Differential effect of soy isoflavones in enhancing high intensity radiotherapy and protecting lung tissue in a pre-clinical model of lung carcinoma

Radiotherapy and Oncology

Volumn 109, Issue 1, 2013, Pages 117-125

  Hillman, Gilda G ^a   Singh Gupta, Vinita ^a   Hoogstra, David J ^a   Abernathy, Lisa ^a   Rakowski, Joseph ^a   Yunker, Christopher K ^a   Rothstein, Shoshana E ^a   Sarkar, Fazlul H ^a   Gadgeel, Shirish ^a   Konski, Andre A ^a   Lonardo, Fulvio ^a   Joiner, Michael C ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Lung cancer; Radiation; Soy isoflavones

Indexed keywords

ISOFLAVONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; BLOOD VESSEL INJURY; CANCER CELL; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER RADIOTHERAPY; CANCER SIZE; CHEMORADIOTHERAPY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG MEGADOSE; HISTOPATHOLOGY; IMMUNOFLUORESCENCE TEST; LOW DRUG DOSE; LUNG ALVEOLUS WALL; LUNG CARCINOMA; LUNG FIBROSIS; LUNG NON SMALL CELL CANCER; LUNG PARENCHYMA; MOUSE; MULTIMODALITY CANCER THERAPY; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INJURY; RADIOSENSITIZATION; SOYBEAN; THERAPY EFFECT; TREATMENT RESPONSE;

LUNG CANCER; RADIATION; SOY ISOFLAVONES;

ANIMALS; CELL LINE, TUMOR; CYTOKINES; FEMALE; HUMANS; ISOFLAVONES; LUNG; LUNG NEOPLASMS; MICE; RADIATION PNEUMONITIS; RADIATION-PROTECTIVE AGENTS; RADIATION-SENSITIZING AGENTS; SOYBEANS;

EID: 84888049540     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2013.08.015     Document Type: Article

References (40)

1. R. Siegel, D. Naishadham, and A. Jemal Cancer statistics, 2012 CA Cancer J Clin 62 2012 10 29
2. J.P. van Meerbeeck, S. Meersschout, and R. De Pauw Modern radiotherapy as part of combined modality treatment in locally advanced non-small cell lung cancer: present status and future prospects Oncologist 13 2008 700 708
3. A.W. Blackstock, and R. Govindan Definitive chemoradiation for the treatment of locally advanced non small-cell lung cancer J Clin Oncol 25 2007 4146 4152
4. J.D. Bradley, K. Bae, and M.V. Graham Primary analysis of the phase II component of a phase I/II dose intensification study using three-dimensional conformal radiation therapy and concurrent chemotherapy for patients with inoperable non-small-cell lung cancer: RTOG 0117 J Clin Oncol 28 2010 2475 2480
5. F.M. Kong, J.A. Hayman, and K.A. Griffith Final toxicity results of a radiation-dose escalation study in patients with non-small-cell lung cancer (NSCLC): predictors for radiation pneumonitis and fibrosis Int J Radiat Oncol Biol Phys 65 2006 1075 1086
6. J.M. Schallenkamp, R.C. Miller, and D.H. Brinkmann Incidence of radiation pneumonitis after thoracic irradiation: dose-volume correlates Int J Radiat Oncol Biol Phys 67 2007 410 416
7. H. Jin, S.L. Tucker, and H.H. Liu Dose-volume thresholds and smoking status for the risk of treatment-related pneumonitis in inoperable non-small cell lung cancer treated with definitive radiotherapy Radiother Oncol 91 2009 427 432
8. R.P. Hill Radiation effects on the respiratory system BJR Suppl 27 2005 75 81
9. S.M. Bentzen Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology Nat Rev Cancer 6 2006 702 713
10. R.P. Hill, A. Zaidi, and J. Mahmood Investigations into the role of inflammation in normal tissue response to irradiation Radiother Oncol 101 2011 73 79
11. P.G. Tsoutsou, and M.I. Koukourakis Radiation pneumonitis and fibrosis: mechanisms underlying its pathogenesis and implications for future research Int J Radiat Oncol Biol Phys 66 2006 1281 1293
12. J.P. Williams, I.L. Jackson, and J.R. Shah Animal models and medical countermeasures development for radiation-induced lung damage: report from an NIAID Workshop Radiat Res 177 2012 e0025 0039
13. J. Yarnold, and M.C. Brotons Pathogenetic mechanisms in radiation fibrosis Radiother Oncol 97 2010 149 161
14. J.P. Williams, C.J. Johnston, and J.N. Finkelstein Treatment for radiation-induced pulmonary late effects: spoiled for choice or looking in the wrong direction? Curr Drug Targets 11 2010 1386 1394
15. G.G. Hillman, V. Singh-Gupta, and L. Runyan Soy isoflavones radiosensitize lung cancer while mitigating normal tissue injury Radiother Oncol 101 2011 329 336
16. G.G. Hillman, Y. Wang, and O. Kucuk Genistein potentiates inhibition of tumor growth by radiation in a prostate cancer orthotopic model Mol Cancer Ther 3 2004 1271 1279
17. G.G. Hillman, Y. Wang, and M. Che Progression of renal cell carcinoma is inhibited by genistein and radiation in an orthotopic model BMC Cancer 7 2007 4
18. J.J. Raffoul, S. Banerjee, and M. Che Soy isoflavones enhance radiotherapy in a metastatic prostate cancer model Int J Cancer 120 2007 2491 2498
19. J.J. Raffoul, S. Banerjee, and V. Singh-Gupta Down-regulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 expression by soy isoflavones enhances prostate cancer radiotherapy in vitro and in vivo Cancer Res 67 2007 2141 2149
20. V. Singh-Gupta, M.C. Joiner, and L. Runyan Soy isoflavones augment radiation effect by inhibiting APE1/Ref-1 DNA repair activity in non-small cell lung cancer J Thorac Oncol 6 2011 688 698
21. V. Singh-Gupta, H. Zhang, and S. Banerjee Radiation-induced HIF-1alpha cell survival pathway is inhibited by soy isoflavones in prostate cancer cells Int J Cancer 124 2009 1675 1684
22. G.G. Hillman, and V. Singh-Gupta Soy isoflavones sensitize cancer cells to radiotherapy Free Radic Biol Med 51 2011 289 298
23. A.E. Para, A. Bezjak, and I.W. Yeung Effects of genistein following fractionated lung irradiation in mice Radiother Oncol 92 2009 500 510
24. S. Morikawa, P. Baluk, and T. Kaidoh Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors Am J Pathol 160 2002 985 1000
25. P. Baluk, S. Morikawa, and A. Haskell Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors Am J Pathol 163 2003 1801 1815
26. G. Bergers, and S. Song The role of pericytes in blood-vessel formation and maintenance Neuro Oncol 7 2005 452 464
27. T. Ashcroft, J.M. Simpson, and V. Timbrell Simple method of estimating severity of pulmonary fibrosis on a numerical scale J Clin Pathol 41 1988 467 470
28. R.H. Hubner, W. Gitter, and N.E. El Mokhtari Standardized quantification of pulmonary fibrosis in histological samples Biotechniques 44 2008 507-511, 514-517
29. X. Ao, L. Zhao, and M.A. Davis Radiation produces differential changes in cytokine profiles in radiation lung fibrosis sensitive and resistant mice J Hematol Oncol 2 2009 6
30. M. Baumann, T. Herrmann, and R. Koch Final results of the randomized phase III CHARTWEL-trial (ARO 97-1) comparing hyperfractionated-accelerated versus conventionally fractionated radiotherapy in non-small cell lung cancer (NSCLC) Radiother Oncol 100 2011 76 85
31. K.P. Farr, A.A. Khalil, and M.M. Knap Development of radiation pneumopathy and generalised radiological changes after radiotherapy are independent negative prognostic factors for survival in non-small cell lung cancer patients Radiother Oncol 107 2013 382 388
32. R. Timmerman, R. Paulus, and J. Galvin Stereotactic body radiation therapy for inoperable early stage lung cancer JAMA 303 2010 1070 1076
33. S. Senan, D.A. Palma, and F.J. Lagerwaard Stereotactic ablative radiotherapy for stage I NSCLC: recent advances and controversies J Thorac Dis 3 2011 189 196
34. S.S. Lo, A. Sahgal, and E.L. Chang Serious complications associated with stereotactic ablative radiotherapy and strategies to mitigate the risk Clin Oncol (R Coll Radiol) 25 2013 378 387
35. V.L. Calveley, S. Jelveh, and A. Langan Genistein can mitigate the effect of radiation on rat lung tissue Radiat Res 173 2010 602 611
36. J. Mahmood, S. Jelveh, and A. Zaidi Mitigation of radiation-induced lung injury with EUK-207 and genistein: effects in adolescent rats Radiat Res 179 2013 125 134
37. G. Ghobadi, B. Bartelds, and S.J. van der Veen Lung irradiation induces pulmonary vascular remodelling resembling pulmonary arterial hypertension Thorax 67 2012 334 341
38. I.U. Ahmad, J.D. Forman, and F.H. Sarkar Soy isoflavones in conjunction with radiation therapy in patients with prostate cancer Nutr Cancer 62 2010 996 1000
39. D. Citrin, A.P. Cotrim, and F. Hyodo Radioprotectors and mitigators of radiation-induced normal tissue injury Oncologist 15 2010 360 371
40. M. Messina, O. Kucuk, and J.W. Lampe An overview of the health effects of isoflavones with an emphasis on prostate cancer risk and prostate-specific antigen levels J AOAC Int 89 2006 1121 1134