Radioprotection of lung tissue by soy isoflavones

Journal of Thoracic Oncology

Volumn 8, Issue 11, 2013, Pages 1356-1364

  Hillman, Gilda G ^a   Singh Gupta, Vinita ^a   Lonardo, Fulvio ^a   Hoogstra, David J ^a   Abernathy, Lisa M ^a   Yunker, Christopher K ^a   Rothstein, Shoshana E ^a   Rakowski, Joseph ^a   Sarkar, Fazlul H ^a   Gadgeel, Shirish ^a   Konski, Andre A ^a   Joiner, Michael C ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Lung; Protection; Radiation; Soy

Indexed keywords

ISOFLAVONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREATHING RATE; BRONCHIOLE; CHRONIC INFLAMMATION; FEMALE; HAIR LOSS; HISTOLOGY; INFLAMMATORY INFILTRATE; LUNG ALVEOLUS; LUNG FIBROSIS; LUNG PARENCHYMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION INJURY; RADIATION PNEUMONIA; RADIATION PROTECTION; SKIN INJURY;

ALOPECIA; ANIMALS; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; ISOFLAVONES; LUNG; MICE; MICE, INBRED BALB C; PHOTONS; PULMONARY FIBROSIS; RADIATION PNEUMONITIS; RADIATION-PROTECTIVE AGENTS; RESPIRATORY MECHANICS; SKIN; SOYBEANS;

EID: 84886585395     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0b013e3182a4713e     Document Type: Article

References (33)

1. Schallenkamp JM, Miller RC, Brinkmann DH, Foote T, Garces YI. Incidence of radiation pneumonitis after thoracic irradiation: Dose-volume correlates. Int J Radiat Oncol Biol Phys 2007;67:410-416
2. Hill RP. Radiation effects on the respiratory system. BJR Suppl 2005;27:75-81
3. Bentzen SM. Preventing or reducing late side effects of radiation therapy: Radiobiology meets molecular pathology. Nat Rev Cancer 2006;6:702-713
4. Yarnold J, Brotons MC. Pathogenetic mechanisms in radiation fibrosis. Radiother Oncol 2010;97:149-161
5. Messina M, Kucuk O, Lampe JW. An overview of the health effects of isoflavones with an emphasis on prostate cancer risk and prostate-specific antigen levels. J AOAC Int 2006;89:1121-1134
6. Ahmad IU, Forman JD, Sarkar FH, et al. Soy isoflavones in conjunction with radiation therapy in patients with prostate cancer. Nutr Cancer 2010;62:996-1000
7. Hillman GG, Singh-Gupta V, Runyan L, et al. Soy isoflavones radiosensitize lung cancer while mitigating normal tissue injury. Radiother Oncol 2011;101:329-336
8. Hillman GG, Wang Y, Kucuk O, et al. Genistein potentiates inhibition of tumor growth by radiation in a prostate cancer orthotopic model. Mol Cancer Ther 2004;3:1271-1279
9. Hillman GG, Wang Y, Che M, et al. Progression of renal cell carcinoma is inhibited by genistein and radiation in an orthotopic model. BMC Cancer 2007;7:4
10. Raffoul JJ, Banerjee S, Che M, et al. Soy isoflavones enhance radiotherapy in a metastatic prostate cancer model. Int J Cancer 2007;120:2491-2498
11. Raffoul JJ, Banerjee S, Singh-Gupta V, et al. Down-regulation of apurinic/ apyrimidinic endonuclease 1/redox factor-1 expression by soy isoflavones enhances prostate cancer radiotherapy in vitro and in vivo. Cancer Res 2007;67:2141-2149
12. Singh-Gupta V, Joiner MC, Runyan L, et al. Soy isoflavones augment radiation effect by inhibiting APE1/Ref-1 DNA repair activity in nonsmall cell lung cancer. J Thorac Oncol 2011;6:688-698
13. Singh-Gupta V, Zhang H, Banerjee S, et al. Radiation-induced HIF- 1alpha cell survival pathway is inhibited by soy isoflavones in prostate cancer cells. Int J Cancer 2009;124:1675-1684
14. Hillman GG, Singh-Gupta V. Soy isoflavones sensitize cancer cells to radiotherapy. Free Radic Biol Med 2011;51:289-298
15. Lo SS, Sahgal A, Chang EL, et al. Serious complications associated with stereotactic ablative radiotherapy and strategies to mitigate the risk. Clin Oncol (R Coll Radiol) 2013;25:378-387
16. Davis IC, Lazarowski ER, Chen FP, Hickman-Davis JM, Sullender WM, Matalon S. Post-infection A77-1726 blocks pathophysiologic sequelae of respiratory syncytial virus infection. Am J Respir Cell Mol Biol 2007;37:379-386
17. Cannizzaro V, Berry LJ, Nicholls PK, et al. Lung volume recruitment maneuvers and respiratory system mechanics in mechanically ventilated mice. Respir Physiol Neurobiol 2009;169:243-251
18. Early MA, Lishnevsky M, Gilchrist JM, et al. Non-invasive diagnosis of early pulmonary disease in PECAM-deficient mice using infrared pulse oximetry. Exp Mol Pathol 2009;87:152-158
19. Para AE, Bezjak A, Yeung IW, Van Dyk J, Hill RP. Effects of genistein following fractionated lung irradiation in mice. Radiother Oncol 2009;92:500-510
20. Williams JP, Johnston CJ, Finkelstein JN. Treatment for radiation-induced pulmonary late effects: Spoiled for choice or looking in the wrong direction? 1386-1394
21. Rubin P, Johnston CJ, Williams JP, McDonald S, Finkelstein JN. A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis. Int J Radiat Oncol Biol Phys 1995;33:99-109
22. Kong FM, Hayman JA, Griffith KA, et al. Final toxicity results of a radiation- dose escalation study in patients with non-small-cell lung cancer (NSCLC): Predictors for radiation pneumonitis and fibrosis. Int J Radiat Oncol Biol Phys 2006;65:1075-1086
23. Travis EL, Down JD. Repair in mouse lung after split doses of X rays. Radiat Res 1981;87:166-174
24. Mahmood J, Jelveh S, Zaidi A, Doctrow SR, Hill RP. Mitigation of radiation- induced lung injury with EUK-207 and genistein: Effects in adolescent rats. Radiat Res 2013;179:125-134
25. Novakova-Jiresova A, van Luijk P, van Goor H, Kampinga HH, Coppes RP. Pulmonary radiation injury: Identification of risk factors associated with regional hypersensitivity. Cancer Res 2005;65:3568-3576
26. Hill RP, Zaidi A, Mahmood J, Jelveh S. Investigations into the role of inflammation in normal tissue response to irradiation. Radiother Oncol 2011;101:73-79
27. Tsoutsou PG, Koukourakis MI. Radiation pneumonitis and fibrosis: Mechanisms underlying its pathogenesis and implications for future research. Int J Radiat Oncol Biol Phys 2006;66:1281-1293
28. Williams JP, Jackson IL, Shah JR, Czarniecki CW, Maidment BW, DiCarlo AL. Animal models and medical countermeasures development for radiation-induced lung damage: Report from an NIAID Workshop. Radiat Res 2012;177:e0025-e0039
29. Chen MF, Chen WC, Lai CH, Hung CH, Liu KC, Cheng YH. Predictive factors of radiation-induced skin toxicity in breast cancer patients. BMC Cancer 2010;10:508
30. Kirova YM, Fromantin I, De Rycke Y, et al. Can we decrease the skin reaction in breast cancer patients using hyaluronic acid during radiation therapy? Results of phase III randomised trial. Radiother Oncol 2011;100:205-209
31. Metz JM, Smith D, Mick R, et al. A phase I study of topical Tempol for the prevention of alopecia induced by whole brain radiotherapy. Clin Cancer Res 2004;10:6411-6417
32. Citrin D, Cotrim AP, Hyodo F, Baum BJ, Krishna MC, Mitchell JB. Radioprotectors and mitigators of radiation-induced normal tissue injury. Oncologist 2010;15:360-371
33. Kim JH, Kolozsvary A, Jenrow KA, Brown SL. Plerixafor, a CXCR4 antagonist, mitigates skin radiation-induced injury in mice. Radiat Res 2012;178:202-206