Determination of trace metals, moisture, pH and assessment of potential toxicity of selected smokeless tobacco products

Indian Journal of Pharmaceutical Sciences

Volumn 75, Issue 3, 2013, Pages 262-269

  Prabhakar, V ^a   Jayakrishnan, G ^a   Nair, S V ^a   Ranganathan, B ^a  

^a AMRITA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

chewing tobacco; potential toxicity; Smokeless tobacco products; tobacco pH; trace metals

Indexed keywords

CADMIUM; CHROMIUM; COPPER; IRON; LEAD; MAGNESIUM; NICKEL; TRACE METAL; ZINC;

ARTICLE; CANCER RISK; CONCENTRATION (PARAMETERS); COPPER BLOOD LEVEL; CYTOTOXICITY; DRY WEIGHT; EXPOSURE; HUMAN; IN VITRO STUDY; IRON BLOOD LEVEL; LEAD BLOOD LEVEL; MAGNESIUM BLOOD LEVEL; MOISTURE; PH; SMOKELESS TOBACCO; TRACE METAL BLOOD LEVEL; VULNERABLE POPULATION; ZINC BLOOD LEVEL;

EID: 84883661287     PISSN: 0250474X     EISSN: 19983743     Source Type: Journal    
DOI: 10.4103/0250-474X.117398     Document Type: Article

References (41)

1. Vijayan VK, Kumar R. Tobacco cessation in India. Indian J Chest Dis Allied Sci 2005;47:5-8.
2. Reddy KS, Gupta PC. Report on tobacco control in India, Executive Summary, 2003. p. 1-32. Available from: http://ctchp.org/index.php?option=com- contentandview=articleandid=168:report-on-tobacco-control-in-indiaandcatid= 228andItemid=287. [Last accessed on 2013 Feb 23].
3. Thankappan KR, Thresia CU. Tobacco use and social status in Kerala. Indian J Med Res 2007;126:300-8. (Pubitemid 350200157)
4. Shimkhada R, Peabody JW. Tobacco control in India. Bull World Health Organ 2003;81:48-52. (Pubitemid 36168653)
5. Schneider G, Krivan V. Multi-elemental analysis of tobacco and smoke condensate by instrumental neutron activation analysis and atomic absorption spectrometry. Int J Environ Anal Chem 93;53:87-100.
6. Hoffmann D, Hoffmann I, El-Bayoumy K. The less harmful cigarette: A controversial issue. A tribute to Ernst L. Wynder. Chem Res Toxicol 2001;14:767-90. (Pubitemid 32663874)
7. Rickert WS, Joza PJ, Trivedi AH. Chemical and toxicological characterization of commercial smokeless tobacco products available on the Canadian market. Regul Toxicol Pharmacol 2009;53:121-33.
8. IARC working group on the evaluation of carcinogenic risks to humans. Smokeless tobacco and some tobacco-specific N-nitrosamines. IARC Monogr Eval Carcinog Risks Hum 2007;89:1-592.
9. Tobprac. Available from: http://www.hc-sc.gc.ca/hc-ps/tobac-tabac/ legislation/reg/indust/method/side-second/nicotine-eng.php. [Last accessed on 2011 Jul 07].
10. Saeed M, Muhammad N, Khan H. Analysis of toxic heavy metals in branded Pakistani herbal products. J Chem Soc Pak 2010;32:471-5.
11. Ajab H, Yasmeen S, Yaqub A. Evaluation of trace metals in tobacco of local and imported cigarette brands used in Pakistan by spectrophotometer through microwave digestion. J Toxicol Sci 2008;33:415-20.
12. Centers for Disease Control and Prevention, Department of Health and Human Services. Notice regarding revisions to the laboratory protocol to measure the quantity of nicotine contained in smokeless tobacco products manufactured, imported, or packaged in the United States. Fed Regist 2009;74:712-9.
13. CORESTA recommended method No56, Determination of water in tobacco and tobacco products by Karl Fischer method, May 2011. p. 1-7. Available from: http://www.coresta.org/Recommended-Methods/CRM-56-update%28May11%29.pdf. [Last accessed on 2013 Feb 23].
14. CORESTA recommended method No57, Determination of water in tobacco and tobacco products by Gas chromatographic analysis, December 2002. p. 1-8. Available from: http://www.coresta.org/Recommended-Methods/CRM-57.pdf. [Last accessed on 2013 Feb 23].
15. Ayo-Yusuf OA, Connolly GN. Applying toxicological risk assessment principles to constituents of smokeless tobacco products: Implications for product regulations. Tob Control 2011;20:53-7.
16. Zakiullah, Saeed M, Muhammad N, Khan SA, Gul F, Khuda F, et al. Assesment of potential toxicity of a smokeless tobacco product (naswar) availaible on the Pakistani market. Tob Control 2012;21:396-401.
17. Järup L, Berglund M, Elinder CG, Nordberg G, Vahter M. Health effects of cadmium exposure: A review of the literature and a risk estimate. Scand J Work Environ Health 1998;24:1-51. (Pubitemid 28161916)
18. Toxicological profile for lead: 2007. Available from: http://www.atsdr.cdc.gov/toxprofiles/tp13.pdf. [Last accessed on 2013 Jan 25].
19. Trumbo P, Yates AA, Schlicker S, Poos M. Dietary reference intakes: Vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium and zinc. J Am Diet Assoc 2001;101:294-301.
20. Ysart G, Miller P, Crews H, Robb P, Baxter M, De L'Argy C, et al. Dietary exposure estimates of 30 elements in the UK total diet study. Food Addit Contam 1999;16:391-403. (Pubitemid 29405934)
21. Ysart G, Miller P, Croasdale M, Crews H, Robb P, Baxter M, et al. 1997 UK total diet study-dietary exposure to aluminium, arsenic, cadmium, copper, lead, mercury, nickel, selenium, tin and zinc. Food Addit Contam 2000;17:775-86.
22. Lauterbach JH, Bao M, Joza PJ, Rickert WS. Free-base nicotine in tobacco products. Part II: Determination of free-base nicotine in the aqueous extracts of smokeless tobacco products and the relevance of these findings to product design parameters. Regul Toxicol Pharm 2011;59:8-18.
23. Armitage AK, Turner DM. Absorption of nicotine in cigarette and cigar smoke through the oral mucosa. Nature 1970;226:1231-2.
24. Tricker AR. Toxicology of tobacco-specific nitrosamines. Rec Adv Tob Sci 2001;27:75-102.
25. Chepiga TA, Morton MJ, Murphy PA. A comparison of the mainstream smoke chemistry and mutagenicity of a representative sample of the US cigarette market with two Kentucky reference cigarettes (K1R4F and K1R5F). Food Chem Toxicol 2000;38:949-62. (Pubitemid 32786713)
26. Rustemeier K, Stabbert R, Haussmann HJ, Roemer E, Carmines EL. Evaluation of the potential effects of ingredients added to cigarettes. Part 2: Chemical composition of main stream smoke. Food Chem Toxicol 2002;40:93-104. (Pubitemid 33132144)
27. FDA (Food and Drug Administration): Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Report of the panel on micronutrients. Food and Drug Administration. Dietary Supplements. Washington DC: National Academy Press; 2001, p. 224-579.
28. Mrugesh T, Dipa L, Manishika G. Effect of lead on human erythrocytes: An in vitro study. Acta Pol Pharm 2011;66:653-6.
29. Ikem A, Egiebor NO. Assessment of trace elements in canned fishes (mackerel, tuna, salmon, sardines and herrings) marketed in Georgia and Alabama (United States of America). J Food Comp Anal 2005;18:771-87. (Pubitemid 40668473)
30. JECFA. Joint FAO/WHO Committee on Food Additives. Evaluation of certain food additives and contaminants. 55th report of the Joint FAO/WHO Committee on Food Additives; 2000. p. 16-20.
31. Agency for toxic substances and disease registry. Draft toxicological profile for cadmium. Atlanta, GA: Agency for Toxic Substances and Disease Registry; 2008. p. 177-84.
32. Powers KM, Smith-Weller T, Franklin GM, Longstreth WT Jr, Swanson PD, Checkoway H. Parkinson's disease risks associated with dietary iron, manganese and other nutrient intakes. Neurology 2003;60:1761-6. (Pubitemid 36737070)
33. Llobet JM, Falco G, Casas C, Teixido A, Domingo JL. Concentrations of arsenic, cadmium, mercury, and lead in common foods and estimated daily intakes by children, adolescents, adults and seniors of Catalonia, Spain. J Agric Food Chem 2003;51:838-42.
34. Yary T, Aazami S. Dietary intake of zinc was inversly associated with depression. Biol Trace Elem Res 2011;145:286-90.
35. Hadjistavri LS, Sarafidis PA, Georgianos PI, Tziolas IM, Aroditis CP, Hitoglou-Makedou A, et al. Beneficial effects of oral magnesium supplementation on insulin sensitivity and serum lipid profile. Med Sci Monit 2010;16:CR307-12.
36. Jaing TH, Hung IH, Chung HT, Lai CH, Liu WM, Chang KW. Acute hypermagnesemia: A rare complication of antacid administration after bone marrow transplantation. Clin Chim Acta 2002;326:201-3.
37. Stepanov I, Villalta PW, Knezevich A, Jensen J, Hatsukami D, Hecht SS. Analysis of twenty three polycyclic aromatic hydrocarbons in smokeless tobacco by gas chromatography: Mass spectrometry. Chem Res Toxicol 2010;23:66-73.
38. Hoffmann D, Adams JD. Carcinogenic tobacco-specific N-nitrosamines in snuff and in the saliva of snuff dippers. Cancer Res 1981;41:4305-8. (Pubitemid 12201332)
39. Calderón J, Ortiz-Pérez D, Yáñez L, Díaz-Barriga F. Human exposure to metals. Pathways of exposure, biomarkers of effect, and host factors. Ecotoxicol Environ Saf 2003;56:93-103. (Pubitemid 36962787)
40. Choubisa SL. Endemic fluorosis in Southern Rajasthan, India. Fluoride 2001;34:61-70. (Pubitemid 32525275)
41. Henningfield JE, Rose C, Giovino G. Brave new world of tobacco disease prevention. Promoting dual tobacco product use? Am J Prev Med 2002;23:226-8 (Pubitemid 35292216)