Inactivation of the human papillomavirus E6 or E7 gene in cervical carcinoma cells by using a bacterial CRISPR/Cas RNA-guided endonuclease

Journal of Virology

Volumn 88, Issue 20, 2014, Pages 11965-11972

  Kennedy, Edward M ^a   Kornepati, Anand V R ^a   Goldstein, Michael ^a   Bogerd, Hal P ^a   Poling, Brigid C ^a   Whisnant, Adam W ^a   Kastan, Michael B ^a   Cullen, Bryan R ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ENDONUCLEASE; PROTEIN P53; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEIN; VIRUS DNA; DNA BINDING PROTEIN; E6 PROTEIN, HUMAN PAPILLOMAVIRUS TYPE 16; E6 PROTEIN, HUMAN PAPILLOMAVIRUS TYPE 18; ONCOPROTEIN; PROTEIN E7; REPRESSOR PROTEIN;

APOPTOSIS; ARTICLE; CANCER GROWTH; CELL CYCLE ARREST; CELL DEATH; CELL VIABILITY; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; CRISPR CAS SYSTEM; DNA CLEAVAGE; DOWNSTREAM PROCESSING; FEMALE; GENE DELETION; GENE INSERTION; GENE MUTATION; GROWTH INHIBITION; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPE 18; PROTEIN EXPRESSION; UTERINE CERVIX CARCINOMA; VIRUS GENOME; VIRUS ONCOGENE; WART VIRUS; ALPHAPAPILLOMAVIRUS; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; TUMOR CELL LINE; UTERINE CERVIX TUMOR; VIROLOGY;

ALPHAPAPILLOMAVIRUS; BASE SEQUENCE; CELL LINE, TUMOR; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; DNA, VIRAL; DNA-BINDING PROTEINS; ENDONUCLEASES; FEMALE; HUMANS; MOLECULAR SEQUENCE DATA; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRUS E7 PROTEINS; REPRESSOR PROTEINS; UTERINE CERVICAL NEOPLASMS;

EID: 84907916621     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01879-14     Document Type: Article

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