Characterisation of nicotine and cancer-enhancing anions in the common smokeless tobacco Afzal in Oman

Sultan Qaboos University Medical Journal

Volumn 15, Issue 4, 2015, Pages e469-e476

  Al Mukhaini, Nawal M ^a   Ba Omar, Taher A ^a   Eltayeb, Elsadig A ^a   Al Shehi, Aisha H ^a  

^a SULTAN QABOOS UNIVERSITY   (Oman)

Author keywords

Anions; Carcinogens; Gas chromatography mass spectrometry; Ion exchange chromatography; Nicotine; Oman; Smokeless tobaccos

Indexed keywords

EID: 84947754509     PISSN: 2075051X     EISSN: 20750528     Source Type: Journal    
DOI: 10.18295/squmj.2015.15.04.005     Document Type: Article

References (39)

1. World Health Organization International Agency for Research on Cancer. IARC monographs on the evaluation of carcinogenic risks to humans: Volume 89 - Smokeless tobacco and some tobacco-specific N-nitrosamines. From: www.monographs.iarc. fr/ENG/Monographs/vol89/mono89.pdf Accessed: Aug 2015.
2. Borgerding MF, Bodnar JA, Curtin GM, Swauger JE. The chemical composition of smokeless tobacco: A survey of products sold in the United States in 2006 and 2007. Regul Toxicol Pharmacol 2012; 64:367-87. doi: 10.1016/j. yrtph.2012.09.003.
3. National Cancer Institute. Smoking and tobacco control monographs: Monograph 2 - Smokeless tobacco or health: An international perspective. From: www.cancercontrol.cancer. gov/brp/tcrb/monographs/2/index.html Accessed: Aug 2015.
4. Stepanov I, Jensen J, Hatsukami D, Hecht SS. New and traditional smokeless tobacco: Comparison of toxicant and carcinogen levels. Nicotine Tob Res 2008; 10:1773-82. doi: 10.1080/14622200802443544.
5. Rickert WS, Joza PJ, Trivedi AH, Momin RA, Wagstaff WG, Lauterbach JH. Chemical and toxicological characterization of commercial smokeless tobacco products available on the Canadian market. Regul Toxicol Pharmacol 2009; 53:121-33. doi: 10.1016/j.yrtph.2008.12.004.
6. Zakiullah MS, Saeed M, Muhammad N, Khan SA, Gul F, Khuda F, et al. Assessment of potential toxicity of a smokeless tobacco product (naswar) available on the Pakistani market. Tob Control 2012; 21:396-401. doi: 10.1136/tc.2010.042630.
7. Prabhakar V, Jayakrishnan G, Nair SV, Ranganathan B. Determination of trace metals, moisture, pH and assessment of potential toxicity of selected smokeless tobacco products. Indian J Pharm Sci 2013; 75:262-9. doi: 10.4103/0250- 474X.117398.
8. Lauterbach JH, Bao M, Joza PJ, Rickert WS. Free-base nicotine in tobacco products: Part II - Determination of free-base nicotine in the aqueous extracts of smokeless tobacco products and the relevance of these findings to product design parameters. Regul Toxicol Pharm 2011; 59:8-18. doi: 10.1016/j. yrtph.2010.09.002.
9. Tomar SL, Henningfield JE. Review of the evidence that pH is a determinant of nicotine dosage from oral use of smokeless tobacco. Tob Control 1997; 6:219-25. doi: 10.1136/tc.6.3.219.
10. Rutqvist LE, Curvall M, Hassler T, Ringberger T, Wahlberg I. Swedish snus and the GothiaTekR standard. Harm Reduct J 2011; 8:11. doi: 10.1186/1477-7517-8-11.
11. Ammigan N, Nagabhushan M, Nair UJ, Amonkar AJ, Bhide SV. Effect of nutritional status on mutagenicity of urine excreted by rats treated with standard/experimental carcinogens. Indian J Exp Biol 1990; 28:711-13.
12. Hsu J, Arcot J, Lee NA. Nitrate and nitrite quantification from cured meat and vegetables and their estimated dietary intake in Australians. Food Chem 2009; 115:334-9. doi: 10.1016/j. foodchem.2008.11.081.
13. Al-Mukhaini N, Ba-Omar T, Eltayeb E, Al-Shehi A. Determination of heavy metals in the common smokeless tobacco Afzal in Oman. Sultan Qaboos Univ Med J 2014; 14:e349-55.
14. Centers for Disease Control and Prevention. Notice regarding requirement for annual submission of the quantity of nicotine contained in the smokeless tobacco products manufactured, imported, or packaged in the United States. Fed Regist 1999; 64:14086-96.
15. Stanfill SB, Connolly GN, Zhang L, Jia LT, Henningfield JE, Richter P, et al. Global surveillance of oral tobacco products: Total nicotine, unionised nicotine and tobacco-specific N-nitrosamines. Tob Control 2011; 20:e2. doi: 10.1136/ tc.2010.037465.
16. Lawler TS, Stanfill SB, Zhang L, Ashley DL, Watson CH. Chemical characterization of domestic oral tobacco products: Total nicotine, pH, unprotonated nicotine and tobaccospecific N-nitrosamines. Food Chem Toxicol 2013: 57:380-6. doi: 10.1016/j.fct.2013.03.011.
17. Centers for Disease Control and Prevention. Laboratory protocol to measure the quantity of nicotine contained in smokeless tobacco products manufactured, imported, or packaged in the United States. Federal Register 2009; 62:24116-19.
18. Hearn BA, Renner CC, Ding YS, Vaughan-Watson C, Stanfill SB, Zhang L, et al. Chemical analysis of Alaskan Iq'mik smokeless tobacco. Nicotine Tob Res 2013; 15:1283-8. doi: 10.1093/ntr/nts270.
19. Digard H, Gale N, Errington G, Peters N, McAdam K. Multianalyte approach for determining the extraction of tobacco constituents from pouched snus by consumers during use. Chem Cent J 2013; 7:55. doi: 10.1186/1752-153X-7-55.
20. Bhisey RA. Chemistry and toxicology of smokeless tobacco. Indian J Cancer 2012; 49: 364-72. doi: 10.4103/0019-509X. 107735.
21. Henningfield JE, Radzius A, Cone EJ. Estimation of available nicotine content of six smokeless tobacco products. Tob Control 1995; 4:57-61. doi: 10.1136/tc.4.1.57.
22. Dani JA, Heinemann S. Molecular and cellular aspects of nicotine abuse. Neuron 1996; 16:905-8. doi: 10.1016/S0896- 6273(00)80112-9.
23. Benowitz NL. Nicotine and smokeless tobacco. CA Cancer J Clin 1988; 38:244-7. doi: 10.3322/canjclin.38.4.244.
24. Idris AM, Ibrahim SO, Vasstrand EN, Johannessen AC, Lillehaug JR, Magnusson B, et al. The Swedish snus and the Sudanese toombak: Are they different? Oral Oncol 1998; 34:558-66. doi: 10.1016/S1368-8375(98)00047-5.
25. Wallström M. Harm and harm reduction in smokeless tobacco users. An in vitro and clinical study. From: gupea.ub.gu.se/ handle/2077/23719 Accessed: Aug 2015.
26. World Health Organization. Environmental health criteria 36: Fluorine and fluorides. From: www.inchem.org/documents/ ehc/ehc/ehc36.htm Accessed: Aug 2015.
27. World Health Organization. Chloride in drinking-water: Background document for development of WHO guidelines for drinking-water quality. From: www.who.int/water_sanitation_ health/dwq/chloride.pdf Accessed: Aug 2015.
28. European Commission. Reports of the Scientific Committee for Food (thirty-eighth series): Opinions of the Scientific Committee for Food on - Nitrates and nitrite. From: ec.europa. eu/food/safety/docs/labelling_nutrition-special_groups_foodchildren- scf_reports_38_en.pdf Accessed: Aug 2015.
29. Reinik M, Tamme T, Roasto M, Juhkam K, Jurtsenko S, Tenńo T, et al. Nitrites, nitrates and N-nitrosoamines in Estonian cured meat products: Intake by Estonian children and adolescents. Food Addit Contam 2005; 22:1098-105. doi: 10.1080/02652030500241827.
30. Food and Agriculture Organization of the United Nations and World Health Organization. Bromide ion. From: www. inchem.org/documents/jmpr/jmpmono/v88pr03.htm Accessed: Aug 2015.
31. National Research Council. Recommended Dietary Allowances. 10th ed. Washington, USA: National Academy Press, 1989. Pp. 186.
32. World Health Organization. Sulfate in drinking water: Background document for development of WHO guidelines for drinking-water quality. From: www.who.int/water_sanitation_ health/dwq/chemicals/sulfate.pdf Accessed: Aug 2015.
33. Takahashi M, Nishikawa A, Furukawa F, Enami T, Hasegawa T, Hayashi Y. Dose-dependent promoting effects of sodium chloride (NaCI) on rat glandular stomach carcinogenesis initiated with N-methyl-N'-nitro-N-nitrosoguanidine. Carcinogenesis 1994; 15:1429-32. doi: 10.1093/carcin/15.7.1429.
34. World Health Organization. Nitrate and nitrite in drinking water: Background document for development of WHO guidelines for drinking-water wuality. From: www.who.int/water_ sanitation_health/dwq/chemicals/nitratenitrite2ndadd.pdf Accessed: Aug 2015.
35. Gangolli SD, van den Brandt P, Feron VJ, Janzowsky C, Koeman JH, Speijers GJ, et al. Nitrate, nitrite and N-nitroso compounds. Eur J Pharmacol 1994; 292:1-38. doi: 10.1016/0926-6917(94)90022-1.
36. Jaffe ER. Methaemoglobinaemia in the differential diagnosis of cyanosis. Hosp Pract (Off Ed) 1985; 20:92-6.
37. Hoffmann D, Djordjevic MV, Fan J, Zang E, Glynn T, Connolly GN. Five leading U.S. commercial brands of moist snuff in 1994: Assessment of carcinogenic N-nitrosamines. J Natl Cancer Inst 1995; 87:1862-9. doi: 10.1093/jnci/87.24.1862.
38. Swedish Match. GOTHIATEKR standard: GOTHIATEKR limits for undesired components. From: www.swedishmatch.com/ en/Snus-and-health/GOTHIATEK/GOTHIATEK-standard/ Accessed: Aug 2015.
39. Joossens JV, Hill MJ, Elliott P, Stamler R, Lesaffre E, Dyer A, et al. Dietary salt, nitrate and stomach cancer mortality in 24 countries: Euopean Cancer Prevention (ECP) and the INTERSALT Cooperative Research Group. Int J Epidemiol 1996; 25:494-504. doi: 10.1093/ije/25.3.494.