Spontaneous hypertension occurs with adipose tissue dysfunction in perilipin-1 null mice

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1862, Issue 2, 2016, Pages 182-191

  Zou, Liangqiang ^a   Wang, Weiyi ^a   Liu, Shangxin ^a   Zhao, Xiaojing ^a   Lyv, Ying ^a   Du, Congkuo ^a   Su, Xueying ^a   Geng, Bin ^a   Xu, Guoheng ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Hypertension; Inflammation; Oxidative stress; Perilipin; Perivascular adipose tissue

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; CHOLESTEROL; GLUCOSE; GLYCEROL; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; PERILIPIN; PERILIPIN 1; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ADIPOSE TISSUE CELL; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; CELL INFILTRATION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ELECTROLYTE BALANCE; ENDOTHELIUM CELL; ESSENTIAL HYPERTENSION; GLUCOSE BLOOD LEVEL; GLYCEROL BLOOD LEVEL; LIPID STORAGE; LIPOLYSIS; MACROPHAGE; MEAN ARTERIAL PRESSURE; MESENTERIC ARTERY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PERIVASCULAR ADIPOSE TISSUE DYSFUNCTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; SMOOTH MUSCLE FIBER; TRIACYLGLYCEROL BLOOD LEVEL; URINE CHEMISTRY; VASCULAR DISEASE; VASCULAR TISSUE; VASOCONSTRICTION; VASODILATATION;

EID: 84947966994     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2015.10.024     Document Type: Article

References (37)

1. Brasaemle D.L. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis. J. Lipid Res. 2007, 48:2547-2559.
2. Greenberg A.S., Egan J.J., Wek S.A., Moos M.C., Londos C., Kimmel A.R. Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes. Proc. Natl. Acad. Sci. U. S. A. 1993, 90:12035-12039.
3. Blanchette-Mackie E.J., Dwyer N.K., Barber T., Coxey R.A., Takeda T., Rondinone C.M., Theodorakis J.L., Greenberg A.S., Londos C. Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes. J. Lipid Res. 1995, 36:1211-1226.
4. Servetnick D.A., Brasaemle D.L., Gruia-Gray J., Kimmel A.R., Wolff J., Londos C. Perilipins are associated with cholesteryl ester droplets in steroidogenic adrenal cortical and Leydig cells. J. Biol. Chem. 1995, 270:16970-16973.
5. Sztalryd C., Xu G., Dorward H., Tansey J.T., Contreras J.A., Kimmel A.R., Londos C. Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation. J. Cell Biol. 2003, 161:1093-1103.
6. Tansey J.T., Sztalryd C., Gruia-Gray J., Roush D.L., Zee J.V., Gavrilova O., Reitman M.L., Deng C.X., Li C., Kimmel A.R., Londos C. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:6494-6499.
7. Zhai W., Xu C., Ling Y., Liu S., Deng J., Qi Y., Londos C., Xu G. Increased lipolysis in adipose tissues is associated with elevation of systemic free fatty acids and insulin resistance in perilipin null mice. Horm. Metab. Res. 2010, 42:247-253.
8. Lohn M., Dubrovska G., Lauterbach B., Luft F.C., Gollasch M., Sharma A.M. Periadventitial fat releases a vascular relaxing factor. FASEB J. 2002, 16:1057-1063.
9. Dubrovska G., Verlohren S., Luft F.C., Gollasch M. Mechanisms of ADRF release from rat aortic adventitial adipose tissue. Am. J. Physiol. Heart Circ. Physiol. 2004, 286:H1107-H1113.
10. Gollasch M. Vasodilator signals from perivascular adipose tissue. Br. J. Pharmacol. 2012, 165:633-642.
11. Fang L., Zhao J., Chen Y., Ma T., Xu G., Tang C., Liu X., Geng B. Hydrogen sulfide derived from periadventitial adipose tissue is a vasodilator. J. Hypertens. 2009, 27:2174-2185.
12. Schleifenbaum J., Kohn C., Voblova N., Dubrovska G., Zavarirskaya O., Gloe T., Crean C.S., Luft F.C., Huang Y., Schubert R., Gollasch M. Systemic peripheral artery relaxation by KCNQ channel openers and hydrogen sulfide. J. Hypertens. 2010, 28:1875-1882.
13. Gandotra S., Le Dour C., Bottomley W., Cervera P., Giral P., Reznik Y., Charpentier G., Auclair M., Delepine M., Barroso I., Semple R.K., Lathrop M., Lascols O., Capeau J., O'Rahilly S., Magre J., Savage D.B., Vigouroux C. Perilipin deficiency and autosomal dominant partial lipodystrophy. N. Engl. J. Med. 2011, 364:740-748.
14. Brasaemle D.L., Barber T., Wolins N.E., Serrero G., Blanchette-Mackie E.J., Londos C. Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein. J. Lipid Res. 1997, 38:2249-2263.
15. Xu C., He J., Jiang H., Zu L., Zhai W., Pu S., Xu G. Direct effect of glucocorticoids on lipolysis in adipocytes. Mol. Endocrinol. 2009, 23:1161-1170.
16. Keech M.K. Electron microscope study of the normal rat aorta. J. Biophys. Biochem. Cytol. 1960, 7:533-538.
17. Keech M.K. Electron microscope study of the lathyritic rat aorta. J. Biophys. Biochem. Cytol. 1960, 7:539-546.
18. Langlois D., Forcheron F., Li J.Y., del Carmine P., Neggazi S., Beylot M. Increased atherosclerosis in mice deficient in perilipin1. Lipids Health Dis. 2011, 10:169.
19. Martinez-Botas J., Anderson J.B., Tessier D., Lapillonne A., Chang B.H., Quast M.J., Gorenstein D., Chen K.H., Chan L. Absence of perilipin results in leanness and reverses obesity in Lepr(db/db) mice. Nat. Genet. 2000, 26:474-479.
20. Hofnagel O., Buers I., Schnoor M., Lorkowski S., Robenek H. Expression of perilipin isoforms in cell types involved in atherogenesis. Atherosclerosis 2007, 190:14-15. author reply 16-17.
21. Paul A., Chang B.H., Li L., Yechoor V.K., Chan L. Deficiency of adipose differentiation-related protein impairs foam cell formation and protects against atherosclerosis. Circ. Res. 2008, 102:1492-1501.
22. Galvez-Prieto B., Dubrovska G., Cano M.V., Delgado M., Aranguez I., Gonzalez M.C., Ruiz-Gayo M., Gollasch M., Fernandez-Alfonso M.S. A reduction in the amount and anti-contractile effect of periadventitial mesenteric adipose tissue precedes hypertension development in spontaneously hypertensive rats. Hypertens. Res. 2008, 31:1415-1423.
23. Takemori K., Gao Y.J., Ding L., Lu C., Su L.Y., An W.S., Vinson C., Lee R.M. Elevated blood pressure in transgenic lipoatrophic mice and altered vascular function. Hypertension 2007, 49:365-372.
24. Faloia E., Gatti C., Camilloni M.A., Mariniello B., Sardu C., Garrapa G.G., Mantero F., Giacchetti G. Comparison of circulating and local adipose tissue renin-angiotensin system in normotensive and hypertensive obese subjects. J. Endocrinol. Investig. 2002, 25:309-314.
25. Galvez-Prieto B., Bolbrinker J., Stucchi P., de Las Heras A.I., Merino B., Arribas S., Ruiz-Gayo M., Huber M., Wehland M., Kreutz R., Fernandez-Alfonso M.S. Comparative expression analysis of the renin-angiotensin system components between white and brown perivascular adipose tissue. J. Endocrinol. 2008, 197:55-64.
26. Cassis L.A., Police S.B., Yiannikouris F., Thatcher S.E. Local adipose tissue renin-angiotensin system. Curr. Hypertens. Rep. 2008, 10:93-98.
27. Kosteli A., Sugaru E., Haemmerle G., Martin J.F., Lei J., Zechner R., Ferrante A.W. Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J. Clin. Invest. 2010, 120:3466-3479.
28. Steinberg H.O., Tarshoby M., Monestel R., Hook G., Cronin J., Johnson A., Bayazeed B., Baron A.D. Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. J. Clin. Invest. 1997, 100:1230-1239.
29. Withers S.B., Agabiti-Rosei C., Livingstone D.M., Little M.C., Aslam R., Malik R.A., Heagerty A.M. Macrophage activation is responsible for loss of anticontractile function in inflamed perivascular fat. Arterioscler. Thromb. Vasc. Biol. 2011, 31:908-913.
30. Greenstein A.S., Khavandi K., Withers S.B., Sonoyama K., Clancy O., Jeziorska M., Laing I., Yates A.P., Pemberton P.W., Malik R.A., Heagerty A.M. Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients. Circulation 2009, 119:1661-1670.
31. Gu P., Xu A. Interplay between adipose tissue and blood vessels in obesity and vascular dysfunction. Rev. Endocr. Metab. Disord. 2013, 14:49-58.
32. Farb M.G., Ganley-Leal L., Mott M., Liang Y., Ercan B., Widlansky M.E., Bigornia S.J., Fiscale A.J., Apovian C.M., Carmine B., Hess D.T., Vita J.A., Gokce N. Arteriolar function in visceral adipose tissue is impaired in human obesity. Arterioscler. Thromb. Vasc. Biol. 2012, 32:467-473.
33. Marchesi C., Ebrahimian T., Angulo O., Paradis P., Schiffrin E.L. Endothelial nitric oxide synthase uncoupling and perivascular adipose oxidative stress and inflammation contribute to vascular dysfunction in a rodent model of metabolic syndrome. Hypertension 2009, 54:1384-1392.
34. Laurent S., Boutouyrie P. The structural factor of hypertension: large and small artery alterations. Circ. Res. 2015, 116:1007-1021.
35. Sun Z. Aging, arterial stiffness, and hypertension. Hypertension 2015, 65:252-256.
36. Arribas S.M., Gonzalez J.M., Briones A.M., Somoza B., Daly C.J., Vila E., Gonzalez M.C., McGrath J.C. Confocal myography for the study of hypertensive vascular remodelling. Clin. Hemorheol. Microcirc. 2007, 37:205-210.
37. Liu S., Geng B., Zou L., Wei S., Wang W., Deng J., Xu C., Zhao X., Lyu Y., Su X., Xu G. Development of hypertrophic cardiomyopathy in perilipin-1 null mice with adipose tissue dysfunction. Cardiovasc. Res. 2015, 105:20-30.