메뉴 건너뛰기




Volumn 5, Issue , 2015, Pages

Role of YAP and TAZ in pancreatic ductal adenocarcinoma and in stellate cells associated with cancer and chronic pancreatitis

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOPROTEIN; SIGNAL PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; WWTR1 PROTEIN, HUMAN; YAP1 (YES-ASSOCIATED) PROTEIN, HUMAN;

EID: 84947709363     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep16759     Document Type: Article
Times cited : (81)

References (81)
  • 2
    • 77951755278 scopus 로고    scopus 로고
    • Pancreatic cancer
    • Hidalgo, M. Pancreatic cancer. N Engl J Med 362, 1605-1617 (2010).
    • (2010) N Engl J Med , vol.362 , pp. 1605-1617
    • Hidalgo, M.1
  • 5
    • 34247197621 scopus 로고    scopus 로고
    • Chronic pancreatitis: Challenges and advances in pathogenesis, genetics, diagnosis, and therapy
    • Witt, H., Apte, M. V., Keim, V. & Wilson, J. S. Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy. Gastroenterology 132, 1557-1573 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 1557-1573
    • Witt, H.1    Apte, M.V.2    Keim, V.3    Wilson, J.S.4
  • 6
    • 84876788888 scopus 로고    scopus 로고
    • Models of acute and chronic pancreatitis
    • Lerch, M. M. & Gorelick, F. S. Models of acute and chronic pancreatitis. Gastroenterology 144, 1180-1193 (2013).
    • (2013) Gastroenterology , vol.144 , pp. 1180-1193
    • Lerch, M.M.1    Gorelick, F.S.2
  • 7
    • 70349678580 scopus 로고    scopus 로고
    • New insights into alcoholic pancreatitis and pancreatic cancer
    • Apte, M., Pirola, R. & Wilson, J. New insights into alcoholic pancreatitis and pancreatic cancer. J Gastroenterol Hepatol 24, Suppl 3, S51-S56 (2009).
    • (2009) J Gastroenterol Hepatol , vol.24 , pp. S51-S56
    • Apte, M.1    Pirola, R.2    Wilson, J.3
  • 8
    • 84864832834 scopus 로고    scopus 로고
    • The role of stroma in pancreatic cancer: Diagnostic and therapeutic implications
    • Erkan, M. et al. The role of stroma in pancreatic cancer: diagnostic and therapeutic implications. Nat Rev Gastroenterol Hepatol 9, 454-467 (2012).
    • (2012) Nat Rev Gastroenterol Hepatol , vol.9 , pp. 454-467
    • Erkan, M.1
  • 9
    • 78650895035 scopus 로고    scopus 로고
    • Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein
    • Zhao, B. et al. Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes Dev 25, 51-63 (2011).
    • (2011) Genes Dev , vol.25 , pp. 51-63
    • Zhao, B.1
  • 10
    • 84876943442 scopus 로고    scopus 로고
    • YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the nonreceptor type protein tyrosine phosphatase 14
    • Huang, J. M. et al. YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the nonreceptor type protein tyrosine phosphatase 14. Oncogene 32, 2220-2229 (2013).
    • (2013) Oncogene , vol.32 , pp. 2220-2229
    • Huang, J.M.1
  • 11
    • 78049451932 scopus 로고    scopus 로고
    • The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program
    • Cai, J., Zhang, N., Zheng, Y., De Wilde, R. F., Maitra, A. & Pan, D. The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. Genes Dev 24, 2383-2388 (2010).
    • (2010) Genes Dev , vol.24 , pp. 2383-2388
    • Cai, J.1    Zhang, N.2    Zheng, Y.3    De Wilde, R.F.4    Maitra, A.5    Pan, D.6
  • 12
    • 77953040994 scopus 로고    scopus 로고
    • The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation
    • Lian, I. et al. The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev 24, 1106-1118 (2010).
    • (2010) Genes Dev , vol.24 , pp. 1106-1118
    • Lian, I.1
  • 13
    • 81055140859 scopus 로고    scopus 로고
    • The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells
    • Cordenonsi, M. et al. The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. Cell 147, 759-772 (2011).
    • (2011) Cell , vol.147 , pp. 759-772
    • Cordenonsi, M.1
  • 14
    • 77951837150 scopus 로고    scopus 로고
    • The Hippo-YAP pathway in organ size control and tumorigenesis: An updated version
    • Zhao, B., Li, L., Lei, Q. & Guan, K. L. The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. Genes Dev 24, 862-874 (2010).
    • (2010) Genes Dev , vol.24 , pp. 862-874
    • Zhao, B.1    Li, L.2    Lei, Q.3    Guan, K.L.4
  • 15
    • 41949138130 scopus 로고    scopus 로고
    • Tumor suppressor LATS1 is a negative regulator of oncogene YAP
    • Hao, Y., Chun, A., Cheung, K., Rashidi, B. & Yang, X. Tumor suppressor LATS1 is a negative regulator of oncogene YAP. J Biol Chem 283, 5496-5509 (2008).
    • (2008) J Biol Chem , vol.283 , pp. 5496-5509
    • Hao, Y.1    Chun, A.2    Cheung, K.3    Rashidi, B.4    Yang, X.5
  • 16
    • 0037249343 scopus 로고    scopus 로고
    • Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis
    • Basu, S., Totty, N. F., Irwin, M. S., Sudol, M. & Downward, J. Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis. Mol Cell 11, 11-23 (2003).
    • (2003) Mol Cell , vol.11 , pp. 11-23
    • Basu, S.1    Totty, N.F.2    Irwin, M.S.3    Sudol, M.4    Downward, J.5
  • 17
    • 35948961118 scopus 로고    scopus 로고
    • Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
    • Zhao, B. et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev 21, 2747-2761 (2007).
    • (2007) Genes Dev , vol.21 , pp. 2747-2761
    • Zhao, B.1
  • 18
    • 79953010044 scopus 로고    scopus 로고
    • Angiomotin-like proteins associate with and negatively regulate YAP1
    • Wang, W., Huang, J. & Chen, J. Angiomotin-like proteins associate with and negatively regulate YAP1. J Biol Chem 286, 4364-4370 (2011).
    • (2011) J Biol Chem , vol.286 , pp. 4364-4370
    • Wang, W.1    Huang, J.2    Chen, J.3
  • 19
    • 79953223677 scopus 로고    scopus 로고
    • Hippo pathway-independent restriction of TAZ and YAP by angiomotin
    • Chan, S. W., Lim, C. J., Chong, Y. F., Pobbati, A. V., Huang, C. & Hong, W. Hippo pathway-independent restriction of TAZ and YAP by angiomotin. J Biol Chem 286, 7018-7026 (2011).
    • (2011) J Biol Chem , vol.286 , pp. 7018-7026
    • Chan, S.W.1    Lim, C.J.2    Chong, Y.F.3    Pobbati, A.V.4    Huang, C.5    Hong, W.6
  • 20
    • 84874767303 scopus 로고    scopus 로고
    • PTPN14 interacts with and negatively regulates the oncogenic function of YAP
    • Liu, X. et al. PTPN14 interacts with and negatively regulates the oncogenic function of YAP. Oncogene 32, 1266-1273 (2013).
    • (2013) Oncogene , vol.32 , pp. 1266-1273
    • Liu, X.1
  • 21
    • 84876184181 scopus 로고    scopus 로고
    • The tyrosine phosphatase PTPN14 is a negative regulator of YAP activity
    • Michaloglou, C. et al. The tyrosine phosphatase PTPN14 is a negative regulator of YAP activity. PLoS One 8, e61916 (2013).
    • (2013) PLoS One , vol.8 , pp. e61916
    • Michaloglou, C.1
  • 22
    • 84906539718 scopus 로고    scopus 로고
    • PTPN14 forms complex with Kibra and LATS1 proteins and negatively regulates the YAP oncogenic function
    • Wilson, K. E., Li, Y. W., Yang, N., Shen, H., Orillion, A. R. & Zhang, J. PTPN14 forms complex with Kibra and LATS1 proteins and negatively regulates the YAP oncogenic function. J Biol Chem 289, 23693-23700 (2014).
    • (2014) J Biol Chem , vol.289 , pp. 23693-23700
    • Wilson, K.E.1    Li, Y.W.2    Yang, N.3    Shen, H.4    Orillion, A.R.5    Zhang, J.6
  • 23
    • 84857993243 scopus 로고    scopus 로고
    • Drosophila Pez acts in Hippo signaling to restrict intestinal stem cell proliferation
    • Poernbacher, I., Baumgartner, R., Marada, S. K., Edwards, K. & Stocker, H. Drosophila Pez acts in Hippo signaling to restrict intestinal stem cell proliferation. Curr Biol 22, 389-396 (2012).
    • (2012) Curr Biol , vol.22 , pp. 389-396
    • Poernbacher, I.1    Baumgartner, R.2    Marada, S.K.3    Edwards, K.4    Stocker, H.5
  • 24
    • 0033617369 scopus 로고    scopus 로고
    • Effects of overexpression of PTP36, a putative protein tyrosine phosphatase, on cell adhesion, cell growth, and cytoskeletons in HeLa cells
    • Ogata, M. et al. Effects of overexpression of PTP36, a putative protein tyrosine phosphatase, on cell adhesion, cell growth, and cytoskeletons in HeLa cells. J Biol Chem 274, 12905-12909 (1999).
    • (1999) J Biol Chem , vol.274 , pp. 12905-12909
    • Ogata, M.1
  • 25
    • 34748870853 scopus 로고    scopus 로고
    • The protein tyrosine phosphatase Pez regulates TGFbeta, epithelial-mesenchymal transition, and organ development
    • Wyatt, L., Wadham, C., Crocker, L. A., Lardelli, M. & Khew-Goodall, Y. The protein tyrosine phosphatase Pez regulates TGFbeta, epithelial-mesenchymal transition, and organ development. J Cell Biol 178, 1223-1235 (2007).
    • (2007) J Cell Biol , vol.178 , pp. 1223-1235
    • Wyatt, L.1    Wadham, C.2    Crocker, L.A.3    Lardelli, M.4    Khew-Goodall, Y.5
  • 26
    • 0038308412 scopus 로고    scopus 로고
    • The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin
    • Wadham, C., Gamble, J. R., Vadas, M. A. & Khew-Goodall, Y. The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin. Mol Biol Cell 14, 2520-2529 (2003).
    • (2003) Mol Biol Cell , vol.14 , pp. 2520-2529
    • Wadham, C.1    Gamble, J.R.2    Vadas, M.A.3    Khew-Goodall, Y.4
  • 27
    • 58149378342 scopus 로고    scopus 로고
    • Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth
    • Inada, A. et al. Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth. Proc Natl Acad Sci USA 105, 19915-19919 (2008).
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 19915-19919
    • Inada, A.1
  • 28
    • 0037931407 scopus 로고    scopus 로고
    • Differentiation and proliferation of endocrine cells in the regenerating rat pancreas after 90% pancreatectomy
    • Hayashi, K. Y., Tamaki, H., Handa, K., Takahashi, T., Kakita, A. & Yamashina, S. Differentiation and proliferation of endocrine cells in the regenerating rat pancreas after 90% pancreatectomy. Arch Histol Cytol 66, 163-174 (2003).
    • (2003) Arch Histol Cytol , vol.66 , pp. 163-174
    • Hayashi, K.Y.1    Tamaki, H.2    Handa, K.3    Takahashi, T.4    Kakita, A.5    Yamashina, S.6
  • 29
    • 38749108893 scopus 로고    scopus 로고
    • Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas
    • Xu, X. et al. Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell 132, 197-207 (2008).
    • (2008) Cell , vol.132 , pp. 197-207
    • Xu, X.1
  • 30
    • 0038795203 scopus 로고    scopus 로고
    • Centroacinar and intercalated duct cells as potential precursors of pancreatic endocrine cells in rats treated with streptozotocin
    • Nagasao, J., Yoshioka, K., Amasaki, H. & Mutoh, K. Centroacinar and intercalated duct cells as potential precursors of pancreatic endocrine cells in rats treated with streptozotocin. Ann Anat 185, 211-216 (2003).
    • (2003) Ann Anat , vol.185 , pp. 211-216
    • Nagasao, J.1    Yoshioka, K.2    Amasaki, H.3    Mutoh, K.4
  • 31
    • 0026747671 scopus 로고
    • The importance of the centroacinar region in cerulein-induced mouse pancreatic growth
    • Gasslander, T., Ihse, I. & Smeds, S. The importance of the centroacinar region in cerulein-induced mouse pancreatic growth. Scand J Gastroenterol 27, 564-570 (1992).
    • (1992) Scand J Gastroenterol , vol.27 , pp. 564-570
    • Gasslander, T.1    Ihse, I.2    Smeds, S.3
  • 32
    • 80053603426 scopus 로고    scopus 로고
    • Duct cells contribute to regeneration of endocrine and acinar cells following pancreatic damage in adult mice
    • 1462 e1451-1456
    • Criscimanna, A. et al. Duct cells contribute to regeneration of endocrine and acinar cells following pancreatic damage in adult mice. Gastroenterology 141, 1451-1462, 1462 e1451-1456 (2011).
    • (2011) Gastroenterology , vol.141 , pp. 1451-1462
    • Criscimanna, A.1
  • 33
    • 33646879441 scopus 로고    scopus 로고
    • Timing and expression pattern of carbonic anhydrase II in pancreas
    • Inada, A., Nienaber, C., Fonseca, S. & Bonner-Weir, S. Timing and expression pattern of carbonic anhydrase II in pancreas. Dev Dyn 235, 1571-1577 (2006).
    • (2006) Dev Dyn , vol.235 , pp. 1571-1577
    • Inada, A.1    Nienaber, C.2    Fonseca, S.3    Bonner-Weir, S.4
  • 34
    • 84055193971 scopus 로고    scopus 로고
    • Pancreatic ductal cells in development, regeneration, and neoplasia
    • Reichert, M. & Rustgi, A. K. Pancreatic ductal cells in development, regeneration, and neoplasia. J Clin Invest 121, 4572-4578 (2011).
    • (2011) J Clin Invest , vol.121 , pp. 4572-4578
    • Reichert, M.1    Rustgi, A.K.2
  • 35
    • 0027535021 scopus 로고
    • Isolation culture, and characterization of human pancreatic duct cells
    • Trautmann, B., Schlitt, H. J., Hahn, E. G. & Lohr, M. Isolation, culture, and characterization of human pancreatic duct cells. Pancreas 8, 248-254 (1993).
    • (1993) Pancreas , vol.8 , pp. 248-254
    • Trautmann, B.1    Schlitt, H.J.2    Hahn, E.G.3    Lohr, M.4
  • 36
    • 33645217472 scopus 로고    scopus 로고
    • Tenascin C and annexin II expression in the process of pancreatic carcinogenesis
    • Esposito, I. et al. Tenascin C and annexin II expression in the process of pancreatic carcinogenesis. J Pathol 208, 673-685 (2006).
    • (2006) J Pathol , vol.208 , pp. 673-685
    • Esposito, I.1
  • 39
    • 9144266295 scopus 로고    scopus 로고
    • Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
    • Hingorani, S. R. et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 4, 437-450 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 437-450
    • Hingorani, S.R.1
  • 40
    • 33748098707 scopus 로고    scopus 로고
    • Pancreas recovery following cerulein-induced pancreatitis is impaired in plasminogen-deficient mice
    • Lugea, A., Nan, L., French, S. W., Bezerra, J. A., Gukovskaya, A. S. & Pandol, S. J. Pancreas recovery following cerulein-induced pancreatitis is impaired in plasminogen-deficient mice. Gastroenterology 131, 885-899 (2006).
    • (2006) Gastroenterology , vol.131 , pp. 885-899
    • Lugea, A.1    Nan, L.2    French, S.W.3    Bezerra, J.A.4    Gukovskaya, A.S.5    Pandol, S.J.6
  • 41
    • 84929347258 scopus 로고    scopus 로고
    • Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis
    • Xue, J. et al. Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis. Nat Commun 6, 7158 (2015).
    • (2015) Nat Commun , vol.6 , pp. 7158
    • Xue, J.1
  • 42
    • 84907305877 scopus 로고    scopus 로고
    • Genetic inhibition of protein kinase Cepsilon attenuates necrosis in experimental pancreatitis
    • Liu, Y. et al. Genetic inhibition of protein kinase Cepsilon attenuates necrosis in experimental pancreatitis. Am J Physiol Gastrointest Liver Physiol 307, G550-563 (2014).
    • (2014) Am J Physiol Gastrointest Liver Physiol , vol.307 , pp. G550-G563
    • Liu, Y.1
  • 43
    • 76249094159 scopus 로고    scopus 로고
    • Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas
    • Rovira, M., Scott, S. G., Liss, A. S., Jensen, J., Thayer, S. P. & Leach, S. D. Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas. Proc Natl Acad Sci USA 107, 75-80 (2010).
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 75-80
    • Rovira, M.1    Scott, S.G.2    Liss, A.S.3    Jensen, J.4    Thayer, S.P.5    Leach, S.D.6
  • 44
    • 78651228289 scopus 로고    scopus 로고
    • Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine
    • Furuyama, K. et al. Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat Genet 43, 34-41 (2011).
    • (2011) Nat Genet , vol.43 , pp. 34-41
    • Furuyama, K.1
  • 45
    • 79951539242 scopus 로고    scopus 로고
    • Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas
    • Kopp, J. L. et al. Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development 138, 653-665 (2011).
    • (2011) Development , vol.138 , pp. 653-665
    • Kopp, J.L.1
  • 46
    • 84870803922 scopus 로고    scopus 로고
    • Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma
    • Kopp, J. L. et al. Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell 22, 737-750 (2012).
    • (2012) Cancer Cell , vol.22 , pp. 737-750
    • Kopp, J.L.1
  • 47
    • 84861221146 scopus 로고    scopus 로고
    • Zebrafish sox9b is crucial for hepatopancreatic duct development and pancreatic endocrine cell regeneration
    • Manfroid, I. et al. Zebrafish sox9b is crucial for hepatopancreatic duct development and pancreatic endocrine cell regeneration. Dev Biol 366, 268-278 (2012).
    • (2012) Dev Biol , vol.366 , pp. 268-278
    • Manfroid, I.1
  • 48
    • 84894041714 scopus 로고    scopus 로고
    • SOX9: A useful marker for pancreatic ductal lineage of pancreatic neoplasms
    • Shroff, S. et al. SOX9: a useful marker for pancreatic ductal lineage of pancreatic neoplasms. Hum Pathol 45, 456-463 (2014).
    • (2014) Hum Pathol , vol.45 , pp. 456-463
    • Shroff, S.1
  • 49
    • 84905459985 scopus 로고    scopus 로고
    • Hippo Coactivator YAP1 Upregulates SOX9 and Endows Esophageal Cancer Cells with Stem-like Properties
    • Song, S. et al. Hippo Coactivator YAP1 Upregulates SOX9 and Endows Esophageal Cancer Cells with Stem-like Properties. Cancer Res 74, 4170-4182 (2014).
    • (2014) Cancer Res , vol.74 , pp. 4170-4182
    • Song, S.1
  • 50
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    • Dor, Y., Brown, J., Martinez, O. I. & Melton, D. A. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429, 41-46 (2004).
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 51
    • 53349178722 scopus 로고    scopus 로고
    • In vivo reprogramming of adult pancreatic exocrine cells to betacells
    • Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J. & Melton, D. A. In vivo reprogramming of adult pancreatic exocrine cells to betacells. Nature 455, 627-632 (2008).
    • (2008) Nature , vol.455 , pp. 627-632
    • Zhou, Q.1    Brown, J.2    Kanarek, A.3    Rajagopal, J.4    Melton, D.A.5
  • 52
    • 66349132211 scopus 로고    scopus 로고
    • Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis
    • Sangiorgi, E. & Capecchi, M. R. Bmi1 lineage tracing identifies a self-renewing pancreatic acinar cell subpopulation capable of maintaining pancreatic organ homeostasis. Proc Natl Acad Sci USA 106, 7101-7106 (2009).
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 7101-7106
    • Sangiorgi, E.1    Capecchi, M.R.2
  • 53
    • 84878282156 scopus 로고    scopus 로고
    • Hippo signaling regulates differentiation and maintenance in the exocrine pancreas
    • 1553 e1541
    • Gao, T. et al. Hippo signaling regulates differentiation and maintenance in the exocrine pancreas. Gastroenterology 144, 1543-1553, 1553 e1541 (2013).
    • (2013) Gastroenterology , vol.144 , pp. 1543-1553
    • Gao, T.1
  • 54
    • 84871862870 scopus 로고    scopus 로고
    • Hippo signaling regulates pancreas development through inactivation of Yap
    • George, N. M., Day, C. E., Boerner, B. P., Johnson, R. L. & Sarvetnick, N. E. Hippo signaling regulates pancreas development through inactivation of Yap. Mol Cell Biol 32, 5116-5128 (2012).
    • (2012) Mol Cell Biol , vol.32 , pp. 5116-5128
    • George, N.M.1    Day, C.E.2    Boerner, B.P.3    Johnson, R.L.4    Sarvetnick, N.E.5
  • 55
    • 84923333865 scopus 로고    scopus 로고
    • Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of beta-Catenin and Yap by PKCzeta
    • Llado, V. et al. Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of beta-Catenin and Yap by PKCzeta. Cell Rep 10, 740-754 (2015).
    • (2015) Cell Rep , vol.10 , pp. 740-754
    • Llado, V.1
  • 56
    • 17144404527 scopus 로고    scopus 로고
    • Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells
    • Bachem, M. G. et al. Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. Gastroenterology 128, 907-921 (2005).
    • (2005) Gastroenterology , vol.128 , pp. 907-921
    • Bachem, M.G.1
  • 57
    • 83755195660 scopus 로고    scopus 로고
    • Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance
    • Zhou, D. et al. Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance. Proc Natl Acad Sci USA 108, E1312-1320 (2011).
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. E1312-E1320
    • Zhou, D.1
  • 58
    • 85018698979 scopus 로고    scopus 로고
    • Dual role of YAP and TAZ in renewal of the intestinal epithelium
    • Imajo, M., Ebisuya, M. & Nishida, E. Dual role of YAP and TAZ in renewal of the intestinal epithelium. Nat Cell Biol 17, 7-19 (2015).
    • (2015) Nat Cell Biol , vol.17 , pp. 7-19
    • Imajo, M.1    Ebisuya, M.2    Nishida, E.3
  • 59
    • 36549074631 scopus 로고    scopus 로고
    • YAP1 increases organ size and expands undifferentiated progenitor cells
    • Camargo, F. D. et al. YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol 17, 2054-2060 (2007).
    • (2007) Curr Biol , vol.17 , pp. 2054-2060
    • Camargo, F.D.1
  • 60
    • 84904875885 scopus 로고    scopus 로고
    • The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors
    • Mahoney, J. E., Mori, M., Szymaniak, A. D., Varelas, X. & Cardoso, W. V. The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors. Dev Cell 30, 137-150 (2014).
    • (2014) Dev Cell , vol.30 , pp. 137-150
    • Mahoney, J.E.1    Mori, M.2    Szymaniak, A.D.3    Varelas, X.4    Cardoso, W.V.5
  • 61
    • 84929948623 scopus 로고    scopus 로고
    • Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung
    • Lange, A. W., Sridharan, A., Xu, Y., Stripp, B. R., Perl, A. K. & Whitsett, J. A. Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung. J Mol Cell Biol 7, 35-47 (2015).
    • (2015) J Mol Cell Biol , vol.7 , pp. 35-47
    • Lange, A.W.1    Sridharan, A.2    Xu, Y.3    Stripp, B.R.4    Perl, A.K.5    Whitsett, J.A.6
  • 62
    • 84902081616 scopus 로고    scopus 로고
    • Hippo pathway activity influences liver cell fate
    • Yimlamai, D. et al. Hippo pathway activity influences liver cell fate. Cell 157, 1324-1338 (2014).
    • (2014) Cell , vol.157 , pp. 1324-1338
    • Yimlamai, D.1
  • 63
    • 84878600591 scopus 로고    scopus 로고
    • Yap controls stem/progenitor cell proliferation in the mouse postnatal epidermis
    • Beverdam, A., Claxton, C., Zhang, X., James, G., Harvey, K. F. & Key, B. Yap controls stem/progenitor cell proliferation in the mouse postnatal epidermis. J Invest Dermatol 133, 1497-1505 (2013).
    • (2013) J Invest Dermatol , vol.133 , pp. 1497-1505
    • Beverdam, A.1    Claxton, C.2    Zhang, X.3    James, G.4    Harvey, K.F.5    Key, B.6
  • 64
    • 84878368948 scopus 로고    scopus 로고
    • MT1-MMP-dependent control of skeletal stem cell commitment via a beta1-integrin/YAP/TAZ signaling axis
    • Tang, Y., et al. MT1-MMP-dependent control of skeletal stem cell commitment via a beta1-integrin/YAP/TAZ signaling axis. Dev Cell 25, 402-416 (2013).
    • (2013) Dev Cell , vol.25 , pp. 402-416
    • Tang, Y.1
  • 65
    • 79953149145 scopus 로고    scopus 로고
    • Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD2 signaling pathway downstream of LIF
    • Tamm, C., Bower, N. & Anneren, C. Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD2 signaling pathway downstream of LIF. J Cell Sci 124, 1136-1144 (2011).
    • (2011) J Cell Sci , vol.124 , pp. 1136-1144
    • Tamm, C.1    Bower, N.2    Anneren, C.3
  • 66
    • 84900561874 scopus 로고    scopus 로고
    • Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma
    • Zhang, W. et al. Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma. Sci Signal 7, ra42 (2014).
    • (2014) Sci Signal , vol.7 , pp. ra42
    • Zhang, W.1
  • 67
    • 84903984143 scopus 로고    scopus 로고
    • Yap1 activation enables bypass of oncogenic kras addiction in pancreatic cancer
    • Kapoor, A. et al. Yap1 activation enables bypass of oncogenic kras addiction in pancreatic cancer. Cell 158, 185-197 (2014).
    • (2014) Cell , vol.158 , pp. 185-197
    • Kapoor, A.1
  • 68
    • 84904024982 scopus 로고    scopus 로고
    • KRAS and YAP1 Converge to Regulate EMT and Tumor Survival
    • Shao, D. D. et al. KRAS and YAP1 Converge to Regulate EMT and Tumor Survival. Cell 158, 171-184 (2014).
    • (2014) Cell , vol.158 , pp. 171-184
    • Shao, D.D.1
  • 69
    • 79955638751 scopus 로고    scopus 로고
    • Alcohol abuse, endoplasmic reticulum stress and pancreatitis
    • Pandol, S. J., Gorelick, F. S., Gerloff, A. & Lugea, A. Alcohol abuse, endoplasmic reticulum stress and pancreatitis. Dig Dis 28, 776-782 (2010).
    • (2010) Dig Dis , vol.28 , pp. 776-782
    • Pandol, S.J.1    Gorelick, F.S.2    Gerloff, A.3    Lugea, A.4
  • 70
    • 84866747307 scopus 로고    scopus 로고
    • Convergent signaling in the regulation of connective tissue growth factor in malignant mesothelioma: TGFβ signaling and defects in the Hippo signaling cascade
    • Fujii, M. et al. Convergent signaling in the regulation of connective tissue growth factor in malignant mesothelioma: TGFβ signaling and defects in the Hippo signaling cascade. Cell Cycle 11, 3373-3379 (2012).
    • (2012) Cell Cycle , vol.11 , pp. 3373-3379
    • Fujii, M.1
  • 71
    • 1542466792 scopus 로고    scopus 로고
    • Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo
    • Ling, Q. et al. Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo. J Clin Invest 113, 38-48 (2004).
    • (2004) J Clin Invest , vol.113 , pp. 38-48
    • Ling, Q.1
  • 72
    • 0346362320 scopus 로고    scopus 로고
    • Annexin II-mediated plasmin generation activates TGF-beta3 during epithelial-mesenchymal transformation in the developing avian heart
    • Krishnan, S., Deora, A. B., Annes, J. P., Osoria, J., Rifkin, D. B. & Hajjar, K. A. Annexin II-mediated plasmin generation activates TGF-beta3 during epithelial-mesenchymal transformation in the developing avian heart. Dev Biol 265, 140-154 (2004).
    • (2004) Dev Biol , vol.265 , pp. 140-154
    • Krishnan, S.1    Deora, A.B.2    Annes, J.P.3    Osoria, J.4    Rifkin, D.B.5    Hajjar, K.A.6
  • 73
    • 70449428712 scopus 로고    scopus 로고
    • Homocysteine inhibits neoangiogenesis in mice through blockade of annexin A2-dependent fibrinolysis
    • Jacovina, A. T. et al. Homocysteine inhibits neoangiogenesis in mice through blockade of annexin A2-dependent fibrinolysis. J Clin Invest 119, 3384-3394 (2009).
    • (2009) J Clin Invest , vol.119 , pp. 3384-3394
    • Jacovina, A.T.1
  • 74
    • 34250885201 scopus 로고    scopus 로고
    • Tissue plasminogen activator induces pancreatic cancer cell proliferation by a non-catalytic mechanism that requires extracellular signal-regulated kinase 1/2 activation through epidermal growth factor receptor and annexin A2
    • Ortiz-Zapater, E. et al. Tissue plasminogen activator induces pancreatic cancer cell proliferation by a non-catalytic mechanism that requires extracellular signal-regulated kinase 1/2 activation through epidermal growth factor receptor and annexin A2. Am J Pathol 170, 1573-1584 (2007).
    • (2007) Am J Pathol , vol.170 , pp. 1573-1584
    • Ortiz-Zapater, E.1
  • 75
    • 79955775515 scopus 로고    scopus 로고
    • Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer
    • Zheng, L. et al. Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer. PLoS One 6, e19390 (2011).
    • (2011) PLoS One , vol.6 , pp. e19390
    • Zheng, L.1
  • 76
    • 0027140743 scopus 로고
    • Enhanced expression of annexin II in human pancreatic carcinoma cells and primary pancreatic cancers
    • Vishwanatha, J. K., Chiang, Y., Kumble, K. D., Hollingsworth, M. A. & Pour, P. M. Enhanced expression of annexin II in human pancreatic carcinoma cells and primary pancreatic cancers. Carcinogenesis 14, 2575-2579 (1993).
    • (1993) Carcinogenesis , vol.14 , pp. 2575-2579
    • Vishwanatha, J.K.1    Chiang, Y.2    Kumble, K.D.3    Hollingsworth, M.A.4    Pour, P.M.5
  • 77
    • 3042616114 scopus 로고    scopus 로고
    • Specific interaction of tissue-type plasminogen activator (t-PA) with annexin II on the membrane of pancreatic cancer cells activates plasminogen and promotes invasion
    • Diaz, V. M., Hurtado, M., Thomson, T. M., Reventos, J. & Paciucci, R. Specific interaction of tissue-type plasminogen activator (t-PA) with annexin II on the membrane of pancreatic cancer cells activates plasminogen and promotes invasion in vitro. Gut 53, 993-1000 (2004).
    • (2004) Vitro. Gut , Issue.53 , pp. 993-1000
    • Diaz, V.M.1    Hurtado, M.2    Thomson, T.M.3    Reventos, J.4    Paciucci, R.5
  • 78
    • 34247644369 scopus 로고    scopus 로고
    • Growth and regeneration of adult beta cells does not involve specialized progenitors
    • Teta, M., Rankin, M. M., Long, S. Y., Stein, G. M. & Kushner, J. A. Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev Cell 12, 817-826 (2007).
    • (2007) Dev Cell , vol.12 , pp. 817-826
    • Teta, M.1    Rankin, M.M.2    Long, S.Y.3    Stein, G.M.4    Kushner, J.A.5
  • 79
    • 48549095907 scopus 로고    scopus 로고
    • Hedgehog signaling is required for effective regeneration of exocrine pancreas
    • Fendrich, V. et al. Hedgehog signaling is required for effective regeneration of exocrine pancreas. Gastroenterology 135, 621-631 (2008).
    • (2008) Gastroenterology , vol.135 , pp. 621-631
    • Fendrich, V.1
  • 80
    • 0035119871 scopus 로고    scopus 로고
    • Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes
    • Zulewski, H. et al. Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes 50, 521-533 (2001).
    • (2001) Diabetes , vol.50 , pp. 521-533
    • Zulewski, H.1
  • 81
    • 84898482404 scopus 로고    scopus 로고
    • MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes
    • Ardestani, A. et al. MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes. Nat Med 20, 385-397 (2014).
    • (2014) Nat Med , vol.20 , pp. 385-397
    • Ardestani, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.