Systemic peripheral artery relaxation by KCNQ channel openers and hydrogen sulfide

Journal of Hypertension

Volumn 28, Issue 9, 2010, Pages 1875-1882

  Schleifenbaum, Johanna ^a   Köhn, Carolin ^a   Voblova, Nadezda ^a,b,e   Dubrovska, Galyna ^a   Zavarirskaya, Olga ^b   Gloe, Torsten ^b   Crean, Christopher S ^d   Luft, Friedrich C ^a   Huang, Yu ^c   Schubert, Rudolf ^b   Gollasch, Maik ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^d China and DValeant Pharmaceuticals North America   (United States)

^e UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

adipocyte derived relaxing factor; ADRF; KCNQ channels; obesity hypertension; perivascular fat

Indexed keywords

10,10 BIS(4 PYRIDINYLMETHYL) 9(10H) ANTHRACENONE; 2 CHLOR 5 [(4,5 DIFLUOROBENZOYL)AMINO]PYRIDINE; CYSTATHIONINE GAMMA LYASE; ETHYL N [2 AMINO 4 [(4 FLUOROPHENYL)METHYLAMINO]PHENYL]CARBAMATE; HYDROGEN SULFIDE; POTASSIUM CHANNEL KCNQ; RETIGABINE; SEROTONIN; UNCLASSIFIED DRUG; VRX 0530727; VRX 0621238; VRX 0621688;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTERY; ARTICLE; BLOOD VESSEL TONE; CLINICAL EVALUATION; MALE; MESENTERIC ARTERY; MOUSE; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SMOOTH MUSCLE FIBER; VASODILATATION;

EID: 77955853941     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/HJH.0b013e32833c20d5     Document Type: Article

References (38)

1. Jentsch TJ. Neuronal KCNQ potassium channels: physiology and role in disease. Nat Rev Neurosci 2000; 1:21-30.
2. Brown DA, Passmore GM. Neural Kcnq (Kv7) channels. Br J Pharmacol 2009; 156:1185-1195.
3. Ohya S, Sergeant GP, Greenwood IA, Horowitz B. Molecular variants of kcnq channels expressed in murine portal vein myocytes: a role in delayed rectifier current. Circ Res 2003; 92:1016-1023.
4. Joshi S, Balan P, Gurney AM. Pulmonary vasoconstrictor action of KCNQ potassium channel blockers. Respir Res 2006; 7:31.
5. Joshi S, Sedivy V,HodycD, Herget J,Gurney AM. KCNQ modulators reveal a key role for KCNQ potassium channels in regulating the tone of rat pulmonary artery smooth muscle. J Pharmacol Exp Ther 2009; 329:368-376.
6. Morecroft I, Murray A, Nilsen M, Gurney AM, MacLean MR. Treatment with the Kv7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension. Br J Pharmacol 2009; 157:1241-1249.
7. Jakob R, Krieglstein J. Influence of flupirtine on a G-protein coupled inwardly rectifying potassium current in hippocampal neurones. Br J Pharmacol 1997; 122:1333-1338.
8. Sattler MB, Williams SK, Neusch C, Otto M, Pehlke JR, Bahr M, Diem R. Flupirtine as neuroprotective add-on therapy in autoimmune optic neuritis. Am J Pathol 2008; 173:1496-1507.
9. Yoro Sy G, Urosevic D, Fellmann L, Greney H, Bousquet P, Feldman J. G-protein inwardly rectifying potassium channels are involved in the hypotensive effect of I1-imidazoline receptor selective ligands. J Hypertens 2008; 26:1025-1032.
10. Arora R, Ng J, Ulphani J, Mylonas I, Subacius H, Shade G, et al. Unique autonomic profile of the pulmonary veins and posterior left atrium. J Am Coll Cardiol 2007; 49:1340-1348.
11. Soltis EE, Cassis LA. Influence of perivascular adipose tissue on rat aortic smooth muscle responsiveness. Clin Exp Hypertens A 1991; 13:277-296.
12. Lohn M, Dubrovska G, Lauterbach B, Luft FC, Gollasch M, Sharma AM. Periadventitial fat releases a vascular relaxing factor. FASEB J 2002; 16:1057-1063.
13. Dubrovska G, Verlohren S, Luft FC, Gollasch M. Mechanisms of ADRF release from rat aortic adventitial adipose tissue. Am J Physiol Heart Circ Physiol 2004; 286:H1107-1113.
14. Gollasch M, Dubrovska G. Paracrine role for periadventitial adipose tissue in the regulation of arterial tone. Trends Pharmacol Sci 2004; 25:647-653.
15. Verlohren S, Dubrovska G, Tsang SY, Essin K, Luft FC, Huang Y, Gollasch M. Visceral periadventitial adipose tissue regulates arterial tone of mesenteric arteries. Hypertension 2004; 44:271-276.
16. Fesus G, Dubrovska G, Gorzelniak K, Kluge R, Huang Y, Luft FC, Gollasch M. Adiponectin is a novel humoral vasodilator. Cardiovasc Res 2007; 75:719-727.
17. Lee RM, Lu C, Su LY, Gao YJ. Endothelium-dependent relaxation factor released by perivascular adipose tissue. J Hypertens 2009; 27:782-790.
18. Brueggemann LI, Moran CJ, Barakat JA, Yeh JZ, Cribbs LL, Byron KL. Vasopressin stimulates action potential firing by protein kinase c-dependent inhibition of KCNQ5 in a7r5 rat aortic smooth muscle cells. Am J Physiol Heart Circ Physiol 2007; 292:H1352-1363.
19. Yang G, Wu L, Jiang B, Yang W, Qi J, Cao K, et al. H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science 2008; 322:587-590.
20. Feng X, Chen Y, Zhao J, Tang C, Jiang Z, Geng B. Hydrogen sulfide from adipose tissue is a novel insulin resistance regulator. Biochem Biophys Res Commun 2009; 380:153-159.
21. Roeloffs R, Wickenden AD, Crean C, Werness S, McNaughton-Smith G, Stables J, et al. In vivo profile of ICA-27243 [n-(6-chloro-pyridin-3-yl)-3,4-difluoro- benzamide], a potent and selective KCNQ2/q3 (Kv7.2/Kv7.3) activator in rodent anticonvulsant models. J Pharmacol Exp Ther 2008; 326:818-828.
22. Tober C, Rostock A, Rundfeldt C, Bartsch R. D-23129: a potent anticonvulsant in the amygdala kindling model of complex partial seizures. Eur J Pharmacol 1996; 303:163-169.
23. Lankau HJ, Menzer M, Rostock A, Arnold T, Rundfeldt C, Unverferth K. 3-aminoand 5-aminopyrazoles with anticonvulsant activity. Arch Pharm (Weinheim) 1999; 332:219-221.
24. Gao YJ, Holloway AC, Zeng ZH, Lim GE, Petrik JJ, Foster WG, Lee RM. Prenatal exposure to nicotine causes postnatal obesity and altered perivascular adipose tissue function. Obes Res 2005; 13:687-692.
25. Yeung SY, Pucovsky V, Moffatt JD, Saldanha L, Schwake M, Ohya S, Greenwood IA. Molecular expression and pharmacological identification of a role for k(v)7 channels in murine vascular reactivity. Br J Pharmacol 2007; 151:758-770.
26. Rogers PA, Chilian WM, Bratz IN, Bryan RM Jr, Dick GM. H2O2 activates redox and 4-aminopyridine-sensitive kv channels in coronary vascular smooth muscle. Am J Physiol Heart Circ Physiol 2007; 292:H1404-1411.
27. Hercule HC, Schunck WH, Gross V, Seringer J, Leung FP, Weldon SM, et al. Interaction between P450 eicosanoids and nitric oxide in the control of arterial tone in mice. Arterioscler Thromb Vasc Biol 2009; 29:54-60.
28. Gao YJ, Zeng ZH, Teoh K, Sharma AM, Abouzahr L, Cybulsky I, et al. Perivascular adipose tissue modulates vascular function in the human internal thoracic artery. J Thorac Cardiovasc Surg 2005; 130:1130-1136.
29. Yang L, Hu BR, Xiang JZ, Wang JL. Adventitium-derived relaxing factor may be a protein factor secreted by adipocytes with nonspecies-specificity and not limited to periadventitial fat. Chin J Pharmacol Toxicol 2005; 19:401-406.
30. Gollasch M, Dubrovska G. Adventitia-derived relaxing factor. MOVD 2009; 1:SSY-5; 96.
31. 2+- activated large-conductance K+ channels. FASEB J 2008; 22:1206.1205.
32. Li A, Xi Q, Umstot ES, Bellner L, Schwartzman ML, Jaggar JH, Leffler CW. Astrocyte-derived co is a diffusible messenger that mediates glutamate-induced cerebral arteriolar dilation by activating smooth muscle cell kca channels. Circ Res 2008; 102:234-241.
33. Fang L, Zhao J, Chen Y, MaT, Xu G, Tang C, etal. Hydrogen sulfide derived from periadventitial adipose tissue is a vasodilator. J Hypertens 2009; Jul 30. [Epub ahead of print]
34. Yan H, Du J, Tang C. The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats. Biochem Biophys Res Commun 2004; 313:22-27.
35. Galvez B, de Castro J, Herold D, Dubrovska G, Arribas S, Gonzalez MC, et al. Perivascular adipose tissue and mesenteric vascular function in spontaneously hypertensive rats. Arterioscler Thromb Vasc Biol 2006; 26:1297-1302.
36. Galvez-Prieto B, Dubrovska G, Cano MV, Delgado M, Aranguez I, Gonzalez MC, et al. A reduction in the amount and anticontractile effect of periadventitial mesenteric adipose tissue precedes hypertension development in spontaneously hypertensive rats. Hypertens Res 2008; 31:1415-1423.
37. Stasko A, BrezovaV, ZaliberaM, BiskupicS, OndriasK. Electron transfer: a primary step in the reactions of sodium hydrosulphide, an H2S/HS(\) donor. Free Radic Res 2009; 43:581-593.
38. Gamper N, Zaika O, Li Y, Martin P, Hernandez CC, Perez MR, et al. Oxidative modification of m-type K(+) channels as a mechanism of cytoprotective neuronal silencing. EMBO J 2006; 25:4996-5004.