A global perspective on the influence of environmental exposures on the nervous system

Nature

Volumn 527, Issue 7578, 2015, Pages S187-S192

  Tshala Katumbay, Desire ^a,b,c   Mwanza, Jean Claude ^d   Rohlman, Diane S ^a,e   Maestre, Gladys ^f   Oria, Reinaldo B ^g  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b National Institute of Biomedical Research   (Congo)

^c UNIVERSITY OF KINSHASA   (Congo)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF IOWA   (United States)

^f Vagelos College of Physicians and Surgeons   (United States)

^g FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CASSAVA; CLIMATE CHANGE; DISEASE INCIDENCE; ENVIRONMENTAL CHANGE; ENVIRONMENTAL RISK; GLOBAL PERSPECTIVE; GLOBALIZATION; INCOME DISTRIBUTION; INDUSTRIALIZATION; INVESTMENT; MARKET TRANSITION; NERVOUS SYSTEM DISORDER; POPULATION GROWTH;

BRAIN DISEASE; CAPACITY BUILDING; CASSAVA; CLIMATE CHANGE; CLINICAL RESEARCH; DEGRADATION KINETICS; DEVELOPED COUNTRY; ENVIRONMENTAL CHANGE; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL HEALTH; ENVIRONMENTAL PROTECTION; EPIGENETICS; FARMING SYSTEM; FOOD INDUSTRY; GENETIC ANALYSIS; HEALTH STATUS; HIGH RISK POPULATION; HUMAN; INFECTION RISK; MENTAL STRESS; METAGENOMICS; MICROENVIRONMENT; MINING; NATURAL DISASTER; NERVOUS SYSTEM; NEUROLOGIC DISEASE; NONHUMAN; PARTICULATE MATTER; POPULATION GROWTH; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; RISK FACTOR; ADVERSE EFFECTS; CHEMICALLY INDUCED; DEVELOPING COUNTRY; ECONOMICS; INDUSTRIALIZATION; INTERNATIONAL COOPERATION; MEDICAL RESEARCH; NERVOUS SYSTEM DISEASES; NEUROCOGNITIVE DISORDERS; TRENDS;

AMAZONIA; NIGER DELTA; NIGERIA; SUB-SAHARAN AFRICA;

MANIHOT ESCULENTA;

BIOMEDICAL RESEARCH; DEVELOPING COUNTRIES; ENVIRONMENTAL EXPOSURE; HUMANS; INDUSTRIAL DEVELOPMENT; INTERNATIONALITY; NERVOUS SYSTEM DISEASES; NEUROCOGNITIVE DISORDERS;

EID: 84947601594     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature16034     Document Type: Review

References (103)

1. Sumner, A. Global Poverty and the New Bottom Billion: What if Three-Quarters of the World's Poor Live in Middle-Income Countries 1-43 (IDS, 2010).
2. World Bank. Data. Low and Middle Income Countries http://data.worldbank.org/income-level/LMY (World Bank, 2015).
3. World Bank. Global Monitoring Report 2014/2015: Ending Poverty and Sharing Prosperity (World Bank, 2015).
4. Lang, V., Lingnau, H. Defining and measuring poverty and inequality post-2015. J. Int. Develop. 27, 399-414 (2015).
5. Haile, M. Weather patterns, food security and humanitarian response in sub-Saharan Africa. Phil. Trans. R. Soc. Lond. B 360, 2169-2182 (2005).
6. Bjorklund, G. Workshop 4 (synthesis): securing food production under climate variability-exploring the options. Water Sci. Technol 49, 147-149 (2004).
7. Kim, K. H., Kabir, E., Ara Jahan, S. A review of the consequences of global climate change on human health. J. Environ. Sci. Health C. Environ. Carcinog. Ecotoxicol. Rev. 32, 299-318 (2014).
8. Rieder, M., Choonara, I. Armed conflict and child health. Arch. Dis. Child. 97, 59-62 (2012).
9. Seccatore, J. et al. An estimation of the artisanal small-scale production of gold in the world. Sci. Total Environ. 496, 662-667 (2014).
10. Banea, M., Tylleskar, T., Rosling, H. Konzo and ebola in Bandundu region of Zaire. Lancet 349, 621 (1997).
11. Jernelov, A. The threats from oil spills: now, then, and in the future. Ambio 39, 353-366 (2010).
12. Levy, B. S., Nassetta, W. J. The adverse health effects of oil spills: a review of the literature and a framework for medically evaluating exposed individuals. Int. J. Occup. Environ. Health 17, 161-167 (2011).
13. Guerrant, R. L. et al. The impoverished gut-a triple burden of diarrhoea, stunting and chronic disease. Nature Rev. Gastroenterol Hepatol. 10, 220-229 (2013).
14. Guerrant, R. L. et al. Magnitude and impact of diarrheal diseases. Arch. Med. Res. 33, 351-355 (2002).
15. Guerrant, R. L. et al. Malnutrition as an enteric infectious disease with long-term effects on child development. Nutr. Rev. 66, 487-505 (2008).
16. Petri, W. A. Jr. et al. Enteric infections, diarrhea, and their impact on function and development. J. Clin. Invest. 118, 1277-1290 (2008).
17. Wang, W. et al. Cassava genome from a wild ancestor to cultivated varieties. Nature Commun. 5, 5110 (2014).
18. Tshala-Katumbay, D. et al. Cassava food toxins, konzo disease, and neurodegeneration in sub-Sahara Africans. Neurology 80, 949-951 (2013).
19. Sarmento, A. et al. Valorization of traditional foods: nutritional and bioactive properties of Cicer arietinum L. and Lathyrus sativus L. pulses. J. Sci. Food Agric. 95, 179-185 (2015).
20. Spencer, P. S., Schaumburg, H. H. Lathyrism: a neurotoxic disease. Neurobehav. Toxicol. Teratol. 5, 625-629 (1983).
21. Marler, T. E., Lindstrom, A. J. Free sugar profile in cycads. Front. Plant. Sci. 5, 526 (2014).
22. Kisby, G. E., Spencer, P. S. Is neurodegenerative disease a long-latency response to early-life genotoxin exposure Int. J. Environ. Res. Public Health 8, 3889-3921 (2011).
23. Banea, J. P. et al. Effectiveness of wetting method for control of konzo and reduction of cyanide poisoning by removal of cyanogens from cassava flour. Food Nutr. Bull. 35, 28-32 (2014).
24. Tylleskar, T. et al. Konzo in the Central African Republic. Neurology 44, 959-961 (1994).
25. Ciglenecki, I. et al. Konzo outbreak among refugees from Central African Republic in Eastern region, Cameroon. Food Chem. Toxicol. 49, 579-582 (2011).
26. Nzwalo, H., Cliff, J. Konzo: from poverty, cassava, and cyanogen intake to toxico-nutritional neurological disease. PLoS Negl. Trop. Dis. 5, e1051 (2011).
27. Mlingi, N. L. et al. Recurrence of konzo in southern Tanzania: rehabilitation and prevention using the wetting method. Food Chem. Toxicol. 49, 673-677 (2011).
28. Cliff, J. et al. Konzo associated with war in Mozambique. Trop. Med. Int. Health 2, 1068-1074 (1997).
29. Okitundu Luwa, E. A. D. et al. Persistence of konzo epidemics in Kahemba, Democratic Republic of Congo: phenomenological and socio-economic aspects. Pan. Afr. Med. J. 18, 213 (2014).
30. Oluwole, O. S. et al. Persistence of tropical ataxic neuropathy in a Nigerian community. J. Neurol. Neurosurg. Psych. 69, 96-101 (2000).
31. Tekle-Haimanot, R. et al. Clinical and electroencephalographic characteristics of epilepsy in rural Ethiopia: a community-based study. Epilepsy Res. 7, 230-239 (1990).
32. Ludolph, A. C. et al. Studies on the aetiology and pathogenesis of motor neuron diseases. 1. Lathyrism: clinical findings in established cases. Brain 110, 149-165 (1987).
33. Ngudi, D. D. et al. Research on motor neuron diseases konzo and neurolathyrism: trends from 1990 to 2010. PLoS Negl. Trop. Dis. 6, e1759 (2012).
34. Lee, S. E. Guam dementia syndrome revisited in 2011. Curr. Opin. Neurol. 24, 517-524 (2011).
35. Kaji, R. et al. ALS-parkinsonism-dementia complex of Kii and other related diseases in Japan. Parkinsonism Relat. Disord. 18 (Suppl 1), S190-S191 (2012).
36. Prendergast, A. J. et al. Stunting is characterized by chronic inflammation in Zimbabwean infants. PLoS ONE 9, e86928 (2014).
37. Patrick, P. D. et al. Limitations in verbal fluency following heavy burdens of early childhood diarrhea in Brazilian shantytown children. Child Neuropsychol. 11, 233-244 (2005).
38. Korpe, P. S., Petri, W. A. Jr. Environmental enteropathy: critical implications of a poorly understood condition. Trends Mol. Med. 18, 328-336 (2012).
39. Petri, W. A., Naylor, C., Haque, R. Environmental enteropathy and malnutrition: do we know enough to intervene BMC Med. 12, 187 (2014).
40. Tilman, D., Clark, M. Global diets link environmental sustainability and human health. Nature 515, 518-522 (2014).
41. Ferguson, K. T. et al. The physical environment and child development: an international review. Int. J. Psychol. 48, 437-468 (2013).
42. Crane, A. L. et al. Longitudinal assessment of chlorpyrifos exposure and effect biomarkers in adolescent Egyptian agricultural workers. J. Expo. Sci. Environ. Epidemiol. 23, 356-362 (2013).
43. Rohlman, D. S. et al. Characterizing exposures and neurobehavioral performance in Egyptian adolescent pesticide applicators. Metab. Brain Dis. 29, 845-855 (2014).
44. Spencer, P. S. et al. The enlarging view of hexacarbon neurotoxicity. Crit. Rev. Toxicol. 7, 279-356 (1980).
45. Tylleskar, T. et al. Konzo, an epidemic spastic paraparesis in Africa, is not associated with antibodies to HTLV-I, HIV, or HIV gag-encoded proteins. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12, 317-318 (1996).
46. Jeannel, D. et al. The risk of tropical spastic paraparesis differs according to ethnic group among HTLV-I carriers in Inongo, Zaire. J. Acquir. Immune Defic. Syndr. 6, 840-844 (1993).
47. Tylleskar, T. et al. Dietary determinants of a non-progressive spastic paraparesis (Konzo): a case-referent study in a high incidence area of Zaire. Int. J. Epidemiol. 24, 949-956 (1995).
48. Vidal, A. C. et al. Maternal stress, preterm birth, and DNA methylation at imprint regulatory sequences in humans. Genet. Epigenet. 6, 37-44 (2014).
49. Bale, T. L. Lifetime stress experience: transgenerational epigenetics and germ cell programming. Dialogues Clin. Neurosci. 16, 297-305 (2014).
50. Maestre, G. et al. Apolipoprotein E and Alzheimer's disease: ethnic variation in genotypic risks. Ann. Neurol. 37, 254-259 (1995).
51. Oria, R. B. et al. ApoE polymorphisms and diarrheal outcomes in Brazilian shanty town children. Braz. J. Med. Biol. Res. 43, 249-256 (2010).
52. Oria, R. B. et al. APOE4 protects the cognitive development in children with heavy diarrhea burdens in Northeast Brazil. Pediatr. Res. 57, 310-316 (2005).
53. Jackson, P. B. et al. Further evidence that the rs1858830 C variant in the promoter region of the MET gene is associated with autistic disorder. Autism Res. 2, 232-236 (2009).
54. Sousa, I. et al. MET and autism susceptibility: family and case-control studies. Eur. J. Hum. Genet. 17, 749-758 (2009).
55. Peng, Y. et al. MET receptor tyrosine kinase as an autism genetic risk factor. Int. Rev. Neurobiol. 113, 135-165 (2013).
56. Volk, H. E. et al. Autism spectrum disorder: interaction of air pollution with the MET receptor tyrosine kinase gene. Epidemiology 25, 44-47 (2014).
57. Charleta, L. et al. Neurodegenerative diseases and exposure to environmental metals Mn, Pb, and Hg. Coord. Chem. Rev. 256, 2147-2163 (2012).
58. Oteiza, P. I., Mackenzie, G. G., Verstraeten, S. V. Metals in neurodegeneration: involvement of oxidants and oxidant-sensitive transcription factors. Mol. Aspects Med. 25, 103-115 (2004).
59. Ali, S. F., Binienda, Z. K., Imam, S. Z. Molecular aspects of dopaminergic neurodegeneration: gene-environment interaction in parkin dysfunction. Int. J. Environ. Res. Public Health 8, 4702-4713 (2011).
60. Dosunmu, R., Alashwal, H., Zawia, N. H. Genome-wide expression and methylation profiling in the aged rodent brain due to early-life Pb exposure and its relevance to aging. Mech. Ageing Dev. 133, 435-443 (2012).
61. Bihaqi, S. W. et al. Infantile postnatal exposure to lead (Pb) enhances tau expression in the cerebral cortex of aged mice: relevance to AD. Neurotoxicology 44, 114-120 (2014).
62. Wang, G. et al. Early life origins of metabolic syndrome: the role of environmental toxicants. Curr. Environ. Health Rep. 1, 78-89 (2014).
63. Collotta, M., Bertazzi, P. A., Bollati, V. Epigenetics and pesticides. Toxicology 307, 35-41 (2013).
64. Singh, S. et al. Influence of CYP2C9, GSTM1, GSTT1 and NAT2 genetic polymorphisms on DNA damage in workers occupationally exposed to organophosphate pesticides. Mutat. Res. 741, 101-108 (2012).
65. Morahan, J. M. et al. Genetic susceptibility to environmental toxicants in ALS. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B, 885-890 (2007).
66. Goodrich, J. M., Basu, N. Variants of glutathione s-transferase pi 1 exhibit differential enzymatic activity and inhibition by heavy metals. Toxicol. In Vitro 26, 630-635 (2012).
67. Currie, E., Vogl, T. Early-life health and adult circumstance in developing countries. Ann. Rev. Econom. 5, 1-36 (2013).
68. Tshala-Katumbay, D. et al. Analysis of motor pathway involvement in konzo using transcranial electrical and magnetic stimulation. Muscle Nerve 25, 230-235 (2002).
69. Boivin, M. J. et al. Neuropsychological effects of konzo: a neuromotor disease associated with poorly processed cassava. Pediatrics 131, e1231-e1239 (2013).
70. Breton, J. et al. Gut microbiota limits heavy metals burden caused by chronic oral exposure. Toxicol. Lett. 222, 132-138 (2013).
71. Alonso, C. et al. Intestinal barrier function and the brain-gut axis. Adv. Exp. Med. Biol. 817, 73-113 (2014).
72. Sommer, F., Backhed, F. The gut microbiota-masters of host development and physiology. Nature Rev. Microbiol. 11, 227-238 (2013).
73. Arrieta, M. C. et al. The intestinal microbiome in early life: health and disease. Front. Immunol. 5, 427 (2014).
74. Gleadow, R. M. et al. Growth and nutritive value of cassava (Manihot esculenta Cranz.) are reduced when grown in elevated CO. Plant Biol. 11 (Suppl 1), 76-82 (2009).
75. Erisman, J. W. et al. Put people at the centre of global risk management. Nature 519, 151-153 (2015).
76. Nean, A., Guillarte, T. Mechanisms of heavy metal neurotoxicity: lead and manganese. Toxicol. Res. 2, 99-114 (2013).
77. Mason, L. H., Harp, J. P., Han, D. Y. Pb neurotoxicity: neuropsychological effects of lead toxicity. Biomed. Res. Int. 2014, 840547 (2014).
78. Sanders, T. et al. Neurotoxic effects and biomarkers of lead exposure: a review. Rev. Environ. Health 24, 15-45 (2009).
79. Farina, M., Rocha, J. B., Aschner, M. Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies. Life Sci. 89, 555-563 (2011).
80. Ercal, N., Gurer-Orhan, H., Aykin-Burns, N. Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage. Curr. Top. Med. Chem. 1, 529-539 (2001).
81. Florea, A. M., Busselberg, D. Occurrence, use and potential toxic effects of metals and metal compounds. Biometals 19, 419-427 (2006).
82. Valko, M., Morris, H., Cronin, M. T. Metals, toxicity and oxidative stress. Curr. Med. Chem. 12, 1161-1208 (2005).
83. Catalani, S. et al. Neurotoxicity of cobalt. Hum. Exp. Toxicol. 31, 421-437 (2012).
84. Kumar, V., Gill, K. D. Aluminium neurotoxicity: neurobehavioural and oxidative aspects. Arch. Toxicol. 83, 965-978 (2009).
85. Harley, K. G. et al. Prenatal and early childhood bisphenol A concentrations and behavior in school-aged children. Environ. Res. 126, 43-50 (2013).
86. Yolton, K. et al. Prenatal exposure to bisphenol A and phthalates and infant neurobehavior. Neurotoxicol. Teratol. 33, 558-566 (2011).
87. Engel, S. M. et al. Prenatal phthalate exposure is associated with childhood behavior and executive functioning. Environ. Health Perspect. 118, 565-571 (2010).
88. Miodovnik, A. et al. Endocrine disruptors and childhood social impairment. Neurotoxicology 32, 261-267 (2011).
89. Jamal, G. A. et al. A clinical neurological, neurophysiological, and neuropsychological study of sheep farmers and dippers exposed to organophosphate pesticides. Occup. Environ. Med. 59, 434-441 (2002).
90. Blanc-Lapierre, A. et al. Cognitive disorders and occupational exposure to organophosphates: results from the PHYTONER study. Am. J. Epidemiol. 177, 1086-1096 (2013).
91. Fonnum, F., Mariussen, E. Mechanisms involved in the neurotoxic effects of environmental toxicants such as polychlorinated biphenyls and brominated flame retardants. J. Neurochem. 111, 1327-1347 (2009).
92. Costa, L. G. et al. A mechanistic view of polybrominated diphenyl esters developmental neurotoxicity. Toxicol. Lett. 15, 282-294 (2014).
93. Linares, V., Belles, M., Domingo, J. L. Human exposure to PBDE and critical evaluation of health hazards. Arch. Toxicol. 89, 335-356 (2015).
94. Viaene, M. Overview of the neurotoxicants effects in solvent-exposed workers. Arch. Public Health 60, 217-232 (2002).
95. Tshala-Katumbay, D. et al. New insights into mechanisms of gamma-diketone-induced axonopathy. Neurochem. Res. 34, 1919-1923 (2009).
96. Kassa, R. M. et al. On the biomarkers and mechanisms of konzo, a distinct upper motor neuron disease associated with food (cassava) cyanogenic exposure. Food Chem. Toxicol. 49, 571-578 (2011).
97. Spencer, P. S. Food toxins, ampa receptors, and motor neuron diseases. Drug Metab. Rev. 31, 561-587 (1999).
98. Makila-Mabe, B.G. et al. Serum 8,12-iso-iPF2alpha-VI isoprostane marker of oxidative damage and cognition deficits in children with konzo. PLoS ONE 9, e107191 (2014).
99. Kang, Y. et al. Arsenic in Chinese coals: distribution, modes of occurrence, and environmental effects. Sci. Total Environ. 412-413, 1-13 (2011).
100. Liu, J. et al. Chronic arsenic poisoning from burning high-arsenic-containing coal in Guizhou, China. Environ. Health Perspect. 110, 119-122 (2002).
101. Block, M. L. et al. Nanometer size diesel exhaust particles are selectively toxic to dopaminergic neurons: the role of microglia, phagocytosis, and NADPH oxidase. FASEB J. 18, 1618-1620 (2004).
102. Kilburn, K. H. Effects of diesel exhaust on neurobehavioral and pulmonary functions. Arch. Environ. Health 55, 11-17 (2000).
103. Costa, L. G. et al. Neurotoxicants are in the air: convergence of human, animal, and in vitro studies on the effects of air pollution on the brain. Biomed. Res. Int. 2014, 736385 (2014).