Investigating the role of rare coding variability in Mendelian dementia genes (APP, PSEN1, PSEN2, GRN, MAPT, and PRNP) in late-onset Alzheimer's disease

Neurobiology of Aging

Volumn 35, Issue 12, 2014, Pages 2881.e1-2881.e6

  Sassi, Celeste ^a,b   Guerreiro, Rita ^a,b   Gibbs, Raphael ^a,b   Ding, Jinhui ^b   Lupton, Michelle K ^c   Troakes, Claire ^c   Al Sarraj, Safa ^c   Niblock, Michael ^c   Gallo, Jean Marc ^c   Adnan, Jihad ^c   Killick, Richard ^c   Brown, Kristelle S ^d   Medway, Christopher ^d   Lord, Jenny ^d   Turton, James ^d   Bras, Jose ^a   Morgan, Kevin ^d   Powell, John F ^c   Singleton, Andrew ^b   Hardy, John ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Alzheimer's disease; APP; Exome sequencing; GRN; MAPT; Neurodegenerative dementia; PRNP; PSEN1; PSEN2

Indexed keywords

AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; PRESENILIN 1; PRESENILIN 2; APP PROTEIN, HUMAN; GRN PROTEIN, HUMAN; MAPT PROTEIN, HUMAN; PRION; PRNP PROTEIN, HUMAN; PSEN1 PROTEIN, HUMAN; PSEN2 PROTEIN, HUMAN; SIGNAL PEPTIDE; TAU PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; APP GENE; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; FEMALE; GENE; GENE MUTATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; GRN GENE; HUMAN; MAJOR CLINICAL STUDY; MALE; MAPT GENE; MOLECULAR PATHOLOGY; NEUROPATHOLOGY; NUCLEOTIDE SEQUENCE; PRNP GENE; PSEN1 GENE; PSEN2 GENE; SEQUENCE ALIGNMENT; UNITED KINGDOM; VERY ELDERLY; DEMENTIA; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; MIDDLE AGED; PRION;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; COHORT STUDIES; DEMENTIA; DIAGNOSIS, DIFFERENTIAL; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; GENETIC VARIATION; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; PRESENILIN-1; PRESENILIN-2; PRIONS; TAU PROTEINS;

EID: 84911430470     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2014.06.002     Document Type: Article

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