Soy Isoflavones Promote Radioprotection of Normal Lung Tissue by Inhibition of Radiation-Induced Activation of Macrophages and Neutrophils

Journal of Thoracic Oncology

Volumn 10, Issue 12, 2015, Pages 1703-1712

  Abernathy, Lisa M ^a,b   Fountain, Matthew D ^a,b   Rothstein, Shoshana E ^b   David, John M ^b   Yunker, Christopher K ^b   Rakowski, Joseph ^b   Lonardo, Fulvio ^b   Joiner, Michael C ^b   Hillman, Gilda G ^a,b  

^a Department of Immunology and Microbiology ^*  (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Lung inflammation; Macrophages; Neutrophils; Radiation; Soy isoflavones

Indexed keywords

ARGINASE 1; DAIDZEIN; GENISTEIN; GLYCITEIN; GLYCOPROTEIN P 15095; INDUCIBLE NITRIC OXIDE SYNTHASE; ISOFLAVONE DERIVATIVE; MYELOPEROXIDASE; RADIOPROTECTIVE AGENT; SOYBEAN EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL SUSPENSION; CONTROLLED STUDY; DRUG DOSE REDUCTION; FEMALE; FLOW CYTOMETRY; GRANULOCYTE; IMMUNOHISTOCHEMISTRY; LEUKOCYTE ACTIVATION; LEUKOCYTE DIFFERENTIAL COUNT; LUNG ALVEOLUS MACROPHAGE; LUNG INJURY; LUNG LAVAGE; LUNG PARENCHYMA; MACROPHAGE ACTIVATION; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE FRACTIONATION; RADIATION INJURY; RADIATION PROTECTION; SOYBEAN; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; DRUG EFFECTS; LUNG; LUNG NEOPLASMS; MACROPHAGE; METABOLISM; NEUTROPHIL; PATHOLOGY; RADIATION INJURIES, EXPERIMENTAL; RADIATION RESPONSE;

ANIMALS; FEMALE; ISOFLAVONES; LUNG; LUNG NEOPLASMS; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MICE, INBRED BALB C; NEUTROPHILS; RADIATION INJURIES, EXPERIMENTAL; RADIATION-PROTECTIVE AGENTS; SOYBEANS;

EID: 84947903734     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0000000000000677     Document Type: Article

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