On the identification of low allele frequency mosaic mutations in the brains of Alzheimer's disease patients

Alzheimer's and Dementia

Volumn 11, Issue 11, 2015, Pages 1265-1276

  Sala Frigerio, Carlo ^a   Lau, Pierre ^a   Troakes, Claire ^b   Deramecourt, Vincent ^c   Gele, Patrick ^c   Van Loo, Peter ^a,d,e   Voet, Thierry ^a,e   De Strooper, Bart ^a,f  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIV LILLE   (France)

^d THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^e WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^f UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Alzheimer's disease; Genetics; Mosaicism; Prion like spread; Somatic mutation

Indexed keywords

AMYLOID PRECURSOR PROTEIN; PRESENILIN 1; PRESENILIN 2; APP PROTEIN, HUMAN; MAPT PROTEIN, HUMAN; PSEN1 PROTEIN, HUMAN; PSEN2 PROTEIN, HUMAN; TAU PROTEIN;

ALZHEIMER DISEASE; AMPLICON; ARTICLE; BRAIN REGION; CELL COUNT; COHORT ANALYSIS; CONTROLLED STUDY; COPY NUMBER VARIATION; DNA EXTRACTION; DNA LIBRARY; DNA SEQUENCE; ENTORHINAL CORTEX; GENE; GENE FREQUENCY; GENE MUTATION; GENOMICS; HETEROZYGOTE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MOSAICISM; NEUROFIBRILLARY TANGLE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SOMATIC MUTATION; AGED; GENETICS; HIGH THROUGHPUT SEQUENCING; METABOLISM; MUTATION; PILOT STUDY; PROCEDURES; VALIDATION STUDY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; COHORT STUDIES; DNA COPY NUMBER VARIATIONS; ENTORHINAL CORTEX; GENE FREQUENCY; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MOSAICISM; MUTATION; PILOT PROJECTS; POLYMORPHISM, SINGLE NUCLEOTIDE; PRESENILIN-1; PRESENILIN-2; SEQUENCE ANALYSIS, DNA; TAU PROTEINS;

EID: 84947865675     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2015.02.007     Document Type: Article

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