Computable cause-and-effect models of healthy and Alzheimer's disease states and their mechanistic differential analysis

Alzheimer's and Dementia

Volumn 11, Issue 11, 2015, Pages 1329-1339

  Kodamullil, Alpha Tom ^a,b   Younesi, Erfan ^a   Naz, Mufassra ^a,b   Bagewadi, Shweta ^a,b   Hofmann Apitius, Martin ^a,b  

^a FRAUNHOFER INSTITUTE FOR ALGORITHMS AND SCIENTIFIC COMPUTING SCAI   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Alzheimer's disease; Alzheimer's disease model; APP; Neurotrophin signaling; OpenBEL; Type 2 diabetes mellitus

Indexed keywords

AMYLOID BETA PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CLATHRIN ASSEMBLY PROTEIN; CLUSTERIN; I KAPPA B KINASE BETA; MICRORNA; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR; NEUROTROPHIN; PHOSPHATIDYLINOSITOL BINDING CLATHRIN ASSEMBLY PROTEIN; PROTEIN KINASE LKB1; UBIQUITIN CARBOXYL TERMINAL ESTERASE L1; UBIQUITIN THIOLESTERASE; UNCLASSIFIED DRUG; AMYLOID PRECURSOR PROTEIN; APP PROTEIN, HUMAN;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; BRAIN NERVE CELL; CELL SURVIVAL; COMORBIDITY; COMPUTER MODEL; CORRELATION ANALYSIS; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC VARIABILITY; INSULIN RELEASE; NERVE CELL DIFFERENTIATION; NERVE CELL GROWTH; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; ANIMAL; BIOLOGICAL MODEL; BRAIN; COMPLICATION; GENETICS; HUMAN; METABOLISM; NERVE CELL; PATHOPHYSIOLOGY; PHYSIOLOGY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; COMORBIDITY; HUMANS; MODELS, NEUROLOGICAL; NEURONS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84947868332     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2015.02.006     Document Type: Article

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