Poorly cross-linked peptidoglycan in MRSA due to mecA induction activates the inflammasome and exacerbates immunopathology

Cell Host and Microbe

Volumn 18, Issue 5, 2015, Pages 604-612

  Müller, Sabrina ^a   Wolf, Andrea J ^a   Iliev, Iliyan D ^a   Berg, Bethany L ^a   Underhill, David M ^a   Liu, George Y ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAM ANTIBIOTIC; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1; INTERLEUKIN 1BETA; PENICILLIN BINDING PROTEIN 2A; PEPTIDOGLYCAN; BACTERIAL PROTEIN; LACTAM; MECA PROTEIN, STAPHYLOCOCCUS AUREUS; PENICILLIN BINDING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CROSS LINKING; CYTOKINE PRODUCTION; DISEASE EXACERBATION; IMMUNOPATHOLOGY; IN VITRO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MORBIDITY; MOUSE; NONHUMAN; PATHOGENICITY; PHAGOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN ISOLATION; PROTEIN STRUCTURE; SOLUBILIZATION; STAPHYLOCOCCAL SKIN INFECTION; ANIMAL; C57BL MOUSE; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; PHYSIOLOGY; STAPHYLOCOCCAL INFECTIONS; VIRULENCE;

ANIMALS; BACTERIAL PROTEINS; INFLAMMASOMES; INTERLEUKIN-1BETA; LACTAMS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICE; MICE, INBRED C57BL; PENICILLIN-BINDING PROTEINS; PEPTIDOGLYCAN; STAPHYLOCOCCAL INFECTIONS; VIRULENCE;

EID: 84947426406     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2015.10.011     Document Type: Article

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