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Volumn 437, Issue 2, 2011, Pages 289-299

Protein kinase Cζ phosphorylates occludin and promotes assembly of epithelial tight junctions

Author keywords

Barrier function; Cell cell adhesion; Epithelium; Phosphothreonine; Protein kinase C (PKC ); Zona occludens 1 (ZO 1)

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CALCIUM; OCCLUDIN; PROTEIN KINASE C ZETA; PROTEIN ZO1; SERINE; SHORT HAIRPIN RNA; THREONINE;

EID: 79959736965     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20110587     Document Type: Article
Times cited : (91)

References (44)
  • 1
    • 10444264499 scopus 로고    scopus 로고
    • The molecular physiology of tight junction pores
    • Van Itallie, C. M. and Anderson, J. M. (2004) The molecular physiology of tight junction pores. Physiology 19, 331-338
    • (2004) Physiology , vol.19 , pp. 331-338
    • Van Itallie, C.M.1    Anderson, J.M.2
  • 2
    • 70449466824 scopus 로고    scopus 로고
    • The tight junction in inflammatory disease: Communication breakdown
    • Edelblum, K. L. and Turner, J. R. (2009) The tight junction in inflammatory disease: communication breakdown. Curr. Opin. Pharmacol. 9, 715-720
    • (2009) Curr. Opin. Pharmacol. , vol.9 , pp. 715-720
    • Edelblum, K.L.1    Turner, J.R.2
  • 4
    • 67649236348 scopus 로고    scopus 로고
    • Alterations in epithelial barrier function and host defense responses in chronic rhinosinusitis
    • Tieu, D. D., Kern, R. C. and Schleimer, R. P. (2009) Alterations in epithelial barrier function and host defense responses in chronic rhinosinusitis. J. Allergy Clin. Immunol. 124, 37-42
    • (2009) J. Allergy Clin. Immunol. , vol.124 , pp. 37-42
    • Tieu, D.D.1    Kern, R.C.2    Schleimer, R.P.3
  • 5
    • 0033061321 scopus 로고    scopus 로고
    • Transmembrane proteins in the tight junction barrier
    • Fanning, A. S., Mitic, L. L. and Anderson, J. M. (1999) Transmembrane proteins in the tight junction barrier. J. Am. Soc. Nephrol. 10, 1337-1345
    • (1999) J. Am. Soc. Nephrol. , vol.10 , pp. 1337-1345
    • Fanning, A.S.1    Mitic, L.L.2    Anderson, J.M.3
  • 6
    • 0033851771 scopus 로고    scopus 로고
    • Molecular physiology and pathophysiology of tight junctions I. Tight junction structure and function: Lessons from mutant animals and proteins
    • Mitic, L. L., Van Itallie, C. M. and Anderson, J. M. (2000) Molecular physiology and pathophysiology of tight junctions I. Tight junction structure and function: lessons from mutant animals and proteins. Am. J. Physiol. Gastrointest. Liver Physiol. 279, G250-G254
    • (2000) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.279
    • Mitic, L.L.1    Van Itallie, C.M.2    Anderson, J.M.3
  • 8
    • 0031893838 scopus 로고    scopus 로고
    • Molecular structure and assembly of the tight junction
    • Denker, B. M. and Nigam, S. K. (1998) Molecular structure and assembly of the tight junction. Am. J. Physiol. 274, F1-F9
    • (1998) Am. J. Physiol. , vol.274
    • Denker, B.M.1    Nigam, S.K.2
  • 10
    • 0034504947 scopus 로고    scopus 로고
    • 'Putting the squeeze' on the tight junction: Understanding cytoskeletal regulation
    • Turner, J. R. (2000) 'Putting the squeeze' on the tight junction: understanding cytoskeletal regulation. Semin. Cell Dev. Biol. 11, 301-308
    • (2000) Semin. Cell Dev. Biol. , vol.11 , pp. 301-308
    • Turner, J.R.1
  • 11
    • 52049083402 scopus 로고    scopus 로고
    • Oxidative stress-induced disruption of epithelial and endothelial tight junctions
    • Rao, R. (2008) Oxidative stress-induced disruption of epithelial and endothelial tight junctions. Front. Biosci. 13, 7210-7226
    • (2008) Front. Biosci. , vol.13 , pp. 7210-7226
    • Rao, R.1
  • 12
    • 0034967963 scopus 로고    scopus 로고
    • Role of protein tyrosine phosphorylation in acetaldehyde-induced disruption of epithelial tight junctions
    • Atkinson, K. J. and Rao, R. K. (2001) Role of protein tyrosine phosphorylation in acetaldehyde-induced disruption of epithelial tight junctions. Am. J. Physiol. Gastrointest. Liver Physiol. 280, G1280-G1288
    • (2001) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.280
    • Atkinson, K.J.1    Rao, R.K.2
  • 13
    • 41249094587 scopus 로고    scopus 로고
    • Role of phospholipase Cγ-induced activation of protein kinase Cε (PKCε) and PKCβI in epidermal growth factor-mediated protection of tight junctions from acetaldehyde in Caco-2 cell monolayers
    • Suzuki, T., Seth, A. and Rao, R. (2008) Role of phospholipase Cγ-induced activation of protein kinase Cε (PKCε) and PKCβI in epidermal growth factor-mediated protection of tight junctions from acetaldehyde in Caco-2 cell monolayers. J. Biol. Chem. 283, 3574-3583
    • (2008) J. Biol. Chem. , vol.283 , pp. 3574-3583
    • Suzuki, T.1    Seth, A.2    Rao, R.3
  • 14
    • 13844308129 scopus 로고    scopus 로고
    • Mechanism of TNF-α modulation of Caco-2 intestinal epithelial tight junction barrier: Role of myosin light-chain kinase protein expression
    • Ma, T. Y., Boivin, M. A., Ye, D., Pedram, A. and Said, H. M. (2005) Mechanism of TNF-α modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression. Am. J. Physiol. Gastrointest. Liver Physiol. 288, G422-G430
    • (2005) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.288
    • Ma, T.Y.1    Boivin, M.A.2    Ye, D.3    Pedram, A.4    Said, H.M.5
  • 15
    • 45849127579 scopus 로고    scopus 로고
    • Role of TNF-α in ileum tight junction alteration in mouse model of restraint stress
    • Mazzon, E. and Cuzzocrea, S. (2008) Role of TNF-α in ileum tight junction alteration in mouse model of restraint stress. Am. J. Physiol. Gastrointest. Liver Physiol. 294, G1268-G1280
    • (2008) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.294
    • Mazzon, E.1    Cuzzocrea, S.2
  • 16
    • 0036305854 scopus 로고    scopus 로고
    • A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease
    • Zolotarevsky, Y., Hecht, G., Koutsouris, A., Gonzalez, D. E., Quan, C., Tom, J., Mrsny, R. J. and Turner, J. R. (2002) A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. Gastroenterology 123, 163-172
    • (2002) Gastroenterology , vol.123 , pp. 163-172
    • Zolotarevsky, Y.1    Hecht, G.2    Koutsouris, A.3    Gonzalez, D.E.4    Quan, C.5    Tom, J.6    Mrsny, R.J.7    Turner, J.R.8
  • 17
    • 20444481707 scopus 로고    scopus 로고
    • Interferon-γ induces internalization of epithelial tight junction proteins via a macropinocytosis-like process
    • DOI 10.1096/fj.04-3260com
    • Bruewer, M., Utech, M., Ivanov, A. I., Hopkins, A. M., Parkos, C. A. and Nusrat, A. (2005) Interferon-γ induces internalization of epithelial tight junction proteins via a macropinocytosis-like process. FASEB J. 19, 923-933 (Pubitemid 40827713)
    • (2005) FASEB Journal , vol.19 , Issue.8 , pp. 923-933
    • Bruewer, M.1    Utech, M.2    Ivanov, A.I.3    Hopkins, A.M.4    Parkos, C.A.5    Nusrat, A.6
  • 18
    • 26244442836 scopus 로고    scopus 로고
    • Mechanism of IFN-? -induced endocytosis of tight junction proteins: Myosin II-dependent vacuolarization of the apical plasma membrane
    • Utech, M., Ivanov, A. I., Samarin, S. N., Bruewer, M., Turner, J. R., Mrsny, R. J., Parkos, C. A. and Nusrat, A. (2005) Mechanism of IFN-? -induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membrane. Mol. Biol. Cell 16, 5040-5052
    • (2005) Mol. Biol. Cell , vol.16 , pp. 5040-5052
    • Utech, M.1    Ivanov, A.I.2    Samarin, S.N.3    Bruewer, M.4    Turner, J.R.5    Mrsny, R.J.6    Parkos, C.A.7    Nusrat, A.8
  • 19
    • 0037258649 scopus 로고    scopus 로고
    • Association of nonreceptor tyrosine kinase c-Yes with tight junction protein occludin by coimmunoprecipitation assay
    • Chen, Y. H. and Lu, Q. (2003) Association of nonreceptor tyrosine kinase c-Yes with tight junction protein occludin by coimmunoprecipitation assay. Methods Mol. Biol. 218, 127-132
    • (2003) Methods Mol. Biol. , vol.218 , pp. 127-132
    • Chen, Y.H.1    Lu, Q.2
  • 20
    • 0036226069 scopus 로고    scopus 로고
    • Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells
    • Chen, Y. H., Lu, Q., Goodenough, D. A. and Jeansonne, B. (2002) Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells. Mol. Biol. Cell 13, 1227-1237
    • (2002) Mol. Biol. Cell , vol.13 , pp. 1227-1237
    • Chen, Y.H.1    Lu, Q.2    Goodenough, D.A.3    Jeansonne, B.4
  • 21
    • 0034703027 scopus 로고    scopus 로고
    • The coiled-coil domain of occludin can act to organize structural and functional elements of the epithelial tight junction
    • Nusrat, A., Chen, J. A., Foley, C. S., Liang, T. W., Tom, J., Cromwell, M., Quan, C. and Mrsny, R. J. (2000) The coiled-coil domain of occludin can act to organize structural and functional elements of the epithelial tight junction. J. Biol. Chem. 275, 29816-29822
    • (2000) J. Biol. Chem. , vol.275 , pp. 29816-29822
    • Nusrat, A.1    Chen, J.A.2    Foley, C.S.3    Liang, T.W.4    Tom, J.5    Cromwell, M.6    Quan, C.7    Mrsny, R.J.8
  • 22
    • 0038146915 scopus 로고    scopus 로고
    • Expression of kinase-inactive c-Src delays oxidative stress-induced disassembly and accelerates calcium-mediated reassembly of tight junctions in the Caco-2 cell monolayer
    • Basuroy, S., Sheth, P., Kuppuswamy, D., Balasubramanian, S., Ray, R. M. and Rao, R. K. (2003) Expression of kinase-inactive c-Src delays oxidative stress-induced disassembly and accelerates calcium-mediated reassembly of tight junctions in the Caco-2 cell monolayer. J. Biol. Chem. 278, 11916-11924
    • (2003) J. Biol. Chem. , vol.278 , pp. 11916-11924
    • Basuroy, S.1    Sheth, P.2    Kuppuswamy, D.3    Balasubramanian, S.4    Ray, R.M.5    Rao, R.K.6
  • 23
    • 1542677112 scopus 로고    scopus 로고
    • Role of phosphatidylinositol 3-kinase in oxidative stress-induced disruption of tight junctions
    • Sheth, P., Basuroy, S., Li, C., Naren, A. P. and Rao, R. K. (2003) Role of phosphatidylinositol 3-kinase in oxidative stress-induced disruption of tight junctions. J. Biol. Chem. 278, 49239-49245
    • (2003) J. Biol. Chem. , vol.278 , pp. 49239-49245
    • Sheth, P.1    Basuroy, S.2    Li, C.3    Naren, A.P.4    Rao, R.K.5
  • 24
    • 63249110007 scopus 로고    scopus 로고
    • Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery
    • Deli, M. A. (2009) Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery. Biochim. Biophys. Acta 1788, 892-910
    • (2009) Biochim. Biophys. Acta , vol.1788 , pp. 892-910
    • Deli, M.A.1
  • 25
    • 0029041046 scopus 로고
    • Regulated assembly of tight junctions by protein kinase C
    • Stuart, R. O. and Nigam, S. K. (1995) Regulated assembly of tight junctions by protein kinase C. Proc. Natl. Acad. Sci. U.S.A. 92, 6072-6076
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 6072-6076
    • Stuart, R.O.1    Nigam, S.K.2
  • 28
    • 0032487494 scopus 로고    scopus 로고
    • An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3
    • DOI 10.1083/jcb.143.1.95
    • Izumi, Y., Hirose, T., Tamai, Y., Hirai, S., Nagashima, Y., Fujimoto, T., Tabuse, Y., Kemphues, K. J. and Ohno, S. (1998) An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3. J. Cell Biol. 143, 95-106 (Pubitemid 28480520)
    • (1998) Journal of Cell Biology , vol.143 , Issue.1 , pp. 95-106
    • Izumi, Y.1    Hirose, T.2    Tamai, Y.3    Hirai, S.-I.4    Nagashima, Y.5    Fujimoto, T.6    Tabuse, Y.7    Kemphues, K.J.8    Ohno, S.9
  • 30
    • 30044442771 scopus 로고    scopus 로고
    • MAPK interacts with occludin and mediates EGF-induced prevention of tight junction disruption by hydrogen peroxide
    • DOI 10.1042/BJ20050959
    • Basuroy, S., Seth, A., Elias, B., Naren, A. P. and Rao, R. (2006) MAPK interacts with occludin and mediates EGF-induced prevention of tight junction disruption by hydrogen peroxide. Biochem. J. 393, 69-77 (Pubitemid 43049303)
    • (2006) Biochemical Journal , vol.393 , Issue.1 , pp. 69-77
    • Basuroy, S.1    Seth, A.2    Elias, B.3    Naren, A.P.4    Rao, R.5
  • 31
    • 22544434673 scopus 로고    scopus 로고
    • Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells
    • D'Souza, T., Agarwal, R. and Morin, P. J. (2005) Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells. J. Biol. Chem. 280, 26233-26240
    • (2005) J. Biol. Chem. , vol.280 , pp. 26233-26240
    • D'Souza, T.1    Agarwal, R.2    Morin, P.J.3
  • 32
    • 2142758644 scopus 로고    scopus 로고
    • Rab13 regulates PKA signaling during tight junction assembly
    • DOI 10.1083/jcb.200312118
    • Kohler, K., Louvard, D. and Zahraoui, A. (2004) Rab13 regulates PKA signaling during tight junction assembly. J. Cell Biol. 165, 175-180 (Pubitemid 38544520)
    • (2004) Journal of Cell Biology , vol.165 , Issue.2 , pp. 175-180
    • Kohler, K.1    Louvard, D.2    Zahraoui, A.3
  • 33
    • 0036901407 scopus 로고    scopus 로고
    • Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-β-catenin complexes from the cytoskeleton by oxidative stress
    • Rao, R. K., Basuroy, S., Rao, V. U., Karnaky, Jr, K. J. and Gupta, A. (2002) Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-β-catenin complexes from the cytoskeleton by oxidative stress. Biochem. J. 368, 471-481
    • (2002) Biochem. J. , vol.368 , pp. 471-481
    • Rao, R.K.1    Basuroy, S.2    Rao, V.U.3    Karnaky Jr., K.J.4    Gupta, A.5
  • 34
    • 34249668828 scopus 로고    scopus 로고
    • Protein phosphatases 2A and 1 interact with occludin and negatively regulate the assembly of tight junctions in the CACO-2 cell monolayer
    • Seth, A., Sheth, P., Elias, B. C. and Rao, R. (2007) Protein phosphatases 2A and 1 interact with occludin and negatively regulate the assembly of tight junctions in the CACO-2 cell monolayer. J. Biol. Chem. 282, 11487-11498
    • (2007) J. Biol. Chem. , vol.282 , pp. 11487-11498
    • Seth, A.1    Sheth, P.2    Elias, B.C.3    Rao, R.4
  • 35
    • 0033783241 scopus 로고    scopus 로고
    • Protein kinase C activation leads to dephosphorylation of occludin and tight junction permeability increase in LLC-PK1 epithelial cell sheets
    • Clarke, H., Soler, A. P. and Mullin, J. M. (2000) Protein kinase C activation leads to dephosphorylation of occludin and tight junction permeability increase in LLC-PK1 epithelial cell sheets. J. Cell Sci. 113, 3187-3196
    • (2000) J. Cell Sci. , vol.113 , pp. 3187-3196
    • Clarke, H.1    Soler, A.P.2    Mullin, J.M.3
  • 36
    • 0034861274 scopus 로고    scopus 로고
    • Enteropathogenic Escherichia coli activates ezrin, which participates in disruption of tight junction barrier function
    • Simonovic, I., Arpin, M., Koutsouris, A., Falk-Krzesinski, H. J. and Hecht, G. (2001) Enteropathogenic Escherichia coli activates ezrin, which participates in disruption of tight junction barrier function. Infect. Immun. 69, 5679-5688
    • (2001) Infect. Immun. , vol.69 , pp. 5679-5688
    • Simonovic, I.1    Arpin, M.2    Koutsouris, A.3    Falk-Krzesinski, H.J.4    Hecht, G.5
  • 37
    • 0035253394 scopus 로고    scopus 로고
    • Zonula adherens formation in Caenorhabditis elegans requires dlg-1, the homologue of the Drosophila gene discs large
    • Bossinger, O., Klebes, A., Segbert, C., Theres, C. and Knust, E. (2001) Zonula adherens formation in Caenorhabditis elegans requires dlg-1, the homologue of the Drosophila gene discs large. Dev. Biol. 230, 29-42
    • (2001) Dev. Biol. , vol.230 , pp. 29-42
    • Bossinger, O.1    Klebes, A.2    Segbert, C.3    Theres, C.4    Knust, E.5
  • 39
    • 0036731483 scopus 로고    scopus 로고
    • Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells
    • Manabe, N., Hirai, S., Imai, F., Nakanishi, H., Takai, Y. and Ohno, S. (2002) Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells. Dev. Dyn. 225, 61-69
    • (2002) Dev. Dyn. , vol.225 , pp. 61-69
    • Manabe, N.1    Hirai, S.2    Imai, F.3    Nakanishi, H.4    Takai, Y.5    Ohno, S.6
  • 40
    • 0037428288 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of occludin attenuates its interactions with ZO-1, ZO-2, and ZO-3
    • DOI 10.1016/S0006-291X(03)00167-0
    • Kale, G., Naren, A. P., Sheth, P. and Rao, R. K. (2003) Tyrosine phosphorylation of occludin attenuates its interactions with ZO-1, ZO-2, and ZO-3. Biochem. Biophys. Res. Commun. 302, 324-329 (Pubitemid 36397924)
    • (2003) Biochemical and Biophysical Research Communications , vol.302 , Issue.2 , pp. 324-329
    • Kale, G.1    Naren, A.P.2    Sheth, P.3    Rao, R.K.4
  • 41
    • 0037106581 scopus 로고    scopus 로고
    • APKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization
    • Suzuki, A., Ishiyama, C., Hashiba, K., Shimizu, M., Ebnet, K. and Ohno, S. (2002) aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization. J. Cell Sci. 115, 3565-3573
    • (2002) J. Cell Sci. , vol.115 , pp. 3565-3573
    • Suzuki, A.1    Ishiyama, C.2    Hashiba, K.3    Shimizu, M.4    Ebnet, K.5    Ohno, S.6
  • 42
    • 0025367731 scopus 로고
    • A method for measuring protein kinase C activity in permeabilized T lymphocytes by using peptide substrates. Evidence for multiple pathways of kinase activation
    • Alexander, D. R., Graves, J. D., Lucas, S. C., Cantrell, D. A. and Crumpton, M. J. (1990) A method for measuring protein kinase C activity in permeabilized T lymphocytes by using peptide substrates. Evidence for multiple pathways of kinase activation. Biochem. J. 268, 303-308
    • (1990) Biochem. J. , vol.268 , pp. 303-308
    • Alexander, D.R.1    Graves, J.D.2    Lucas, S.C.3    Cantrell, D.A.4    Crumpton, M.J.5
  • 43
    • 33846065117 scopus 로고    scopus 로고
    • Depletion of E-cadherin disrupts establishment but not maintenance of cell junctions in Madin-Darby canine kidney epithelial cells
    • Capaldo, C. T. and Macara, I. G. (2007) Depletion of E-cadherin disrupts establishment but not maintenance of cell junctions in Madin-Darby canine kidney epithelial cells. Mol. Biol. Cell 18, 189-200
    • (2007) Mol. Biol. Cell , vol.18 , pp. 189-200
    • Capaldo, C.T.1    Macara, I.G.2
  • 44
    • 67650306418 scopus 로고    scopus 로고
    • Protein phosphatase 2A plays a role in hydrogen peroxide-induced disruption of tight junctions in Caco-2 cell monolayers
    • Sheth, P., Samak, G., Shull, J. A., Seth, A. and Rao, R. (2009) Protein phosphatase 2A plays a role in hydrogen peroxide-induced disruption of tight junctions in Caco-2 cell monolayers. Biochem. J. 421, 59-70
    • (2009) Biochem. J. , vol.421 , pp. 59-70
    • Sheth, P.1    Samak, G.2    Shull, J.A.3    Seth, A.4    Rao, R.5


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