MicroRNA-130b targets Fmr1 and regulates embryonic neural progenitor cell proliferation and differentiation

Biochemical and Biophysical Research Communications

Volumn 439, Issue 4, 2013, Pages 493-500

  Gong, Xi ^a   Zhang, Kunshan ^b   Wang, Yanlu ^a   Wang, Junbang ^a   Cui, Yaru ^a   Li, Siguang ^b   Luo, Yuping ^a  

^a NANCHANG UNIVERSITY   (China)

^b TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Differentiation; Fmr1; MiR 130b; Neural progenitor cells; Proliferation

Indexed keywords

FRAGILE X MENTAL RETARDATION PROTEIN; LUCIFERASE; MICRORNA; MICRORNA 130B; PROTEIN; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYONIC NEURAL PROGENITOR CELL; FRAGILE X SYNDROME; GENE ACTIVITY; GENE OVEREXPRESSION; MOUSE; NEURAL STEM CELL; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; UPREGULATION;

DIFFERENTIATION; FMR1; MIR-130B; NEURAL PROGENITOR CELLS; PROLIFERATION;

5' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; CELL PROLIFERATION; EMBRYO, MAMMALIAN; EMBRYONIC STEM CELLS; FRAGILE X MENTAL RETARDATION PROTEIN; HEK293 CELLS; HUMANS; MICE; MICRORNAS; MOLECULAR SEQUENCE DATA; NEURAL STEM CELLS; NEURONS; TRANSFECTION; UP-REGULATION;

EID: 84884704157     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.08.096     Document Type: Article

References (34)

1. Bardoni B., Davidovic L., Bensaid M., Khandjian E.W. The fragile X syndrome: exploring its molecular basis and seeking a treatment. Expert Rev. Mol. Med. 2006, 8:1-16.
2. Jacquemont S., Hagerman R.J., Hagerman P.J., Leehey M.A. Fragile-X syndrome and fragile X-associated tremor/ataxia syndrome: two faces of FMR1. Lancet Neurol. 2007, 6:45-55.
3. Loomis E.W., Eid J.S.P., et al. Sequencing the unsequenceable: expanded CGG-repeat alleles of the fragile X gene. Genome Res. 2013, 23:121-128.
4. Ashley C.T., Wilkinson K.D., Reines D., Warren S.T. FMR1 protein: conserved RNP family domains and selective RNA binding. Science 1993, 62:563-566.
5. Siomi H., Siomi M.C., Nussbaum R.L., Dreyfuss G. The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein. Cell 1993, 4:291-298.
6. Khandjian E.W., Fortin A., Thibodeau A., et al. A heterogeneous set of FMR1 proteins is widely distributed in mouse tissues and is modulated in cell culture. Hum. Mol. Genet. 1995, 4:783-789.
7. Bagni C., Greenough W.T. From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome. Nat. Rev. Neurosci. 2005, 6:376-387.
8. Bassell G.J., Warren S.T. Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function. Neuron 2008, 60:201-214.
9. De Rubeis S., Bagni C. Fragile X mental retardation protein control of neuronal mRNA metabolism: insights into mRNA stability. Mol. Cell. Neurosci. 2010, 43:43-50.
10. Darnell J.C., Jensen K.B., Jin P., et al. Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function. Cell 2001, 107:489-499.
11. Brown V., Jin P., Ceman S., et al. Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. Cell 2001, 107:477-487.
12. Edbauer D., Neilson J.R., Foster K.A., et al. Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. Neuron 2010, 65:373-384.
13. Guo W., Allan A.M., Zong R., et al. Ablation of FMRP in adult neural stem cells disrupts hippocampus-dependent learning. Nat. Med. 2011, 17:559-565.
14. Luo Y., Shan G., Guo W., et al. Fragile X mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells. PLoS Genet. 2010, 6:e1000898.
15. Bagga S., Bracht J., Hunter S., et al. Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell 2005, 122:553-563.
16. Pillai R.S., Bhattacharyya S.N., Artus C.G., et al. Inhibition of translational initiation by Let-7 microRNA in human cells. Science 2005, 309:1573-1576.
17. Heneghan H.M., Miller N., Kerin M.J. Role of microRNAs in obesity and the metabolic syndrome. Obes. Rev. 2010, 11:354-361.
18. Åkerblom M., Sachdeva R., Barde I., et al. MicroRNA-124 is a subventricular zone neuronal fate determinant. J. Neurosci. 2012, 32:8879-8889.
19. Schickel R., Boyerinas B., Park S.M., Peter M.E. MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death. Oncogene 2008, 27:5959-5974.
20. Zhao C., Sun G., Li S., Shi Y. A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination. Nat. Struct. Mol. Biol. 2009, 16:365-371.
21. Szulwach K.E., Li X., Smrt R.D., et al. Cross talk between microRNA and epigenetic regulation in adult neurogenesis. J. Cell Biol. 2010, 189:127-141.
22. Smrt R.D., Szulwach K.E., Pfeiffer R.L., et al. MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1. Stem Cells 2010, 28:1060-1070.
23. Paddison P.J., Caudy A.A., Bernstein E., et al. Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev. 2002, 16:948-958.
24. Krek A., Grün D., Poy M.N., et al. Combinatorial microRNA target predictions. Nat. Genet. 2005, 37:495-500.
25. Lewis B.P., Burge C.B., Bartel D.P. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005, 120:15-20.
26. Wang X., El Naqa I.M. Prediction of both conserved and nonconserved microRNA targets in animals. Bioinformatics 2008, 24:325-332.
27. Burmistrova O.A., Goltsov A.Y., Abramova L.I., et al. MicroRNA in schizophrenia: genetic and expression analysis of miR-130b (22q11). Biochemistry (Mosc) 2007, 72:578-582.
28. Epstein A.M., Bauer C.R., Ho A., et al. Drosophila Fragile X protein controls cellular proliferation by regulating cbl levels in the ovary. Dev. Biol. 2009, 330:83-92.
29. Callan M.A., Cabernard C., Heck J., et al. Fragile X protein controls neural stem cell proliferation in the Drosophila brain. Hum. Mol. Genet. 2010, 19:3068-3079.
30. Telias M., Segal M., Ben-Yosef D. Neural differentiation of fragile X human embryonic stem cells reveals abnormal patterns of development despite successful neurogenesis. Dev. Biol. 2013, 374:32-45.
31. Castrén M., Tervonen T., Kärkkäinen V., et al. Altered differentiation of neural stem cells in fragile X syndrome. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:17834-17839.
32. Eadie B.D., Zhang W.N., Boehme F., et al. Fmr1 knockout mice show reduced anxiety and alterations in neurogenesis that are specific to the ventral dentate gyrus. Neurobiol. Dis. 2009, 36:361-373.
33. Bartel D.P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116:281-297.
34. Zongaro S., Hukema R., D'Antoni S., et al. The 3' UTR of Fmr1 mRNA is a target of miR-101, miR-129-5p and miR-221: implications for the molecular pathology of FXTAS at the synapse. Hum. Mol. Genet. 2013, 22:1971-1982.