Gold nanoparticles increase endothelial paracellular permeability by altering components of endothelial tight junctions, and increase blood-brain barrier permeability in mice

Toxicological Sciences

Volumn 148, Issue 1, 2015, Pages 192-203

  Li, Ching Hao ^a,b   Shyu, Ming Kwang ^c   Jhan, Cheng ^d   Cheng, Yu Wen ^e   Tsai, Chi Hao ^d   Liu, Chen Wei ^d   Lee, Chen Chen ^f   Chen, Ruei Ming ^b,e,g   Kang, Jaw Jou ^d  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^f CHINA MEDICAL UNIVERSITY   (Taiwan)

^g TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

blood brain barrier; Endothelial barrier; paracellular permeability; protein kinase C zeta (PKC ); tight junction

Indexed keywords

GOLD NANOPARTICLE; PROTEIN KINASE C ZETA; TIGHT JUNCTION PROTEIN; DRUG CARRIER; GOLD; METAL NANOPARTICLE; NERVE PROTEIN; PROTEASOME; PROTEIN KINASE C;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOSENSOR; BLOOD BRAIN BARRIER; CAPILLARY ENDOTHELIAL CELL; CELL VIABILITY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; MEMBRANE PERMEABILITY; MOUSE; MTT ASSAY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TIGHT JUNCTION; TRANSMISSION ELECTRON MICROSCOPY; UMBILICAL VEIN ENDOTHELIAL CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; CAPILLARY PERMEABILITY; CELL CULTURE; CHEMISTRY; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; METABOLISM; PARTICLE SIZE; PHOSPHORYLATION; PROTEIN PROCESSING; TOXICOKINETICS; TUMOR CELL LINE; ULTRASTRUCTURE; VASCULAR ENDOTHELIUM;

ANIMALS; BLOOD-BRAIN BARRIER; CAPILLARY PERMEABILITY; CELL LINE, TUMOR; CELLS, CULTURED; DRUG CARRIERS; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; GOLD; HUMANS; MALE; METAL NANOPARTICLES; MICE, INBRED ICR; NERVE TISSUE PROTEINS; PARTICLE SIZE; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN KINASE C; PROTEIN PROCESSING, POST-TRANSLATIONAL; TIGHT JUNCTION PROTEINS; TIGHT JUNCTIONS; TOXICOKINETICS;

EID: 84947779009     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfv176     Document Type: Article

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