Engineering Duplex RNAs for Challenging Targets: Recognition of GGGGCC/CCCCGG Repeats at the ALS/FTD C9orf72 Locus

Chemistry and Biology

Volumn 22, Issue 11, 2015, Pages 1505-1511

  Hu, Jiaxin ^a   Liu, Jing ^a   Li, Liande ^a   Gagnon, Keith T ^b   Corey, David R ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; DUPLEX RNA; RNA; UNCLASSIFIED DRUG; C9ORF72 PROTEIN, HUMAN; DOUBLE STRANDED RNA; MICROSATELLITE DNA; PROTEIN; SMALL INTERFERING RNA;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CHROMOSOME 9; CONTROLLED STUDY; DNA BASE COMPOSITION; EXPANDED HEXANUCLEOTIDE REPEAT; FRONTOTEMPORAL DEMENTIA; GENE CONTROL; GENE LOCUS; GENE SILENCING; GENETIC ENGINEERING; HUMAN; HUMAN CELL; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA CLEAVAGE; RNA INTERFERENCE; RNA SEQUENCE; RNA STRUCTURE; CELL LINE; CHEMISTRY; FLUORESCENCE MICROSCOPY; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION;

AMYOTROPHIC LATERAL SCLEROSIS; BASE SEQUENCE; CELL LINE; FRONTOTEMPORAL DEMENTIA; GENETIC LOCI; HUMANS; MICROSATELLITE REPEATS; MICROSCOPY, FLUORESCENCE; PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, DOUBLE-STRANDED; RNA, SMALL INTERFERING;

EID: 84947918546     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2015.09.016     Document Type: Article

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