-
1
-
-
0026846928
-
The role of angiogenesis in tumor growth
-
Folkman J. The role of angiogenesis in tumor growth. Semin Cancer Biol 1992;3:65-71.
-
(1992)
Semin Cancer Biol
, vol.3
, pp. 65-71
-
-
Folkman, J.1
-
2
-
-
12244292196
-
Differentiation and definition of vascular-targeted therapies
-
Siemann DW, Bibby MC, Dark GG et al. Differentiation and definition of vascular-targeted therapies. Clin Cancer Res 2005;11:416-420.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 416-420
-
-
Siemann, D.W.1
Bibby, M.C.2
Dark, G.G.3
-
3
-
-
33751583518
-
Drug insight: Vascular disrupting agents and angiogenesis-novel approaches for drug delivery
-
Cooney MM, Heeckeren W, Bhakta S et al. Drug insight: Vascular disrupting agents and angiogenesis-novel approaches for drug delivery. Nat Clin Pract Oncol 2006;3:682- 692.
-
(2006)
Nat Clin Pract Oncol
, vol.3
, pp. 682-692
-
-
Cooney, M.M.1
Heeckeren, W.2
Bhakta, S.3
-
5
-
-
0033962101
-
Relationship of vascular maturation in breast cancer blood vessels to vascular density and metastasis, assessed by expression of a novel basement membrane component, LH39
-
Kakolyris S, Fox S, Koukourakis M et al. Relationship of vascular maturation in breast cancer blood vessels to vascular density and metastasis, assessed by expression of a novel basement membrane component, LH39. Br J Cancer 2000;82:844-851.
-
(2000)
Br J Cancer
, vol.82
, pp. 844-851
-
-
Kakolyris, S.1
Fox, S.2
Koukourakis, M.3
-
6
-
-
0035906856
-
3D microvascular architecture of precancerous lesions and invasive carcinomas of the colon
-
Konerding MA, Fait E, Gaumann A. 3D microvascular architecture of precancerous lesions and invasive carcinomas of the colon. Br J Cancer 2001; 84:1354 -1362.
-
(2001)
Br J Cancer
, vol.84
, pp. 1354-1362
-
-
Konerding, M.A.1
Fait, E.2
Gaumann, A.3
-
7
-
-
0025122289
-
The relationship between regional variations in blood flow and histology in a transplanted rat fibrosarcoma
-
Tozer GM, Lewis S, Michalowski A et al. The relationship between regional variations in blood flow and histology in a transplanted rat fibrosarcoma. Br J Cancer 1990;61:250 -257.
-
(1990)
Br J Cancer
, vol.61
, pp. 250-257
-
-
Tozer, G.M.1
Lewis, S.2
Michalowski, A.3
-
8
-
-
0020081554
-
Endothelial cell proliferation as a novel approach to targeting tumour therapy
-
Denekamp J. Endothelial cell proliferation as a novel approach to targeting tumour therapy. Br J Cancer 1982;45:136 -139.
-
(1982)
Br J Cancer
, vol.45
, pp. 136-139
-
-
Denekamp, J.1
-
9
-
-
34247249906
-
Vascular disrupting agents in clinical development
-
Hinnen P, Eskens F. Vascular disrupting agents in clinical development. Br J Cancer 2007;96:1159 -1165.
-
(2007)
Br J Cancer
, vol.96
, pp. 1159-1165
-
-
Hinnen, P.1
Eskens, F.2
-
10
-
-
24744453094
-
Taking down tumors: Vascular disrupting agents entering clinical trials
-
O'Hanlon LH. Taking down tumors: Vascular disrupting agents entering clinical trials. J Natl Cancer Inst 2005;97:1244 -1245.
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 1244-1245
-
-
O'Hanlon, L.H.1
-
11
-
-
2642571660
-
Vascular-targeting therapies for treatment of malignant disease
-
Siemann DW, Chaplin DJ, Horsman MR. Vascular-targeting therapies for treatment of malignant disease. Cancer 2004;100:2491-2499.
-
(2004)
Cancer
, vol.100
, pp. 2491-2499
-
-
Siemann, D.W.1
Chaplin, D.J.2
Horsman, M.R.3
-
12
-
-
0842311621
-
Vascular targeting agents as cancer therapeutics
-
Thorpe PE. Vascular targeting agents as cancer therapeutics. Clin Cancer Res 2004;10:415- 427.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 415-427
-
-
Thorpe, P.E.1
-
13
-
-
0027368441
-
-
Burrows FJ, Thorpe PE. Eradication of large solid tumors in mice with an immunotoxin directed against tumor vasculature. Proc Natl Accad Sci U S A 1993;90:8996 -9000.
-
Burrows FJ, Thorpe PE. Eradication of large solid tumors in mice with an immunotoxin directed against tumor vasculature. Proc Natl Accad Sci U S A 1993;90:8996 -9000.
-
-
-
-
14
-
-
19344378137
-
Vascular disrupting agents: A new class of drug in cancer therapy
-
Gaya AM, Rustin GJ. Vascular disrupting agents: A new class of drug in cancer therapy. Clin Oncol (R Coll Radiol) 2005;17:277-290.
-
(2005)
Clin Oncol (R Coll Radiol)
, vol.17
, pp. 277-290
-
-
Gaya, A.M.1
Rustin, G.J.2
-
15
-
-
33646551448
-
Antitubulin agents for the treatment of cancer-a medicinal chemistry update
-
Mahindroo N, Liou JP, Chang JY et al. Antitubulin agents for the treatment of cancer-a medicinal chemistry update. Expert Opin Ther Pat 2006;16: 647-691.
-
(2006)
Expert Opin Ther Pat
, vol.16
, pp. 647-691
-
-
Mahindroo, N.1
Liou, J.P.2
Chang, J.Y.3
-
16
-
-
0031775298
-
Enhancement of tumor radiation response by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid
-
Wilson WR, Li AE, Cowan DS et al. Enhancement of tumor radiation response by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid. Int J Radiat Oncol Biol Phys 1998;42:905-908.
-
(1998)
Int J Radiat Oncol Biol Phys
, vol.42
, pp. 905-908
-
-
Wilson, W.R.1
Li, A.E.2
Cowan, D.S.3
-
17
-
-
0035131992
-
Comparative effects of combretastatin A-4 disodium phosphate and 5, 6-dimethylxanthenone-4-acetic acid on blood perfusion in a murine tumour and normal tissues
-
Murata R, Overgaard J, Horsman MR. Comparative effects of combretastatin A-4 disodium phosphate and 5, 6-dimethylxanthenone-4-acetic acid on blood perfusion in a murine tumour and normal tissues. Int J Radiat Biol 2001;77:195-204.
-
(2001)
Int J Radiat Biol
, vol.77
, pp. 195-204
-
-
Murata, R.1
Overgaard, J.2
Horsman, M.R.3
-
18
-
-
0029063213
-
Induction of tumour necrosis factoralpha by single and repeated doses of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid
-
Philpott M, Baguley BC, Ching LM. Induction of tumour necrosis factoralpha by single and repeated doses of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid. Cancer Chemother Pharmacol 1995;36:143-148.
-
(1995)
Cancer Chemother Pharmacol
, vol.36
, pp. 143-148
-
-
Philpott, M.1
Baguley, B.C.2
Ching, L.M.3
-
19
-
-
0037341637
-
Antivascular therapy of cancer: DMXAA
-
Baguley BC. Antivascular therapy of cancer: DMXAA. Lancet Oncol 2003;4:141-148.
-
(2003)
Lancet Oncol
, vol.4
, pp. 141-148
-
-
Baguley, B.C.1
-
20
-
-
0034812637
-
The antitumour agent 5,6-dimethylxanthenone-4-acetic acid acts in vitro on human mononuclear cells as a costimulator with other inducers of tumour necrosis factor
-
Philpott M, Ching LM, Baguley BC. The antitumour agent 5,6-dimethylxanthenone-4-acetic acid acts in vitro on human mononuclear cells as a costimulator with other inducers of tumour necrosis factor. Eur J Cancer 2001;37:1930 -1937.
-
(2001)
Eur J Cancer
, vol.37
, pp. 1930-1937
-
-
Philpott, M.1
Ching, L.M.2
Baguley, B.C.3
-
21
-
-
0031016945
-
Mechanisms of enhancement of the antitumour activity of melphalan by the tumour-blood-flow inhibitor 5,6-dimethylxanthenone-4-acetic acid
-
Pruijn FB, van Daalen M, Holford NH et al. Mechanisms of enhancement of the antitumour activity of melphalan by the tumour-blood-flow inhibitor 5,6-dimethylxanthenone-4-acetic acid. Cancer Chemother Pharmacol 1997;39:541-546.
-
(1997)
Cancer Chemother Pharmacol
, vol.39
, pp. 541-546
-
-
Pruijn, F.B.1
van Daalen, M.2
Holford, N.H.3
-
22
-
-
0037222218
-
Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)
-
Siim BG, Lee AE, Shalal-Zwain S et al. Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA). Cancer Chemother Pharmacol 2003;51:43-52.
-
(2003)
Cancer Chemother Pharmacol
, vol.51
, pp. 43-52
-
-
Siim, B.G.1
Lee, A.E.2
Shalal-Zwain, S.3
-
23
-
-
33645659565
-
5,6-dimethylxanthenone-4-acetic acid in the treatment of refractory tumors: A phase I safety study of a vascular disrupting agent
-
McKeage MJ, Fong P, Jeffery M et al. 5,6-dimethylxanthenone-4-acetic acid in the treatment of refractory tumors: A phase I safety study of a vascular disrupting agent. Clin Cancer Res 2006;12:1776 -1784.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 1776-1784
-
-
McKeage, M.J.1
Fong, P.2
Jeffery, M.3
-
24
-
-
34247266033
-
Phase Ib/II study of DMXAA combined with carboplatin and paclitaxel in non-small cell lung cancer (NSCLC)
-
389s
-
McKeage M. Phase Ib/II study of DMXAA combined with carboplatin and paclitaxel in non-small cell lung cancer (NSCLC). J Clin Oncol 2006; 24(suppl 18):389s.
-
(2006)
J Clin Oncol
, vol.24
, Issue.SUPPL. 18
-
-
McKeage, M.1
-
25
-
-
57449103348
-
Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer
-
McKeage MJ, von Pawel J, Reck M et al. Randomised phase II study of ASA404 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer. Br J Cancer 2008;99:2006 -2012.
-
(2008)
Br J Cancer
, vol.99
, pp. 2006-2012
-
-
McKeage, M.J.1
von Pawel, J.2
Reck, M.3
-
26
-
-
67449123059
-
Phase II study of ASA404 (vadimezan, 5,6-dimethylxanthenone-4-acetic acid/DMXAA) 1800 mg/m2 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer
-
April 29 [Epub ahead of print
-
McKeage MJ, Reck M, Jameson MB et al. Phase II study of ASA404 (vadimezan, 5,6-dimethylxanthenone-4-acetic acid/DMXAA) 1800 mg/m2 combined with carboplatin and paclitaxel in previously untreated advanced non-small cell lung cancer. Lung Cancer 2009; April 29 [Epub ahead of print].
-
(2009)
Lung Cancer
-
-
McKeage, M.J.1
Reck, M.2
Jameson, M.B.3
-
27
-
-
70450216884
-
Comparison of safety and efficacy between squamous and non-squamous non-small cell lung cancer (NSCLC) patients in phase II study of DMXAA (ASA404)
-
441s
-
McKeage MJ, Jameson MB. Comparison of safety and efficacy between squamous and non-squamous non-small cell lung cancer (NSCLC) patients in phase II study of DMXAA (ASA404). J Clin Oncol 2008;26(suppl 15): 441s.
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL. 15
-
-
McKeage, M.J.1
Jameson, M.B.2
-
28
-
-
40349112067
-
-
Available at, accessed February 23, 2009
-
National Cancer Institute. PDQ National Cancer Institute Clinical Trials Database. Available at http://www.cancer.gov/clinical-trials, accessed February 23, 2009.
-
PDQ National Cancer Institute Clinical Trials Database
-
-
-
29
-
-
0024513175
-
Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4
-
Pettit GR, Singh SB, Hamel E et al. Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4. Experientia 1989;45: 209-211.
-
(1989)
Experientia
, vol.45
, pp. 209-211
-
-
Pettit, G.R.1
Singh, S.B.2
Hamel, E.3
-
30
-
-
0029044610
-
Antineoplastic agents 322. Synthesis of combretastatin A-4 prodrugs
-
Pettit GR, Temple C Jr, Narayanan VL et al. Antineoplastic agents 322. Synthesis of combretastatin A-4 prodrugs. Anticancer Drug Des 1995;10: 299-309.
-
(1995)
Anticancer Drug Des
, vol.10
, pp. 299-309
-
-
Pettit, G.R.1
Temple Jr, C.2
Narayanan, V.L.3
-
31
-
-
27644466314
-
Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling
-
Vincent L, Kermani P, Young LM et al. Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling. J Clin Invest 2005;115:2992-3006.
-
(2005)
J Clin Invest
, vol.115
, pp. 2992-3006
-
-
Vincent, L.1
Kermani, P.2
Young, L.M.3
-
32
-
-
0030951899
-
Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature
-
Dark GG, Hill SA, Prise V et al. Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature. Cancer Res 1997; 57:1829 -1834.
-
(1997)
Cancer Res
, vol.57
, pp. 1829-1834
-
-
Dark, G.G.1
Hill, S.A.2
Prise, V.3
-
33
-
-
0031770618
-
The effect of combretastatin A-4 disodium phosphate in a C3H mouse mammary carcinoma and a variety of murine spontaneous tumors
-
Horsman MR, Ehrnrooth E, Ladekarl M et al. The effect of combretastatin A-4 disodium phosphate in a C3H mouse mammary carcinoma and a variety of murine spontaneous tumors. Int J Radiat Oncol Biol Phys 1998;42: 895-898.
-
(1998)
Int J Radiat Oncol Biol Phys
, vol.42
, pp. 895-898
-
-
Horsman, M.R.1
Ehrnrooth, E.2
Ladekarl, M.3
-
34
-
-
0034906627
-
Combretastatin A-4 prodrug study of effect on the growth and the microvasculature of colorectal liver metastases in a murine model
-
Malcontenti-Wilson C, Muralidharan V, Skinner S et al. Combretastatin A-4 prodrug study of effect on the growth and the microvasculature of colorectal liver metastases in a murine model. Clin Cancer Res 2001;7:1052-1060.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1052-1060
-
-
Malcontenti-Wilson, C.1
Muralidharan, V.2
Skinner, S.3
-
35
-
-
0035417875
-
Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: Intravital microscopy and measurement of vascular permeability
-
Tozer GM, Prise VE, Wilson J et al. Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: Intravital microscopy and measurement of vascular permeability. Cancer Res 2001; 61:6413- 6422.
-
(2001)
Cancer Res
, vol.61
, pp. 6413-6422
-
-
Tozer, G.M.1
Prise, V.E.2
Wilson, J.3
-
36
-
-
0033119771
-
Combretastatin A-4 phosphate as a tumor vascular-targeting agent: Early effects in tumors and normal tissues
-
Tozer GM, Prise VE, Wilson J et al. Combretastatin A-4 phosphate as a tumor vascular-targeting agent: Early effects in tumors and normal tissues. Cancer Res 1999;59:1626 -1634.
-
(1999)
Cancer Res
, vol.59
, pp. 1626-1634
-
-
Tozer, G.M.1
Prise, V.E.2
Wilson, J.3
-
37
-
-
33947504434
-
Tumor antivascular effects of radiotherapy combined with combretastatin a4 phosphate in human non-small-cell lung cancer
-
Ng QS, Goh V, Carnell D et al. Tumor antivascular effects of radiotherapy combined with combretastatin a4 phosphate in human non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 2007;67:1375-1380.
-
(2007)
Int J Radiat Oncol Biol Phys
, vol.67
, pp. 1375-1380
-
-
Ng, Q.S.1
Goh, V.2
Carnell, D.3
-
38
-
-
68049088344
-
Volumetric perfusion CT assessment of concurrent combretastatin-A4-phosphate (CA4P) and radiotherapy (RT) in non-small cell lung cancer
-
634s
-
Mandeville HC, Goh V, Ng QS et al. Volumetric perfusion CT assessment of concurrent combretastatin-A4-phosphate (CA4P) and radiotherapy (RT) in non-small cell lung cancer. J Clin Oncol 2008;26(suppl 15):634s.
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL. 15
-
-
Mandeville, H.C.1
Goh, V.2
Ng, Q.S.3
-
39
-
-
0034109559
-
Combination chemotherapy with combretastatin A-4 phosphate and 5-fluorouracil in an experimental murine colon adenocarcinoma
-
Grosios K, Loadman PM, Swaine DJ et al. Combination chemotherapy with combretastatin A-4 phosphate and 5-fluorouracil in an experimental murine colon adenocarcinoma. Anticancer Res 2000;20:229 -233.
-
(2000)
Anticancer Res
, vol.20
, pp. 229-233
-
-
Grosios, K.1
Loadman, P.M.2
Swaine, D.J.3
-
40
-
-
0035233996
-
Combretastatin A-4 and doxorubicin combination treatment is effective in a preclinical model of human medullary thyroid carcinoma
-
Nelkin BD, Ball DW. Combretastatin A-4 and doxorubicin combination treatment is effective in a preclinical model of human medullary thyroid carcinoma. Oncol Rep 2001;8:157-160.
-
(2001)
Oncol Rep
, vol.8
, pp. 157-160
-
-
Nelkin, B.D.1
Ball, D.W.2
-
41
-
-
0034472914
-
Combretastatins novel vascular targeting drugs for improving anti-cancer therapy. Combretastatins and conventional therapy
-
Horsman MR, Murata R, Breidahl T et al. Combretastatins novel vascular targeting drugs for improving anti-cancer therapy. Combretastatins and conventional therapy. Adv Exp Med Biol 2000;476:311-323.
-
(2000)
Adv Exp Med Biol
, vol.476
, pp. 311-323
-
-
Horsman, M.R.1
Murata, R.2
Breidahl, T.3
-
42
-
-
0034773165
-
E7070, a novel sulfonamide agent with potent antitumor activity in vitro and in vivo
-
Ozawa Y, Sugi NH, Nagasu T et al. E7070, a novel sulfonamide agent with potent antitumor activity in vitro and in vivo. Eur J Cancer 2001;37:2275-2282.
-
(2001)
Eur J Cancer
, vol.37
, pp. 2275-2282
-
-
Ozawa, Y.1
Sugi, N.H.2
Nagasu, T.3
-
43
-
-
33646741205
-
The pharmacokinetics and safety of ABT-751, a novel, orally bioavailable sulfonamide antimitotic agent: Results of a phase 1 study
-
Hande KR, Hagey A, Berlin J et al. The pharmacokinetics and safety of ABT-751, a novel, orally bioavailable sulfonamide antimitotic agent: Results of a phase 1 study. Clin Cancer Res 2006;9:2834 -2840.
-
(2006)
Clin Cancer Res
, vol.9
, pp. 2834-2840
-
-
Hande, K.R.1
Hagey, A.2
Berlin, J.3
-
44
-
-
44649138596
-
A phase II study of ABT-751 in patients with advanced non-small cell lung cancer
-
Mauer AM, Cohen EE, Ma PC et al. A phase II study of ABT-751 in patients with advanced non-small cell lung cancer. J Thor Oncol 2008;3:631-636.
-
(2008)
J Thor Oncol
, vol.3
, pp. 631-636
-
-
Mauer, A.M.1
Cohen, E.E.2
Ma, P.C.3
-
45
-
-
68049087341
-
A phase I trial of ABT-751 and carboplatin (C) in patients (pts) with previously treated non-small cell lung cancer (NSCLC)
-
674s
-
Dragnev KH, Rigas JR, DisalvoWM et al. A phase I trial of ABT-751 and carboplatin (C) in patients (pts) with previously treated non-small cell lung cancer (NSCLC). J Clin Oncol 2006;24(suppl 18):674s.
-
(2006)
J Clin Oncol
, vol.24
, Issue.SUPPL. 18
-
-
Dragnev, K.H.1
Rigas, J.R.2
DisalvoWM3
-
46
-
-
0030697347
-
Phenylahistin: A new mammalian cell cycle inhibitor produced by Aspergillus ustus
-
Kanoh K, Kohno S, Asari T et al. Phenylahistin: A new mammalian cell cycle inhibitor produced by Aspergillus ustus. Bioorg Med Chem Lett 1997;7:2847-2852.
-
(1997)
Bioorg Med Chem Lett
, vol.7
, pp. 2847-2852
-
-
Kanoh, K.1
Kohno, S.2
Asari, T.3
-
47
-
-
68049100832
-
Phase I study of NPI-2358 (a novel vascular disrupting agent) in patients with solid tumors and lymphomas
-
159s
-
Mita AC, Yee LK, Papadopoulos KP et al. Phase I study of NPI-2358 (a novel vascular disrupting agent) in patients with solid tumors and lymphomas. J Clin Oncol 2008;26(suppl 15):159s.
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL. 15
-
-
Mita, A.C.1
Yee, L.K.2
Papadopoulos, K.P.3
-
48
-
-
0035914261
-
Measuring changes in human tumour vasculature in response to therapy using functional imaging techniques
-
Anderson H, Price P, Blomley M et al. Measuring changes in human tumour vasculature in response to therapy using functional imaging techniques. Br J Cancer 2001;85:1085-1093.
-
(2001)
Br J Cancer
, vol.85
, pp. 1085-1093
-
-
Anderson, H.1
Price, P.2
Blomley, M.3
|