Cassava food toxins, Konzo disease, and neurodegeneration in sub-Sahara Africans

Neurology

Volumn 80, Issue 10, 2013, Pages 949-951

  Tshala Katumbay, D ^a,b   Mumba, N ^b   Okitundu, L ^b   Kazadi, K ^b   Banea, M ^c   Tylleskar T ^d   Boivin, M ^e   Muyembe Tamfum, J J ^b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF KINSHASA   (Congo)

^c Institut National de Recherches Biomédicales ^*  (Congo)

^d UNIVERSITY OF BERGEN   (Norway)

^e MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYANIC ACID; CYANIDE; LINAMARIN; THIOCYANATE;

AFRICAN AMERICAN; CASSAVA; COGNITION; EVOKED MUSCLE RESPONSE; HUMAN; KONZO DISEASE; MOTOR NEURON DISEASE; NERVE DEGENERATION; NEUROTOXICITY; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SEROLOGY; SPASTIC PARAPLEGIA;

AFRICA SOUTH OF THE SAHARA; HUMANS; MANIHOT; MOTOR NEURON DISEASE; PLANT POISONING; PLANTS, TOXIC; TOXINS, BIOLOGICAL;

EID: 84876265895     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e3182840b81     Document Type: Review

References (5)

1. Kisby GE, Spencer PS. Is neurodegenerative disease a long-latency response to early-life genotoxin exposure? Int J Environ Res Public Health 2011;8:3889-3921.
2. Tshala-Katumbay DD, Spencer PS. Toxic disorders of the upper motor neuron system. In: Eisen A, Shaw P, editors. Handbook of Clinical Neurology, Vol 82. New York: Elsevier; 2007:353-372.
3. Howlett WP, Brubaker GR, Mlingi N, Rosling H. Konzo, an epidemic upper motor neuron disease studied in Tanzania. Brain 1990;113:223-235.
4. Tshala-Katumbay D, Eeg-Olofsson KE, Kazadi-Kayembe T, Tylleskär T, Fällmar P. Analysis of motor pathway involvement in konzo using transcranial electrical and magnetic stimulation. Muscle Nerve 2002;25:230-235.
5. Kassa RM, Kasensa NL, Monterroso VH, et al. On the biomarkers and mechanisms of konzo, a distinct upper motor neuron disease associated with food (cassava) cyanogenic exposure. Food Chem Toxicol 2011;49:571-578.