Salvia miltiorrhiza extract protects white matter and the hippocampus from damage induced by chronic cerebral hypoperfusion in rats

BMC Complementary and Alternative Medicine

Volumn 15, Issue 1, 2015, Pages

  Kim, Min Soo ^a,d   Bang, Ji Hye ^a,b   Lee, Jun ^a,e   Kim, Hyeon Woo ^c   Sung, Sang Hyun ^c   Han, Jung Soo ^d   Jeon, Won Kyung ^a  

^a Korea Institute of Oriental Medicine (KIOM)   (South Korea)

^b Keimyung University   (South Korea)

^c Seoul National University   (South Korea)

^d Konkuk University   (South Korea)

^e University of Science and Technology (UST)   (South Korea)

Author keywords

Chronic cerebral hypoperfusion; Myelin basic protein; Salvia miltiorrhiza; Toll like receptor

Indexed keywords

CAFFEIC ACID; CARRIER PROTEINS AND BINDING PROTEINS; INTERLEUKIN 1BETA; INTERLEUKIN 6; IONIZED CALCIUM BINDING ADAPTOR MOLECULE 1; MYELIN BASIC PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; PLANT MEDICINAL PRODUCT; PROTOCATECHUALDEHYDE; ROSMARINIC ACID; SALVIA MILTIORRHIZA EXTRACT; SALVIANIC ACID A; SALVIANOLIC ACID A; SALVIANOLIC ACID B; SALVIANOLIC ACID E; SALVIANOLIC ACID G; SALVIANOLIC ACID L; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; HERBACEOUS AGENT; PROTECTIVE AGENT; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; BRAIN PROTECTION; CAROTID ARTERY OBSTRUCTION; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG MECHANISM; DRUG STRUCTURE; HIPPOCAMPAL TISSUE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; MULTIINFARCT DEMENTIA; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PROTEIN EXPRESSION; RAT; UPREGULATION; WESTERN BLOTTING; WHITE MATTER; WISTAR RAT; ANIMAL; BRAIN ISCHEMIA; CHEMISTRY; DRUG EFFECTS; GENETICS; HUMAN; INJURIES; METABOLISM; PERFUSION; SALVIA MILTIORRHIZA;

ANIMALS; BRAIN ISCHEMIA; DRUGS, CHINESE HERBAL; HIPPOCAMPUS; HUMANS; INTERLEUKIN-1BETA; INTERLEUKIN-6; MALE; PERFUSION; PROTECTIVE AGENTS; RATS; RATS, WISTAR; SALVIA MILTIORRHIZA; TUMOR NECROSIS FACTOR-ALPHA; WHITE MATTER;

EID: 84947813959     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/s12906-015-0943-6     Document Type: Article

References (55)

1. Joutel A, Corpechot C, Ducros A, Vahedi K, Chabriat H, Mouton P, et al. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature. 1996;383(6602):707-10.
2. Cechetti F, Pagnussat AS, Worm PV, Elsner VR, Ben J, da Costa MS, et al. Chronic brain hypoperfusion causes early glial activation and neuronal death, and subsequent long-term memory impairment. Brain Res Bull. 2012;87(1):109-16.
3. Bang J, Jeon WK, Lee IS, Han JS, Kim BY. Biphasic functional regulation in hippocampus of rat with chronic cerebral hypoperfusion induced by permanent occlusion of bilateral common carotid artery. PLoS One. 2013;8(7):e70093.
4. Farkas E, Luiten PG, Bari F. Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases. Brain Res Rev. 2007;54(1):162-80.
5. O'Sullivan M. Leukoaraiosis. Pract Neurol. 2008;8(1):26-38.
6. Cho KO, La HO, Cho YJ, Sung KW, Kim SY. Minocycline attenuates white matter damage in a rat model of chronic cerebral hypoperfusion. J Neurosci Res. 2006;83(2):285-91.
7. Lee KM, Bang JH, Han JS, Kim BY, Lee IS, Kang HW, et al. Cardiotonic pill attenuates white matter and hippocampal damage via inhibiting microglial activation and downregulating ERK and p38 MAPK signaling in chronic cerebral hypoperfused rat. BMC Complement Altern Med. 2013;13:334.
8. Saito K, Suyama K, Nishida K, Sei Y, Basile AS. Early increases in TNF-alpha, IL-6 and IL-1 beta levels following transient cerebral ischemia in gerbil brain. Neurosci Lett. 1996;206(2-3):149-52.
9. Yang QW, Li JC, Lu FL, Wen AQ, Xiang J, Zhang LL, et al. Upregulated expression of toll-like receptor 4 in monocytes correlates with severity of acute cerebral infarction. J Cereb Blood Flow Metab. 2008;28(9):1588-96.
10. Jeon WK, Ma J, Choi BR, Han SH, Jin Q, Hwang BY, et al. Effects of Fructus mume Extract on MAPK and NF-kappaB Signaling and the Resultant Improvement in the Cognitive Deficits Induced by Chronic Cerebral Hypoperfusion. Evid Based Complement Altern Med. 2012;2012:450838.
11. Caso JR, Pradillo JM, Hurtado O, Lorenzo P, Moro MA, Lizasoain I. Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke. Circulation. 2007;115(12):1599-608.
12. Chen X, Guo J, Bao J, Lu J, Wang Y. The anticancer properties of Salvia miltiorrhiza Bunge (Danshen): a systematic review. Med Res Rev. 2014;34(4):768-94.
13. Chan TY. Interaction between warfarin and danshen (Salvia miltiorrhiza). Ann Pharmacother. 2001;35(4):501-4.
14. Liu J, Shen HM, Ong CN. Salvia miltiorrhiza inhibits cell growth and induces apoptosis in human hepatoma HepG(2) cells. Cancer Lett. 2000;153(1-2):85-93.
15. Ji XY, Tan BK, Zhu YZ. Salvia miltiorrhiza and ischemic diseases. Acta Pharmacol Sin. 2000;21(12):1089-94.
16. Wang B-Q. Salvia miltiorrhiza: Chemical and pharmacological review of a medicinal plant. J Med Plants Res. 2010;4(25):2813-20.
17. Stumpf C, Fan Q, Hintermann C, Raaz D, Kurfurst I, Losert S, et al. Anti-inflammatory effects of danshen on human vascular endothelial cells in culture. Am J Chin Med. 2013;41(5):1065-77.
18. Song YH, Liu Q, Lv ZP, Chen YY, Zhou YC, Sun XG. Protection of a polysaccharide from Salvia miltiorrhiza, a Chinese medicinal herb, against immunological liver injury in mice. Int J Biol Macromol. 2008;43(2):170-5.
19. Choi BR, Kwon KJ, Park SH, Jeon WK, Han SH, Kim HY, et al. Alternations of Septal-hippocampal System in the Adult Wistar Rat with Spatial Memory Impairments Induced by Chronic Cerebral Hypoperfusion. Exp Neurobiol. 2011;20(2):92-9.
20. Kim M-S, Jeon WK, Lee KW, Park YH, Han J-S. Ameliorating Effects of Ethanol Extract of Fructus mume on Scopolamine-Induced Memory Impairment in Mice. Evid Based Complement Altern Med. 2015;2015:102734.
21. Cai ZY, Yan Y, Chen R. Minocycline reduces astrocytic reactivation and neuroinflammation in the hippocampus of a vascular cognitive impairment rat model. Neurosci Bull. 2010;26(1):28-36.
22. Lim GP, Yang F, Chu T, Chen P, Beech W, Teter B, et al. Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. J Neurosci. 2000;20(15):5709-14.
23. Selmaj KW, Raine CS. Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann Neurol. 1988;23(4):339-46.
24. Wakita H, Tomimoto H, Akiguchi I, Lin JX, Ihara M, Ohtani R, et al. Ibudilast, a phosphodiesterase inhibitor, protects against white matter damage under chronic cerebral hypoperfusion in the rat. Brain Res. 2003;992(1):53-9.
25. Miki K, Ishibashi S, Sun L, Xu H, Ohashi W, Kuroiwa T, et al. Intensity of chronic cerebral hypoperfusion determines white/gray matter injury and cognitive/motor dysfunction in mice. J Neurosci Res. 2009;87(5):1270-81.
26. Kurumatani T, Kudo T, Ikura Y, Takeda M. White matter changes in the gerbil brain under chronic cerebral hypoperfusion. Stroke. 1998;29(5):1058-62.
27. Olson JK, Miller SD. Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J Immunol. 2004;173(6):3916-24.
28. Ziegler G, Harhausen D, Schepers C, Hoffmann O, Rohr C, Prinz V, et al. TLR2 has a detrimental role in mouse transient focal cerebral ischemia. Biochem Biophys Res Commun. 2007;359(3):574-9.
29. Zarember KA, Godowski PJ. Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J Immunol. 2002;168(2):554-61.
30. Tanimura N, Saitoh S, Matsumoto F, Akashi-Takamura S, Miyake K. Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling. Biochem Biophys Res Commun. 2008;368(1):94-9.
31. Takahashi K, Ouyang X, Komatsu K, Nakamura N, Hattori M, Baba A, et al. Sodium tanshinone IIA sulfonate derived from Danshen (Salvia miltiorrhiza) attenuates hypertrophy induced by angiotensin II in cultured neonatal rat cardiac cells. Biochem Pharmacol. 2002;64(4):745-9.
32. Han JY, Fan JY, Horie Y, Miura S, Cui DH, Ishii H, et al. Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion. Pharmacol Ther. 2008;117(2):280-95.
33. Kang BY, Chung SW, Kim SH, Ryu SY, Kim TS. Inhibition of interleukin-12 and interferon-gamma production in immune cells by tanshinones from Salvia miltiorrhiza. Immunopharmacology. 2000;49(3):355-61.
34. Lin YL, Lee TF, Huang YJ, Huang YT. Antiproliferative effect of salvianolic acid A on rat hepatic stellate cells. J Pharm Pharmacol. 2006;58(7):933-9.
35. Nakazawa T, Xui N, Hesong Z, Kinoshita M, Chiba T, Kaneko E, et al. Danshen inhibits oxysterol-induced endothelial cell apoptosis in vivo. J Atheroscler Thromb. 2005;12(3):132-7.
36. Woo KS, Yip TW, Chook P, Kwong SK, Szeto CC, Li JK, et al. Cardiovascular Protective Effects of Adjunctive Alternative Medicine (Salvia miltiorrhiza and Pueraria lobata) in High-Risk Hypertension. Evid Based Complement Altern Med. 2013;2013:132912.
37. Qian Q, Qian S, Fan P, Huo D, Wang S. Effect of Salvia miltiorrhiza hydrophilic extract on antioxidant enzymes in diabetic patients with chronic heart disease: a randomized controlled trial. Phytother Res. 2012;26(1):60-6.
38. Shen J, Yang K, Sun C, Zheng M. Analysis of active components in Salvia miltiorrhiza injection based on vascular endothelial cell protection. Acta Pharma. 2014;64(3):325-34.
39. Chen T, Liu W, Chao X, Zhang L, Qu Y, Huo J, et al. Salvianolic acid B attenuates brain damage and inflammation after traumatic brain injury in mice. Brain Res Bull. 2011;84(2):163-8.
40. Chen YH, Du GH, Zhang JT. Salvianolic acid B protects brain against injuries caused by ischemia-reperfusion in rats. Acta Pharmacol Sin. 2000;21(5):463-6.
41. Du GH, Qiu Y, Zhang JT. Salvianolic acid B protects the memory functions against transient cerebral ischemia in mice. J Asian Nat Prod Res. 2000;2(2):145-52.
42. Safaeian L, Tameh A, Ghannadi A, Naghani E, Tavazoei H, Alavi S. Protective effects of Echium amoenum Fisch. and CA Mey. against cerebral ischemia in the rats. Adv Biomed Res. 2015;4(1):107.
43. Wangensteen H, Samuelsen AB, Malterud KE. Antioxidant activity in extracts from coriander. Food Chem. 2004;88(2):293-7.
44. Vekaria RH, Patel MN, Bhalodiya PN, Patel V, Desai TR, Tirgar PR. Evaluation of neuroprotective effect of Coriandrum sativum linn. against ischemic-reperfusion insult in brain. Internatational J Phytopharmacology. 2012;3(2):186-93.
45. Lo CJ, Lin JG, Kuo JS, Chiang SY, Chen SC, Liao ET, et al. Effect of salvia miltiorrhiza bunge on cerebral infarct in ischemia-reperfusion injured rats. Am J Chin Med. 2003;31(2):191-200.
46. Cai M, Shin BY, Kim DH, Kim JM, Park SJ, Park CS, et al. Neuroprotective effects of a traditional herbal prescription on transient cerebral global ischemia in gerbils. J Ethnopharmacol. 2011;138(3):723-30.
47. Kim SK, Cho KO, Kim SY. The plasticity of posterior communicating artery influences on the outcome of white matter injury induced by chronic cerebral hypoperfusion in rats. Neurol Res. 2009;31(3):245-50.
48. Popko B, Puckett C, Lai E, Shine HD, Readhead C, Takahashi N, et al. Myelin deficient mice: expression of myelin basic protein and generation of mice with varying levels of myelin. Cell. 1987;48(4):713-21.
49. Wakita H, Tomimoto H, Akiguchi I, Matsuo A, Lin JX, Ihara M, et al. Axonal damage and demyelination in the white matter after chronic cerebral hypoperfusion in the rat. Brain Res. 2002;924(1):63-70.
50. Minami M, Katayama T, Satoh M. Brain cytokines and chemokines: roles in ischemic injury and pain. J Pharmacol Sci. 2006;100(5):461-70.
51. Banik NL. Pathogenesis of myelin breakdown in demyelinating diseases: role of proteolytic enzymes. Crit Rev Neurobiol. 1992;6(4):257-71.
52. Chakravarty S, Herkenham M. Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines. J Neurosci. 2005;25(7):1788-96.
53. Shinya K, Ito M, Makino A, Tanaka M, Miyake K, Eisfeld AJ, et al. The TLR4-TRIF pathway protects against H5N1 influenza virus infection. J Virol. 2012;86(1):19-24.
54. Cao CX, Yang QW, Lv FL, Cui J, Fu HB, Wang JZ. Reduced cerebral ischemia-reperfusion injury in Toll-like receptor 4 deficient mice. Biochem Biophys Res Commun. 2007;353(2):509-14.
55. Kim DH, Jeon SJ, Jung JW, Lee S, Yoon BH, Shin BY, et al. Tanshinone congeners improve memory impairments induced by scopolamine on passive avoidance tasks in mice. Eur J Pharmacol. 2007;574(2):140-7.