메뉴 건너뛰기




Volumn 21, Issue 32, 2015, Pages 4763-4772

New antiangiogenetic therapy beyond bevacizumab in the treatment of advanced non small cell lung cancer

Author keywords

Angiogenesis; Bevacizumab; Multi target inhibitors; Non small cell lung cancer; Targeted therapy; VEGF

Indexed keywords

AFLIBERCEPT; AXITINIB; BEVACIZUMAB; CEDIRANIB; FIBROBLAST GROWTH FACTOR; LINIFANIB; MOTESANIB; NINTEDANIB; OLARATUMAB; PAZOPANIB; PLATELET DERIVED GROWTH FACTOR; RAMUCIRUMAB; SORAFENIB; SUNITINIB; VADIMEZAN; VANDETANIB; VASCULOTROPIN; ANGIOGENESIS INHIBITOR; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

EID: 84947966922     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612821666150729120009     Document Type: Review
Times cited : (8)

References (96)
  • 3
    • 84866597083 scopus 로고    scopus 로고
    • Metastatic non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • Peters S, Adjei AA, Gridelli C, Reck M, Kerr K, Felip E. Metastatic non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2012; 23: Suppl 7, vii56-64.
    • (2012) Ann Oncol , vol.23 , pp. 56-64
    • Peters, S.1    Adjei, A.A.2    Gridelli, C.3    Reck, M.4    Kerr, K.5    Felip, E.6
  • 4
    • 64249116652 scopus 로고    scopus 로고
    • First and second-line therapy for advanced non small cell lung cancer
    • Sculier JP, Moro-Sibilot D. First and second-line therapy for advanced non small cell lung cancer. Eur Respir J 2009; 33: 915-30.
    • (2009) Eur Respir J , vol.33 , pp. 915-930
    • Sculier, J.P.1    Moro-Sibilot, D.2
  • 5
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: An organizing principle for drug discovery?
    • Folkman J. Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 2007; 6(4): 273-86.
    • (2007) Nat Rev Drug Discov , vol.6 , Issue.4 , pp. 273-286
    • Folkman, J.1
  • 6
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
    • Jain RK. Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med 2001; 7(9): 987-9.
    • (2001) Nat Med , vol.7 , Issue.9 , pp. 987-989
    • Jain, R.K.1
  • 7
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000; 407(6801): 249-57.
    • (2000) Nature , vol.407 , Issue.6801 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 8
    • 27944473690 scopus 로고    scopus 로고
    • VEGF as a key mediator of angiogenesis in cancer
    • Carmeliet P. VEGF as a key mediator of angiogenesis in cancer. Oncology 2005; 69 (Suppl 3): 4-10.
    • (2005) Oncology , vol.69 , pp. 4-10
    • Carmeliet, P.1
  • 9
    • 0030996171 scopus 로고    scopus 로고
    • Angiogenesis as a prognostic indicator of survival in non-small cell lung carcinoma: A prospective study
    • Fontanini G, Lucchi M, Vignati S, et al. Angiogenesis as a prognostic indicator of survival in non-small cell lung carcinoma: a prospective study. J Natl Cancer Inst 1997; 89(12): 881-6.
    • (1997) J Natl Cancer Inst , vol.89 , Issue.12 , pp. 881-886
    • Fontanini, G.1    Lucchi, M.2    Vignati, S.3
  • 10
    • 0030668890 scopus 로고    scopus 로고
    • Tumor angiogenesis and biologic markers in resected stage I NSCLC
    • Lucchi M, Fontanini G, Mussi A, et al. Tumor angiogenesis and biologic markers in resected stage I NSCLC. Eur J Cardiothorac Surg 1997; 12(4): 535-41.
    • (1997) Eur J Cardiothorac Surg , vol.12 , Issue.4 , pp. 535-541
    • Lucchi, M.1    Fontanini, G.2    Mussi, A.3
  • 11
    • 0028342437 scopus 로고
    • Angiogenesis: An indicator of metastasis in non-small cell lung cancer invading the thoracic inlet
    • Macchiarini P, Fontanini G, Dulmet E, et al. Angiogenesis: an indicator of metastasis in non-small cell lung cancer invading the thoracic inlet. Ann Thorac Surg 1994; 57(6): 1534-9.
    • (1994) Ann Thorac Surg , vol.57 , Issue.6 , pp. 1534-1539
    • McChiarini, P.1    Fontanini, G.2    Dulmet, E.3
  • 12
    • 31344474845 scopus 로고    scopus 로고
    • Angiogenesis in non-small cell lung cancer: The prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood
    • Bremnes RM, Camps C, Sirera R. Angiogenesis in non-small cell lung cancer: the prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood. Lung Cancer 2006; 51(2): 143-58.
    • (2006) Lung Cancer , vol.51 , Issue.2 , pp. 143-158
    • Bremnes, R.M.1    Camps, C.2    Sirera, R.3
  • 13
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005; 23: 1011-27.
    • (2005) J Clin Oncol , vol.23 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 14
    • 33747855481 scopus 로고    scopus 로고
    • Comparing antibody and small-molecule therapies for cancer
    • Imai K, Takaoka A. Comparing antibody and small-molecule therapies for cancer. Nat Rev Cancer 2006; 6: 714-27.
    • (2006) Nat Rev Cancer , vol.6 , pp. 714-727
    • Imai, K.1    Takaoka, A.2
  • 15
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006; 355: 2542-50.
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 16
    • 68049108414 scopus 로고    scopus 로고
    • Vascular disrupting agents: A novel mechanism of action in the battle against non small cell lung cancer
    • Gridelli C, Rossi A, Maione P, et al. Vascular disrupting agents: a novel mechanism of action in the battle against non small cell lung cancer. Oncologist 2009; 14: 612-20.
    • (2009) Oncologist , vol.14 , pp. 612-620
    • Gridelli, C.1    Rossi, A.2    Maione, P.3
  • 17
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • Kerbel RS. Tumor angiogenesis. N Engl J Med 2008; 358(19): 2039-49.
    • (2008) N Engl J Med , vol.358 , Issue.19 , pp. 2039-2049
    • Kerbel, R.S.1
  • 18
    • 84255215015 scopus 로고    scopus 로고
    • Rationale for targeting VEGF, FGF, and PDGF for the treatment of NSCLC
    • Ballas MS, Chachoua A. Rationale for targeting VEGF, FGF, and PDGF for the treatment of NSCLC. Oncol Targets Ther 2011; 4: 43-58.
    • (2011) Oncol Targets Ther , vol.4 , pp. 43-58
    • Ballas, M.S.1    Chachoua, A.2
  • 19
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G, Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 2008; 8(8): 592-603.
    • (2008) Nat Rev Cancer , vol.8 , Issue.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 21
    • 84859415553 scopus 로고    scopus 로고
    • Molecular pathways: Fibroblast growth factor signaling: A new therapeutic opportunity in cancer
    • Brooks AN, Kilgour E, Smith PD. Molecular pathways: fibroblast growth factor signaling: a new therapeutic opportunity in cancer. Clin Cancer Res 2012; 18: 1855-62.
    • (2012) Clin Cancer Res , vol.18 , pp. 1855-1862
    • Brooks, A.N.1    Kilgour, E.2    Smith, P.D.3
  • 22
    • 0036133533 scopus 로고    scopus 로고
    • Rate of endothelial expansion is controlled by cell: Cell adhesion
    • Underwood PA, Bean PA, Gamble JR. Rate of endothelial expansion is controlled by cell: cell adhesion. Int J Biochem Cell Biol 2002; 34(1): 55-69.
    • (2002) Int J Biochem Cell Biol , vol.34 , Issue.1 , pp. 55-69
    • Underwood, P.A.1    Bean, P.A.2    Gamble, J.R.3
  • 23
    • 0026022620 scopus 로고
    • Human microvascular endothelial cells express receptors for platelet-derived growth factor
    • Beitz JG, Kim IS, Calabresi P, Frackelton AR. Human microvascular endothelial cells express receptors for platelet-derived growth factor. Proc Natl Acad Sci USA 1991; 88: 2021-5.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 2021-2025
    • Beitz, J.G.1    Kim, I.S.2    Calabresi, P.3    Frackelton, A.R.4
  • 24
    • 57049093954 scopus 로고    scopus 로고
    • Comprehensive dissection of PDGFPDGFR signaling pathways in PDGFR genetically defined cells
    • Wu E, Palmer N, Tian Z, et al. Comprehensive dissection of PDGFPDGFR signaling pathways in PDGFR genetically defined cells. PLoS One 2008; 3: e3794.
    • (2008) PLoS One , vol.3
    • Wu, E.1    Palmer, N.2    Tian, Z.3
  • 25
    • 0345798150 scopus 로고    scopus 로고
    • Endothelial and non endothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors
    • Abramsson A, Lindblom P, Betsholtz C. Endothelial and non endothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors. J Clin Invest 2003; 112(8): 1142-51.
    • (2003) J Clin Invest , vol.112 , Issue.8 , pp. 1142-1151
    • Abramsson, A.1    Lindblom, P.2    Betsholtz, C.3
  • 26
    • 67649298020 scopus 로고    scopus 로고
    • Bevacizumab: Current indications and future development for management of solid tumors
    • Jenab-Wolcott J, Giantonio BJ. Bevacizumab: current indications and future development for management of solid tumors. Expert Opin Biol Ther 2009; 9(4): 507-17.
    • (2009) Expert Opin Biol Ther , vol.9 , Issue.4 , pp. 507-517
    • Jenab-Wolcott, J.1    Giantonio, B.J.2
  • 27
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006; 355(24): 2542-50.
    • (2006) N Engl J Med , vol.355 , Issue.24 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 28
    • 62449124416 scopus 로고    scopus 로고
    • Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for non squamous non-small cell lung cancer: AVAil
    • Reck M, von Pawel J, Zatloukal P, et al. Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for non squamous non-small cell lung cancer: AVAil. J Clin Oncol 2009; 27(8): 1227-34.
    • (2009) J Clin Oncol , vol.27 , Issue.8 , pp. 1227-1234
    • Reck, M.1    von Pawel, J.2    Zatloukal, P.3
  • 29
    • 77951473661 scopus 로고    scopus 로고
    • Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for non squamous non-small-cell lung cancer: Results from a randomized phase III trial (AVAiL)
    • Reck M, von Pawel J, Zatloukal P, et al. Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for non squamous non-small-cell lung cancer: results from a randomized phase III trial (AVAiL). Ann Oncol 2010; 21: 1804-9.
    • (2010) Ann Oncol , vol.21 , pp. 1804-1809
    • Reck, M.1    von Pawel, J.2    Zatloukal, P.3
  • 30
    • 2942657615 scopus 로고    scopus 로고
    • Randomized Phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
    • Johnson DH, Fehrenbacher L, Novotny WF, et al. Randomized Phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 2004; 22(11): 2184-91.
    • (2004) J Clin Oncol , vol.22 , Issue.11 , pp. 2184-2191
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny, W.F.3
  • 31
    • 77955268612 scopus 로고    scopus 로고
    • Safety and efficacy of first-line bevacizumab-based therapy in advanced non-squamous non-small cell lung cancer (SAiL, MO19390): A phase 4 study
    • Crino L, Dansin E, Garrido P, et al. Safety and efficacy of first-line bevacizumab-based therapy in advanced non-squamous non-small cell lung cancer (SAiL, MO19390): a phase 4 study. Lancet Oncol 2010; 11(8): 733-40.
    • (2010) Lancet Oncol , vol.11 , Issue.8 , pp. 733-740
    • Crino, L.1    Dansin, E.2    Garrido, P.3
  • 32
    • 71649086292 scopus 로고    scopus 로고
    • Preliminary safety and effectiveness of bevacizumab (BV)-based treatment in subpopulations of patients (pts) with non-small cell lung cancer (NSCLC) from the ARIES study: A bevacizumab (BV) treatment observational cohort study (OCS)
    • Abstract 8040
    • Fischbach NA, Spigel D, Brahmer J, et al. Preliminary safety and effectiveness of bevacizumab (BV)-based treatment in subpopulations of patients (pts) with non-small cell lung cancer (NSCLC) from the ARIES study: a bevacizumab (BV) treatment observational cohort study (OCS). J Clin Oncol 2009; 27(15S). Abstract 8040.
    • (2009) J Clin Oncol , vol.27 , Issue.15 S
    • Fischbach, N.A.1    Spigel, D.2    Brahmer, J.3
  • 33
    • 63049122188 scopus 로고    scopus 로고
    • Retrospective evaluation of the clinical and radiographic risk factors associated with severe pulmonary hemorrhage in first-line advanced, unresectable nonsmall cell lung cancer treated with Carboplatin and Paclitaxel plus bevacizumab
    • Sandler AB, Schiller JH, Gray R, et al. Retrospective evaluation of the clinical and radiographic risk factors associated with severe pulmonary hemorrhage in first-line advanced, unresectable nonsmall cell lung cancer treated with Carboplatin and Paclitaxel plus bevacizumab. J Clin Oncol 2009; 27(9): 1405-12.
    • (2009) J Clin Oncol , vol.27 , Issue.9 , pp. 1405-1412
    • Sandler, A.B.1    Schiller, J.H.2    Gray, R.3
  • 34
    • 77954682879 scopus 로고    scopus 로고
    • Ramucirumab (IMC-1121B): A novel attack on angiogenesis
    • Spratlin JL, Mulder KE, Mackey JR. Ramucirumab (IMC-1121B): a novel attack on angiogenesis. Future Oncol 2010; 6: 1085-94.
    • (2010) Future Oncol , vol.6 , pp. 1085-1094
    • Spratlin, J.L.1    Mulder, K.E.2    McKey, J.R.3
  • 35
    • 77649213706 scopus 로고    scopus 로고
    • Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2
    • Spratlin JL, Cohen RB, Eadens M, et al. Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2. J Clin Oncol 2010; 28: 780-7.
    • (2010) J Clin Oncol , vol.28 , pp. 780-787
    • Spratlin, J.L.1    Cohen, R.B.2    Eadens, M.3
  • 36
    • 84906903314 scopus 로고    scopus 로고
    • Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): A multicentre, double-blind, randomised phase 3 trial
    • Garon EB, Ciuleanu TE, Arrieta O, et al. Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial. Lancet 2014; 384: 665-73.
    • (2014) Lancet , vol.384 , pp. 665-673
    • Garon, E.B.1    Ciuleanu, T.E.2    Arrieta, O.3
  • 37
    • 78651060614 scopus 로고    scopus 로고
    • BRIDGE: An open-label phase II trial evaluating the safety of bevacizumab + carboplatin/ paclitaxel as first-line treatment for patients with advanced, previously untreated, squamous non-small cell lung cancer
    • Hainsworth JD, Fang L, Huang JE. BRIDGE: an open-label phase II trial evaluating the safety of bevacizumab + carboplatin/ paclitaxel as first-line treatment for patients with advanced, previously untreated, squamous non-small cell lung cancer. J Thorac Oncol 2011; 6: 109-14.
    • (2011) J Thorac Oncol , vol.6 , pp. 109-114
    • Hainsworth, J.D.1    Fang, L.2    Huang, J.E.3
  • 38
    • 84925706983 scopus 로고    scopus 로고
    • A phase II, open-label study of ramucirumab in combination with paclitaxel and carboplatin as first-line therapy in patients with stage IIIB/IV non- small-cell lung cancer
    • Camidge DR, Berge EM, Doebele RC, et al. A phase II, open-label study of ramucirumab in combination with paclitaxel and carboplatin as first-line therapy in patients with stage IIIB/IV non- small-cell lung cancer. J Thorac Oncol 2014; 9: 1532-9.
    • (2014) J Thorac Oncol , vol.9 , pp. 1532-1539
    • Camidge, D.R.1    Berge, E.M.2    Doebele, R.C.3
  • 40
    • 20144389471 scopus 로고    scopus 로고
    • Targeting the platelet-derived growth factor receptor alpha with a neutralizing human monoclonal antibody inhibits the growth of tumor xenografts: Implications as a potential therapeutic target
    • Loizos N, Xu Y, Huber J, et al. Targeting the platelet-derived growth factor receptor alpha with a neutralizing human monoclonal antibody inhibits the growth of tumor xenografts: implications as a potential therapeutic target. Mol Cancer Ther 2005; 4(3): 369-79.
    • (2005) Mol Cancer Ther , vol.4 , Issue.3 , pp. 369-379
    • Loizos, N.1    Xu, Y.2    Huber, J.3
  • 42
    • 49649123154 scopus 로고    scopus 로고
    • BIBF 1120: Triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy
    • Hilberg F, Roth GJ, Krssak M, Kautschitsch S, Sommergruber W, Tontsch-Grunt U. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res 2008; 68: 4774-82.
    • (2008) Cancer Res , vol.68 , pp. 4774-4782
    • Hilberg, F.1    Roth, G.J.2    Krssak, M.3    Kautschitsch, S.4    Sommergruber, W.5    Tontsch-Grunt, U.6
  • 43
    • 77952325749 scopus 로고    scopus 로고
    • Phase I open-label study of continuous treatment with BIBF 1120, a triple angiokinase inhibitor pemetrexed in pretreated non-small cell lung cancer patients
    • Ellis PM, Kaiser R, Zhao Y, Stopfer P, Gyorffy S, Hanna N. Phase I open-label study of continuous treatment with BIBF 1120, a triple angiokinase inhibitor pemetrexed in pretreated non-small cell lung cancer patients. Clin Cancer Res 2010; 16: 2881-9.
    • (2010) Clin Cancer Res , vol.16 , pp. 2881-2889
    • Ellis, P.M.1    Kaiser, R.2    Zhao, Y.3    Stopfer, P.4    Gyorffy, S.5    Hanna, N.6
  • 44
    • 79957452054 scopus 로고    scopus 로고
    • A phase II double-blind study to investigate efficacy and safety of two doses of the triple angiokinase inhibitor BIBF 1120 in patients with relapsed advanced non-small-cell lung cancer
    • Reck M, Kaiser R, Eschbach C, et al. A phase II double-blind study to investigate efficacy and safety of two doses of the triple angiokinase inhibitor BIBF 1120 in patients with relapsed advanced non-small-cell lung cancer. Ann Oncol 2011; 22: 1374-81
    • (2011) Ann Oncol , vol.22 , pp. 1374-1381
    • Reck, M.1    Kaiser, R.2    Eschbach, C.3
  • 45
    • 84886412848 scopus 로고    scopus 로고
    • Nintedanib (BIBF 1120) plus docetaxel in NSCLC patients progressing after one prior chemotherapy regimen: Results of Lume-Lung 1, a randomized, doubleblind, phase III trial
    • Reck M, Kaiser R, Mellemgaard A, et al. Nintedanib (BIBF 1120) plus docetaxel in NSCLC patients progressing after one prior chemotherapy regimen: results of Lume-Lung 1, a randomized, doubleblind, phase III trial. J Clin Oncol 2013; 31: LBA8011.
    • (2013) J Clin Oncol , vol.31
    • Reck, M.1    Kaiser, R.2    Mellemgaard, A.3
  • 46
    • 84886393615 scopus 로고    scopus 로고
    • Lume-lung 2: A multicenter, randomized, double-blind, phase III study of nintedanib plus pemetrexed versus placebo plus pemetrexed in patients with advanced nonsquamous non-small cell lung cancer (NSCLC) after failure of first-line chemotherapy
    • Hanna NH, Kaiser R, Sullivan RN. Lume-lung 2: a multicenter, randomized, double-blind, phase III study of nintedanib plus pemetrexed versus placebo plus pemetrexed in patients with advanced nonsquamous non-small cell lung cancer (NSCLC) after failure of first-line chemotherapy. J Clin Oncol 2013; 31: 8034.
    • (2013) J Clin Oncol , vol.31 , pp. 8034
    • Hanna, N.H.1    Kaiser, R.2    Sullivan, R.N.3
  • 47
    • 0037386774 scopus 로고    scopus 로고
    • Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase
    • Ciardiello F, Caputo R, Damiano V, et al. Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase. Clin Cancer Res 2003; 9(4): 1546-56
    • (2003) Clin Cancer Res , vol.9 , Issue.4 , pp. 1546-1556
    • Ciardiello, F.1    Caputo, R.2    Damiano, V.3
  • 48
    • 77954035012 scopus 로고    scopus 로고
    • Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): A double-blind, randomised, phase 3 trial
    • Herbst RS, Sun Y, Eberhardt WEE, et al. Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial. Lancet Oncol 2010; 11: 619-26.
    • (2010) Lancet Oncol , vol.11 , pp. 619-626
    • Herbst, R.S.1    Sun, Y.2    Eberhardt, W.E.E.3
  • 49
    • 79952742483 scopus 로고    scopus 로고
    • Vandetanib plus pemetrexed for the second-line treatment of advanced non-small-cell lung cancer: A randomized, double-blind phase III trial
    • de Boer RH, Arrieta Ó, Yang CH, et al. Vandetanib plus pemetrexed for the second-line treatment of advanced non-small-cell lung cancer: a randomized, double-blind phase III trial. J Clin Oncol 2011; 29: 1067-74.
    • (2011) J Clin Oncol , vol.29 , pp. 1067-1074
    • de Boer, R.H.1    Arrieta, Ó.2    Yang, C.H.3
  • 50
    • 79952748468 scopus 로고    scopus 로고
    • Phase III trial of vandetanib compared with erlotinib in patients with previously treated advanced non-small-cell lung cancer
    • Natale RB, Thongprasert S, Greco FA, et al. Phase III trial of vandetanib compared with erlotinib in patients with previously treated advanced non-small-cell lung cancer. J Clin Oncol 2011; 29: 1059-66.
    • (2011) J Clin Oncol , vol.29 , pp. 1059-1066
    • Natale, R.B.1    Thongprasert, S.2    Greco, F.A.3
  • 51
    • 84861720010 scopus 로고    scopus 로고
    • Vandetanib versus placebo in patients with advanced non-small-cell lung cancer after prior therapy with an epidermal growth factor receptor tyrosine kinase inhibitor: A randomized, double-blind phase III trial (ZEPHYR)
    • Lee JS, Hirsh V, Park K, et al. Vandetanib versus placebo in patients with advanced non-small-cell lung cancer after prior therapy with an epidermal growth factor receptor tyrosine kinase inhibitor: a randomized, double-blind phase III trial (ZEPHYR). J Clin Oncol 2012; 30: 1114-21.
    • (2012) J Clin Oncol , vol.30 , pp. 1114-1121
    • Lee, J.S.1    Hirsh, V.2    Park, K.3
  • 52
    • 44649149619 scopus 로고    scopus 로고
    • The tyrosine kinase inhibitor cediranib for non-small cell lung cancer and other thoracic malignancies
    • Nikolinakos P, Heymach JV. The tyrosine kinase inhibitor cediranib for non-small cell lung cancer and other thoracic malignancies. J Thorac Oncol 2008; 3: 131-4.
    • (2008) J Thorac Oncol , vol.3 , pp. 131-134
    • Nikolinakos, P.1    Heymach, J.V.2
  • 53
    • 20144370978 scopus 로고    scopus 로고
    • AZD2171: A highly potent, orally bioavailable, vascular endothelial growth factor receptor- 2 tyrosine kinase inhibitor for the treatment of cancer
    • Wedge SR, Kendrew J, Hennequin LF, et al. AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor- 2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res 2005; 65: 4389-400.
    • (2005) Cancer Res , vol.65 , pp. 4389-4400
    • Wedge, S.R.1    Kendrew, J.2    Hennequin, L.F.3
  • 54
    • 73949092851 scopus 로고    scopus 로고
    • Randomized, double-blind trial of carboplatin and paclitaxel with either daily oral cediranib or placebo in advanced non-small-cell lung cancer: NCIC clinical trials group BR24 study
    • Goss GD, Arnold A, Shepherd FA, et al. Randomized, double-blind trial of carboplatin and paclitaxel with either daily oral cediranib or placebo in advanced non-small-cell lung cancer: NCIC clinical trials group BR24 study. J Clin Oncol 2010; 28: 49-55.
    • (2010) J Clin Oncol , vol.28 , pp. 49-55
    • Goss, G.D.1    Arnold, A.2    Shepherd, F.A.3
  • 55
    • 84870427372 scopus 로고    scopus 로고
    • A randomized double-blind trial of carboplatin plus paclitaxel (CP) with daily oral cediranib (CED), an inhibitor of vascular endothelial growth factor receptors, or placebo (PLA) in patients (pts) with previously untreated advanced non-small cell lung cancer (NSCLC): NCIC Clinical Trials Group study BR29
    • Laurie SA, Solomon BJ, Seymour L. A randomized double-blind trial of carboplatin plus paclitaxel (CP) with daily oral cediranib (CED), an inhibitor of vascular endothelial growth factor receptors, or placebo (PLA) in patients (pts) with previously untreated advanced non-small cell lung cancer (NSCLC): NCIC Clinical Trials Group study BR29. J Clin Oncol 2012; 30(Suppl 15): 7511.
    • (2012) J Clin Oncol , vol.30 , pp. 7511
    • Laurie, S.A.1    Solomon, B.J.2    Seymour, L.3
  • 56
    • 84871977845 scopus 로고    scopus 로고
    • A randomized phase II study of gemcitabine and carboplatin with or without cediranib as first-line therapy in advanced non-small cell lung cancer: North Central Cancer Treatment Group Study N0528
    • Dy GK, Mandrekar SJ, Nelson GD, et al. A randomized phase II study of gemcitabine and carboplatin with or without cediranib as first-line therapy in advanced non-small cell lung cancer: North Central Cancer Treatment Group Study N0528. J Thorac Oncol 2013; 8(1): 79-88.
    • (2013) J Thorac Oncol , vol.8 , Issue.1 , pp. 79-88
    • Dy, G.K.1    Mandrekar, S.J.2    Nelson, G.D.3
  • 57
    • 80054718410 scopus 로고    scopus 로고
    • Cediranib, a VEGF receptor 1, 2, and 3 inhibitor, and pemetrexed in patients (pts) with recurrent non-small cell lung cancer (NSCLC)
    • Gadgeel SM, Ruckdeschel JC, Wozniak AJ, et al. Cediranib, a VEGF receptor 1, 2, and 3 inhibitor, and pemetrexed in patients (pts) with recurrent non-small cell lung cancer (NSCLC). J Clin Oncol 2011; 29 (Suppl 15): 7564.
    • (2011) J Clin Oncol , vol.29 , pp. 7564
    • Gadgeel, S.M.1    Ruckdeschel, J.C.2    Wozniak, A.J.3
  • 59
    • 55749088393 scopus 로고    scopus 로고
    • Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
    • Wilhelm SM, Adnane L, Newell P, Villanueva A, Llovet JM, Lynch M. Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther 2008; 7(10): 3129-40.
    • (2008) Mol Cancer Ther , vol.7 , Issue.10 , pp. 3129-3140
    • Wilhelm, S.M.1    Adnane, L.2    Newell, P.3    Villanueva, A.4    Llovet, J.M.5    Lynch, M.6
  • 60
    • 77951639655 scopus 로고    scopus 로고
    • Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced nonsmall- cell lung cancer
    • Scagliotti G, Novello S, von Pawel J, et al. Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced nonsmall- cell lung cancer. J Clin Oncol 2010; 28(11): 1835-42.
    • (2010) J Clin Oncol , vol.28 , Issue.11 , pp. 1835-1842
    • Scagliotti, G.1    Novello, S.2    von Pawel, J.3
  • 61
    • 79551690910 scopus 로고    scopus 로고
    • Sorafenib (S) gemcitabine/ cisplatin (GC) vs. GC alone in the first-line treatment of advanced non-small cell lung cancer (NSCLC): Phase III NSCLC research experience utilizing sorafenib (NEXUS) trial
    • Gatzemeier U, Eisen T, Santoro A, et al. Sorafenib (S) gemcitabine/ cisplatin (GC) vs. GC alone in the first-line treatment of advanced non-small cell lung cancer (NSCLC): Phase III NSCLC research experience utilizing sorafenib (NEXUS) trial. Ann Oncol 2010; 21(Suppl 8).
    • (2010) Ann Oncol , vol.21
    • Gatzemeier, U.1    Eisen, T.2    Santoro, A.3
  • 62
    • 79959306917 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled, phase II trial of sorafenib and erlotinib or erlotinib alone in previously treated advanced non-small-cell lung cancer
    • Spigel DR, Burris HA, Greco FA, Shipley DL, Friedman EK, Waterhouse DM. Randomized, double-blind, placebo-controlled, phase II trial of sorafenib and erlotinib or erlotinib alone in previously treated advanced non-small-cell lung cancer. J Clin Oncol 2011; 29: 2582-9.
    • (2011) J Clin Oncol , vol.29 , pp. 2582-2589
    • Spigel, D.R.1    Burris, H.A.2    Greco, F.A.3    Shipley, D.L.4    Friedman, E.K.5    Waterhouse, D.M.6
  • 63
    • 84873680338 scopus 로고    scopus 로고
    • Monotherapy administration of sorafenib in patients with non-small cell lung cancer: Phase III randomized, double-blind, placebo-controlled MISSION trial
    • Paz-Ares L, Hirsh V, Zhang L. Monotherapy administration of sorafenib in patients with non-small cell lung cancer: phase III randomized, double-blind, placebo-controlled MISSION trial. Ann Oncol 2012; 23 (Suppl 9): 33.
    • (2012) Ann Oncol , vol.23 , pp. 33
    • Paz-Ares, L.1    Hirsh, V.2    Zhang, L.3
  • 64
    • 84857871901 scopus 로고    scopus 로고
    • A randomized phase II study of pemetrexed (PEM) with or without sorafenib (S) as second-line therapy in advanced non-small cell lung cancer (NSCLC) of nonsquamous histology
    • [Abstract 7513]
    • Molina JR, Dy GK, Foster NR, et al. A randomized phase II study of pemetrexed (PEM) with or without sorafenib (S) as second-line therapy in advanced non-small cell lung cancer (NSCLC) of nonsquamous histology. J Clin Oncol 2011; 29: [Abstract 7513].
    • (2011) J Clin Oncol , vol.29
    • Molina, J.R.1    Dy, G.K.2    Foster, N.R.3
  • 65
    • 0037468875 scopus 로고    scopus 로고
    • Discovery of 5-[5-fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylicacid (2diethylaminoethyl) amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase
    • Sun L, Liang C, Shirazian S, Zhou Y, Miller T, Cui J. Discovery of 5-[5-fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylicacid (2diethylaminoethyl) amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase. J Med Chem 2003; 46: 1116-9
    • (2003) J Med Chem , vol.46 , pp. 1116-1119
    • Sun, L.1    Liang, C.2    Shirazian, S.3    Zhou, Y.4    Miller, T.5    Cui, J.6
  • 66
    • 39149120621 scopus 로고    scopus 로고
    • Multicenter, phase II trial of sunitinib in previously treated, advanced nonsmall- cell lung cancer
    • Mark A Socinski, Silvia Novello, Julie R Brahmer, et al. Multicenter, phase II trial of sunitinib in previously treated, advanced nonsmall- cell lung cancer. J Clin Oncol 2008; 26: 650-6.
    • (2008) J Clin Oncol , vol.26 , pp. 650-656
    • Socinski, M.A.1    Novello, S.2    Brahmer, J.R.3
  • 67
    • 70350655546 scopus 로고    scopus 로고
    • Phase II study of continuous daily sunitinib dosing in patients previously treated advanced non-small cell lung cancer
    • S Novello, GV Scagliotti, R Rosell, et al. Phase II study of continuous daily sunitinib dosing in patients previously treated advanced non-small cell lung cancer. Br J Cancer 2009; 101: 1543-8
    • (2009) Br J Cancer , vol.101 , pp. 1543-1548
    • Novello, S.1    Scagliotti, G.V.2    Rosell, R.3
  • 68
    • 84863936062 scopus 로고    scopus 로고
    • Scagliotti, Maciej Krzakowski, Aleksandra Szczesna, et al. Sunitinib plus erlotinib versus placebo plus erlotinib in patients with previously treated advanced non-small-cell lung cancer: A Phase III Trial
    • Giorgio V. Scagliotti, Maciej Krzakowski, Aleksandra Szczesna, et al. Sunitinib plus erlotinib versus placebo plus erlotinib in patients with previously treated advanced non-small-cell lung cancer: A Phase III Trial. J Clin Oncol 2012; 30: 2070-8.
    • (2012) J Clin Oncol , vol.30 , pp. 2070-2078
    • Giorgio, V.1
  • 69
    • 84888644402 scopus 로고    scopus 로고
    • CALGB 30704: A randomized phase II study to assess the efficacy of pemetrexed or sunitinib or pemetrexed plus sunitinib in the second-line treatment of advanced non-small cell lung cancer (NSCLC)
    • Heist RS, Wang XF, Hodgson L, et al. CALGB 30704: a randomized phase II study to assess the efficacy of pemetrexed or sunitinib or pemetrexed plus sunitinib in the second-line treatment of advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2012; 30 (Suppl 15): 7513.
    • (2012) J Clin Oncol , vol.30 , pp. 7513
    • Heist, R.S.1    Wang, X.F.2    Hodgson, L.3
  • 70
    • 84928944052 scopus 로고    scopus 로고
    • Sunitinib (S) switch maintenance in advanced non-small cell lung cancer (NSCLC): An ALLIANCE (CALGB 30607), randomized, placebo-controlled phase III trial
    • (suppl; abstr 8040)
    • Socinski MA, Wang XF, Baggstrom MQ, et al. Sunitinib (S) switch maintenance in advanced non-small cell lung cancer (NSCLC): An ALLIANCE (CALGB 30607), randomized, placebo-controlled phase III trial. J Clin Oncol 32: 5s, 2014 (suppl; abstr 8040).
    • (2014) J Clin Oncol , vol.32 , pp. 5
    • Socinski, M.A.1    Wang, X.F.2    Baggstrom, M.Q.3
  • 71
    • 33749000911 scopus 로고    scopus 로고
    • AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts
    • Polverino A, Coxon A, Starnes C, Diaz Z, DeMelfi T, Wang L. AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer Res 2006; 66: 8715-21.
    • (2006) Cancer Res , vol.66 , pp. 8715-8721
    • Polverino, A.1    Coxon, A.2    Starnes, C.3    Diaz, Z.4    DeMelfi, T.5    Wang, L.6
  • 72
    • 79955795090 scopus 로고    scopus 로고
    • Motesanib NSCLC Phase II Study Investigators. A phase II, multicenter, open-label randomized study of motesanib or bevacizumab in combination with paclitaxel and carboplatin for advanced nonsquamous non-small-cell lung cancer
    • Blumenschein GR Jr, Kabbinavar F, Menon H, Mok TS, Stephenson J, Beck JT. Motesanib NSCLC Phase II Study Investigators. A phase II, multicenter, open-label randomized study of motesanib or bevacizumab in combination with paclitaxel and carboplatin for advanced nonsquamous non-small-cell lung cancer. Ann Oncol 2011; 22: 2057-67.
    • (2011) Ann Oncol , vol.22 , pp. 2057-2067
    • Blumenschein, G.R.1    Kabbinavar, F.2    Menon, H.3    Mok, T.S.4    Stephenson, J.5    Beck, J.T.6
  • 73
    • 84865095318 scopus 로고    scopus 로고
    • International, randomized, placebo-controlled, double-blind phase III study of motesanib plus carboplatin/paclitaxel in patients with advanced nonsquamous non-small-cell lung cancer: MONET1
    • Scagliotti GV, Vynnychenko I, Park K, et al. International, randomized, placebo-controlled, double-blind phase III study of motesanib plus carboplatin/paclitaxel in patients with advanced nonsquamous non-small-cell lung cancer: MONET1. J Clin Oncol 2012; 30: 2829-36.
    • (2012) J Clin Oncol , vol.30 , pp. 2829-2836
    • Scagliotti, G.V.1    Vynnychenko, I.2    Park, K.3
  • 74
    • 84893352389 scopus 로고    scopus 로고
    • Phase III study (MONET1) of motesanib plus carboplatin/paclitaxel in patients with advanced nonsquamous non small-cell lung cancer (NSCLC): Asian subgroup analysis
    • Kubota K, Ichinose Y, Scagliotti G, et al. Phase III study (MONET1) of motesanib plus carboplatin/paclitaxel in patients with advanced nonsquamous non small-cell lung cancer (NSCLC): Asian subgroup analysis. Ann Oncol 2014; 25: 529-36.
    • (2014) Ann Oncol , vol.25 , pp. 529-536
    • Kubota, K.1    Ichinose, Y.2    Scagliotti, G.3
  • 75
    • 33847405376 scopus 로고    scopus 로고
    • Pazopanib: A novel multitargeted tyrosine kinase inhibitor
    • Sonpavde G, Hutson TE. Pazopanib: A novel multitargeted tyrosine kinase inhibitor. Curr Oncol Rep 2007; 9: 115-9.
    • (2007) Curr Oncol Rep , vol.9 , pp. 115-119
    • Sonpavde, G.1    Hutson, T.E.2
  • 76
    • 84892165925 scopus 로고    scopus 로고
    • An open-label, multicenter, randomized, phase II study of pazopanib in combination with pemetrexed in first-line treatment of patients with advanced-stage non-small-cell lung cancer
    • Scagliotti V, Felip E, Besse B, et al. An open-label, multicenter, randomized, phase II study of pazopanib in combination with pemetrexed in first-line treatment of patients with advanced-stage non-small-cell lung cancer. J Thoracic Oncol 2013; 8(12): 1529-37.
    • (2013) J Thoracic Oncol , vol.8 , Issue.12 , pp. 1529-1537
    • Scagliotti, V.1    Felip, E.2    Besse, B.3
  • 77
    • 85039814565 scopus 로고    scopus 로고
    • Double blind randomized phase III study of maintenance pazopanib (PZ) versus placebo (P) in non small cell lung cancer (NSCLC) patients (PTS) non progressive after first line chemotherapy [CT] (EORTC LUNG CANCER GROUP, 08092): MAPPING
    • O'Brien. M.E.R, Gaafar R, Hasan B, et al. Double blind randomized phase III study of maintenance pazopanib (PZ) versus placebo (P) in non small cell lung cancer (NSCLC) patients (PTS) non progressive after first line chemotherapy [CT] (EORTC LUNG CANCER GROUP, 08092): MAPPING. Ann Oncol 2014 (Suppl 4): iv426-70.
    • (2014) Ann Oncol , pp. 426-470
    • O'Brien, M.E.R.1    Gaafar, R.2    Hasan, B.3
  • 78
    • 84947942527 scopus 로고    scopus 로고
    • Phase II study of maintenance therapy with pazopanib or pemetrexed in patients with advanced non-small cell lung cancer (NSCLC) who have not progressed following platinum-based chemotherapy. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA
    • Abstract nr C71
    • Konduri K, Smith D, Compton N, Lockheed DE, Chakrabarti D, Bhatt K. Phase II study of maintenance therapy with pazopanib or pemetrexed in patients with advanced non-small cell lung cancer (NSCLC) who have not progressed following platinum-based chemotherapy. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013; 12(11 Suppl): Abstract nr C71.
    • (2013) Philadelphia (PA): AACR; Mol Cancer Ther , vol.12 , Issue.11
    • Konduri, K.1    Smith, D.2    Compton, N.3    Lockheed, D.E.4    Chakrabarti, D.5    Bhatt, K.6
  • 79
    • 77955503066 scopus 로고    scopus 로고
    • Phase II proof-of-concept study of pazopanib monotherapy in treatment-naive patients with stage i/ii resectable non-small-cell lung cancer
    • Altorki N, Lane ME, Bauer T, et al. Phase II proof-of-concept study of pazopanib monotherapy in treatment-naive patients with stage i/ii resectable non-small-cell lung cancer. J Clin Oncol 2010; 28: 3131- 7.
    • (2010) J Clin Oncol , vol.28 , pp. 3131-3137
    • Altorki, N.1    Lane, M.E.2    Bauer, T.3
  • 80
    • 24944453855 scopus 로고    scopus 로고
    • Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: Pharmacokinetic and clinical results
    • Rugo HS, Herbst RS, Liu G, et al. Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical results. J Clin Oncol 2005; 23: 5474- 83.
    • (2005) J Clin Oncol , vol.23 , pp. 5474-5483
    • Rugo, H.S.1    Herbst, R.S.2    Liu, G.3
  • 81
    • 68949127256 scopus 로고    scopus 로고
    • Efficacy and safety of axitinib in patients with advanced non-small-cell lung cancer: Results from a phase II study
    • Schiller JH, Larson T, Ou SH, et al. Efficacy and safety of axitinib in patients with advanced non-small-cell lung cancer: results from a phase II study. J Clin Oncol 2009; 27: 3836-41.
    • (2009) J Clin Oncol , vol.27 , pp. 3836-3841
    • Schiller, J.H.1    Larson, T.2    Ou, S.H.3
  • 82
    • 84895480028 scopus 로고    scopus 로고
    • Randomised phase II study of axitinib or bevacizumab combined with paclitaxel/ carboplatin as first-line therapy for patients with advanced non-small-cell lung cancer
    • Twelves CJ, Chmielowska E, Havel L, et al. Randomised phase II study of axitinib or bevacizumab combined with paclitaxel/ carboplatin as first-line therapy for patients with advanced non-small-cell lung cancer. Ann Oncol 2014; 25: 132-8.
    • (2014) Ann Oncol , vol.25 , pp. 132-138
    • Twelves, C.J.1    Chmielowska, E.2    Havel, L.3
  • 83
    • 84900002806 scopus 로고    scopus 로고
    • Randomized phase II study of pemetrexed/cisplatin with or without axitinib for nonsquamous non-small-cell lung cancer
    • Belani CP, Yamamoto N, Bondarenko IM, et al. Randomized phase II study of pemetrexed/cisplatin with or without axitinib for nonsquamous non-small-cell lung cancer. BMC Cancer 2014; 14: 290.
    • (2014) BMC Cancer , vol.14 , pp. 290
    • Belani, C.P.1    Yamamoto, N.2    Bondarenko, I.M.3
  • 84
    • 34147102941 scopus 로고    scopus 로고
    • ABT-869, a multitargeted receptor tyrosine kinase inhibitor: Inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia
    • Shankar DB, Li J, Tapang P, et al. ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia. Blood 2007; 109: 3400- 08.
    • (2007) Blood , vol.109 , pp. 3400-3408
    • Shankar, D.B.1    Li, J.2    Tapang, P.3
  • 85
    • 80051801904 scopus 로고    scopus 로고
    • Phase 2 trial of linifanib (ABT-869) in patients with advanced non-small cell lung cancer
    • Eng-Huat T, Glenwood GD, Salgia R, et al. Phase 2 trial of linifanib (ABT-869) in patients with advanced non-small cell lung cancer. J Thoracic Oncol 2011; 6(8): 1418-25.
    • (2011) J Thoracic Oncol , vol.6 , Issue.8 , pp. 1418-1425
    • Eng-Huat, T.1    Glenwood, G.D.2    Salgia, R.3
  • 86
    • 84922341727 scopus 로고    scopus 로고
    • Randomized phase II study of carboplatin and paclitaxel with either linifanib or placebo for advanced nonsquamous non-small-cell lung cancer
    • 10
    • Ramalingam SS, Shtivelband M, Soo RA, et al. Randomized phase II study of carboplatin and paclitaxel with either linifanib or placebo for advanced nonsquamous non-small-cell lung cancer. J Clin Oncol 2015 10; 33(5): 433-41.
    • (2015) J Clin Oncol , vol.33 , Issue.5 , pp. 433-441
    • Ramalingam, S.S.1    Shtivelband, M.2    Soo, R.A.3
  • 87
    • 33847048710 scopus 로고    scopus 로고
    • Alternative vascularization mechanisms in cancer: Pathology and therapeutic implications
    • Dome B, Hendrix MJ, Paku S, Tovari J, Timar J. Alternative vascularization mechanisms in cancer: Pathology and therapeutic implications. Am J Pathol 2007; 170: 1-15.
    • (2007) Am J Pathol , vol.170 , pp. 1-15
    • Dome, B.1    Hendrix, M.J.2    Paku, S.3    Tovari, J.4    Timar, J.5
  • 89
    • 57449103348 scopus 로고    scopus 로고
    • Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced nonsmall cell lung cancer
    • McKeage MJ, Von Pawel J, Reck M, et al. Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced nonsmall cell lung cancer. Br J Cancer 2008; 99: 2006-12.
    • (2008) Br J Cancer , vol.99 , pp. 2006-2012
    • McKeage, M.J.1    Von Pawel, J.2    Reck, M.3
  • 91
    • 84857815036 scopus 로고    scopus 로고
    • Antisoma plc. Press release. November 11
    • Antisoma plc. Antisoma announces outcome of ASA404 ATTRACT- 2 trial. Press release. November 11, 2010. http: //www.antisoma.com/asm/media/press/pr2010/2010-11-11/.
    • (2010) Antisoma announces outcome of ASA404 ATTRACT- 2 trial
  • 92
    • 84867602821 scopus 로고    scopus 로고
    • Aflibercept and docetaxel versus docetaxel alone after platinum failure in patients with advanced or metastatic non-small-cell lung cancer: A randomized, controlled phase III trial
    • Ramlau R, Gorbunova V, Ciuleanu TE, et al. Aflibercept and docetaxel versus docetaxel alone after platinum failure in patients with advanced or metastatic non-small-cell lung cancer: a randomized, controlled phase III trial. J Clin Oncol 2012; 30: 3640-7.
    • (2012) J Clin Oncol , vol.30 , pp. 3640-3647
    • Ramlau, R.1    Gorbunova, V.2    Ciuleanu, T.E.3
  • 93
    • 40949111793 scopus 로고    scopus 로고
    • Cell adhesion molecules, vascular endothelial growth factor, and basic fibroblast growth factor in patients with non-small cell lung cancer treated with chemotherapy with or without bevacizumab-an Eastern Cooperative Oncology Group Study
    • Dowlati A, Gray R, Sandler AB, Schiller JH, Johnson DH. Cell adhesion molecules, vascular endothelial growth factor, and basic fibroblast growth factor in patients with non-small cell lung cancer treated with chemotherapy with or without bevacizumab-an Eastern Cooperative Oncology Group Study. Clin Cancer Res 2008; 14(5): 1407-12.
    • (2008) Clin Cancer Res , vol.14 , Issue.5 , pp. 1407-1412
    • Dowlati, A.1    Gray, R.2    Sandler, A.B.3    Schiller, J.H.4    Johnson, D.H.5
  • 94
    • 74949090109 scopus 로고    scopus 로고
    • Distinct patterns of cytokine and angiogenic factor modulation and markers of benefit for vandetanib and/or chemotherapy in patients with non-small-cell lung cancer
    • Hanrahan EO, Lin HY, Kim ES, et al. Distinct patterns of cytokine and angiogenic factor modulation and markers of benefit for vandetanib and/or chemotherapy in patients with non-small-cell lung cancer. J Clin Oncol 2010; 28: 193-201.
    • (2010) J Clin Oncol , vol.28 , pp. 193-201
    • Hanrahan, E.O.1    Lin, H.Y.2    Kim, E.S.3
  • 95
    • 77949894217 scopus 로고    scopus 로고
    • Clinical course of advanced non-small cell lung cancer patients experiencing hypertension during treatment with bevacizumab in combination with carboplatin and paclitaxel on ECOG 4599
    • Dahlberg SE, Sandler AB, Brahmer JR, Schiller JH, Johnson DH. Clinical course of advanced non-small cell lung cancer patients experiencing hypertension during treatment with bevacizumab in combination with carboplatin and paclitaxel on ECOG 4599. J Clin Oncol 2010; 28: 949-54.
    • (2010) J Clin Oncol , vol.28 , pp. 949-954
    • Dahlberg, S.E.1    Sandler, A.B.2    Brahmer, J.R.3    Schiller, J.H.4    Johnson, D.H.5
  • 96
    • 78049399444 scopus 로고    scopus 로고
    • Analysis of early hypertension (HTN) and clinical outcome with bevacizumab (BV)
    • [Abstract 3039]
    • Hurwitz H, Douglas PS, Middleton JP, et al. Analysis of early hypertension (HTN) and clinical outcome with bevacizumab (BV). J Clin Oncol 2010; 28: [Abstract 3039].
    • (2010) J Clin Oncol , vol.28
    • Hurwitz, H.1    Douglas, P.S.2    Middleton, J.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.