Effect of salvia miltiorrhiza hydrophilic extract on antioxidant enzymes in diabetic patients with chronic heart disease: A randomized controlled trial

Phytotherapy Research

Volumn 26, Issue 1, 2012, Pages 60-66

  Qian, Qingwen ^a   Qian, Shuhong ^a   Fan, Ping ^b   Huo, Dongxia ^a   Wang, Shijin ^a  

^a ZHENGZHOU UNIVERSITY   (China)

^b Zhengzhou 2nd People Hospital   (China)

Author keywords

chronic heart disease; diabetes; lipid profile; oxidative stress; Salvia miltiorrhiza

Indexed keywords

ACARBOSE; ANTIDIABETIC AGENT; ARYLDIALKYLPHOSPHATASE; GLIBENCLAMIDE; GLIPIZIDE; GLUTATHIONE; GLUTATHIONE REDUCTASE; MALONALDEHYDE; PLACEBO; SALVIA MILTIORRHIZA EXTRACT; SUPEROXIDE DISMUTASE;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; CHRONIC DISEASE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC DIET; DRUG EFFECT; DRUG SAFETY; ENZYME ACTIVITY; HEART DISEASE; HUMAN; MAJOR CLINICAL STUDY; OXIDATIVE STRESS; RANDOMIZED CONTROLLED TRIAL;

AGED; ANTIOXIDANTS; ARYLDIALKYLPHOSPHATASE; BIOLOGICAL MARKERS; CHRONIC DISEASE; DIABETES COMPLICATIONS; DIABETES MELLITUS; DRUGS, CHINESE HERBAL; GLUTATHIONE; GLUTATHIONE REDUCTASE; HEART DISEASES; HUMANS; HYPOGLYCEMIC AGENTS; MALONDIALDEHYDE; MIDDLE AGED; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT ROOTS; SALVIA MILTIORRHIZA; SUPEROXIDE DISMUTASE;

SALVIA MILTIORRHIZA;

EID: 84855710097     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3513     Document Type: Article

References (43)

1. Bakirel T, Bakirel U, Keles OU, Ulgen SG, Yardibi H,. 2008. In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits. J Ethnopharmacol 116: 64-73.
2. Baynes JW, Thorpe SR,. 1999. Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes 48: 1-9. (Pubitemid 29019345)
3. Bose AK, Mocanu MM, Carr RD, Yellon DM,. 2007. Myocardial ischaemia-reperfusion injury is attenuated by intact glucagon like peptide-1 (GLP-1) in the in vitro rat heart and may involve the p70s6K pathway. Cardiovasc Drugs Ther 21: 253-256. (Pubitemid 47387464)
4. Cao Y, Chai JG, Chen YC, et al,. 2009. Beneficial effects of danshensu, an active component of Salvia miltiorrhiza, on homocysteine metabolism via the trans-sulphuration pathway in rats. Br J Pharmacol 157: 482-490.
5. Chen Y, Huang W, Lui, Q,. 2004. [ Effect on of Danshen injection on oxidant/antioxidant system of geriatric refractory heart failure ]. Pract Clin Med 5: 15-17.
6. Cheng TO,. 2007. Cardiovascular effects of Danshen. Int J Cardiol 121: 9-22. (Pubitemid 47287779)
7. Di Lisa F, Kaludercic N, Carpi A, Menabo R, Giorgio M,. 2009. Mitochondria and vascular pathology. Pharmacol Rep 61: 123-130.
8. Doupis J, Rahangdale S, Gnardellis C, Pena SE, Malhotra A, Veves A,. 2011. Effects of diabetes and obesity on vascular reactivity, inflammatory cytokines, and growth factors. Obesity 19: 729-735.
9. El-Sharaky AS, Wahby MM, Bader El-Dein MM, Fawzy RA, El-Shahawy IN,. 2009. Mutual anti-oxidative effect of gossypol acetic acid and gossypol-iron complex on hepatic lipid peroxidation in male rats. Food Chem Toxicol 47: 2735-2741.
10. Guo ZJ, Zhang Y, Tang X, Li H, Sun QS,. 2008. Pharmacokinetic interaction between tanshinones and polyphenolic extracts of Salvia miltiorrhiza Bunge after intravenous administration in rats. Biol Pharm Bull 31: 1469-1474.
11. Hamamdzic D, Fenning RS, Patel D, et al,. 2010. Akt pathway is hypoactivated by synergistic actions of diabetes mellitus and hypercholesterolemia resulting in advanced coronary artery disease. Am J Physiol Heart Circ Physiol 299: H699-H706.
12. He Q, Zhao H, Chen W, Luo Z, Yu X, Wang W,. 2009. [ Prevention Chinese patients with Hypertension by treatment with S. miltiorrhiza and Valsartan ]. Guiding J Trad Chin Med Pharm 4: 15-17.
13. Hung YC, Wang PW, Pan TL, Bazylak G, Leu YL,. 2009. Proteomic screening of antioxidant effects exhibited by radix Salvia miltiorrhiza aqueous extract in cultured rat aortic smooth muscle cells under homocysteine treatment. J Ethnopharmacol 124: 463-474.
14. Jarvik GP, Rozek LS, Brophy VH, et al,. 2000. Paraoxonase (PON1) phenotype is a better predictor of vascular disease than is PON1(192) or PON1(55) genotype. Arterioscler Thromb Vasc Biol 20: 2441-2447.
15. Kim HY, Okamoto T, Yokozawa T,. 2009. Beneficial effects of Chinese prescription Kangen-karyu on diabetes associated with hyperlipidemia, advanced glycation endproducts, and oxidative stress in streptozotocin-induced diabetic rats. J Ethnopharmacol 124: 263-269.
16. Kim JY, Kim KM, Nan JX, et al,. 2003. Induction of apoptosis by tanshinone I via cytochrome c release in activated hepatic stellate cells. Pharmacol Toxicol 92: 195-200. (Pubitemid 36461223)
17. Krentz AJ,. 2003. Lipoprotein abnormalities and their consequences for patients with type 2 diabetes. Diab Obes Metab 5 (Suppl 1): S19-S27. (Pubitemid 37483614)
18. Lee SH, Han JS, Heo SJ, Hwang JY, Jeon YJ,. 2009. Protective effects of dieckol isolated from Ecklonia cava against high glucose-induced oxidative stress in human umbilical vein endothelial cells. Toxicol In Vitro 24: 375-381.
19. Leosco D, Rengo G, Iaccarino G, et al,. 2008. Exercise promotes angiogenesis and improves beta-adrenergic receptor signalling in the post-ischaemic failing rat heart. Cardiovasc Res 78: 385-394. (Pubitemid 351556096)
20. Li J,. 2010. Effect of Danshen root on antioxidant function in diabetic rats induced by STZ. Progr Vet Med 31: 30-33.
21. Lopes-Virella MF, Virella G,. 1992. Immune mechanisms of atherosclerosis in diabetes mellitus. Diabetes 41 (Suppl 2): 86-91.
22. Masini E, Cuzzocrea S, Mazzon E, Marzocca C, Mannaioni PF, Salvemini D,. 2002. Protective effects of M40403, a selective superoxide dismutase mimetic, in myocardial ischaemia and reperfusion injury in vivo. Br J Pharmacol 136: 905-917. (Pubitemid 34836865)
23. Merkler M, Reiner Z,. 2007. The burden of hyperlipidaemia and diabetes in cardiovascular diseases. Fundam Clin Pharmacol 21 (Suppl 2): 1-3. (Pubitemid 350132286)
24. Mize C, Langdon R,. 1962. Hepatic glutathione reductase. I. Purification and general kinetic properties. J Biol Chem 237: 1589-1595.
25. Nakagami H, Kaneda Y, Ogihara T, Morishita R,. 2005. Endothelial dysfunction in hyperglycemia as a trigger of atherosclerosis. Curr Diab Rev 1: 59-63.
26. Potenza MA, Gagliardi S, Nacci C, Carratu MR, Montagnani M,. 2009. Endothelial dysfunction in diabetes: from mechanisms to therapeutic targets. Curr Med Chem 16: 94-112.
27. Qi L, Wang T, Shi X, Li Q,. 2001. [ Effect of Salvia miltiorrhiza injection on antioxidation in patients with stable angina ]. Acta Univ Med Nahui 4: 287-289.
28. Qian S, Huo D, Qian Q,. 2008. Paraoxonase 1 activity in Northern Chinese diabetic patients with chronic renal failure. Acta Endocrinol (Buc) 3: 243-249.
29. Rodriguez MI, Escames G, Lopez LC, et al,. 2007. Melatonin administration prevents cardiac and diaphragmatic mitochondrial oxidative damage in senescence-accelerated mice. J Endocrinol 194: 637-643. (Pubitemid 47471232)
30. Rojas A, Mercadal E, Figueroa H, Morales MA,. 2008. Advanced glycation and ROS: a link between diabetes and heart failure. Curr Vasc Pharmacol 6: 44-51.
31. Tang PL, He FW, Pan TM,. 2006. Study of the protective effects on the ischemic and anoxic central nerve system of Danshen's hydrosoluble compositions. Hebei Med 6: 523-525.
32. Uchida K, Takase H, Nomura Y, et al,. 1994. Development of atherosclerosis in alloxan diabetic rats. J Atheroscler Thromb 1: 118-128.
33. Ungvari Z, Gupte SA, Recchia FA, Batkai S, Pacher P,. 2005. Role of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure. Curr Vasc Pharmacol 3: 221-229. (Pubitemid 40933045)
34. Wang Z, Zhu B, Xu N, Jin J, Tang FWH,. 2009. [ Effects of the extracts of Salvia miltiorrhiza on metabolism of plasma lipid and glucose in hyperlipidemic hamsters ]. Lishizhen Med Mat Med Res 22: 1067-1070.
35. Wei Y,. 1990. [ Inhibition of Salvia miltiorrhiza extract on lipid peroxidation in rat heart, liver, brain and tests ]. J Gannan Med Coll 4: 211-214.
36. Wu B, Liu M, Zhang S,. 2004. Dan Shen agents for acute ischaemic stroke. Cochrane Database Syst Rev: CD004295.
37. Xu G, Zhao W, Zhou Z, Zhang R, Zhu W, Liu X,. 2009. Danshen extracts decrease blood C reactive protein and prevent ischemic stroke recurrence: a controlled pilot study. Phytother Res 23: 1721-1725.
38. Xue M, Qian Q, Adaikalakoteswari A, Rabbani N, Babaei-Jadidi R, Thornalley PJ,. 2008. Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease. Diabetes 57: 2809-2817.
39. Yamagishi SI, Nakamura K, Matsui T, Ueda SI, Imaizumi T,. 2007. Role of postprandial hyperglycaemia in cardiovascular disease in diabetes. Int J Clin Pract 61: 83-87.
40. Zhang HS, Wang SQ,. 2007. Nrf2 is involved in the effect of tanshinone IIA on intracellular redox status in human aortic smooth muscle cells. Biochem Pharmacol 73: 1358-1366.
41. Zhang SJ, Cheng ZX, Lin YW, Qin J, Cheng YH, Liu SL,. 2007. [ Effect of composite salviae dropping pill on hyperlipemia patients with phlegm and blood stasis syndrome ]. Zhongguo Zhong Yao Za Zhi 32: 440-443.
42. Zhang XL, Wen L, Chen YJ, Zhu Y,. 2009. Vascular endothelial growth factor up-regulates the expression of intracellular adhesion molecule-1 in retinal endothelial cells via reactive oxygen species, but not nitric oxide. Chin Med J Engl 122: 338-343.
43. Zhang Y, Wu T, Cui L, Zhang X, et al,. 2008. Regulatory effects of the active fraction of Salvia miltiorrhiza and salvianolic acid B on the blood-lipid spectrum of ovariectomized rats. J Liaoning Univ Trad Chin Med 10: 146-148.