Allele-selective inhibition of mutant atrophin-1 expression by duplex and single-stranded RNAs

Biochemistry

Volumn 53, Issue 28, 2014, Pages 4510-4518

  Hu, Jiaxin ^a   Liu, Jing ^a   Narayanannair, K Jayaprakash ^b   Lackey, Jeremy G ^b   Kuchimanchi, Satya ^b   Rajeev, Kallanthottathil G ^b   Manoharan, Muthiah ^b   Swayze, Eric E ^c   Lima, Walt F ^c   Prakash, Thazha P ^c   Xiang, Qin ^d   Martinez, Carlos ^d   Corey, David R ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b ALNYLAM PHARMACEUTICALS   (United States)

^c ISIS PHARMACEUTICALS   (United States)

^d Sigma Custom Products   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ELECTROPHORESIS; GENE ENCODING; NUCLEOTIDES; PROTEINS; RNA;

DISEASE GENES; GEL ELECTROPHORESIS; GENE SILENCING; NEURODEGENERATIVE DISORDERS; POTENTIAL TARGETS; PROTEIN EXPRESSIONS; RNA DUPLEXES; TRINUCLEOTIDE;

GENE EXPRESSION;

ATAXIN 3; ATROPHIN 1; COMPLEMENTARY RNA; HUNTINGTIN; MESSENGER RNA; MUTANT PROTEIN; SINGLE STRANDED RNA; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CAG REPEAT; CONTROLLED STUDY; CROSS REACTION; DENTATORUBROPALLIDOLUYSIAN ATROPHY; GENE SILENCING; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RNA STABILITY; TRINUCLEOTIDE REPEAT;

ALLELES; CELL LINE; GENE EXPRESSION REGULATION; HUMANS; MICRORNAS; MUTAGENESIS, INSERTIONAL; MYOCLONIC EPILEPSIES, PROGRESSIVE; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; REPRESSOR PROTEINS; RNA, DOUBLE-STRANDED; RNA, MESSENGER; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 84904634045     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi500610r     Document Type: Article

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