSE; MUTAGENESIS; NERVE CELL; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROCESSING; PROTEIN SYNTHESIS; RNA PROBE; RNA SEQUENCE; SITE DIRECTED MUTAGENESIS; SYNAPSE; TRANSLATION REGULATION; ANIMAL; BIOTINYLATION; CELL CULTURE; DENDRITE; GEL MOBILITY SHIFT ASSAY; GENE LOCUS; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; REPORTER GENE; RNA STABILITY; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY;

3' UNTRANSLATED REGIONS; ALLELES; ANIMALS; BASE SEQUENCE; BIOTINYLATION; CELLS, CULTURED; DENDRITES; ELAV-LIKE PROTEIN 1; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FRAGILE X MENTAL RETARDATION PROTEIN; GENES, REPORTER; GENETIC LOCI; HUMANS; LUCIFERASES; MALE; MICE; MOLECULAR SEQUENCE DATA; NEURONS; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; RECEPTORS, GLUTAMATE; RNA STABILITY; RNA, MESSENGER; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; SYNAPSES; TANDEM MASS SPECTROMETRY;

EID: 84947967434     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1514260112     Document Type: Article

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