Brazilein suppresses inflammation through inactivation of IRAK4-NF-kb pathway in LPS-induced Raw264.7 macrophage cells

International Journal of Molecular Sciences

Volumn 16, Issue 11, 2015, Pages 27589-27598

  Kim, Kui Jin ^a   Yoon, Kye Yoon ^a   Yoon, Hyung Sun ^b   Oh, Sei Ryang ^c   Lee, Boo Yong ^a  

^a Department of Internal Medicine   (South Korea)

^b Soonchunhyang University   (South Korea)

^c Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

Brazilein; Functional food; Health benefits; Inflammation; IRAK4; MAPK; NF B; Toll like receptors

Indexed keywords

CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 11; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOCYTE CHEMOTACTIC PROTEIN 1; STRESS ACTIVATED PROTEIN KINASE; ANTIINFLAMMATORY AGENT; AUTACOID; BENZOPYRAN DERIVATIVE; BRAZILEIN; CYTOKINE; INDENE DERIVATIVE; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; PROTEIN BINDING;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOWNSTREAM PROCESSING; ENZYME LINKED IMMUNOSORBENT ASSAY; FUNCTIONAL FOOD; GENE INACTIVATION; GENE TRANSLOCATION; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATION; LUCIFERASE ASSAY; MACROPHAGE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SIGNAL TRANSDUCTION; TRANSIENT TRANSFECTION; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CELL LINE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZOPYRANS; CELL LINE; CELLS, CULTURED; CYCLOOXYGENASE 2; CYTOKINES; GENE EXPRESSION REGULATION; INDENES; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; LIPOPOLYSACCHARIDES; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MICE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PROTEIN BINDING; SIGNAL TRANSDUCTION;

EID: 84947549123     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms161126048     Document Type: Article

References (38)

1. Villiger, P.M.; Terkeltaub, R.; Lotz, M. Production of monocyte chemoattractant protein-1 by inflamed synovial tissue and cultured synoviocytes. J. Immunol. 1992, 149, 722–727.
2. Malyshev, I.Y.; Shnyra, A. Controlled modulation of inflammatory, stress and apoptotic responses in macrophages. Curr. Drug Targets Immune Endocr. Metab. Disord. 2003, 3, 1–22.
3. Lynch, M.A. The multifaceted profile of activated microglia. Mol. Neurobiol. 2009, 40, 139–156.
4. Brown, K.L.; Cosseau, C.; Gardy, J.L.; Hancock, R.E. Complexities of targeting innate immunity to treat infection. Trends Immunol. 2007, 28, 260–266.
5. O'Neill, L.A. Tlrs: Professor mechnikov, sit on your hat. Trends Immunol. 2004, 25, 687–693.
6. Akira, S.; Uematsu, S.; Takeuchi, O. Pathogen recognition and innate immunity. Cell 2006, 124, 783–801.
7. Beutler, B.; Rietschel, E.T. Innate immune sensing and its roots: The story of endotoxin. Nat. Rev. Immunol. 2003, 3, 169–176.
8. Lu, Y.C.; Yeh, W.C.; Ohashi, P.S. Lps/tlr4 signal transduction pathway. Cytokine 2008, 42, 145–151.
9. Akira, S.; Takeda, K. Toll-like receptor signalling. Nat. Rev. Immunol. 2004, 4, 499–511.
10. Kawai, T.; Akira, S. Tlr signaling. Cell Death Differ. 2006, 13, 816–825.
11. Gohda, J.; Matsumura, T.; Inoue, J. Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not Toll/il-1 receptor domain-containing adaptor-inducing IFN-_(TRIF)-dependent pathway in TLR signaling. J. Immunol. 2004, 173, 2913–2917.
12. Sato, S.; Sanjo, H.; Takeda, K.; Ninomiya-Tsuji, J.; Yamamoto, M.; Kawai, T.; Matsumoto, K.; Takeuchi, O.; Akira, S. Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat. Immunol. 2005, 6, 1087–1095.
13. Keating, S.E.; Maloney, G.M.; Moran, E.M.; Bowie, A.G. IRAK-2 participates in multiple Toll-like receptor signaling pathways to NF_B via activation of TRAF6 ubiquitination. J. Biol. Chem. 2007, 282, 33435–33443.
14. Takaesu, G.; Ninomiya-Tsuji, J.; Kishida, S.; Li, X.; Stark, G.R.; Matsumoto, K. Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway. Mol. Cell. Biol. 2001, 21, 2475–2484.
15. Chang, L.; Karin, M. Mammalian map kinase signalling cascades. Nature 2001, 410, 37–40.
16. Fitzgerald, K.A.; McWhirter, S.M.; Faia, K.L.; Rowe, D.C.; Latz, E.; Golenbock, D.T.; Coyle, A.J.; Liao, S.M.; Maniatis, T. Ikkepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat. Immunol. 2003, 4, 491–496.
17. Sato, M.; Suemori, H.; Hata, N.; Asagiri, M.; Ogasawara, K.; Nakao, K.; Nakaya, T.; Katsuki, M.; Noguchi, S.; Tanaka, N. et al. Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-_/_ gene induction. Immunity 2000, 13, 539–548.
18. Wang, X.; Sakuma, T.; Asafu-Adjaye, E.; Shiu, G.K. Determination of ginsenosides in plant extracts from panax ginseng and panax quinquefolius l. By lc/ms/ms. Anal. Chem. 1999, 71, 1579–1584.
19. Goh, F.G.; Midwood, K.S. Intrinsic danger: Activation of Toll-like receptors in rheumatoid arthritis. Rheumatology 2012, 51, 7–23.
20. Martinez-Soto, J.C.; Garcia-Vazquez, F.A.; Gumbao, D.; Landeras, J.; Gadea, J. Assessment of two thawing processes of cryopreserved human sperm in pellets. Cryobiology 2012, 63, 131–136.
21. Sasaki, Y.; Hosokawa, T.; Nagai, M.; Nagumo, S. In vitro study for inhibition of no production about constituents of sappan lignum. Biol. Pharm. Bull. 2007, 30, 193–196.
22. Bae, I.K.; Min, H.Y.; Han, A.R.; Seo, E.K.; Lee, S.K. Suppression of lipopolysaccharide-induced expression of inducible nitric oxide synthase by brazilin in raw 264.7 macrophage cells. Eur. J. Pharmacol. 2005, 513, 237–242.
23. Shen, J.; Zhang, H.; Lin, H.; Su, H.; Xing, D.; Du, L. Brazilein protects the brain against focal cerebral ischemia reperfusion injury correlating to inflammatory response suppression. Eur. J. Pharmacol. 2007, 558, 88–95.
24. Ye, M.; Xie, W.D.; Lei, F.; Meng, Z.; Zhao, Y.N.; Su, H.; Du, L.J. Brazilein, an important immunosuppressive component from caesalpinia sappan l. Int. Immunopharmacol. 2006, 6, 426–432.
25. Zhong, X.; Wu, B.; Pan, Y.J.; Zheng, S. Brazilein inhibits survivin protein and mRNA expression and induces apoptosis in hepatocellular carcinoma HepG2 cells. Neoplasma 2009, 56, 387–392.
26. Tak, P.P.; Firestein, G.S. Nf-kappab: A key role in inflammatory diseases. J. Clin. Investig. 2001, 107, 7–11.
27. Yang, F.; Oz, H.S.; Barve, S.; de Villiers, W.J.; McClain, C.J.; Varilek, G.W. The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-_B activation by inhibiting I _B kinase activity in the intestinal epithelial cell line IEC-6. Mol. Pharmacol. 2001, 60, 528–533.
28. Pan, M.H.; Lin-Shiau, S.Y.; Ho, C.T.; Lin, J.H.; Lin, J.K. Suppression of lipopolysaccharide-induced nuclear factor-kappab activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of ikappab kinase activity in macrophages. Biochem. Pharmacol. 2000, 59, 357–367.
29. Hsieh, C.Y.; Tsai, P.C.; Chu, C.L.; Chang, F.R.; Chang, L.S.; Wu, Y.C.; Lin, S.R. Brazilein suppresses migration and invasion of MDA-MB-231 breast cancer cells. Chem. Biol. Interact. 2013, 204, 105–115.
30. Schulze-Osthoff, K.; Ferrari, D.; Riehemann, K.; Wesselborg, S. Regulation of NF-κB activation by map kinase cascades. Immunobiology 1997, 198, 35–49.
31. Fujioka, S.; Niu, J.; Schmidt, C.; Sclabas, G.M.; Peng, B.; Uwagawa, T.; Li, Z.; Evans, D.B.; Abbruzzese, J.L.; Chiao, P.J. NF-κB and AP-1 connection: Mechanism of NF-κB-dependent regulation of AP-1 activity. Mol. Cell. Biol. 2004, 24, 7806–7819.
32. Guo, L.L.; Xiao, S.; Guo, Y. Activation of transcription factors NF-κB and AP-1 and their relations with apoptosis associated-proteins in hepatocellular carcinoma. World J. Gastroenterol. 2005, 11, 3860–3865.
33. Ryu, S.J.; Choi, H.S.; Yoon, K.Y.; Lee, O.H.; Kim, K.J.; Lee, B.Y. Oleuropein suppresses lps-induced inflammatory responses in raw 264.7 cell and zebrafish. J. Agric. Food Chem. 2015, 63, 2098–2105.
34. Kim, K.J.; Yoon, K.Y.; Lee, B.Y. Low molecular weight fucoidan from the sporophyll of undaria pinnatifida suppresses inflammation by promoting the inhibition of mitogen-activated protein kinases and oxidative stress in raw264.7 cells. Fitoterapia 2012, 83, 1628–1635.
35. Huang, G.J.; Huang, S.S.; Deng, J.S. Anti-inflammatory activities of inotilone from phellinus linteus through the inhibition of MMP-9, NF-κB, and MAPK activation in vitro and in vivo. PLoS ONE 2012, 7, e35922.
36. Shao, H.J.; Jeong, J.B.; Kim, K.J.; Lee, S.H. Anti-inflammatory activity of mushroom-derived hispidin through blocking of nf-kappab activation. J. Sci. Food Agric. 2015, 95, 2482–2486.
37. Li, X. IRAK4 in TLR/IL-1R signaling: Possible clinical applications. Eur. J. Immunol. 2008, 38, 614–618.
38. Oh, S.R.; Kim, D.S.; Lee, I.S.; Jung, K.Y.; Lee, J.J.; Lee, H.K. Anticomplementary activity of constituents from the heartwood of caesalpinia sappan. Planta Med. 1998, 64, 456–458.